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YELLOW FEVER

Yellow fever is an acute viral hemorrhagic disease transmitted by infected mosquitoes. 

Yellow fever is an acute, contagious, notifiable viral hemorrhagic fever endemic in central and South America and Africa.

The name derives from the jaundice (yellowing of the skin and eyes) that affects some patients. 

Aetiology:

Yellow fever is caused by the yellow fever virus (YFV), an arbovirus belonging to the Flavivirus genus of the Flaviviridae family. The virus is approximately 25-65 nm in size and can survive at 40°C for a month and in a freeze-dried state for many years.

Forms and Routes of Transmission:

The primary mode of transmission is through the bite of infected Aedes mosquitoes (primarily Aedes aegypti in urban areas and Aedes africanus in sylvatic/jungle cycles). These mosquitoes become infected when they feed on the blood of infected primates (monkeys, apes) or humans.

There are two main transmission cycles:

• Sylvatic (Jungle) Cycle: This cycle involves transmission between monkeys and mosquitoes in forested areas. Humans can become infected through contact with this sylvatic cycle if they venture into these areas.
• Urban Cycle: This cycle occurs in urban areas where Aedes aegypti mosquitoes are abundant and feed on both infected humans and other humans. This cycle is responsible for larger outbreaks.

Incubation Period:

The incubation period for yellow fever is typically 3 to 6 days, but can range from 2 to 15 days. This is the time between the bite of an infected mosquito and the onset of symptoms.

Pathology:

After entering the body through a mosquito bite, the virus multiplies in lymph nodes and organs (liver, kidneys, heart, lungs, spleen, brain, digestive tract). The virus primarily affects specialized epithelial or myocardial cells. Cellular changes range from cloudy swelling to generalized fatty changes, coagulation, and necrosis.

• Liver: Destruction of epithelial cells in liver lobes.
• Kidneys: Necrosis of tubular epithelium.
• GIT: Hemorrhage due to damage of blood vessels.

Death can result from liver or kidney failure (or both). Damage to the sino-atrial node, bundle of His, and myocardial cells can also contribute.

Clinical Features

Yellow fever presents in two phases:

Phase 1 (Acute Phase): This phase usually lasts 3-4 days and includes:

• Sudden onset of fever (often high, 38.3°C to 40°C or higher)
• Severe headache
• Muscle aches (particularly back pain)
• Shivering
• Nausea and vomiting
• Loss of appetite
• Fatigue
• Malaise

Phase 2 (Toxic Phase): This phase doesn\’t always occur and only develops in severe cases. It\’s characterized by:

• Jaundice (yellowing of the skin and whites of the eyes)
• Bleeding (from the nose, mouth, or gums – hemorrhage)
• Abdominal pain
• Dark urine
• Low blood pressure (hypotension)
• Impaired kidney function
• Delirium
• Shock
• Seizures

A short period of recovery may occur, followed by a return of fever and rapid deterioration with liver and kidney failure.

• Continuous abdominal pain with vomiting of altered blood (\”coffee ground\” or fresh blood) or black vomit (melena), and potentially diarrhoea.
• Bleeding from eyes, nose, mouth, bladder, rectum, and other organs.
• Heavy proteinuria (protein in the urine) with oliguria (decreased urine output) and granular casts, red blood cells (RBCs), and haemoglobin (Hb) in the urine.
• Death occurs with increasing proteinuria, haemorrhage, rising pulse, hypotension, and oliguria.

Diagnosis and Investigations:

Diagnosis is based on:

• Clinical presentation: Symptoms are highly suggestive.
• Serological tests: Detection of IgM antibodies in the blood using ELISA (enzyme-linked immunosorbent assay) or other methods indicates recent infection. LFT’s and RFT’s
• Virus isolation: This can be performed from blood samples during the acute phase of illness, but is less commonly used due to the availability of serological testing.
• PCR (Polymerase Chain Reaction): Detection of viral RNA in blood samples. This is a more sensitive technique for confirming diagnosis.

Management:

Aims:

The primary aims of management are:

• To provide supportive care to manage symptoms.
• To prevent complications.
• To reduce mortality.

Medical Management:

No specific antiviral treatment is available for yellow fever. Management focuses on supportive care, including:

• Fluid and electrolyte balance: Careful monitoring and replacement are crucial.
• Respiratory support: Oxygen therapy as needed.
• Blood pressure management: Vasopressors if needed.
• Seizure control: Anticonvulsants as needed.
• Monitoring for organ dysfunction: Close monitoring of kidney function, liver function and other organ systems is critical.
• Nutritional support: Enteral or parenteral nutrition as necessary.

Nursing Care:

Nursing care is essential and focuses on:

• Monitoring vital signs: Frequent monitoring of temperature, heart rate, blood pressure, respiratory rate, and oxygen saturation.
• Fluid balance management: Careful monitoring of fluid intake and output.
• Neurological assessment: Regular neurological checks for signs of encephalopathy.
• Skin assessment: Monitoring for jaundice and signs of bleeding.
• Hygiene: Maintaining personal hygiene to prevent skin breakdown.
• Pain management: Providing analgesics as needed.
• Emotional support: Providing emotional support to the patient and their family.

Prevention:

• Vaccination: The most effective preventive measure is vaccination. A single dose of the yellow fever vaccine provides lifelong protection.
• Mosquito Control: Reducing mosquito breeding sites through eliminating standing water, using insecticides and using mosquito nets.
• Personal Protective Measures: Wearing protective clothing (long sleeves, long pants) and using insect repellent containing DEET or other EPA-approved repellents when in endemic areas.

Complications:

• Hepatitis: Liver inflammation can lead to liver failure.
• Renal failure: Kidney damage can result in acute kidney injury or failure.
• Encephalitis: Brain inflammation can lead to neurological deficits.
• Myocarditis: Heart muscle inflammation.
• Hemorrhagic manifestations: Severe bleeding can be life threatening.
• Shock: This can be fatal if not promptly managed.
• Death: Yellow fever can be fatal in a significant proportion of severe cases.

HAEMORRHAGIC FEVERS

Ebola and Marburg

• Ebola and Marburg are severe zoonotic multisystem febrile diseases caused by RNA viruses. They are notifiable diseases.

Ebola Virus:

• Morphology: The Ebola virus is filamentous, often resembling a \”U\” or \”S\” shape. It measures approximately 2 μm (micrometers) in length and 70-80 nm (nanometers) in diameter. It has an internal structure (nucleoprotein core) enclosed within an external envelope studded with numerous glycoprotein spikes.
• Multiplication: The virus replicates by budding from its internal structures.

Types of Ebola Viruses:

Ebola Virus (EBOV): This is the species most commonly associated with severe outbreaks in humans.

• EBO-Zaire (EBO-Z): This subtype has a high fatality rate, averaging around 89%.
• EBO-Sudan (EBO-S): This subtype has a fatality rate of 41.65%, although this can vary depending on factors like treatment and location.

Vectors:

• Mosquitoes and Termites: While there have been theories suggesting these insects could play a role in transmission, there is no definitive evidence to support their role as vectors for Ebola.
• Bats: The most likely primary reservoir for Ebola viruses. They can harbor the virus without showing symptoms and transmit it to other animals or humans.
• Dogs: While some sources mention dogs, there is no clear evidence to suggest they are a significant reservoir for Ebola.

Transmission:

Human-to-Human:

• Direct contact with infected bodily fluids, such as blood, vomit, feces, urine, and saliva.
• Contact with contaminated materials like clothing, bedding, needles, and medical equipment.
• Sexual contact with a survivor who is still shedding the virus in semen (this can last for months after recovery).

Animal-to-Human: Contact with infected animals (particularly primates like chimpanzees and gorillas) or their bodily fluids.

Mosquitoes: As mentioned above, mosquitoes are not considered reliable vectors for Ebola virus transmission.

 

Pathology:

The Ebola virus affects multiple tissues throughout the body, not just a specific organ. It causes widespread damage, including:

• Necrotic Lesions: The virus leads to cell death (necrosis) in various organs, affecting their functionality.
• Immune System Suppression: Ebola weakens the immune system, making individuals vulnerable to other infections.

Incubation Period:

• Primary Infection: The incubation period typically ranges from 2 to 21 days after exposure.
• Secondary Infection: For transmission from human to human, the incubation period is the same, 2 to 21 days.

Causes:

Ebola Virus: The causative agent is the Ebola virus, a member of the Filoviridae family. There are five known species of Ebola virus:

• Zaire ebolavirus (responsible for the most severe outbreaks)
• Sudan ebolavirus
• Reston ebolavirus (not known to cause disease in humans)
• Taï Forest ebolavirus
• Bundibugyo ebolavirus

Marburg: Marburg virus

Risk Factors:

• Communities Around Game Parks: Proximity to wildlife increases the risk of exposure.
• Endemic Areas: Regions with a history of EVD outbreaks.
• Cultural Practices: Burial rituals involving close contact with the deceased can facilitate transmission.
• Poor Infection Control: Inadequate sanitation and hygiene practices in healthcare settings can increase the spread.
• History of Exposure: Contact with infected individuals within 2-21 days prior to symptom onset (e.g., sexual partners, breastfeeding mothers).
• Contact with Infected Animals: Handling infected animals (like monkeys, bats, and infected game meat).

Clinical Features:

Early Signs (Non-Specific):

• Sudden Fever: A rapid onset of high fever (often exceeding 101.5 °F / 38.6 °C).
• Weakness: General feeling of weakness and exhaustion.
• Headache: Intense headache.
• Muscle Pain: Pain in muscles and joints.
• Loss of Appetite: Decreased appetite or inability to eat.
• Conjunctivitis: Inflammation of the conjunctiva (white part of the eye).

Late Signs:

• Diarrhea: Profuse diarrhea, sometimes with blood.
• Vomiting: Severe vomiting.
• Mucosal and Gastrointestinal Bleeding: Bleeding from the nose, gums, eyes, and rectum.
• Chest Pain: Pain in the chest area.
• Respiratory Distress: Difficulty breathing.
• Circulatory Shock: Low blood pressure and impaired blood flow.
• CNS Dysfunction: Confusion, seizures, and coma.
• Miscarriage in Pregnancy: EVD can cause miscarriage or stillbirth in pregnant women.
• Elevated AST and ALT: Elevated levels of liver enzymes, indicating liver damage.
• Kidney Injury: Damage to the kidneys, potentially leading to kidney failure.
• Electrolyte Abnormalities: Imbalances in electrolytes (minerals like potassium and sodium) in the body.

Other clinical presentations include; 

• Sudden Onset: Symptoms usually appear abruptly.
• Severe Headache: Intense headache is a common initial symptom.
• Myalgia and Fever: Muscle pain (myalgia) and high fever (often exceeding 38.5 °C).
• Conjunctival Inflammation: Inflammation of the conjunctiva (white part of the eye).
• Gingival Bleeding: Bleeding from the gums.
• Sore Throat: Sore throat with associated chest pain.
• Abdominal Pain: Pain in the abdomen.
• Nausea, Vomiting, and Diarrhea: These symptoms are prominent features of EVD, with diarrhea often being profuse and watery.
• Signs of Dehydration: Dehydration can develop due to fluid loss from vomiting and diarrhea.
• Severe Bleeding: Internal and external bleeding may occur from the gastrointestinal tract, gums, nose, and other orifices. This typically develops between the 5th and 7th days.
• Morbiliform Rash: A rash similar to measles may appear on the 7th day.
• Neurological Manifestations: Neurological complications such as psychosis and hemiplegia (weakness or paralysis on one side of the body) can occur.
• Death: Death often occurs around the 9th day, but can happen between the 2nd and 21st days.

Note: Hemorrhage is not always a prominent feature of EVD. It\’s important to remember that EVD symptoms can vary significantly.

Differential Diagnosis:

• Malaria: A parasitic disease that also causes fever, headache, and muscle aches.
• Meningitis: Inflammation of the membranes surrounding the brain and spinal cord.
• Shigellosis: A bacterial infection causing diarrhea, abdominal cramps, and fever.
• Typhoid Fever: A bacterial infection causing high fever, headache, and constipation.
• Anthrax: A bacterial infection causing skin lesions, fever, and respiratory problems.
• Sepsis: A serious bacterial infection causing fever, chills, and rapid heart rate.
• Viral Hepatitis: Inflammation of the liver caused by viruses like hepatitis A, B, or C.
• Dengue Fever: A viral infection transmitted by mosquitoes, causing fever, headache, and muscle pain.

Investigations:

Blood Sample for Specific Testing: Blood samples from suspected EVD cases should be collected by trained healthcare professionals wearing proper PPE.

• Laboratory Testing: The blood sample needs to be sent to a reference laboratory for specific tests to identify the Ebola virus.
• Real-Time PCR: This is the preferred method for detecting Ebola virus.
• Antigen and Antibody Detection: ELISA (enzyme-linked immunosorbent assay) and other antibody tests can identify Ebola virus antigens and antibodies.

Postmortem: If an individual dies from EVD, postmortem examination is critical for confirmation and to prevent further spread.

Notification: Immediately notify the district surveillance focal person if you suspect a case of EVD.

Management

Management Aims:

• Fluid Replacement: Maintain adequate hydration to compensate for fluid loss.
• Prevention of Spread: Isolate the patient and implement strict infection control measures.
• Conservation of Energy: Provide rest and supportive care to conserve energy.
• Symptom Relief: Administer medications to manage symptoms like fever, pain, and vomiting.

Specific Management:

1. Admission: Admit the patient to an isolated room in a medical ward, providing complete bed rest.

• Bed Preparation: Use a freshly prepared bed, with a comfortable position for the patient (supine or semi-recumbent depending on their condition).

2. Protection:

• Handwashing: Strict handwashing before and after attending to the patient.
• Isolation: Isolate the patient in a designated room, and implement barrier nursing techniques. Healthcare workers and patient attendants should wear gowns, gloves, goggles, and gumboots to prevent contact with bodily fluids.
• Identification Tag: Place an \”INFECTIOUS\” tag on the door to alert others about the infectious nature of the room.

3. Fluid Replacement: Administer intravenous fluids (N/S, RL, and Dextrose 5%) according to the doctor\’s prescription.

4. Hygiene:

• Patient Hygiene: Maintain cleanliness of the patient\’s skin, secretions, and stool. Disinfect with bleach solutions before disposal.
• Bed Pans: Scrub bed pans thoroughly with strong detergent, rinse, and dry.
• Patient\’s Orifices: Wash and dry the patient\’s orifices. Apply perineal pads if needed for profuse diarrhea.
• Linens: Disinfect linens in a bleach solution for at least 6 hours. Label and transport them in \”infected linen\” bags to be sluiced, boiled, dried, and ironed.
• Room Disinfection: Mop the room, scrub the floors and walls, disinfect lockers, and wash and boil patient utensils for at least 10 minutes.
• Refuse Disposal: Place food and hospital refuse in polythene bags and incinerate.

5. Diet: Provide a fluid diet in the acute stage, primarily through IV fluids and oral fluids as much as possible.

6. Terminal Disinfection: Thoroughly disinfect the room and all contaminated materials after the patient is discharged.

7. Notification: Report the case to health authorities to inform the public health system about the outbreak.

Health Education:

• Patient Attendants: Educate patient attendants about the infection, its mode of transmission, and prevention measures.
• General Public: Inform the general public about the disease, its signs and symptoms, and preventative measures.
• Patient Care: Ensure the patient feels supported and understood, preventing isolation and stigma.

Prevention:

• Avoid Contact: Minimize contact with the patient\’s blood and secretions.
• Personal Protective Equipment: Wear proper PPE (gowns, gloves, masks, eye protection) when providing care.
• Safe Burial Practices: Use safe burial practices to prevent transmission during funerals.
• Vaccination: The Ebola vaccine is available and should be considered for high-risk individuals.
• Isolation: Isolate infected individuals in designated Ebola treatment centers.
• Contact Tracing: Identify and monitor individuals who have come into contact with infected persons.

Prevention Complications:

• Shock: Monitor for signs of shock (low blood pressure, rapid heart rate, weakness, and cool, clammy skin).
• Organ Failure: Monitor for signs of organ failure (e.g., jaundice for liver failure, decreased urine output for kidney failure).
• Disseminated Intravascular Coagulation (DIC): Be aware of the signs of DIC (bleeding from multiple sites, bruising, and difficulty controlling bleeding).
• Meningitis: Monitor for signs of meningitis (stiff neck, headache, fever).
• Encephalitis: Monitor for signs of encephalitis (confusion, seizures).
• Secondary Infections: Monitor for signs of secondary infections (fever, cough, difficulty breathing).
• Psychological Trauma: Provide psychological support to patients and their families to address potential psychological trauma.

Brucellosis (Undulant Fever, Malta Fever, Abortus Fever)

Brucellosis is a zoonotic bacterial infection of acute onset, commonly known as undulant fever, Malta fever, or abortus fever. 

It\’s primarily an occupational disease among people working with infected livestock or associated fresh animal products. This includes butchers, farmers, abattoir workers, and vendors of contaminated roasted meat (muchomo).

Incubation Period:

The incubation period for brucellosis is typically 2-4 weeks, but can range from 1 to 8 weeks.

Forms of Transmission:

• Direct Contact: Contact with infected animals, particularly during handling, slaughtering, or birthing, can lead to transmission.
• Ingestion: Consuming unpasteurized milk, cheese, or other dairy products from infected animals is a common route of transmission.
• Inhalation: Inhaling contaminated aerosols, particularly in settings where animal products are processed or handled, can lead to infection.
• Accidental Exposure: Laboratory workers or those handling animal products in agricultural settings may be at risk of accidental exposure.

Routes of Transmission:

• Occupational Exposure: Farmers, veterinarians, slaughterhouse workers, and laboratory workers are at increased risk of exposure due to their close contact with infected animals.
• Consumption of Contaminated Products: Consuming unpasteurized milk, cheese, or other dairy products from infected animals is a common route of transmission.
• Accidental Exposure: Accidental exposure to contaminated materials or aerosols, particularly in laboratory settings, can lead to infection.

 

Causes/Aetiology:

Brucella Species: The most common species of Brucella that infect humans are:

• Brucella abortus (cattle)
• Brucella melitensis (goats and sheep)
• Brucella suis (pigs)
• Brucella canis (dogs)

Clinical Features:

Brucellosis is known for its diverse range of symptoms, which can appear anywhere from a few days to several weeks after infection. Common features include:

1. Fever: High-grade fever, often accompanied by chills and sweats.
2. Fatigue and Weakness: Profound fatigue, lethargy, and muscle aches.
3. Headache and Stiff Neck: Persistent headache, often accompanied by neck stiffness.
4. Arthritis and Muscle Pain: Pain and inflammation in joints, particularly in the spine and large joints.
5. Sweating: Excessive sweating, particularly at night.
6. Weight Loss: Unintentional weight loss due to poor appetite and decreased food intake.
7. Depression: Emotional disturbances, including depression, anxiety, and irritability.
8. Splenomegaly and Hepatomegaly: Enlargement of the spleen and liver.
9. Orchitis: Inflammation of the testicles in men.
10. Endocarditis: Infection of the heart valves.
11. Meningitis: Inflammation of the meninges (membranes surrounding the brain and spinal cord).

Differential Diagnosis:

• Typhoid fever: Similar symptoms, including high fever, headache, and muscle aches.
• Malaria: Fever episodes that coincide with mosquito bites.
• Tuberculosis: Chronic cough, night sweats, and weight loss.
• Trypanosomiasis (sleeping sickness): Fever, headache, and fatigue, often accompanied by neurological symptoms.
• Other causes of prolonged fever: Other infections, autoimmune disorders, and certain cancers can also cause prolonged fever.

Definitive Diagnosis and Investigations:

• Blood Culture: A positive blood culture for Brucella is considered the definitive diagnosis.
• Serological Tests: Serological tests, such as the agglutination test and the enzyme-linked immunosorbent assay (ELISA), can detect antibodies against Brucella bacteria.
• Other Tests: Additional tests, such as bone marrow culture, urine culture, or biopsy, may be necessary depending on the clinical presentation.
• Blood: Complement fixation test or agglutination test (where possible).
• Isolation of the infectious agent from blood, bone marrow, or other tissues by culture.

Management:

Treatment:

Adults and children > 8 years:

• Doxycycline 100 mg every 12 hours for 6 weeks
• Plus gentamicin 5-7 mg/kg IV daily for 2 weeks
• Or ciprofloxacin 500 mg twice daily for 2 weeks

Children < 8 years:

• Cotrimoxazole 24 mg/kg every 12 hours for 6 weeks
• Plus gentamicin 5-7 mg/kg IV in single or divided doses for 2 weeks

Caution:

• Treatment duration must be adhered to at all times.
• Ciprofloxacin is contraindicated in children <12 years.
• Doxycycline and gentamicin are contraindicated in pregnancy.

Prevention:

• Public health education:

1. Drinking only pasteurized or boiled milk.
2. Careful handling of pigs, goats, dogs, and cattle, especially if a person has wounds or cuts.

• Veterinary services: Provide veterinary services for domestic animals to prevent the spread of infection.
• Safe handling practices: Use proper hygiene practices when handling animals and wear protective clothing.
• Occupational safety: Implement safety protocols and use PPE in occupational settings where exposure to infected animals or their products is likely.
• Food safety: Consume only pasteurized milk, cheese, and other dairy products. Avoid eating raw or undercooked meat from animals suspected of being infected with Brucella.
• Travel precautions: Advise travelers to countries where brucellosis is endemic to be aware of the risks and take necessary precautions.

Complications:

• Endocarditis: Infection of the heart valves, which can be life-threatening.
• Meningitis: Inflammation of the meninges, which can lead to neurological complications.
• Arthritis: Inflammation of joints, particularly in the spine and large joints.
• Osteomyelitis: Infection of the bone, which can lead to bone damage and disability.
• Hepatitis: Inflammation of the liver.
• Orchitis: Inflammation of the testicles in men.
• Chronic Fatigue Syndrome: Persistent fatigue and other symptoms, which can significantly impact quality of life.
• Neurological complications: Neurological complications can occur in severe cases and may include encephalitis, seizures, and coma.

HOME VISITING IN COMMUNITY HEALTH

Home visiting is highly essential to community health services, as a large number of patients are found in their homes.

Home visiting refers to the process of providing nursing care to patients at their residences.

Objectives of Home Visiting:

• Establish close relationships with the community and families.
• Assess the living conditions of families and identify how these conditions affect their health.
• Promote family health by providing health education tailored to the age and developmental stage of each family member.
• Monitor the skills learned during health education sessions.
• Demonstrate to families how to administer necessary healthcare to other family members.
• Refer families to appropriate specialized services when needed.

Factors Influencing the Growth of Home Visiting Services:

• Increasing elderly population facing chronic illnesses.
• Increased prevalence of HIV/AIDS.
• Advanced technology enabling home-based healthcare services.
• Rising cost of healthcare.
• Growing demand for consumer satisfaction.

Principles of Home Visiting:

When conducting home visits, community nurses should adhere to these essential principles:

• Purposeful and beneficial: Home visits should be planned with a clear objective and be beneficial to the patients.
• Needs-driven: The purpose of each visit should align with the specific needs of the patient.
• Beyond surveys and statistics: Home visits shouldn\’t solely rely on surveys or data collection but should incorporate health education and practical support.
• Regular and flexible: Visits should be scheduled regularly but adjusted according to the patient\’s needs.
• Educational: Home visits provide excellent opportunities for health education.
• Convenient and acceptable: Visits should be convenient for the patient and respect their preferences.
• Demonstrative: Home visits should provide nurses with the opportunity to demonstrate hygienic principles.

Effective Home Visiting Practices:

• Family-centered approach: The nurse should actively involve each family member in the care process.
• Positive relationships: Nurses and families should work collaboratively to build strong, trusting relationships that support goal achievement.
• Respect for patient autonomy: Nurses must respect the patient\’s right to accept or refuse care and participate in setting and reaching goals.
• Record-keeping: Home visits should be documented in the patient\’s medical records to ensure continuity of care.

Advantages of Home Visits:

• Provides an ideal setting for implementing the nursing process.
• Offers an opportunity to assess the home and family situation.
• Allows nurses to provide services in the patient\’s familiar environment.
• Facilitates strong relationships between nurses and families.
• Addresses family concerns and clarifies doubts.
• Enables nurses to observe family practices and the progress of care.
• Supports modification of care plans based on observations.
• Offers a viable option for patients unable or unwilling to travel.
• Creates a comfortable atmosphere for discussing concerns and needs.

Components of Home Visiting:

1. Initiation Phase: The community health nurse clarifies the source of referral for the visit, its purpose, and shares this information with the family.

2. Pre-visit Activities: Prior to the visit, nurses gather information about the family, including location, distance, address, and the reason for the visit. This may involve reviewing family folders, consulting other nurses or family members, or contacting health agencies. Information gathered may include age, sex, family structure, culture, values, problems, current care, etc. This information helps the nurse plan appropriately for the visit and address the patient\’s needs effectively.

3. Activities During Home Visits: Community health nurses use their skills to build rapport and trust with the family, which is crucial for a positive relationship. The nurse-patient relationship is vital for providing healthcare services in the community. The nurse introduces herself, establishes her professional identity, and builds the nurse-patient relationship. This relationship should be characterized by:

• One person possessing knowledge and skills that can benefit another.
• The needs of the person receiving assistance taking priority.
• The relationship being self-limiting based on the goals to be achieved.
• The person receiving assistance needing and utilizing the support.
• The assistance being provided competently.
  During visits, the nurse assesses the family\’s needs and plans nursing care accordingly.

4. Termination Phase: The termination of home visits occurs when:

• The nurse-patient goals are achieved, health is restored, and the patient can function without nursing assistance.
• The patient changes residence or moves to another care setting.
• The nurse transfers the patient\’s care to another nurse or caregiver.

5. Post-visit Activities: These include recording and reporting. The nurse documents important events within the family, reports necessary information to higher authorities, discusses family problems with colleagues and other health team members, and plans accurately to meet the family\’s needs.

Areas Associated with Home Visiting:

• General cleanliness
• Solid waste disposal
• Latrine/Toilet facilities
• Personal hygiene
• Infant vaccination (under 1 year)
• Women\’s vaccination
• Antenatal care
• Presence of insects or rodents in the home
• Feeding practices for children over 2 years old
• Family planning
• Presence of sick individuals in the house and actions taken.

Limitations of Home Visiting:

• Time-consuming
• Limited equipment can be transported to homes.
• Appointments may not be kept.
• Uncooperative or violent family members.
• Some homes may be geographically inaccessible.
• Language barriers.

Problems with Home Visits:

• Time and energy consumption: Community health nurses may spend a considerable amount of time traveling to and from homes, which can impact the time available for providing care.
• Non-acceptance: Families may not accept the nurse due to cultural differences, personal characteristics, or socioeconomic status.
• Language barriers: Communication difficulties can arise if the nurse is unfamiliar with the local language.
• Role confusion: Some individuals or families may not fully understand the role of a nurse in home visiting, leading to confusion about expectations.

Vaccines and Immunoglobulins

Vaccines are special preparations of antigenic materials that can be used to stimulate the development of antibodies and thus confer active immunity against a specific disease or a number of diseases. 

Vaccines may be single component or mixed combined vaccines.

Types of Vaccines

Live Attenuated Vaccines: These vaccines contain live microbes that have been weakened (attenuated). Live attenuated vaccines usually confer immunity with a single dose which is of long duration. They may be dangerous in recipients who are immunocompromised because these patients are unable to mount an effective immune response.

Examples:

• Mumps vaccines
• Measles vaccines
• BCG vaccines
• Rubella vaccines
• Chickenpox vaccines

Killed or Inactivated Vaccines: This type of vaccine contains whole inactivated microbes. Inactivated vaccines may require a series of injections in order to produce an adequate body response and in most cases booster doses are required.

Examples:

• Polio vaccines

Toxoids: Toxoid vaccines use bacterial toxins that have been rendered harmless. Administration of the toxoid causes the recipient\’s immune system to manufacture antitoxins directed against the bacterial toxins.

Examples:

• Tetanus toxoid

Immunity

Immunity is the body\’s ability to resist infections afforded by the presence of circulating antibodies and white blood cells.

Types of Immunity

• Active Immunity: Active immunity is induced by the administration of microorganisms or their products which act as antigens to induce the body to produce antibodies.
• Passive Immunity: Passive immunity is obtained by injecting preparations made from the plasma of immune individuals with adequate levels of antibodies to the disease for which protection is sought. Treatment should be given as soon as possible after exposure for effective results. This type of immunity lasts for only a few weeks.

Poliomyelitis Vaccine

Available Preparations:

• Oral suspension of live attenuated poliomyelitis virus

Indications:

• Active immunization against poliomyelitis

Contraindications:

• Hypersensitivity to any of the ingredients
• Patients with diarrhea or vomiting
• Immunocompromised patients
• Pregnancy

Dosage:

• 2 drops at birth
• 2 drops at 6 weeks
• 2 drops at 10 weeks
• 2 drops at 14 weeks

Side Effects:

• Rarely seen

Drug Interactions:

• Concomitant administration with immunosuppressant drugs

Key Issues to Note:

• Live polio vaccine loses potency once the container has been opened; therefore, discard any unused preparation
• Breastfeeding does not interfere with immunization even though polio antibodies may be excreted in breast milk
• If the vaccine is vomited, repeat the dose immediately
• A child who has previously had polio should nevertheless be immunized to offer complete protection

Measles Vaccine

Available Preparations:

• Injection powder for solution (live attenuated measles virus)

Available Brands: Sii® measles vaccine live

Indications:

• Active immunization against measles

Contraindications:

• Hypersensitivity to any antibiotic present in the vaccine
• Hypersensitivity to eggs

Dosage:

• 0.5 ml SC at 9 months (left upper arm)

Side Effects:

• Fever
• Malaise
• Thrombocytopenia
• Headache
• Rashes

Key Issues to Note:

• Vaccination is recommended in all children at the age of 9 months
• Maternal antibodies may interfere with an effective immune response to the vaccine if given in the first 6 months of life
• The vaccine may be given at 6 months in case there is an outbreak in the community
• Vaccination should not be given to patients with untreated active tuberculosis

Measles, Mumps, and Rubella Vaccine (MMR Vaccine)

Available Preparations:

• Injection of live attenuated measles, mumps, and rubella virus

Available Brands: Sii® measles, mumps, and rubella vaccine, Trimovax®, Priorix®

Indications:

• Active immunization against measles, mumps, and rubella

Contraindications:

• Pregnancy
• Hypersensitivity to any antibacterial such as neomycin or kanamycin used in the manufacturing process
• Immunosuppressed patients

Dosage:

• By deep SC or by intramuscular injection 0.5 ml (12-15 months)

Side Effects:

• Fever
• Parotid swelling
• Malaise
• Rash

Drug Interactions:

• Concomitant administration with immunosuppressant drugs

BCG Vaccine

Available Preparations:

• Powder for injection of live bacteria of a strain derived from the bacillus of Calmette and Guerin

Indications:

• Active immunization against tuberculosis

Contraindications:

• Generalized edema
• Immunosuppressed patients
• Antimycobacterial treatment
• Previous TB infections

• Generalized skin diseases

• Tuberculin reaction > 5 mm

Dosage:

• 0.05 ml intradermally in the right upper arm (infants less than 12 months)
• 0.1 ml intradermally on the right upper arm (adults and children greater than 12 months)

Side Effects:

• Keloid formation
• Lymphadenitis
• Localized necrotic ulceration
• Anaphylaxis
• Disseminated BCG infection in immunosuppressed patients

Drug Interactions:

• Concomitant administration with immunosuppressant drugs

DPT Vaccine

Available Preparations:

• Powder for injection

Available Brands: TriPacel®, Infanrix®

Indications:

• Active immunization against diphtheria, tetanus, and pertussis

Dosage:

• Infant: 0.5 ml by intramuscular or deep SC injection at 6, 10, and 14 weeks

Side Effects:

• Irritability
• Restlessness
• Limb swelling
• Malaise
• Peripheral neuropathy
• Myalgia
• Urticaria
• Headache
• Fever
• Loss of appetite

Tetanus Toxoid Vaccine

Available Preparations:

• Injection

Available Brands: Sii® tetanus toxoid vaccine, Tetavax®

Indications:

• Active immunization against tetanus and neonatal tetanus

Dosage:

• Women 15-45 years of age including pregnant women: 0.5 ml deep SC or intramuscular injection at first contact or as early as possible during pregnancy (TT1)
• TT2 (0.5 ml) at least 4 weeks after TT1 or during subsequent pregnancy
• TT3 (0.5 ml) at least 6 months after TT2 or during the subsequent pregnancy
• TT4 (0.5 ml) at least 1 year after TT3 or during subsequent pregnancy
• TT5 (0.5 ml) at least 1 year after TT4 or during subsequent pregnancy

Note: To achieve lifelong protection against tetanus, 5 doses of TT are required.

Side Effects:

• Peripheral neuropathy

Anti-Tetanus Immunoglobulin

Available Preparations:

• Injection 1500 IU

Available Brands: Tetanea®

Indications:

• Passive immunization against tetanus as part of the management of tetanus-prone wounds

Dosage:

• Adult and Children: 1 ml by IM injection. Give additional dose if wound is older than 12 hours or heavily contaminated

Side Effects:

• Local reactions
• Fever
• Pain and tenderness at the site of injection
• Headache

Yellow Fever Vaccine

Available Preparations:

• Injection powder + solvent of live attenuated virus

Available Brands: Stamaril®

Indications:

• Active immunization against yellow fever

Contraindications:

• Immunosuppressed patients
• Known hypersensitivity to any of the ingredients
• Infants under 4 months of age
• Hypersensitivity to eggs

Dosage:

1. Infants at 9 months: 0.5 ml by SC injection
2. Immunization of travelers and others at risk:

• Adult and Children over 9 months: 0.5 ml
• Infants 4-9 months: 0.5 ml only if the risk of yellow fever is unavoidable

Side Effects:

• Headache
• Fever
• Weakness
• Diarrhea
• Myalgia
• Influenza-like symptoms
• Nausea

Drug Interactions:

• Concomitant administration with immunosuppressant drugs
• Cholera vaccine should not be given together with yellow fever vaccine

Typhoid Vaccine

Available Preparations:

• Injection VI capsular polysaccharide typhoid 25 mcg/0.5 ml

Available Brands: Typhim Vi®, Typherix®

Indications:

• Active immunization against typhoid

Contraindications:

• Immunosuppressed patients
• Febrile illness
• Known hypersensitivity to any of the ingredients

Dosage:

• Adult and children over 2 years: By deep SC (subcutaneous) or intramuscular 0.5 ml with booster doses every 3 years for those at continued risk

Side Effects:

• Headache
• Allergic reaction
• Myalgia
• Fever
• Nausea
• Malaise
• Swelling and pain

Key Issues to Note:

• Typhoid fever prevention becomes effective after 2-3 weeks after injection
• Typhoid is rare in children under 2 years; therefore, to immunize in this age group should be based on the risk of exposure
• The vaccine offers protection for a minimum duration of 3 years

Pneumococcal Vaccine

Available Preparations:

• Injection in form of 23-valent polysaccharide vaccine 25 mcg/0.5 ml

Available Brands: Pneumo 23®

Indications:

Immunization against pneumococcal infections in:

• Sickle cell disease in children over 2 years of age
• Immunocompromised patients over 5 years at increased risk of pneumococcal infection

Contraindications:

• Severe allergic reaction to any of the ingredients

Dosage:

• Adult and children over 2 years: 0.5 ml deep SC or IM as a single dose

Side Effects:

• Fever
• Myalgia
• Pain and erythema at injection site

Key Issues to Note:

• Revaccination is recommended every 5-10 years in high-risk patients

Meningococcal Vaccine

Available Preparations:

Injection

• Bivalent vaccine from group A and C
• Tetravalent vaccine from groups A, C, Y, and W135

Available Brands: Meningo A + C®, Mencevax ACWY®

Indications:

• Active immunization against Neisseria meningitidis infections such as meningitis and septicemia

Contraindications:

• Allergy to diphtheria toxoid
• Febrile conditions

Dosage:

• Bivalent: 0.5 ml deep SC or IM injection as a single dose
• Tetravalent: 0.5 ml deep SC injection as a single dose

Side Effects:

• Allergic reaction
• Anaphylaxis
• Erythema

Key Issues to Note:

• Do not use in children under 2 years except in epidemic situations

Cholera Vaccine

Available Preparations:

• Oral vaccine containing live attenuated or inactivated

Available Brands: Dukoral®

Indications:

• Immunization for travelers over 2 years of age at high risk of cholera infections

Contraindications:

• History of hypersensitivity to any of the ingredients
• Acute GIT or febrile

Dosage:

• Children 2-6 years: 3 doses given at intervals of at least 1 week. Give a booster after 6 months if still at risk
• Adult and Children over 6 years of age: 2 doses given at 1-week intervals. Give a booster after 2 years if still at risk

Side Effects:

• Abdominal discomfort
• Headache
• Diarrhea
• Fever

Key Issues to Note:

• Avoid food and drinks 1 hour before and after taking the vaccine

Rabies Vaccine

Available Preparations:

• Injection 2.5 IU/dose

Available Brands: Sii rabivax®, Lyssavac berna®, Verorab®

Indications:

• Active immunization against rabies
• Post-exposure treatment to prevent rabies in patients who have been bitten by rabid animals
• Pre-exposure prophylaxis in persons at high risk of being bitten by rabid animals

Contraindications:

• Known hypersensitivity to any of the ingredients

Dosage:

• Pre-exposure prophylaxis: 1 ml by deep subcutaneous or intramuscular injection on days 0, 7, and 28
• Post-exposure treatment: 1 ml by deep subcutaneous or intramuscular injection on days 0, 3, 7, 14, and 30

Side Effects:

• Pain at injection site
• Fever
• Erythema at injection site
• Malaise
• Nausea
• Myalgia
• Headache
• Hypersensitivity reaction

Hepatitis B Vaccine

Available Preparations:

• Injection containing inactivated hepatitis B surface antigen

Available Brands: Euvax B adult®, Euvax B paed®, Engerix B®

Indications:

• Active immunization against hepatitis B infection

Contraindications:

• History of hypersensitivity

Dosage:

• Adult and Children over 15 years: 1 ml with an interval of 1 month between the 1st and 2nd dose and 5 months between the 2nd and 3rd doses. Total of 3 doses
• Children below 15 years: 0.5 ml with 1 month between the 1st and 2nd dose, and 5 months between the 2nd and 3rd dose
• Infants: 0.5 ml intramuscular injection at 6 weeks, 10 weeks, and 14 weeks of age

Side Effects:

• Abdominal pain
• GIT disturbance
• Sleep disturbance
• Lymphadenopathy
• Muscle and joint pains
• Dizziness
• Peripheral neuropathy

• Myalgia

Key Issues to Note:

• Immunocompromised patients may need further doses

Anti-D (Rho) Immunoglobulin

A Rhesus-negative mother may develop antibodies against Rho antigen red cells when she carries a Rhesus-positive fetus and fetal red cells enter her circulation during childbirth, abortion, or miscarriage. Rho immunoglobulin is used to prevent non-sensitized mothers from producing antibodies which may cause hemolytic disease of the newborn.

Available Preparations:

• Injection

Indications:

• Prevention of Rhesus D sensitization in females who are Rhesus D negative

Contraindications:

• Rhesus-positive individuals
• Isolated immunoglobulin A deficiency

Dosage:

• Following birth of Rhesus-positive infant: 500 units deep IM immediately or within 72 hours
• Following stillbirth: 250 units per episode immediately or within 72 hours
• Antenatal prophylaxis: 500 units given at 28 and 34 weeks of pregnancy. A further dose is still needed immediately or within 72 hours of delivery

Side Effects:

• Local tenderness and stiffness
• Fever
• Nausea
• Vomiting
• Back pain
• Abdominal pain
• Myalgia
• Malaise
• Sweating
• Skin rash

Drugs Used in Anaesthesia

Anaesthesia is defined as the absence of feelings, sensation, or pain. Anaesthetics are drugs that reduce or abolish sensation, affecting either the whole body (general anaesthetics) or a particular area or region (local anaesthetics).

Local Anaesthetics

Local anaesthetics provide brief periods of anaesthesia in a small localized area of the skin and adjacent tissues. They may be administered in two ways: topically for surface anaesthesia and by injection for infiltration anaesthesia.

Topical anaesthetics are usually applied to the skin or the mucous membrane to relieve itching, insect bites, hemorrhoids, pruritus, and minor surgical procedures.

Infiltration anaesthesia may be achieved by injecting a local anaesthetic into the immediate area of surgery. It is commonly used during dental extraction and biopsies.

Examples:

• Lidocaine (lignocaine)
• Bupivacaine
• Mepivacaine

Note: Lignocaine is sometimes combined with epinephrine (adrenaline), a powerful vasoconstrictor, that decreases blood flow to the tissue where it is injected. Adrenaline controls bleeding and also prolongs the anaesthetic action of lignocaine.

General Anaesthetics

General anaesthetic drugs are normally given IV or by inhalation to produce rapid, reversible loss of consciousness and insensibility to surgical stimuli.

Examples: 

Inhaled Anaesthetics:

• Halothane
• Nitrous oxide
• Ether

Intravenous Anaesthetics:

• Ketamine
• Midazolam
• Propofol

Ketamine

Available Preparations:

• Injection: 50 mg/ml

Available Brands: Ketajex®, Ketalar®

Pharmacokinetics: Ketamine is rapidly and well absorbed after IM injection, rapidly enters the CNS, metabolized by the liver, and excreted in urine.

Indications:

• Induction and maintenance of anaesthesia
• Pain relief
• Diagnostic maneuvers and procedures not involving intense pain

Contraindications:

• Thyrotoxicosis
• Hypertension (including pre-eclampsia)
• History of cerebrovascular accident
• Raised intracranial pressure
• Psychiatric disorders, particularly hallucinations
• Severe cardiac disease
• Recent myocardial infarction
• Stroke
• Known hypersensitivity to ketamine
• Cerebral trauma
• Eye injury

Dosage:

Induction:

• Intravenous Injection: 1-4.5 mg/kg (2 mg/kg usually produces anaesthesia lasting 5-10 minutes)
• Intramuscular Injection: 6.5-13 mg/kg (duration of anaesthesia up to 25 minutes)
• IV Infusion: 0.5-2 mg/kg initially, then infuse at 10-45 mcg/kg/minute, adjust according to response

Maintenance:

• Intravenously: Increments of half or full dose repeated as required
• Analgesic for painful procedures: IV 1-1.5 mg/kg slowly over 2-5 minutes. Give half dose every 10 minutes if required for prolonged procedures

Administration Instructions:

• Dilute dose with an equal volume of water for injection, sodium chloride 0.9%, or glucose 5% before IV injection
• Give IV slowly; rapid administration may result in respiratory depression and enhanced hypertensive response

Side Effects:

• Raised blood pressure and pulse rate
• Increased muscle tone
• Lacrimation
• Hypersalivation
• Raised intracranial pressure
• Redness of the skin
• Postoperative nausea and vomiting
• Pain on injection
• Irrational behavior during recovery

Drug Interactions:

• Inhalation anaesthetics such as halothane may prolong the effect of ketamine and delay recovery
• Prolonged recovery occurs when barbiturates or opioids are given concurrently with ketamine
• Ketamine should not be used with ergometrine
• Concomitant use with thyroid hormones may cause hypertension and tachycardia

Key Issues to Note:

• Warn the patient to avoid tasks requiring motor coordination and/or mental alertness for 24 hours after anaesthesia
• Keep verbal, tactile, and visual stimulation to a minimum during induction and recovery

Lidocaine

Available Preparations:

• Solution: 1%, 2%
• Topical Gel: 2-4%
• Combinations: Xylocaine® (Lidocaine + epinephrine)

Note: Epinephrine is often added to delay absorption and thus reduce anaesthetic systemic toxicity and keep it in contact with nerve fibers, prolonging the duration of action.

Pharmacokinetics: Lidocaine is effectively absorbed from the mucous membranes, widely distributed throughout the body, metabolized in the liver, and excreted in urine.

Indications:

• Infiltration anaesthesia
• Surface anaesthesia of mucous membrane
• Dental anaesthesia
• Ventricular arrhythmias
• Relief of pain in hemorrhoids

Contraindications:

• Adjacent skin infection
• Hypersensitivity
• Heart block
• Hypovolemia
• Severe anemia
• Myasthenia gravis
• Spinal anaesthesia in dehydrated patients

Dosage:

Dental Anaesthesia: Using 2% solution with epinephrine

• Adult: 20-100 mg (1-5 ml)

Local Infiltration and Peripheral Nerve Block: Using 1% solution with epinephrine

• Adult: Up to 400 mg (up to 40 ml)

Note: Use lower doses for elderly, epileptic, or acutely ill patients. Do not use solution containing preservatives for spinal, epidural, intravenous, or regional anaesthesia.

Side Effects:

• Dizziness
• Lightheadedness
• Tremors
• Numbness
• Restlessness
• Convulsions
• Unconsciousness
• Headache
• Blurred vision
• Hypotension
• Cardiac arrest
• Backache
• Sense of heat
• Hypersensitivity reaction
• Urinary retention

Drug Interactions:

• Anti-convulsants may increase the cardiac depressant effect of lidocaine
• Cimetidine and beta-blockers may increase plasma concentration of lidocaine, leading to increased risk of toxicity
• Use of opioid analgesics peri-operatively may have additive respiratory and cardiac depressant effects

Key Issues to Note:

• Doses should be reduced in acute and chronic hepatic diseases
• If solutions discolor or precipitate, they should be discarded

Drugs Used in the Treatment of Cancer

Cancer is a disease characterized by a shift in the control mechanisms that govern cell survival, proliferation, and differentiation. 

Uncontrolled multiplication of cells leads to the formation of tumors that may be benign or malignant. Benign tumors do not spread to other tissues, while malignant tumors do.

Types of Cancer

• Carcinoma: Affects the skin and cells in the tissue lining internal organs.
• Sarcoma: Affects muscles, bones, and fibrous tissues.
• Leukemia: Affects white blood cells.
• Lymphoma: Affects the lymph glands.

Drugs used in the treatment of cancer either kill cancer cells or modify their growth.

Table 1: Classification of Anticancer Drugs

Class	Examples
Antimetabolites	Methotrexate, 5-Fluorouracil, Cytarabine, 6-Mercaptopurine
Antitumor Antibiotics	Bleomycin, Dactinomycin
Alkylating Agents	Cyclophosphamide, Busulfan, Chlorambucil, Carmustine, Dacarbazine, Melphalan
Anthracyclines	Daunorubicin, Doxorubicin, Idarubicin
Vinca Alkaloids	Vincristine, Vinblastine
Platinum Analogs	Cisplatin
Hormonal Agents	Tamoxifen, Estrogen
Others	Hydroxyurea, Procarbazine

Bleomycin

Available Preparations:

• Powder for Injection: 15 units/vial

Available Brands: Blenoxane®

Pharmacokinetics: IM administration results in lower serum levels than those occurring after equivalent IV doses. It distributes widely into total body water, mainly in the skin, lungs, kidneys, peritoneum, and lymphatic tissue. It undergoes extensive tissue inactivation in the liver and kidney; bleomycin and its metabolites are excreted primarily in urine.

Indications:

• Squamous cell carcinoma (head, neck, penis, cervix)
• Testicular carcinoma
• Non-Hodgkin\’s lymphoma
• Lymphosarcoma

Contraindications:

• Pregnancy
• Breastfeeding
• Previous allergic reaction

Dosage:

• A test dose of 1-2 units given 2-4 hours prior to therapy is recommended.
• 0.25-0.5 unit/kg body weight or 10-20 units/m² body surface area given IV, IM, or SC once or twice weekly.

Side Effects:

• Skin rash
• Striae
• Redness of the skin
• Fever
• Acute anaphylactoid reaction
• Anorexia
• Urticaria
• Pruritus
• Hyperpigmentation
• Stomatitis
• Hyperkeratosis
• Weight loss
• Progressive pulmonary fibrosis
• Mucositis
• Pneumonitis
• Phlebitis
• Vomiting

Drug Interactions:

• Cisplatin may decrease bleomycin clearance and increase the risk of bleomycin toxicity.
• Concomitant use may decrease serum levels of phenytoin and digoxin.

Key Issues to Note:

• Increased pigmentation, particularly affecting the flexures and subcutaneous sclerotic plaques, may occur.
• A test dose should be administered before starting therapy to check for hypersensitivity reactions.
• Monitor pulmonary function tests during treatment.

Doxorubicin

Available Preparations:

• Powder for Injection: 10 mg/vial, 50 mg/vial

Available Brands: Doxorubin®

Pharmacokinetics: It distributes widely into body tissues, with the highest concentrations found in the liver, heart, kidneys, skin, and muscles; it does not cross the blood-brain barrier. It is metabolized both in the liver and plasma; excreted largely in feces, with small amounts in urine.

Indications:

• Acute leukemia
• Lymphomas
• Breast carcinoma
• Thyroid carcinoma
• Non-Hodgkin\’s lymphoma
• Ovarian carcinoma
• Bone and soft tissue sarcomas
• Hodgkin\’s disease
• Kaposi\’s sarcoma in patients with AIDS
• Transitional cell bladder carcinoma

Contraindications:

• Hepatic dysfunction
• Cardiomyopathy
• Pregnancy and lactation
• Persistent myelosuppression
• Severe cardiac failure
• Recent myocardial infarction

Dosage:

• 60-74 mg/m² or 1.2-2.4 mg/kg once every 3 weeks as a single intravenous injection of a solution in sodium chloride 0.9% or glucose 5% over 3 minutes or more.
• Children: 35-75 mg/m² as a single intravenous injection, once every 3 weeks.

Side Effects:

• Bone marrow depression
• Anorexia
• Hyperpigmentation of nail beds
• Diarrhea
• Irreversible CHF
• Reversible alopecia
• Nausea and vomiting
• Stomatitis
• Fever and chills
• Urticaria
• Conjunctivitis
• Lacrimation

Drug Interactions:

• Cholestasis induced by mercaptopurine may be potentiated by the concurrent administration of doxorubicin.
• Concomitant use of daunorubicin or cyclophosphamide may potentiate the cardiotoxicity of doxorubicin through additive effects on the heart.
• Serum digoxin, carbamazepine, and phenytoin levels may be decreased if used concomitantly with doxorubicin.
• Phenobarbitone increases the elimination of doxorubicin.

Key Issues to Note:

• Notify the patient that the urine may turn red for the first 1-2 days.
• Doxorubicin may induce hyperuricemia; therefore, monitor the patient\’s blood uric acid levels.
• Encourage the patient to take adequate fluid intake to increase urine output and facilitate excretion of uric acid.
• Advise the patient to call if fever, bleeding, and sore throat occur.
• Avoid exposure to sunlight to prevent sunburns.
• Warn the patient that alopecia will occur. Explain that hair growth should resume 2-5 months after the drug is stopped.
• Tell the patient not to receive any immunization during therapy and for several weeks after.
• Advise the patient to avoid exposure to people with infections.

Methotrexate

Available Preparations:

• Tablets: 2.5 mg
• Injection: 25 mg/ml

Available Brands: Texol®

Indications:

• Treatment and palliation of solid tumors
• Burkitt\’s lymphoma
• Leukemia
• Psoriasis

Contraindications:

• Known hypersensitivity to methotrexate
• Pregnancy and lactation
• Severe hepatic and renal impairment
• Bone marrow suppression
• Anemia
• Immunodeficiency syndromes
• Active infection

Dosage:

• Leukemia: 15-30 mg/m² orally, intramuscularly, or intravenously; once a week.

Side Effects:

• Nausea and vomiting
• Stomatitis
• Diarrhea
• Anorexia
• Malaise
• Headache
• Skin rash
• Dermatitis
• Pruritus
• Dizziness
• Blurred vision

Drug Interactions:

• Concomitant use with probenecid and salicylates increases the therapeutic and toxic effects of methotrexate by inhibiting its renal clearance.
• Alcohol enhances the hepatotoxicity caused by methotrexate.
• Phenytoin, co-trimoxazole may give additive antifolate activity and increase the risk of methotrexate toxicity.

Key Issues to Note:

• Full blood count, urea, and liver function tests should be carried out prior to and during treatment.
• Folinic acid is required for rescue procedures.
• Patients with hyperuricemia should maintain adequate fluid intake and alkalinization of urine.

Vincristine

Available Preparations:

• Solution for Injection: 1 mg/ml, 0.1 mg/ml

Available Brands: Cristol®

Indications:

• Leukemias
• Lymphomas
• Some solid tumors

Contraindications:

• Demyelinating form of Charcot-Marie-Tooth syndrome
• Pregnancy
• Breastfeeding mothers
• Current radiotherapy to the liver
• Known hypersensitivity to vincristine

Dosage:

• Adult: IV 1.4 mg/m² up to a max weekly dose of 2 mg/m².
• Children: IV 2 mg/m² once a week.
• Children < 10 kg: 0.05 mg/kg once a week.

Side Effects:

• Hair loss
• Stomatitis
• Constipation
• Abdominal cramps
• Diarrhea
• Skin rash
• Headache
• Jaw pain
• Hoarseness
• Diplopia
• Nausea and vomiting
• Abdominal distention
• Urinary tract disturbance
• Peripheral neuropathy

Drug Interactions:

• Vincristine may decrease digoxin plasma levels and renal excretion.
• Vincristine may reduce phenytoin plasma levels.

Key Issues to Note:

• Allopurinol may be given to prevent uric acid nephropathy.
• Stool softeners should be used for constipation prophylaxis.
• Vincristine is a tissue irritant; care should be taken to avoid extravasation.

Tamoxifen

Available Preparations:

• Tablets: 10 mg, 20 mg

Available Brands: Nolvadex®

Pharmacokinetics: Tamoxifen is well absorbed after oral administration, distributed widely into total body water, metabolized extensively in the liver, and excreted primarily in feces.

Indications:

• Breast cancer
• Female infertility (induction of ovulation)

Contraindications:

• Known hypersensitivity to tamoxifen
• History of deep vein thrombosis or pulmonary embolism in high-risk women
• Pregnancy

Dosage:

• Breast cancer: 20 mg daily.
• Induction of ovulation (infertility): 20 mg daily on days 2, 3, 4, and 5 of the cycle; if necessary, the daily dose may be increased to 40 mg then 80 mg for subsequent courses.

Side Effects:

• Hot flushes
• Nausea
• Vomiting
• Lightheadedness
• Bone pain
• Confusion
• Vaginal bleeding
• Vaginal discharge
• Headache
• Decreased libido
• Weakness

Drug Interactions:

• Estrogen may decrease the effect of tamoxifen.
• The anticoagulant effect of oral anticoagulants may be increased by tamoxifen.
• Bromocriptine may elevate serum levels of tamoxifen.

Key Issues to Note:

• Adverse effects may be controlled by dosage reduction.
• Use cautiously in pre-existing leukopenia and thrombocytopenia.
• Advise women not to become pregnant during therapy with tamoxifen.

Drugs Used in the Treatment of Obstetric and Gynecological Disorders

Drugs for Menstrual Disorders

The main disorders associated with menstruation that may require treatment include:

• Amenorrhoea
• Dysmenorrhoea
• Menorrhagia
• Premenstrual syndrome
• Menopause

Amenorrhoea

Amenorrhoea is the absence of menstruation. A break in menstruation of 6 months or more is considered pathological in an adult woman who is not pregnant, lactating, or has reached menopause.

Amenorrhoea may be classified as:

• Primary Amenorrhoea: Occurs when a female fails to have her first menstrual cycle by age 16 in the presence of normal secondary sexual characteristics.
• Secondary Amenorrhoea: The absence of menses for 6 months or more in a woman whose normal menstruation has been established.

Management

• Identification and correction of any underlying disorder

Dysmenorrhoea

Dysmenorrhoea is painful menstruation that prevents normal activity and requires medication.

Dysmenorrhoea may be classified as:

• Primary Dysmenorrhoea: Usually begins with the first menstrual period and is characterized by cramping lower abdominal pain, nausea, vomiting, headache, and faintness. The cause is thought to be due to excessive prostaglandin production that causes the uterus to contract painfully.
• Secondary Dysmenorrhoea: Usually affects older women who complain of congested ache with lower abdominal cramps which usually starts a few days before menstruation. It is associated with various disorders such as endometriosis, pelvic inflammatory disease, fibroids, or the presence of an IUD.

Drugs used in the treatment of primary dysmenorrhoea inhibit either ovulation or prostaglandin production.

Examples:

• NSAIDs such as mefenamic acid, ibuprofen, indomethacin, naproxen, piroxicam, and diclofenac
• Oral contraceptives
• Progestogens (norethisterone)
• Antispasmodics (hyoscine and drotaverin)

Menorrhagia

Menorrhagia is excessive menstrual bleeding. It may be associated with pelvic disorders such as fibroids, use of copper intrauterine devices, complications of pregnancy, malignant tumors, or dysfunctional bleeding. Menorrhagia may lead to iron deficiency anemia as well as impairing the quality of life of the patient.

Drugs used in the treatment of menorrhagia include:

• Combined oral contraceptives
• Mefenamic acid
• Norethisterone
• Medroxyprogesterone
• Tranexamic acid

Pre-menstrual Syndrome

Pre-menstrual syndrome is a cyclic recurrence of psychological and physical symptoms that affect women in the days before menstruation. Symptoms include increased irritability, depression, anxiety, bloating, headache, and breast tenderness.

Drugs used in the treatment of pre-menstrual syndrome include:

• Calcium supplements
• Pyridoxine (vitamin B6)
• Bromocriptine
• Spironolactone
• Mefenamic acid
• Fluoxetine
• Paroxetine
• Atenolol

Note:

• Bromocriptine, mefenamic acid, and spironolactone suppress physical symptoms.
• Fluoxetine, paroxetine, and atenolol mostly suppress psychological symptoms.

Menopause

Menopause is the occurrence of no menstrual periods for one year after the age of 40 or permanent cessation of ovulation after loss of ovarian activity.

Signs and Symptoms:

• Atrophic vaginitis
• Dyspareunia
• Complete cessation of menses
• Heavier bleeding
• Osteoporosis
• Anxiety
• Depression
• Insomnia
• Inability to concentrate
• Irritability
• Decreased libido
• Urinary incontinence
• Hot flashes
• Night sweats
• Headache
• Tiredness

Treatment involves the use of hormone replacement therapy and vaginal lubricants.

Norethisterone

Available Preparations:

• Tablets: 5 mg

Available Brands: Regulate-N®, Primolut-N®

Indications:

• Dysfunctional uterine bleeding
• Pre-menstrual syndrome
• Delay of menstruation
• Endometriosis
• Dysmenorrhoea
• Contraception

Contraindications:

• Pregnancy
• Severe liver impairment
• Previous or existing liver tumors
• Severe arterial disease
• Undiagnosed vaginal bleeding
• Porphyria
• Hypersensitivity to norethisterone

Dosage:

• Dysfunctional Bleeding:

1. To stop bleeding: 5 mg 3 times daily for 10 days
2. To prevent bleeding: 5 mg twice daily from day 19-26 of the cycle

• Dysmenorrhoea: 5 mg 3 times daily from day 5-24 for 3-4 cycles
• Endometriosis: 10-15 mg daily for 4-6 months or longer starting on day 5 of cycle (if spotting occurs, increase dose to 20-25 mg daily, reduce once bleeding has stopped)
• Delay of Menstruation: 5 mg 3 times daily starting 3 days before anticipated onset of menstruation (menstruation occurs 2-3 days after stopping)
• Pre-menstrual Syndrome: 5 mg 2-3 times daily from day 19-26 for seven cycles

Side Effects:

• Nausea
• Dizziness
• Headache
• Menstrual disturbance
• Weight gain
• Depression
• Insomnia

Dydrogesterone

Available Preparations:

• Tablets: 10 mg

Available Brands: Duphaston®

Indications:

• Endometriosis
• Dysfunctional uterine bleeding
• Pre-menstrual syndrome
• Habitual and threatened abortion
• Hormone replacement therapy
• Infertility
• Dysmenorrhoea
• Amenorrhoea
• Irregular cycles

Contraindications:

• Severe liver impairment
• Previous or existing liver tumors
• Severe arterial disease
• Undiagnosed vaginal bleeding
• Porphyria
• Known hypersensitivity to dydrogesterone

Dosage:

• Endometriosis: 10 mg 2-3 times daily from day 5-25 of cycle or continuously
• Dysfunctional Bleeding:

1. To stop bleeding: 10 mg twice daily (together with an estrogen) for 5-7 days
2. To prevent bleeding: 10 mg twice daily (together with an estrogen) from day 11-25 of cycle

• Dysmenorrhoea: 10 mg twice daily from day 5-25 of cycle
• Amenorrhoea: 10 mg twice daily from day 11-25 of cycle with estrogen therapy from day 1-25 of cycle
• Pre-menstrual Syndrome: 10 mg twice daily from day 12-26 of cycle
• Irregular Cycles: 10 mg twice daily from day 11-25 of cycle
• Habitual Abortion: 10 mg twice daily from day 11-25 of cycle until conception, then continuously until week 20 of pregnancy

Side Effects:

• Nausea
• Dizziness
• Headache
• Menstrual disturbance
• Weight gain
• Depression
• Insomnia

Drugs for Infertility

Infertility refers to the inability of a woman to conceive or of a man to induce conception. The most common cause of infertility is the failure of either ovulation in females or spermatogenesis in males. In females, infertility may also be due to obstruction of the fallopian tubes or diseases of the lining of the uterus (endometrium).

Drugs used in the treatment of infertility include:

• Clomifene
• Bromocriptine
• Tamoxifen

Clomifene

Available Preparations:

• Tablets: 50 mg

Available Brands: Clomid®, Clominol®

Pharmacokinetics: It is readily absorbed from the GIT, metabolized by the liver, and excreted in feces.

Indications:

• Anovulatory infertility

Contraindications:

• Liver disease
• Ovarian cysts
• Hormone-dependent tumors
• Known hypersensitivity to clomifene
• Pregnancy (exclude before treatment)
• Undiagnosed abnormal uterine bleeding

Dosage:

• Adult: 50 mg daily for 5 days, starting within 5 days of the onset of menstruation (preferably on the second day) or at any time if cycles have ceased.
• If ovulation does not occur, a second course of 100 mg daily for 5 days may be given starting as early as 30 days after the previous one. In general, 3 courses of therapy are adequate to assess whether ovulation is obtainable.

Side Effects:

• Visual disturbance
• Hot flushes
• Abdominal discomfort
• Abnormal uterine bleeding
• Headache
• Intermenstrual spotting
• Insomnia
• Endometriosis
• Ovarian hyperstimulation
• Dizziness
• Hair loss
• Nausea and vomiting
• Breast tenderness
• Weight gain
• Depression
• Menorrhagia

Key Issues to Note:

• Advise the patient of the possibility of multiple births. The risk increases with higher doses.
• Since the drug may cause dizziness or visual disturbances, warn the patient to avoid hazardous tasks until the response to the drug is known.

Drugs Used in the Treatment of Pre-eclampsia and Eclampsia

Pre-eclampsia is a condition that develops late in pregnancy after the 20th week of gestation, characterized by hypertension, proteinuria, and edema of the legs, hands, and face. Severe pre-eclampsia (BP > 160/110 mmHg) may result in morbidity and mortality for the mother or baby. It can lead to poor intrauterine growth and early delivery.

Eclampsia

Eclampsia is the occurrence of seizures or coma in a mother with pre-eclampsia occurring at greater than 20 weeks of gestation or less than 48 hours postpartum. Eclampsia is a threat to both mother and baby and must be treated immediately.

Drugs used in eclampsia include:

• Magnesium sulphate
• Hydralazine

Magnesium Sulphate

Available Preparations:

• Injection: 50%

Indications:

• Eclampsia (prevention of recurrent seizures)
• Severe renal failure
• Myocardial damage
• Intestinal obstruction

Dosage:

By Intravenous Injection:

• Start with a loading dose of 4 g by IV infusion in 0.9% sodium chloride over 15 to 20 minutes. Then administer a maintenance dose of 1 g per hour by continuous IV infusion for at least 24 hours until the last seizure.
• Alternatively, start with a loading dose of 4 g by IV infusion in 0.9% sodium chloride over 15 to 20 minutes. Then administer by IM 10 g (5 g in each buttock) followed by 5 g every 4 hours for at least 24 hours after delivery or the last seizure.
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Side Effects:

• Nausea and vomiting
• Flushing of skin
• Respiratory depression
• Coma
• Arrhythmias
• Thirst
• Hypotension
• Confusion
• Muscle weakness
• Loss of tendon reflexes

Drug Interactions:

• Magnesium sulphate potentiates the effects of calcium channel blockers and neuromuscular blockers.
• Concomitant use with alcohol and other CNS depressants may increase the CNS depressant effects of magnesium sulphate.

Key Issues to Note:

• IV bolus must be injected slowly to avoid respiratory or cardiac arrest.
• Discontinue the drug as soon as the needed effect is achieved.
• When giving repeated doses, test knee jerk reflex before each dose; if absent, discontinue magnesium.

Drugs for Endometriosis

Endometriosis is a medical condition characterized by the growth of endometrial tissue outside the uterine cavity. 

It affects women in their reproductive years. Patients may be asymptomatic or have pelvic pain, menstrual changes, bowel symptoms, or infertility.

Drugs used in the treatment of endometriosis include:

• Danazol
• NSAIDs
• Progesterone
• Combined oral contraceptives

Danazol

Available Preparations:

• Capsules: 50 mg, 100 mg, 200 mg

Available Brands: Gonablok®

Pharmacokinetics: It is well absorbed following oral administration, extensively metabolized in the liver, and excreted in urine.

Indications:

• Endometriosis
• Benign fibrocystic breast disease
• Dysfunctional uterine bleeding
• Prevention of hereditary angioedema
• Gynaecomastia in males
• Pre-menstrual syndrome
• Prolactinomas
• Female infertility
• Amenorrhoea
• Acromegaly

Contraindications:

• Markedly impaired renal, hepatic, or cardiac function
• Undiagnosed abnormal vaginal bleeding
• Pregnancy and lactation
• Porphyria
• Androgen tumor
• History of thromboembolic disease

Dosage:

• Endometriosis: 100-400 mg twice daily for 3-9 months
• Benign Breast Disorder: 50-200 mg twice daily, adjusted according to response for 3-6 months
• Dysfunctional Uterine Bleeding: 200 mg daily for 3-6 months
• Hereditary Angioedema: 200 mg 2-3 times daily reduced according to patient response
• Gynaecomastia: 200 mg daily increased after 2 months to 400 mg daily if no response occurs

Side Effects:

• Acne
• Oily skin
• Weight gain
• Mild hirsutism
• Nausea
• Skin rash
• Menstrual disturbance
• Hot flashes
• Changes in libido
• Oedema
• Hair loss
• Headache
• Backache
• Tremors
• Amenorrhoea
• Sweating
• Vaginal dryness and irritation
• Deepening of the voice

Drug Interactions:

• Warfarin anticoagulant effects may be enhanced by danazol.
• Danazol may increase the effect of carbamazepine.
• Danazol may cause decreases in blood glucose levels, which may require adjustment of insulin or oral hypoglycemic drugs.

Key Issues to Note:

• The drug should not be discontinued without consulting the prescriber.
• Therapy may take up to several months for full benefit depending on the purpose of treatment.
• The drug may cause photosensitivity; therefore, avoid direct exposure to sunlight.
• To treat endometriosis and fibrocystic breast disease, danazol therapy should begin during menstruation.
• Advise the patient to report voice changes.
• Advise female patients that amenorrhea usually occurs after 6-8 weeks of therapy.
• Avoid administration of danazol with a fatty meal.
• Use non-hormonal contraceptive measures and discontinue the drug if you suspect pregnancy.

Drugs for Contraception

Contraception refers to the various methods used to prevent pregnancy. These methods can be either medical or non-medical and may be used by men, women, or both.

Common methods of contraception include:

• Abstinence
• Barrier methods (male and female condoms)
• Intrauterine devices (IUD)
• Hormonal contraceptives
• Female or male sterilization
• Emergency contraceptives

Oral Contraceptives

Oral contraceptives are divided into two:

• Combined oral contraceptives
• Progestogen-only pills

Combined Oral Contraceptives

Oral combined contraceptives contain low doses of estrogen and progesterone. They are the most widely used contraceptives and have the lowest failure rate in terms of unwanted pregnancies. They are suitable for women who regularly experience exceptionally painful, heavy, or prolonged periods.

Mode of Action: They inhibit ovulation, reduce receptivity of endometrium to implantation, and thicken cervical mucus to form a barrier to sperm.

Indications:

• Contraception
• Dysfunctional uterine bleeding
• Dysmenorrhoea
• Endometriosis
• Pre-menstrual syndrome
• Menorrhagia

Contraindications:

• Pregnancy
• History of thromboembolic disorder
• Pulmonary hypertension
• Active viral hepatitis
• Unexplained uterine bleeding
• History of breast or hepatic cancer
• Migraine
• Atrial fibrillation
• Severe cirrhosis

Side Effects:

• Breakthrough bleeding
• Changes in weight
• Changes in libido
• Venous thromboembolism
• Fluid retention
• Amenorrhoea
• Photosensitivity
• Breast enlargement and tenderness
• Nausea and vomiting
• Depression
• Acne
• Cervical cancer
• Headache
• Stroke

• Increased blood pressure

Examples of Combined Oral Contraceptives:

MICROGYNON®/NEF®:

• Composition: Levonorgestrel 0.15 mg, Ethinylestradiol 0.03 mg, Ferrous fumarate 75 mg (7 brown tablets)
• Dosage: 1 tablet daily for 28 days starting on day 1 of the menstruation cycle with the active tablets.

PILL PLAN®:

• Composition: Norgestrel 0.3 mg, Ethinylestradiol 0.03 mg, Ferrous fumarate 75 mg (7 brown tablets)
• Dosage: 1 tablet daily for 28 days starting on day 1 of the menstruation cycle with the active tablets.

LO-FEMENAL®:

• Composition: Norgestrel 0.3 mg, Ethinylestradiol 0.03 mg, Ferrous fumarate 75 mg (7 brown tablets)
• Dosage: 1 tablet daily starting on day 1 of the menstruation cycle with the active tablets.

Progestogen-Only Pills

Progestogen-only pills are often recommended for women who react to estrogen in the combined pill or where combined pills are not suitable because of age or medical history. They may be used by breastfeeding mothers since they do not affect the quantity and quality of the milk produced. Progestogen-only pills have a higher failure rate compared to combined pills and must be taken at the same time each day for maximum contraceptive effect.

Mode of Action: Progestogen thickens the cervical mucus, which impedes the passage of sperm, disrupts the menstrual cycle including preventing the release of the eggs from the ovaries, and changes the endometrium reducing the potential for implantation.

Indications:

• Contraception
• Emergency contraception
• Endometriosis
• Menstrual disorders

Contraindications:

• Pregnancy
• Undiagnosed vaginal bleeding
• Porphyria
• Active viral hepatitis
• Breast or liver cancer
• Severe arterial disease

• Severe cirrhosis

Side Effects:

• Nausea
• Spotting
• Dizziness
• Breast discomfort
• Depression
• Amenorrhoea
• Vomiting
• Weight gain
• Headache
• Prolonged bleeding
• Acne

Examples:

OVRETTE®:

• Composition: Norgestrel 0.075 mg
• Dosage: 1 tablet daily starting on day 1 of the menstruation cycle.

SOFT SURE®:

• Composition: Levonorgestrel 0.03 mg
• Dosage: 1 tablet daily at the same time each day.

Emergency Contraceptives

Emergency contraceptives are effective if the dose is taken ideally within 12 hours but not later than 72 hours of unprotected intercourse.

Examples:

POSTINOR®:

• Composition: Levonorgestrel 0.75 mg
• Dosage: 1.5 mg (2 tablets) as a single dose as soon as possible within 12 hours but not later than 72 hours.

POSTINOR-2®:

• Composition: Levonorgestrel 0.75 mg
• Dosage: 1.5 mg (2 tablets) as a single dose as soon as possible within 12 hours but not later than 72 hours.

Parenteral Progestogen-Only Contraceptives

Parenteral progestogen-only contraceptives provide reliable suppression of ovulation by suppressing the luteinizing hormone.

Indications:

• Contraception

Side Effects:

• Menstrual irregularities
• Spotting
• Breast tenderness
• Loss of bone mineral density
• Prolonged bleeding
• Amenorrhoea
• Weight gain

Contraindications:

• History of breast cancer
• Pregnancy

Examples:

• Medroxyprogesterone

Medroxyprogesterone

Available Preparations:

• 150 mg/ml

Available Brands: Depo-Provera, Injecta Plan

Dosage:

• By deep intramuscular injection: 150 mg within the first 5 days of the cycle, repeated every 12 weeks (3 months).

Drugs Used in the Management of Central Nervous System Disorders

Drugs Used in the Treatment of Depression

Depression is a mental state characterized by diverse psychological symptoms such as low mood, loss of interest and enjoyment of activities, and reduced energy. Depression is associated with physical symptoms such as:

• Fatigue
• Anxiety
• Sleep disturbance
• Reduction in libido
• Decreased productivity
• Changes in appetite or weight
• Loss of concentration
• Loss of interest (depressed mood)
• Thoughts of death and suicide

Drugs used in the treatment of depression include:

• Tricyclic antidepressants
• Selective Serotonin Reuptake Inhibitors (SSRIs)
• Monoamine Oxidase Inhibitors (MAOIs)
• Other antidepressant drugs (Atypical antidepressants)

Tricyclic Antidepressants

These drugs inhibit the reuptake of norepinephrine and serotonin at the presynaptic neuron, prolonging neuronal activity.

Examples:

• Amitriptyline
• Imipramine
• Clomipramine

Amitriptyline

Available Preparations:

• Tablets: 25 mg

Available Brands: Laroxyl®

Pharmacokinetics: Amitriptyline is absorbed rapidly from the GIT, distributed widely into the body, including the CNS and breast milk, metabolized in the liver to active metabolites, and excreted in urine.

Indications:

• Depression where sedation is required
• Nocturnal enuresis in children
• Peripheral neuropathy
• Post-herpetic neuralgia
• Migraine prophylaxis
• Tension headache
• Adjuvant in pain management

Contraindications:

• Known hypersensitivity to the drug
• Recent myocardial infarction
• Severe liver disease
• Manic phase
• Coma or severe respiratory depression
• Prostatic hypertrophy
• Glaucoma

Dosage:

Depression:

• Adult: Initially 75 mg daily in divided doses or as a single dose at bedtime. Increased gradually according to response to 150 mg.

Nocturnal Enuresis:

Children:

• 7-10 years: 10-20 mg at night
• 11-16 years: 25-50 mg at night. Maximum period of treatment is 3 months.

Peripheral Neuropathy: Initially 10-25 mg daily at night, increased if necessary to 75 mg daily.

Migraine Prophylaxis: Initially 10 mg at night, increased according to response to a maintenance dose of 50-75 mg at night.

Adjuvant Pain Management: 10-25 mg at night, up to a max of 150 mg.

Side Effects:

• Dry mouth
• Sedation
• Constipation
• Postural hypotension
• Difficulty with micturition
• Blurred vision
• Cardiac arrhythmias
• Unpleasant taste
• Somnolence
• Photosensitivity
• Interference with sexual function
• Nausea
• Tremors
• Sweating
• Skin rashes
• Headache
• Urticaria
• Hypomania
• Weight gain
• Increased appetite

Drug Interactions:

• Cimetidine, valproic acid may increase amitriptyline blood concentration and risk of toxicity
• Alcohol, anticonvulsants, phenothiazines, and sedative hypnotics may increase CNS depression caused by amitriptyline
• Carbamazepine reduces the serum concentration of amitriptyline
• Concurrent use of amitriptyline with phenylephrine, ephedrine may increase blood pressure
• Amitriptyline may decrease the hypotensive effect of methyldopa

Key Issues to Note:

• Inform the patient that full therapeutic effect may delay up to 4 weeks
• Avoid alcoholic beverages while taking this drug
• Warn the patient not to stop taking the drug suddenly
• The drug causes drowsiness and may impair activities that need mental alertness

Selective Serotonin Reuptake Inhibitors (SSRIs)

Their efficacy is similar to that of tricyclic antidepressants but with fewer side effects because of low affinity for muscarinic, histaminergic, and adrenergic receptors.

Examples:

• Fluoxetine
• Paroxetine
• Sertraline
• Citalopram

Mode of Action: The antidepressant action of SSRIs is by inhibiting the reuptake of the neurotransmitter serotonin.

Fluoxetine

Available Preparations:

• Capsules: 20 mg

Available Brands: Prozac®, Nuzac®, Trizac®, Fludac®, Flocept®

Pharmacokinetics: Fluoxetine is well absorbed after oral administration, metabolized in the liver to active metabolites, and excreted in urine.

Indications:

• Major depression
• Obsessive-compulsive disorder
• Bulimia nervosa
• Premenstrual dysphoric disorder
• Panic disorders
• Post-traumatic stress disorder
• Hot flushes

Contraindications:

• Hypersensitivity to fluoxetine
• Severe renal failure
• Unstable epilepsy
• Manic phase

Dosage:

• Depression: 20 mg once daily, increased after 3-4 weeks if necessary. Find at appropriate intervals thereafter, max 60 mg once daily.
• Elderly: 20-40 mg once daily, max 60 mg.
• Bulimia Nervosa: 60 mg once daily, max 80 mg once daily.
• Obsessive-Compulsive Disorder: Initially 20 mg once daily, increased after 2 weeks if necessary, max dose 60 mg.

1. Elderly: 20-40 mg once daily, max 60 mg.

• Panic Disorders: 10 mg once daily, do not exceed 20 mg daily.
• Premenstrual Dysphoric Disorder: 20 mg once daily.

Side Effects:

• Headache
• Insomnia
• Somnolence
• Constipation
• Abdominal pain
• Dry mouth
• Dizziness
• Anxiety
• Tremor
• Sedation
• Fatigue
• Mania
• Sweating
• Pharyngitis
• Euphoria
• Dyspnea
• Nervousness
• Sleep disturbance
• Drowsiness

Drug Interactions:

• Alcohol and other CNS depressants may increase CNS depression
• Fluoxetine may increase phenytoin blood concentration and risk of toxicity
• Fluoxetine may increase the effect of warfarin; therefore, the dose may need adjustments
• Fluoxetine may increase the blood levels and toxicity of lithium
• Fluoxetine inhibits the metabolism of carbamazepine and haloperidol

Key Issues to Note:

• Full antidepressant effect may be delayed until 4 weeks of treatment
• Give a lower dose in patients with hepatic and renal impairment
• Avoid taking alcohol during drug therapy

Drugs Used in the Treatment of Manic Disorders

Mania is a state of mind characterized by excessive cheerfulness and increased activity.

Signs and Symptoms:

• Hyperactivity
• Excessive enthusiasm
• Decreased need for sleep
• Flight of ideas
• Inflated self-esteem
• Talkativeness
• Extreme self-confidence
• Delusions

Acute mania usually begins abruptly and symptoms increase over several days. Manic episodes may be precipitated by:

• Use of antidepressants
• Lack of enough sleep
• Stressors
• CNS stimulants
• Bright light

Bipolar disorder (manic depression) is a mixed affective disorder in which the patient experiences alternating episodes of hypomania or mania and depression.

Management of Manic Disorders:

• Mild Symptoms of Mania: Lithium alone or in combination with benzodiazepine
• Severe Symptoms of Mania: Lithium plus antipsychotic drugs

Note: In acute attack of mania, lithium carbonate may be given concurrently with antipsychotic in order to bring the symptoms under control. Lithium carbonate has a slow onset of action which takes up to 2 weeks before therapeutic benefit is fully achieved.

Drugs used in the treatment of mania include:

• Lithium carbonate
• Sodium valproate
• Carbamazepine
• Lamotrigine

Lithium Carbonate

Available Preparations:

• Tablets: 300 mg

Available Brands: Camcolit®

Pharmacokinetics: It is completely absorbed from the GIT after oral administration, distributed widely into the body including breast milk. It is not metabolized and is excreted unchanged in urine.

Indications:

• Prophylaxis of mania
• Treatment of acute mania
• Manic phase of bipolar disorder
• Recurrent depression
• Aggressive or self-mutilating behavior

Contraindications:

• Pregnancy

• Severe renal impairment

• Cardiac disease

• Lactation

• Untreated hypothyroidism

• Disturbance of electrolyte balance

• Hypersensitivity to the drug

Dosage:

Adult and Children over 12 years:

• Acute Mania: 300 mg 3-4 times, maintenance dose 2.4 g/day.

• Prophylaxis: Initially 300-400 mg daily.

Side Effects:

• Nausea

• Diarrhea

• Muscle weakness

• Polyuria

• Vertigo

• Tremors

• Loss of concentration

• Hypothyroidism

• Impaired renal function

• Hypermagnesemia

• Disturbances of thyroid function

• Exacerbation of psoriasis

• Weight gain

• Oedema

• Mild drowsiness

• Sexual dysfunction

Drug Interactions:

• Concurrent use of lithium with thiazide diuretics may decrease renal excretion and enhance lithium toxicity

• Lithium may interfere with pressor effects of sympathomimetic agents and may decrease the effects of chlorpromazine

• Tetracyclines, phenytoin, carbamazepine, and methyldopa may increase lithium toxicity

• Concomitant use with haloperidol or other antipsychotic agents may result in severe encephalopathy

• Use of lithium with SSRIs may increase GI and CNS adverse effects

• Indomethacin and other NSAIDs decrease renal excretion of lithium

Key Issues to Note:

• The drug may be taken with food or milk to reduce GI upset

• Lithium should be discontinued before electroconvulsive therapy

• Patient should maintain adequate water intake

• Avoid large amounts of caffeine, which will interfere with drug\’s effectiveness

• The drug should not be stopped abruptly

Drugs Used in the Treatment of Epilepsy

Epilepsy is a disorder of brain function characterized by recurrent seizures that have a sudden onset. A patient should not be described as having epilepsy until a second non-febrile seizure occurs.

Seizure: A seizure is a paroxysmal discharge of cerebral neurons accompanied by a clinical phenomenon apparent to the patient or to an observer.

Classification of Epilepsy

Epileptic seizures (fits) present in several different forms depending on the site of the discharge and whether the discharge remains localized or spreads.

Partial Seizures: These are epileptic seizures in which the neuronal discharge remains localized in one area of the brain. They result in a disturbance of function such as abnormal sensation or movement of the limb without loss of consciousness. Partial seizures are subdivided as follows:

• Simple partial seizures (consciousness is not impaired)
• Complex partial seizures (consciousness is impaired)

Partial seizures may become secondarily generalized seizures if the neuronal discharge spreads to involve the entire brain.

Generalized Seizures: Generalized seizures are characterized by a neuronal discharge involving the whole brain with loss of consciousness. They are subdivided as follows:

• Tonic-clonic seizures (grand mal)

• Myoclonic seizures

• Atonic seizures

• Absence seizures (petit mal)

Absence Seizures (Petit Mal): These are generalized seizures characterized by a sudden loss of consciousness lasting for a few seconds. It is usually accompanied by motor activity which may vary from eyelid blinking to more extensive tonic body movement. It is common in children and juveniles.

Myoclonic Seizures: These are characterized by brief jerks in the limbs which may be single or multiple. The duration of the seizure is a few seconds. It mainly occurs in children and juveniles.

Atonic Seizures: Atonic seizures are characterized by loss of postural tone; the head sags or the patient falls down.

Generalized Tonic-Clonic Seizures (Grand Mal Fits): These are characterized by a sudden attack with loss of consciousness and violent body jerking lasting 3-5 minutes. The patient regains consciousness spontaneously; incontinence, tongue biting, or other injuries may occur during the episode. Grand mal fits may be due to:

• Family history of epilepsy

• Uncontrolled febrile convulsions in children

• Head injuries

• Infections (e.g., meningitis, HIV)

• Birth trauma to an infant

• Alcohol and drug abuse

Status Epilepticus: It is a seizure lasting for more than 30 minutes or several fits following one another without restoration of consciousness in between the fits. Status epilepticus is a common complication of grand mal epilepsy and it\’s a medical emergency.

Management of Status Epilepticus:

• Position the patient to avoid injury

• Give oxygen to support respiration

• If hypoglycemia is suspected, give a bolus of 50 ml of 50% glucose IV

• Consider giving parenteral thiamine if alcohol abuse is suspected

• Give anticonvulsants such as diazepam IV, lorazepam IV, clonazepam, midazolam

• Slow intravenous injection of phenytoin may be given if seizures recur or fail to respond to diazepam 30 minutes after it began

• Phenytoin by intravenous infusion should be given at a dose of 15 mg/kg body weight at a rate not greater than 50 mg/minute.

• Monitoring of blood pressure and ECG is necessary and phenytoin should be diluted with sodium chloride (normal saline) at a ratio of 1 mg of phenytoin: 1 ml of normal saline

Table 1: Summary of Choices of Antiepileptic Drugs

Seizure Type	Treatment Options
Partial Seizures	Carbamazepine, sodium valproate, pregabalin, lamotrigine, gabapentin, phenytoin
Generalized Tonic-Clonic Seizures (Grand Mal)	Carbamazepine, lamotrigine, sodium valproate, phenytoin
Absence Seizures (Petit Mal)	Ethosuximide, sodium valproate
Myoclonic Seizures	Sodium valproate, clonazepam
Status Epilepticus	Diazepam, clonazepam, midazolam, and phenytoin

Note: Monotherapy is preferable to a multiple-drug regimen and treatment is therefore initiated with a single drug, increasing the dose gradually until seizures are brought under control or adverse effects become severe. If treatment with the first drug fails, it is preferable to try alternative single first-line antiepileptics before giving combinations of drugs. The change-over from one antiepileptic to another should be made cautiously, withdrawing the first drug only when the new regimen has been largely established. Drugs with different modes of action should be selected for combined therapy, to reduce the risk of additive adverse effects. Many antiepileptic drugs interact with each other; therefore, precautions must be taken during prescribing.

Carbamazepine

Available Preparations:

• Tablets: 100 mg, 200 mg

• Syrup: 20 mg/ml

Available Brands: Tegretol®, Storilat®, Carbatol®, Carbadac®, Carbazina®

Pharmacokinetics: It is absorbed slowly from the GIT, distributed widely throughout the body, crosses the placenta, and accumulates in fetal tissue. It is metabolized by the liver to an active metabolite and is excreted in urine and feces.

Indications:

• Partial and secondary generalized tonic-clonic seizures

• Mixed partial or generalized seizure disorder

• Trigeminal neuralgia

• Prophylaxis in bipolar disorder

• Neuropathic pain

• Alcohol withdrawal

Contraindications:

• Hypersensitivity to carbamazepine and TCAs

• History of bone marrow depression

• Porphyria

Dosage:

• Epilepsy: Initially 100-200 mg 1-2 times daily, increased gradually after 2 weeks to the usual dose 400-1200 mg daily in divided doses. In some cases up to 1.6-2 g daily may be needed.

• Elderly: Initially 50 mg twice daily then increase to 400-1200 mg daily.

• Children 1 month – 12 years: Initially 5 mg/kg at night or 2.5 mg/kg twice daily, increased as necessary by 2.5-5 mg/kg every 3-7 days. Maintenance dose 5 mg/kg 2-3 times daily. Doses up to 20 mg/kg daily may be used.

• Trigeminal Neuralgia: Initially 100 mg 1-2 times daily, increased gradually according to response to 200 mg 3-4 times daily. Up to 1 g daily may be required in some cases.

• Prophylaxis of Bipolar Disorder Unresponsive to Lithium: Initially 400 mg daily in divided doses, increased until symptoms are controlled. Usual range 400-600 mg daily, max 1.6 g daily.

• Neuropathic Pain: Initially 100 mg twice daily, increased gradually until pain is relieved. Maintenance dose 200-600 mg daily. Do not exceed 1.2 g daily.

Side Effects:

• Nausea

• Ataxia

• Vomiting

• Dizziness

• Drowsiness

• Dry mouth

• Blurred vision

• Headache

• Anorexia

• Agitation

• Diarrhea

• Confusion

• Constipation

• Impotence

• Thrombocytopenia

• Arthralgia

• Stevens-Johnson syndrome

• Gynaecomastia

Drug Interactions:

• Clarithromycin, erythromycin, cimetidine, isoniazid may inhibit hepatic metabolism of carbamazepine with resultant increase of its serum concentration and toxicity

• Rifampicin, phenytoin, and phenobarbital may decrease serum concentrations of carbamazepine

• Antimalarial drugs may antagonize the activity of carbamazepine

• Use with alcohol and other CNS drugs may potentiate adverse effects of carbamazepine

• Use with verapamil may significantly increase the serum levels of carbamazepine

• Carbamazepine may decrease the effectiveness of theophylline and oral contraceptives

• Carbamazepine may increase the metabolism of warfarin, valproic acid, haloperidol, and phenytoin

Key Issues to Note:

• Take carbamazepine with food to prevent stomach upset

• Swallow controlled-release tablets whole, do not chew or crush them

• Grapefruit juice may increase the absorption and blood concentration of carbamazepine

• The drug is structurally similar to TCAs; some risk of activating latent psychosis or agitation in elderly patients exists

• Avoid alcohol during therapy

• The drug may cause drowsiness and impair ability to perform activities requiring mental alertness or physical coordination

• The drug may cause dry mouth and photosensitivity reactions

Phenytoin

Available Preparations:

• Tablets: 100 mg

• Injection: 50 mg/ml

Available Brands: Phenyto-S®, Epanutin®

Pharmacokinetics: It is absorbed slowly from the small intestine, distributed widely throughout the body, metabolized by the liver to inactive metabolites, and excreted in urine.

Indications:

• Generalized tonic-clonic seizures

• Partial seizures

• Status epilepticus

• Cardiac arrhythmias

• Trigeminal neuralgia or severe pain

• Control of seizures associated with neurosurgery or traumatic injury to the head

Contraindications:

• Hypersensitivity to phenytoin or other hydantoins

• Sinus bradycardia

• Avoid parenteral use in sinus bradycardia

• Sino-atrial block

• 2nd and 3rd degree heart block

• Stokes-Adams syndrome (IV)

• Hepatitis

Dosage:

Oral:

• Adult: Initially 150-300 mg daily as a single dose or in 2 divided doses, increased gradually according to response to the usual dose 200-500 mg daily.
• Children: Initially 5 mg/kg daily in 2 divided doses, usual dose range 4-8 mg/kg daily, max 300 mg daily.

Arrhythmias:

• Adults: Loading dose 250 mg 4 times a day for 1 day, then 250 mg/day for 2 days, maintenance dose 300-400 mg/day 1-4 times a day.

Side Effects:

• Gastric intolerance

• Drowsiness

• Confusion

• Slurred speech

• Gum hyperplasia

• Headache

• Sedation

• Insomnia

• Blurred vision

• Skin rashes

• Acne

• Hirsutism

• Nausea

• Nystagmus

• Vomiting

• Diplopia

• Behavioral disturbance

• Tremors

• Anorexia

• Constipation

• Blood disorders

• Coarse facies

• Fever

Drug Interactions:

• Alcohol and other CNS depressants may increase CNS depression

• Anticoagulants, cimetidine, fluoxetine, fluconazole, ketoconazole, isoniazid, and sulphonamides may increase phenytoin blood concentration and risk of toxicity

• Lidocaine, propranolol may increase cardiac depressant effects caused by phenytoin

• Phenytoin may decrease the effects of oral contraceptives, corticosteroids, haloperidol, furosemide, doxycycline, etc.

• Therapeutic effects of phenytoin may be decreased by barbiturates, carbamazepine, ethanol, folic acid, antacids, charcoal, and pyridoxine among others

Key Issues to Note:

• To ensure consistent absorption, phenytoin should be administered at the same time with regards to meals

• Phenytoin may be taken with food or milk to decrease GI upset

• Avoid alcohol during therapy

• Abrupt withdrawal may precipitate status epilepticus

• Advise the patient to maintain good oral hygiene

Sodium Valproate

Available Preparations:

• Tablets: 200 mg, 300 mg

• Syrup: 200 mg/5 ml

Available Brands: Epilim®, Petilin®, Valparin Chrono®

Indications:

• Generalized tonic-clonic seizures

• Partial seizures

• Atonic seizures

• Absence seizures

• Myoclonic seizures

• Acute manic phase of bipolar disorder

• Prophylaxis of migraine

Contraindications:

• Hypersensitivity to sodium valproate

• Family history of severe hepatic dysfunction

• Pregnancy

• Active liver disease

• Porphyria

• Pancreatitis

Dosage:

• Adult: Initially 600 mg daily in 2 divided doses, preferably after food, increased by 200 mg daily every 3 days to a max of 2.5 g daily, usual maintenance dose 1-2 g daily.

• Children under 12 years with body weight over 20 kg: Initially 400 mg daily in divided doses, increased according to response, usual range 20-30 mg/kg daily, max 35 mg/kg daily.

• Children < 20 kg: Initially 20 mg/kg daily in divided doses.

Side Effects:

• Nausea

• Vomiting

• Increased appetite

• Abdominal cramps

• Sedation

• Thrombocytopenia

• Behavioral disturbance

• Hyperammonemia

• Menstrual disturbances

• Tremor

• Ataxia

• Oedema

• Diarrhea

• Weight gain

• Gastric irritation

• Transient hair loss

• Drowsiness

Drug Interactions:

• Sodium valproate increases plasma concentrations of phenobarbital, primidone, phenytoin, zidovudine

• Aspirin may increase the effect of sodium valproate

• Sodium valproate absorption may be reduced by colestyramine

• Cimetidine and erythromycin may increase the effect of sodium valproate

• Concomitant use with clonazepam may cause absence seizures

• Antacids may increase the oral absorption of sodium valproate

Key Issues to Note:

• Avoid alcohol during therapy

• The drug may cause drowsiness and impair ability to perform activities requiring mental alertness or physical coordination

• The drug should not be withdrawn abruptly

Phenobarbitone

Available Preparations:

• Tablets: 30 mg

Available Brands: B-tone®

Pharmacokinetics: Phenobarbitone is well absorbed after oral administration, distributed widely to body tissues, metabolized by the liver, and excreted in urine.

Indications:

• Generalized tonic-clonic seizures

• Partial seizures

• Neonatal seizures

• Febrile convulsions

• Status epilepticus

Contraindications:

• Hypersensitivity to phenobarbitone

• Absence seizures

• Porphyria

• Respiratory depression

• Severe liver impairment

Dosage:

Generalized Tonic-Clonic Seizures, Partial Seizures:

• Adult: 60-180 mg once daily at night
• Children: 5-8 mg/kg daily

Febrile Convulsions:

• Children: Up to 8 mg/kg daily

Side Effects:

• Sedation

• Ataxia

• Nystagmus

• Somnolence

• Respiratory depression

• Behavioral disturbance

• Megaloblastic anemia

• Mental depression

• Allergic skin reaction

• Confusion

• Constipation

• Hypotension

• Drowsiness

• Slurred speech

Drug Interactions:

• Phenobarbitone may increase the metabolism of carbamazepine

• Phenobarbitone may decrease the effect of digoxin, corticosteroids, oral anticoagulants, tricyclic antidepressants, oral contraceptives, and metronidazole

• The sedative effect of phenobarbitone is enhanced by other CNS depressants including alcohol

• Sodium valproate increases the blood concentration and risk of toxicity of phenobarbitone

Key Issues to Note:

• Avoid alcoholic beverages during therapy

• The drug may cause drowsiness and impair ability to perform activities requiring mental alertness

• The drug should not be withdrawn abruptly after prolonged use

Anxiolytics, Sedatives, and Hypnotics

Anxiety is an emotional condition characterized by feelings such as apprehension and fear, accompanied by symptoms such as tachycardia, increased respiration, sweating, and tremor.

Drugs used in the treatment of anxiety include:

• Benzodiazepines
• Antidepressants (Anxiety frequently co-exists with depression)
• Beta blockers (may help to control physical symptoms such as tremor)

Note:

• Antidepressants can initially exacerbate anxiety (their therapeutic response takes at least 2 weeks), therefore combined therapy with benzodiazepines may be required initially.

• Benzodiazepines should be used for a maximum of 4 weeks, and the dose should be gradually reduced after the first 2 weeks to avoid the risk of dependence.

Insomnia

Insomnia is the inability to achieve or maintain sleep. It often leaves sufferers feeling unrefreshed by sleep and may lead to impaired daytime performance.

Insomnia is classified as follows:

• Transient Insomnia: It may occur in those who normally sleep well and may be due to environmental stress such as noise, shift work, or jet lag. It may also be associated with acute disorders.

• Short-term Insomnia: It is often related to an emotional problem (e.g., ongoing personal stress) or medical illness such as acute pain.

• Chronic Insomnia: Most cases of chronic insomnia are caused by psychiatric disorders such as depression, anxiety, dementia, psychosis, or substance abuse, or physical causes such as pain or pruritus.

Drugs used in the treatment of insomnia include:

• Benzodiazepines

• Antidepressants

Benzodiazepines

This class includes:

• Diazepam

• Midazolam

• Bromazepam

• Alprazolam

• Clonazepam

• Nitrazepam

• Chlordiazepoxide

• Lorazepam

Diazepam

Available Preparations:

• Tablets: 5 mg

• Rectal: 10 mg

• Injection: 10 mg/2 ml

Available Brands: Valium®, Cozepam®, Solina®

Pharmacokinetics: Diazepam is rapidly absorbed from the GIT following oral administration, distributed widely throughout the body, metabolized in the liver to the active metabolite, and excreted in urine and a small amount in feces.

Indications:

• Status epilepticus

• Febrile convulsions

• Convulsions due to poisoning

• Anxiety disorders

• Insomnia

• Control of muscle spasms

• Management of alcohol withdrawal

Contraindications:

• Hypersensitivity to diazepam

• Respiratory depression

• Severe hepatic impairment

• Acute pulmonary insufficiency

• Sleep apnea

• Comatose patients

• Acute narrow-angle glaucoma

• Acute alcohol intoxication

• Infants less than 1 month

Dosage:

Oral:

• Anxiety: 2-10 mg 2-4 times daily
• Insomnia Associated with Anxiety: 5-15 mg at bedtime
• Muscle Spasms: 2-10 mg 2-4 times a day
• Acute Alcohol Withdrawal: 10 mg 2-4 times for the first 24 hours, reduce to 5 mg 3-4 times on the next day as required
• Severe Acute Anxiety, Control of Acute Panic Attacks, Acute Alcohol Withdrawal, Muscle Spasms:

1. By IM or slow IV injection: 10 mg repeated if necessary after not less than 4 hours

• Status Epilepticus: By slow IV at a rate of 5 mg/min

1. Adult: 10-20 mg repeated if necessary after 30-60 minutes
2. Children: 200-300 mcg/kg or 1 mg/year of age

• Seizures Associated with Poisoning: By slow IV at a rate of 5 mg/min

1. Adult: 10-20 mg

By Rectum as a Rectal Solution:

• Adult and Children over 3 years: 10 mg, repeat the dose after 5 minutes if necessary
• Children 1-3 years and elderly: 5 mg, repeat the dose after 5 minutes if necessary

Side Effects:

• Drowsiness

• Sedation

• Dependence

• Muscle weakness

• Hypotension

• Visual disturbance

• Changes in libido

• Urinary retention or incontinence

• Hypersensitivity reactions

• Ataxia

• Headache

• Confusion

• Vertigo

• Skin rash

• Tremor

• Blood disorders

• Amnesia

Drug Interactions:

• Alcohol and other CNS depressants may increase CNS depression caused by diazepam

• Antacids may decrease the rate of absorption of diazepam

• Heavy smoking accelerates diazepam metabolism, thus lowering clinical effectiveness

• Oral contraceptives may impair the metabolism of diazepam

• Cimetidine, isoniazid, erythromycin may inhibit the breakdown of diazepam leading to increased levels in blood

• Diazepam may inhibit the therapeutic effect of levodopa

Key Issues to Note:

• Administer the drug with food or water but not grapefruit juice

• Avoid alcohol and caffeine during therapy

• The drug may cause drowsiness and impair the ability to perform activities requiring mental alertness

• Diazepam should not be discontinued suddenly; instead, decrease the dosage slowly over 8-12 weeks after long-term therapy

Drugs Used in the Treatment of Parkinsonism

Parkinson\’s disease is a neurodegenerative disorder characterized by tremor, muscle rigidity, slowed movement, and postural instability as a result of an imbalance between dopamine and acetylcholine neurotransmitters in the striatum.

Drugs used in the treatment of Parkinson\’s disease aim at restoring the natural balance between dopamine deficiency and relative cholinergic excess in the brain.

Classification of Drugs Used for Parkinson\’s Disease

Dopaminergics

These drugs increase or enhance the action of dopamine in the brain.

Examples:

• Bromocriptine
• Carbidopa
• Levodopa
• Cabergoline

Antimuscarinics

These drugs inhibit the action of acetylcholine in the brain.

Examples:

• Benzhexol

• Benztropine mesylate

Antimuscarinics are often effective in the early stages of Parkinson\’s disease and are effective in the treatment of drug-induced Parkinsonism.

Bromocriptine

Available Preparations:

• Tablets: 2.5 mg

Available Brands: Lactodel®, Parlodel®, Dopagon®, Brameston®

Pharmacokinetics: Bromocriptine is poorly absorbed when given orally, undergoes first-pass metabolism. It is metabolized completely in the liver and majorly excreted through bile.

Indications:

• Parkinson\’s disease
• Suppression of lactation
• Puerperal breast engorgement
• Male hyperprolactinemia
• Premenstrual symptoms
• Benign breast diseases
• Prolactinomas
• Female infertility
• Amenorrhoea
• Acromegaly

Contraindications:

• Patients hypersensitive to ergot alkaloids
• Pregnancy
• Severe ischemic heart disease
• Uncontrolled hypertension

Dosage:

• Parkinson\’s Disease and Infertility: 1.25 mg at night for 7 days, increase to 2.5 mg for the second week, 2.5 mg twice daily for the third week, and then 2.5 mg 3 times daily for the fourth week. Then increasing by 2.5 mg every 3-14 days according to response to a usual range of 10-40 mg daily taken with food
• Suppression of Lactation: 2.5 mg daily for 2-3 days, increased to 2.5 mg twice daily for 2 weeks
• Amenorrhoea and Benign Breast Disease: Initially 1.25 mg once daily at bedtime, gradually increased to 2.5 mg 2-3 times daily

Side Effects:

• Dizziness
• Dry mouth
• Confusion
• Headache
• Constipation
• Leg cramps
• Allergic skin reactions
• Fatigue
• Cold fingers and toes
• Nausea
• Postural hypotension
• Hair loss
• Lightheadedness
• Abdominal cramps
• Vomiting
• Insomnia
• Nasal congestion

Drug Interactions:

• Antipsychotic drugs may oppose the action of bromocriptine and increase the risk of Parkinsonism
• Erythromycin and other macrolide antibiotics may lead to increased levels of bromocriptine and the risk of adverse effects
• Domperidone and metoclopramide may reduce the hypoprolactinemic effects of bromocriptine
• Alcohol intolerance may result when high doses of bromocriptine are administered together with alcohol

Key Issues to Note:

• Side effects may be minimized by gradual introduction of the drug
• The drug may be administered with meals to minimize GI distress
• Take precautions while driving or operating machines since dizziness or drowsiness may occur at the beginning of therapy
• Advise the patient to limit alcohol use during treatment
• Inform the patient that it may take 6-8 weeks or longer for menses to be reinstated

Levodopa with Carbidopa

Available Preparations:

• Tablets

Available Brands: Sinemet® (Levodopa/Carbidopa) 100/10

Pharmacokinetics: Levodopa is fairly well absorbed when given orally, though food reduces the rate and extent of its absorption. Carbidopa enhances levodopa bioavailability. It is metabolized in the liver to dopamine and excreted in urine.

Indications:

• Parkinson\’s disease

Contraindications:

• Closed-angle glaucoma
• Hypersensitivity to any of the ingredients
• Bronchial asthma
• Severe cardiovascular disease
• Undiagnosed skin lesions or history of melanoma

Dosage:

• Initially 50-100 mg of levodopa with 10-12.5 mg of carbidopa 3-4 times daily (1/2 – 1 tablet of Sinemet 110, 3-4 times daily). Increased by 50-100 mg daily or on alternate days according to response up to 800 mg levodopa with 80-100 mg carbidopa in divided doses

Side Effects:

• Nausea
• Dizziness
• Palpitations
• Dark urine
• Abnormal movements
• Visual abnormalities
• Nervousness/agitation
• Dry mouth
• Depression
• Headache
• Fluid retention
• Tongue irritation
• Muscle twitching

Drug Interactions:

• Pyridoxine reverses the effect of levodopa
• Absorption of levodopa may be reduced by iron
• Antipsychotic drugs may reduce the effect of levodopa
• Antacids may increase the absorption of levodopa

Key Issues to Note:

• Gastric irritation may be reduced by taking the drug after food
• Treatment should be started with low doses, then gradually increased according to the response
• Inform the patient that therapeutic response may be slow
• Warn the patient of the possible dizziness and orthostatic hypotension, especially at the beginning of therapy

Antipsychotics (Neuroleptic) Drugs

Schizophrenia

Schizophrenia is a chronic psychotic illness characterized by a disintegration of the process of thinking, contact with reality, and emotional responsiveness. 

It is more common in males and usually begins in late adolescence to the early twenties.

Clinical Features of Schizophrenia

Clinical features of schizophrenia are often presented as positive or negative symptoms:

Positive Symptoms:

• Delusions
• Hallucinations
• Thought disorders
• Disorganized behaviors
• Agitation

Negative Symptoms:

• Lack of drive
• Apathy
• Social withdrawal
• Poor self-care
• Poverty of speech

Positive symptoms are seen as exaggeration of normal function and are common in the acute phase. Negative symptoms are viewed as loss of normal function and are prominent in the chronic phase.

Most drugs are effective against positive symptoms except atypical antipsychotics such as olanzapine which are effective against both positive and negative symptoms.

Drugs used in the treatment of schizophrenia can be classified as either typical (first generation) or atypical (second generation) antipsychotics.

Table 1: Classification of Antipsychotic Drugs and Their Target Symptoms

Class	Drug	Target Symptoms
Phenothiazines (Typical)	Chlorpromazine	Hallucinations Delusion Irrational behavior
Fluphenazine
Trifluoperazine
Promethazine
Thioridazine
Butyrophenone (Typical)	Haloperidol	Elevated mood, expansive self-image, grandiose delusion
Droperidol
Atypical Antipsychotic	Risperidone	Hallucinations, delusions
Clozapine
Olanzapine

Note:

• Drug treatment must be started as soon as possible for better results
• Acute psychotic symptoms such as hallucination or delusions can be controlled using drugs such as haloperidol or chlorpromazine
• Positive symptoms tend to respond better to drugs than negative symptoms
• Treatment for schizophrenia is not curative and long-term maintenance therapy (2-5 years) is usually required to prevent relapse

Haloperidol

Available Preparations:

• Tablets: 5 mg, 10 mg
• Injection: 5 mg/ml, 50 mg/ml

Available Brands: Decanoas®, Haldol®, Haloxen®, Haldol

Pharmacokinetics: Haloperidol is relatively well absorbed following oral administration, distributed widely into the body, with high concentrations in adipose tissue. It is metabolized by the liver and excreted in urine and a small amount in feces.

Indications:

• Schizophrenia
• Behavior disturbance
• Nausea and vomiting
• Mania
• Severe anxiety
• Intractable hiccups

Contraindications:

• CNS depression
• Comatose states
• Severe hepatic disease
• Known hypersensitivity to haloperidol

Dosage:

Oral:

• Schizophrenia and Other Psychosis, Mania, Psychomotor Agitation, Violent Behavior, and Severe Anxiety (Adjunct):

1. Adult: Initially 0.5-5 mg 2-3 times daily, increased as needed up to 20 mg/day, maintenance usually 2-10 mg/day

• Acute Psychosis: 2-10 mg IM 6-8 hourly interval until symptoms are controlled
• Long-term Therapy: 10-20 mg up to max of 100 mg deep IM of decanoate injection may be given
• Nausea and Vomiting: 0.5-2 mg daily by IM injection
• Intractable Hiccups: Orally 0.5 mg 3 times daily, adjusted according to response

IM or Slow IV Injection:

• Acute Psychosis: 2-10 mg IM 6-8 hourly interval until symptoms are controlled

Side Effects:

• Dry mouth
• Weight gain
• Lethargy
• Sedation
• Restlessness or akathisia
• Constipation
• Muscle stiffness
• Hypotension
• Muscle cramping
• Blurred vision
• Increased appetite
• Tinnitus
• Swelling of female breasts
• Depression
• Decreased sexual function
• Peripheral edema

Drug Interactions:

• Alcohol and other CNS depressants may increase CNS depression
• Rifampicin accelerates the metabolism of haloperidol resulting in reduced plasma concentration
• Haloperidol enhances the hypotensive effect of prazosin
• Haloperidol enhances the sedative effect of clonazepam, codeine, and diazepam
• Carbamazepine accelerates the metabolism of haloperidol
• Haloperidol may inhibit blood pressure response to centrally acting antihypertensives such as methyldopa
• Beta blockers may inhibit haloperidol metabolism, increasing plasma levels and toxicity
• Haloperidol may antagonize the therapeutic effect of bromocriptine on prolactin secretion
• Haloperidol may inhibit metabolism and increase toxicity of phenytoin

Key Issues to Note:

• Tardive dyskinesia may occur after prolonged use and may disappear spontaneously or persist for life
• Protect the drug from light; slight yellowing of the injection is common and does not affect potency
• Advise the patient to report side effects such as extrapyramidal reactions
• Elderly patients usually require lower initial doses and a more gradual dosage adjustment
• The drug is not recommended for children under 3 years because they are prone to extrapyramidal reactions
• Avoid alcohol and other medications that cause sedation

Endocrine and Metabolic Drugs

Drugs Used in Diabetes Mellitus

Diabetes mellitus is a chronic disorder characterized by hyperglycemia, altered metabolism of carbohydrates, proteins, and fats, due to insulin deficiency or resistance.

Classification of Diabetes Mellitus

Diabetes mellitus is classified into two:

• Type 1 diabetes mellitus
• Type 2 diabetes mellitus

Type 1 Diabetes Mellitus

This type of diabetes is due to autoimmune destruction of the beta cells. It is more common in young children than adults. Patients with type 1 diabetes require exogenous insulin for survival.

Type 2 Diabetes Mellitus

Type 2 diabetes usually presents in obese adults and has a strong family history. It is caused by insulin deficiency and insulin resistance.

Drugs used in the treatment of diabetes mellitus include:

• Oral antidiabetic drugs
• Insulin

Oral Antidiabetic Drugs

Oral antidiabetic drugs are used in the treatment of type 2 diabetes mellitus which has not responded to lifestyle modification.

Classification of Oral Antidiabetics

Oral antidiabetics are classified as follows:

• Sulfonylureas
• Biguanides
• Thiazolidinediones
• Alpha-glucosidase inhibitors

Sulfonylureas

Sulfonylureas are structurally related to sulfonamides. They are divided into generations as follows:

First Generation

• Tolbutamide
• Chlorpropamide

Second Generation

• Glibenclamide
• Glimepiride
• Gliclazide
• Glipizide

Mode of Action

Sulfonylureas act by stimulating insulin secretion from the beta cells of the pancreas, thus increasing insulin levels. Increased insulin secretion results in lowering of blood glucose levels. These drugs are only effective in the presence of functioning beta cells.

Tolbutamide

Available Preparations:

• Tablets: 500 mg

Pharmacokinetics

Tolbutamide is readily absorbed after oral administration, metabolized in the liver, and excreted in the urine and feces chiefly as metabolites.

Indications

• Type 2 diabetes mellitus

Contraindications

• Severe hepatic and renal impairment
• Presence of ketoacidosis
• Breastfeeding
• Pregnancy
• Porphyria
• Insulin-dependent diabetes mellitus

Dosage

• Adult: 500-1500 mg daily in 2 divided doses, max 2 g daily

Side Effects

• Nausea and vomiting
• Constipation
• Dyspepsia
• Hypoglycemia
• Headache
• Diarrhea
• Skin rash
• Tinnitus
• Taste alteration

Drug Interactions

• Beta-blockers may mask hypoglycemic symptoms caused by tolbutamide
• Hypoglycemic effect caused by tolbutamide may be reduced by corticosteroids
• Disulfiram-like reaction may occur when tolbutamide is taken concurrently with alcohol
• Hypoglycemic effect of tolbutamide may be increased by sulfonamide antibiotics, ranitidine, and cimetidine

Key Issues to Note

• Tolbutamide should be given with or immediately after food
• Elderly, debilitated patients, and those with impaired renal or hepatic function usually require a lower initial dose
• Because of its complete metabolism and short duration of action, it is recommended in the elderly
• The drug should not be taken at bedtime because of the potential for nocturnal hypoglycemia
• Avoid alcohol while taking tolbutamide

Glibenclamide

Available Preparations:

• Tablets: 5 mg

Available Brands: Daonil®, Glibol®, Glibetics®, Euglucon®, Betanase®, Diaben®, Glamide®

Combinations: Duotrol® (Glibenclamide/Metformin) 5/500

Pharmacokinetics

Glibenclamide is reliably and almost completely absorbed when taken orally, metabolized in the liver to weakly active metabolites, and excreted in urine and feces.

Indications

• Type 2 diabetes mellitus

Contraindications

• Presence of ketoacidosis
• Type 1 diabetes mellitus
• Severe renal and hepatic impairment
• Pregnancy and breastfeeding
• Previous hypersensitivity to the drug

Dosage

• Initially 5 mg in the morning, dose adjusted according to response, max 15 mg/day

Side Effects

• Headache
• Weakness
• Epigastric fullness
• Hypoglycemia
• Dizziness
• Nausea
• Weight gain
• Heartburn

Drug Interactions

• Beta-blockers may mask warning symptoms of hypoglycemia caused by glibenclamide
• Hypoglycemic effect of glibenclamide is reduced by drugs which are insulin antagonists such as bendrofluazide, oral contraceptives, and glucocorticoids
• Metformin has a synergistic hypoglycemic action with glibenclamide
• Alcohol increases the hypoglycemic effect caused by glibenclamide and may also cause disulfiram-like reaction
• An enhanced hypoglycemic response to glibenclamide may occur when given together with drugs such as aspirin, cimetidine, fluconazole, and ketoconazole

Key Issues to Note

• Glibenclamide should be given with or 30 minutes before a meal
• Warn the patient of the possibility of hypoglycemia and advise on how to manage it
• Encourage the patient to maintain lifestyle modifications
• Glibenclamide tablets should be stored in a cool, dry place and protected from light
• Avoid alcohol while taking the drug

Biguanides

Biguanides are the drugs of choice in the treatment of type 2 diabetes mellitus in overweight patients. They do not increase insulin secretion; therefore, they do not usually cause hypoglycemia or weight gain. Metformin is the only available biguanide. It may be combined with a sulfonylurea to provide better glycemic control.

Mode of Action

Biguanides act by decreasing the production of glucose by the liver and also promote the uptake of glucose by tissues.

Metformin

Available Preparations:

• Tablets: 500 mg, 850 mg, 1000 mg

Available Brands: Glyformin®, Glucophage®, Glucomet®, Metformin-Denk®, Glycomet®, Bigomet®

Combinations:

• Avandamet® (Rosiglitazone/Metformin) 2/500
• Pionorm-M® (Pioglitazone/Metformin) 30/500
• Piosafe-M® (Pioglitazone/Metformin) 15/500

Pharmacokinetics

Metformin is slowly and incompletely absorbed when taken orally. Food delays or decreases the extent of absorption. It is excreted mainly as unchanged drug in urine.

Indications

• Type 2 diabetes mellitus
• Polycystic ovary syndrome

Contraindications

• Pregnancy
• Hepatic dysfunction
• Acute metabolic acidosis
• Pancreatitis
• Renal dysfunction
• Breastfeeding

Dosage

• Initially 500 mg with breakfast for 1 week, then 500 mg with breakfast and evening meal for at least 1 week, then 500 mg with breakfast, lunch, and evening meal, max 2 g daily in divided doses

Side Effects

• Nausea
• Anorexia
• Rash
• Lactic acidosis
• Malabsorption of vitamin B12
• Vomiting
• Diarrhea
• Metallic taste
• Abdominal pain

Drug Interactions

• There is an increased risk of hypoglycemia when metformin is given with digoxin or furosemide
• Alcohol increases the risk of lactic acidosis associated with metformin
• Nifedipine may enhance the absorption of metformin
• Metformin may interfere with vitamin B12 absorption
• Cimetidine increases peak metformin blood concentrations

Key Issues to Note

• Advise the patient not to change or discontinue the drug without consulting the prescriber
• Avoid alcohol during treatment
• Advise the patient to take the drug with meals
• Extended-release tablets should be taken whole without chewing or crushing

Insulin

Insulin is a hormone produced by the beta cells of the pancreatic islets of Langerhans.

It plays an important role in the regulation of carbohydrate, protein, and fat metabolism. Insulin lowers blood glucose by inhibiting glycogenolysis and gluconeogenesis in the liver and stimulates glucose uptake by muscles and adipose tissues.

Insulin is used in the treatment of type 1 diabetes mellitus and is also used in type 2 diabetes mellitus in the following cases:

• Severe infection
• Major surgery
• Ketoacidosis
• During pregnancy
• When hyperglycemia does not respond to non-pharmacological measures and oral antidiabetics

Sources of Insulin

Insulin for therapeutic use is extracted from the pancreas of any of the following:

• Cattle
• Pig
• Human

Types of Insulin Preparations

There are 3 main types of insulin preparations which differ in time of onset and duration of action. They include:

• Short-acting insulin (e.g., insulin soluble) – It is the only insulin that can be given by IV bolus, IV infusion, or IM
• Intermediate-acting insulin (e.g., insulin zinc suspension – Lente) – Have slower onset of action but with prolonged duration of action. They are formulated to dissolve more gradually when administered
• Long-acting insulin (e.g., glargine – Lantus) – Has a duration of action of 24 hours

Insulin Administration

Insulin is usually given subcutaneously in the buttock, abdomen, anterior thigh, and dorsal arm. Absorption is usually most rapid from the abdomen, followed by the arm, then the buttock and thigh. The rate of absorption is increased by massage, hot bath, or exercise. The type of insulin used depends on the type of diabetes, patient\’s age, and blood glucose levels.

Soluble Insulin

Available Preparations:

• Injection: 100 IU/ml

Available Brands: Actrapid®

Indications

• Type 1 diabetes mellitus
• Diabetic ketoacidosis
• During pregnancy, surgery, trauma, infections, and fever

Contraindications

• Hypersensitivity to insulin
• Hypoglycemia

Dosage

• Insulin dosage is individualized and determined in accordance with the needs of the patient, usual range 0.3-1 unit/kg/day

Side Effects

• Hypoglycemia
• Skin rash
• Edema
• Fat hypertrophy at injection site
• Local reaction
• Urticaria
• Abdominal bloating
• Blurred vision

Drug Interactions

• Alcohol may increase the effects of insulin
• Beta-blockers may mask signs and symptoms of hypoglycemia
• Corticosteroids antagonize effects of insulin and result in increased glucose levels
• ACE inhibitors may increase the hypoglycemic effect of insulin

Key Issues to Note

• Advise the patient to watch out for symptoms of hypoglycemia such as fatigue, confusion, headache, hunger, rapid breathing
• Advise the patient to always carry a quick source of sugar to rectify hypoglycemia when it occurs
• Injection sites should be rotated to avoid lipodystrophy