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Introduction to Reproductive Health

Introduction to Reproductive Health

INTRODUCTION TO REPRODUCTIVE HEALTH

Reproductive Health is an integral aspect of health care, included in the minimal health care package. The knowledge, skills, and attitude gained from this course will help students manage and counsel clients with health problems related to reproductive health.

Reproductive Health is when a person is well, not only physically but also mentally and socially, in all matters related to the reproductive system and how it functions.

Reproductive health is defined as a state of complete physical, mental and social well being and not merely the absence of the disease or infirmity on all matters related to reproductive function and its processes involved.

This is a process concerned with peoples‘ ability to have a responsible, satisfying and safe sex  life, their capability to reproduce and having the freedom to decide if, when and how often to do so. 

Reproductive health includes having: 

  1. Satisfying, safe sex life. 
  2. Ability to reproduce. 
  3. Successful maternal and infant survival outcome. 
  4. Freedom to control reproduction. 
  5. Information about and access to safer, effective and affordable methods of family planning. 
  6. Ability to minimize gynecological disease throughout life.
COMPONENTS OF REPRODUCTIVE HEALTH

COMPONENTS OF REPRODUCTIVE HEALTH

Safe Motherhood:

  • Preconception care
  • Antenatal care
  1. Maternal nutrition
  2. Focused antenatal care
  3. Immunization for tetanus, hepatitis B, etc.
  4. EMTCT of HIV/AIDS
  • Clean safe delivery
  • Emergency obstetric care
  • Postnatal (newborn care) and postpartum care
  • Breastfeeding/infant feeding
  • IEC and community mobilization
  • Post-abortion care services
  • Comprehensive abortion care

Family Planning:

  • Medical eligibility for family planning services
  • Provision of contraceptives and natural family planning
  • Emergency contraceptive
  • Management and follow-up for side effects of contraceptives
  • Infection prevention and quality care
  • Adolescent reproductive health

STIs/HIV/AIDS:

  • Behavioral change counseling
  • Condom promotion and distribution
  • Counseling and testing
  • STI management and treatment
  • Infection prevention and quality of care
  • Partner notification and treatment
  • Treatment compliance
  • Sexually Transmitted Infection, including HIV and AIDS
  • EMTCT

Sexual and Adolescent Health:

  • Behavior change counseling
  • Provision of adolescent-friendly services
  • Provision of contraceptive services
  • Screening and management of STIs
  • Sexual and Gender-Based Violence

Maternal and Child Health (MCH) (Safe Motherhood):

  • Preconception care
  • Antenatal care
  1. Maternal nutrition
  2. Focused antenatal care
  3. Immunization for tetanus, hepatitis B, etc.
  4. EMTCT of HIV/AIDS
  • Clean safe delivery
  • Emergency obstetric care
  • Postnatal (newborn care) and postpartum care
  • Breastfeeding/infant feeding
  • IEC and community mobilization
  • Post-abortion care services
  • Comprehensive abortion care

Reproductive Organ Cancers:

  • Screening and referral
  • Definitive management
  • Palliative care

Gender-Related Issues:

  • Advocacy
  • Partner involvement
  • Community involvement
  • Specialized management
  • Multi-sectorial collaboration
  • Legal support

Menopause and Andropause:

  • Symptomatic treatment
  • Hormonal replacement
  • Partner involvement
  • Advice on exercise and nutrition

Problems affecting women’s reproductive health/common RH concerns for women.

  • Anaemia
  • Unregulated fertility
  • Malnutrition
  • Infertility
  • STIs, HIV, and AIDS
  • Uterine fibroids
  • Maternal mortality and morbidity
  • Endometriosis
  • Poverty
  • Female Genital Mutilation
  • Gynaecological cancers
  • Sexual gender-based violence
  • Early marriage
  • Unintended pregnancy

Importance of reproductive health 

  1. Promotion of maternal and child health 
  2. Reduces maternal morbidity and mortality 
  3. Promotes free women‘s involvement in all matters related to reproductive health issues  e.g. family planning 
  4. Promotes prompt treatment and detection of life threatening cases throughout  reproductive life 
  5. It promotes safer sex practices and reduces the incidence of rampant sexual related abuses
  6. Reduces government expenditure on reproductive related health issues thus promotes  quality standard of living. 

Problems being faced during the implementation of Reproductive Health in Uganda 

The following are some of the problems being encountered during the implementation of  reproductive health services in Uganda; 

  1. Low socio-economic status (poverty): This is the major setback as many people in  Uganda live within poverty level which in turn makes them unable to access even the least  costly services. For instance, the Uganda Demographic Health Survey shows that  mortality rates are high in women from low socio-economic status as these women  are likely to be less privileged in the fields of nutrition, housing, quality education etc 
  2.  Improper/underutilization of the existing services: This can be attributed to several factors that lead to the improper or inadequate use of the existing services. These factors include: Lack of Awareness and Education, Stigma and Cultural Barriers, Limited Access to Services, Cost and Affordability, e.t.c
  3. Delivery of substandard care i.e. when the care provided is below the generally  accepted level available at that particular coupled up shortages of resources and under-equipped facilities 
  4. Lack of communication and referral facilities: This could be due to poor coordination  between lower health facilities with the higher ones backed-up by geographical  barriers, transport means like ambulances etc. 
  5. Poor cultural perspectives on reproductive health; variety of cultural practices are the  basic obstacles to Reproductive Health Services for instance, female genital  mutilation, early marriages, denying women to eat certain foods etc. 
  6. Lack of awareness by the community on issues related to reproductive health.
  7. Inadequate supply of resources related to reproductive health. This therefore makes  the little existing services disproportionately consumed by the overwhelming  individuals who visit the health Centers. 
  8. Inadequate skilled staff  specially trained on issues pertaining reproductive health.  The number of skilled staff to deliver various Reproductive Health Services in  Uganda is appalling as compared to the number of clients who desperately need the  scarce services. 
  9. Improper evaluation and supervision of reproductive health services to ascertain its  progress and successes .
  10. Lack of support from men, opinion leaders and development partners as they are  considered change agents in the community 
  11. Misappropriation and embezzlement of funds specially designed to facilitate  reproductive health services.

Ways through which Reproductive Health Services can be improved in Uganda.

It is a coordinated long term effort within the families, opinion leaders, communities, and health systems.

It also involves the national legislation and policies where action may vary in respect of an individual, and the government ought to make Reproductive Health a priority of public concern and to periodically evaluate the program to ascertain the successes.

1. Quality Obstetric and Referral Services: Upgrade facilities, ensure ongoing training for healthcare providers.

2. Decentralization of Services: Establish satellite clinics in underserved areas. Work with local governments to set up and manage decentralized clinics, ensuring accessibility for rural populations.

3. Empowerment and Education: Promote women’s education and economic opportunities. Collaborate with educational institutions, NGOs, and businesses to create scholarship programs and vocational training.

4. Community Sensitization: Conduct community workshops, health talks, and media campaigns. Engage local influencers, utilize community radio, and distribute informational materials.

5. Improving Standard Delivery of Care: Organize regular refresher courses for healthcare personnel. Establish a training calendar, facilitate workshops, and provide resources for continuous learning.

6. Proper Utilization of Services: Develop outreach programs and streamline service information. Engage community health workers for door-to-door awareness, and utilize digital platforms for service updates.

7. Discouraging Cultural Practices: Advocate for and enforce legislation against harmful practices. Collaborate with legal authorities, NGOs, and community leaders to raise awareness and enforce laws.

8. Penalization for Misuse of Funds: Institute transparent financial monitoring systems. Regular audits, community involvement in financial oversight, and legal consequences for mismanagement.

9. Male and Community Engagement:  Establish community support groups, involve men in awareness campaigns. Conduct community meetings, involve male leaders in reproductive health initiatives, and celebrate positive male involvement.

Introduction to Reproductive Health Read More »

DOMICILIARY CARE

DOMICILIARY CARE

DOMICILIARY CARE

Domiciliary care is an obstetric care given to a mother in her home during pregnancy, labour and puerperium.

Types of Domiciliary Care

  1.  Type one domiciliary midwifery care “continuity:; In this type the woman is cared for in her home all through during antenatal period delivery and postnatal care. The woman will only visit a health unit or hospital only when there is a problem that requires specialized care or more gadgets to be used. This care is known as continuity of care or fragmented care. In this case one midwife provides all the care to the woman.
  2.  Type two, community, integrated or centralized care; In this care service is integrated (mixed) in a way that part of the care may be given at home and some in the health setting like a hospital. Usually antenatal or delivery may be offered in the hospital and puerperium period managed at home. This is the type of care that student midwives and nurses offer as part of their midwifery part two and is compulsory for them.
  3.  Employee or independent practitioner in domiciliary; This is a type of care in which a midwife practices as a private midwife in the community but not necessarily on one woman. The midwife may have a maternity Centre for all or part of the care or she may combine it with one to one community midwifery care. This is the commonest type of domiciliary care in Uganda.

Forms of Domiciliary Care
Characteristics of patterns of domiciliary care depend on a number of factors and these can be:

  • Decision of the midwife
  • Decision of the woman / family
  •  Location and nature of community
  •  Availability of basic requirements for domiciliary care

Objectives of Domiciliary Care.

  1.  Domiciliary midwifery care  to take midwifery near to the community thus increasing accessibility to services

  2.  To encourage full participation and involvement of male partners and family members in the birth process so as to get their full support

  3.  To reduce on maternal / infant morbidity and mortality as the midwife has less workload and concentrates on one woman.

  4.  To reduce on hospital/health facility over crowding

  5.  To promote midwife-mother relationship and mutual understanding between the woman and the midwife.

Domiciliary Care given by midwives
  1.  Care before conception
    >   Health education to young girls on good nutrition and hygiene
    >   Teaching young girls about life skills
    >    Immunization of young girls with tetanus toxoid
    >    Counselling adolescents on reproductive health and other social issues
  2.  Care during pregnancy
    >   Immunization
    >   Antenatal check ups
    >   Treatment of minor problems.    >   Health education on problems in pregnancy
  3. Care during labour
    >   Care of mother in Labour
    >   Use of partograph to monitor labour
    >   Delivering of the baby
    >   Infection prevention
  4. Care after delivery
    >   Immunization
    >   Care of mother and baby
    >   Postnatal exercises
    >   Family planning

Advantages of Domiciliary Services.

  • Domiciliary services promotes midwife – mother relationships and thus minimizing fears and phobias of childbirth
  • It promotes continuity of care and close supervision of the mother thus – contributing to the reduction of maternal / infant morbidity and mortality
  •  Increases access to health services as the woman is found in her home instead of herself looking for the services
  •  Domiciliary is cost effective to a certain level as only relevant care will be given to individual women and at the same time the woman will continue her responsibilities especially supervision of the home
  •  It gives peace of mind to the mother, husband children and other house members because the woman remains at home
  •  It promotes woman centered care including choice control over services rendered and also encourages continuity of care.
  •  It promotes privacy and security and respect the mother with less interference and exposure
  • Promotes good communication and openness. Only relevant information is given to the mother and her family. As the midwife knows the woman personally, she understands better their concerns, lives, and challenges and assists them accordingly.
  •  Promotes autonomy to the midwife and there is job satisfaction
  •  It promotes creativity, problem solving skills and maturity in service with good experience.
 

Brief History of Domiciliary Care

 Throughout the ages, women have depended upon a skilled person, usually another woman to be with them during child birth
 In United Kingdom, the midwives skills are increasingly valued and midwives are being urged to expand their role even further in the field of public health.

  • In Uganda in 1960’s(May 1968), this is when the midwife would look after the mother in the home environment.  Midwives would do antenatal care, deliver mothers in their own homes and continue to give post natal care in the mother’s home.
     >    This would also give opportunity for the midwife to give health education to the other family members.
    >     In the 1970s when the political system in Uganda changed, leading to a lot of insecurity, the midwives stopped delivering mothers at home  and instead delivered mothers in hospitals and maternity units. Then the midwives continued to nurse the mothers and their babies at the mother’s home.
     > These services have continued today and are being practiced by Private Midwives and the student midwives who are undertaking Registered Midwifery Course of Diploma in Midwifery Course.
Types/ Groups of mothers Needing Domiciliary care
  • Group 1: Women with less risk of getting complications
    Women who have ever delivered one baby but have not exceeded five – that is gravid two to four.
    This group of women if they did not experience any major complication in pregnancy labour and puerperium, can be care for in the community throughout, pregnancy labour and puerperium
  • Group 2: These are the women who are suspected of developing a complication, though they may not develop them at all. For examples: primigravida – pregnant for the first time,
    Grand multi para – has delivered more than four times, short women- less than 152cm high, women with previous complications that are likely to occur again e.g. cord prolapsed.
    This group of women may be cared for only for antenatal or delivery and puerperium depending on other factors as detected on history and assessment.
  • Group 3: These are the high Risk Mothers, women who come with obvious complications, or are highly suspected of developing various complications. Examples: Multiple pregnancy – those with medical conditions like cardiac diseases, diabetes mellitus, sickle cell disease.

Common Drugs used in Domiciliary 

  •  Ergometrine
  •  Ferrous sulphate
  •  Folic acid
  •  Panadol
  •  Chloroquine

How Domiciliary is carried out.

  •  Booking

A mother who has to be booked must be with the following
>  Must be normal with no risk factors like CPD,
>  Grande multi parity, multiple pregnancy

  •  Home delivery

The following must be put in consideration
(a).   Well ventilated home without without overcrowding
(b).   Clean house, good hygiene in and around the house
(c).   The house should have more than 4 bedrooms, toilets
and kitchen
(d).   The floor must be cemented
(e).   There must be tap water
(f).   There must be easy means of boiling water

  •  Enough equipment especially for the mother and baby(bathing)
  •  Husband and wife should be willing for the care
  •  The distance from the home to hospital should be less than 2 miles.
QUALITIES OF A MIDWIFE

In normal circumstances the midwife should be a qualified senior student midwife with enough knowledge
(a)  She must create a friendly relationship between her, the mother and family
(b)   She must remember that she does not belong to the family and is only a guest so she must adopt her behavior in relation to the family routine
(c)   No commands or orders should be given but advices, the midwife should be flexible
(d)   She should show interest in the family
(e)   Avoid embarrassing the mother in the family

(f)   She has to apply her professional code of conduct and stay in the home only as a midwife
(g)   Quick and correct judgment has to be applied in providing the best care expected

DOMICILIARY BAGS

The midwife must be equipped with the following

  •  Sphyginomanometer
  •  Stethoscope
  •  Urine testing strips
  •  Clinical thermometer
  •  Spirit for baby’s cord
  •  Swabs in the gallipot and cord ligatures
  •  Receivers, dissecting forceps, artery forceps, scissors
  •  Antiseptic lotion
  •  Plastic apron and tape measure
  •  Drugs like Panadol, and iron tablets

 

Care

Here in Uganda a mother is delivered in the hospital then cared for in her home for seven day including the 1st days in the hospital

ANTENATAL CARE
Normally a mother is booked on her 1st visit at 12wks.It should be during this time when the midwife inspect the home of the mother until the mother is delivered in the hospital and cared for the first 2 days and  then 5 days at home

PUEPERIUM
During puerperium the midwife continues to visit the mother daily at her home. If there is any indication of complication arising of the mother requires extra supervision and support additional visits will be made
The midwife observes the mother’s general condition both mentally and physically, ask her how she is feeling. Inquire about the baby particularly feeding, sleeping, passage of urine and stool.

If the mother appears stressed, depressed, or anxious about the baby or any other problem. The midwife should sit, listens and responds. The time spent listening and discussing problems with the mother invariably of great value to her wellbeing
The midwife inquires whether the mother is sleeping and eating well passing urine without difficult or discomfort and has had a bowel action.
She take the mothers vitals and carries out a full postnatal examination of the breast, abdomen to palpate the uterus, vulva to inspect lochia and perineum.

Any abnormality detected should be discussed with the mother and appropriate advice is given. Postnatal exercises are taught on the first day after delivery and the mother is encouraged to practice them dairy throughout puerperium
On the first postnatal visit the midwife usually assists the mother to bath there after the mother should have a bath on her own should be twice or more daily, mother should be advised to change her pads frequently.

Adequate rest and sleep are essential and though ambulating is good but the mother should rest and sleep at appropriate time each day.
The mid wife performs a daily examination on the baby and shows the mother how to bath and dress the baby and attend to the cord.

 

  • > She observes its general condition,  examine him from head to toe observing the skin, eyes, mouth and cord for any signs of infection or any abnormality.
  • > Stool should be observed and the passage of urine.
  • > Baby should be observed whether breastfeeding well
  • > At the last visit, the mid wife advises the mother when to go back to postnatal clinic and the baby to health clinic.
  • > Health educate and demonstrates to the mother the postnatal exercises. 

DOMICILIARY CARE Read More »

PARTOGRAPH

PARTOGRAPH

PARTOGRAPH

Partograph is a graph or tool used to monitor fetal condition, maternal condition and labour progress during the active 1st stage of labour so as to be able to detect any abnormalities and be able to take action.
It’s only used during 1st stage of labour. It is used for recording salient conditions of the mother and the fetus.

USES OF A PARTOGRAPH

  1. To detect labour that is not progressing normally.
  2. To indicate when augmentation of labour is appropriate.
  3. To recognize CPD when obstruction occurs.
  4. It increases the quality of all observations on the mother and fetus in labour.
  5. It serves as an “early warning system”
  6. It assists on early decision of transfer and augmentation.

Who should not use a partograph?

  • Women with problems which are identified before labour starts or during labour which needs special attention.
  • Women not anticipating vaginal delivery (elective C/S).

Parts of a Partograph

A partograph has 3 parts i.e. –

  • Fetal part
  • Maternal part
  • Labour progress part

Observations charted on a partograph:

  1. The progress of labour
    >  Cervical dilatation 4 hourly
    >  Descent 2 hourly
    >  Uterine contractions
  2. Fetal condition
    >  Fetal heart rate ½ hourly
    >  Membranes and liquor 4 hourly
    >  Moulding of the fetal skull 4 hourly.
  3.  Maternal condition
    >  Pulse ½ hourly
    >  Blood Pressure 2 hourly
    >Respiration and >  temperature 4 hourly
    Urine; – volume 2 hourly, acetone, proteins and sugars.
    >  Drugs
    >  I.V fluids 2 hourly and Oxytocin regimen.
Starting a partograph:
  • The partograph should be started only when a woman is in active phase of labour.
  • Contractions must be 1 or more in 10 minutes.
  • Cervical dilatation should be 4cm or more.
FETAL CONDITION
  1. Fetal heart;
    It is taken 1/2 hourly unless there is need to check frequently i.e. if abnormal every 15 minutes and if it remains abnormal over 3 observations, take action. The normal fetal heart rate is 120-160b/m. below 120b/m or above 160b/m indicates fetal distress.
  2. Molding;
    This is felt on VE. It is charted according to grades.
    State of moulding                                         Record
    Absence of moulding.                                     (-)
    Bones are separate and sutures felt   (0)
    Bones are just touching each other   (+)
    Bone are over lapping but can be Separated (++)
    Bones are over lapping but cannot be separated (+++)
  3. Liquor amnii;
    This is observed when membranes are raptured artificially or spontaneously.
    It has different colour with different meaning and meconium stained liquor has grades.
    State of liquor Record
    Clear (normal)     (C)
    Light green in colour (m+)       Moderate green, more slippery       (m++)      Thick green, meconium stained   (m+++)       Blood stained    (B)
  4. Membranes;State of membranes  Record
  • Membranes intact    (I)
  • Membranes raptured   (R)
LABOUR PROGRESS

5. Cervical dilatation,
The dilatation of the cervix is plotted with an “X”. Vaginal examination is done at admission and once in 4 hours. Usually we start recording on a partograph at 4cm.
Alert line starts at 4cm of cervical dilation to a point of expected full dilatation at a rate of 1cm per hour
Action line– parallel and at 4 hours to the right of the alert line.

6. Descent of presenting part.
Descent is assessed by abdominal palpation. It is measured in terms of fifths above the brim.
The width of five fingers is a guide to the expression in the fifth of the head above the brim.
A head that is ballotable above the brim will accommodate the full width of five fingers.
As the head descends, the portion of the head remaining above the brim will be represented by fewer fingers.
It is generally accepted that the head is engaged when the portion of the head above the brim is represented by 2 or less fingers.
Descent is plotted with an “O” on the graph

7. Uterine contractions This is done ½ hourly for every 30 minutes. The duration, frequency and strength of contraction is observed. Observe the contractions within 10 minutes.

-Mild contractions last for less than 20 seconds.
-Moderate contractions last for 20-40 seconds.
-Strong contractions last for 40 seconds and above.
When plotting and shedding contractions use the following symbols.
Dots for mild contractions
Diagonal lines for moderate contractions
Shade for strong contractions

MATERNAL CONDITION
  1. Pulse; this is checked every 30 minutes. The normal pulse is 70-90b/min.
    The raised pulse may indicate maternal distress, infection especially if she had rapture of membranes for 8-12 hours and in case of low pulse, it can be due to collapse of the mother.
  2. Blood pressure; it is taken 2 hourly. The normal is 90/60-140/90mmHg. Any raise of 30mmHG systolic and 20mmhg diastolic from what is regarded as normal or if repeated over 3 times and remains high, test urine for albumen to rule out pre-eclampsia.
  3. Temperature; this is taken 4 hourly. The normal range is between 37.2 0 c to 37.5 0 c. Any raise in temperature may be due to infections, dehydration as a sign of maternal distress or if a mother had early rapture of membranes.
  4. Urine; the mother should pass urine atleast every after 2 hours and urine should be tested on admission.
  5. Fluids; she should be encouraged to take atleast 250-300 mls every 30 minutes. Any type of fluid can be given hot or cold except alcohol. The fluid should be sweetened in order to give her
    strength.
Further management in the normal 1st stage of labour
 Nursing care
  1. Emotional support:

Midwife should rub the mothers backto relieve pain.
Allow the mother to move around or sit in bed if membranes are still intact.
Re-assure the mother and keep her informed about the progress of labour to relieve anxiety.
Allow her to talk to relatives and husband.
Allow her to read or do knitting.

2. Nutrition;
Encourage mother to take light and easily digested food like bread, soup and sweet tea to rehydrate her and provide energy.

3. Elimination;
Taking care of the bladder and bowel. Encourage mother to empty bladder every 2 hours during labour. Every specimen is measured and tested for acetone, albumen, sugars and findings interpreted and recorded.
Pass catheter if mother is unable to pass urine.

4. Personal hygiene;
Allow mother to go for bath in early labour or on admission if condition allows. If membranes rapture, give a clean pad and ask mother to change frequently to prevent infections.
VE should be done only after aseptic technique.

5. Ambulation and position:
In early labour, mother is encouraged to walk around to aid descent of presenting part.
During contractions, ask mother to lean forward supporting herself on a chair or bed to reduce discomfort.
Allow mother to adopt a position of her choice except supine position.
Mother should be confined to bed when membranes rapture in advanced stage of labour.

6. Prevention of infections
Strict aseptic technique should be maintained when doing a VE and vulval swabbing.
When membranes rapture early, vulval toileting should be done 4 hourly to reduce the risk of infections. Put mother on antibiotics to avoid risk of ascending infections in early raptured of membranes.
Frequent sponging is done, bed linen changed when necessary when a mother is confined in bed.
The midwife should pay attention to her own hygiene and be careful to wash her hands before and after attending to the mother.

7. Sleep and rest
Mother is encouraged to rest when there is no contraction (rest in between contractions).

What to report
  • Abnormality found in urine.
  • Failure to pass urine.
  • Rise in temperature, pulse and BP.
  • Hypertonic uterine contractions.
  • Rapture of membranes with meconium stained liquor grade 2 and 3.
  • Failure of presenting part to descend despite good uterine contractions.
  • Tenderness of abdomen.
  • Bleeding per vagina.
  • Fall in BP.
  • Raise in fetal heart rate.
Complications
  • Infections
  • Early rapture of membranes
  • Cord prolapse
  • Supine hypotensive syndrome
  • Fetal distress
  • Maternal distress
  • APH
  • PET and eclampsia
  • Prolonged labour
  • Obstructed labour

PARTOGRAPH Read More »

MINOR DISORDERS OF PREGNANCY

MINOR DISORDERS OF PREGNANCY

MINOR DISORDERS OF PREGNANCY

These are referred to as minor because they are not life threatening.
The causes can be;-

  • Hormonal changes
  • Accommodation changes
  • Metabolic changes and
  • Postural changes
DIGESTIVE SYSTEM
Nausea and vomiting (morning sickness)

This is due to hormonal changes progesterone and Oestrogen and high level of HCG, it occurs from 4-16 weeks. This decreases when the placenta fully takes over.
Management
-Light snacks
-Carbohydratesnack like cassava, a hard crackers
-Avoid sweet things
-Coming out of the bed slowly.

Heart burn

Burning sensation in the media sternal region progesterone relaxes the cardiac sphincter and allows reflux of gastric contents into esophagus most troublesome between 30-40 weeks, because of pressure on stomach from growing uterus.
Management
-Avoid bending
-Small frequent meals
-Sleeping with more pillows
-Persistent heart burn antiacids like magnesium triscilicate.

Excessive salivation (ptyalism)

From 8 weeks, hormones are thought to be the cause. It may accompany heart burn. Counseling is helpful.

Constipation

Progesterone cause relaxation of the plain muscles and decreased peristalsis of the gut.
Management
-Increased intake of water, fresh fruit, vegetables and whole meal foods in diet.
-Glass of warm water in the morning, before tea and breakfast may activate the gut.
– Exercise can be helpful especially walking.
Aperients are only considered as a last resort.

Pica

This is when a mother craves for certain foods or unnatural substances.
The cause is unknown but hormones and changes in metabolism are attributed to it.

MUSCULO SKELETAL SYSTEM

This can be due to hormones Relaxin. Discuss with woman and let her be aware, it will disappear after delivery.

Leg cramps

Cause of leg cramp in pregnancy is unknown may be due to ischemia or a result from changes in PH or electrolyte status.
Management
-Mother to dorsiflex the foot and raise foot of bed.
-Gentle leg movement before sleeping at night.
-Others-use of vit B complements and calcium.

Backache

The weight of the pregnant uterus and altered posture increase susceptibility which is exacerbated by progesterone and Relaxin causing relaxation and softening of ligaments of the pelvis.
Management
-Avoid high heeled shoes.
-Sit on a comfortable chair or support the back on a wall while seated.
-Have extra rest during the day.

CIRCULATORY SYSTEM
Fainting

In early pregnancy, it may occur due to vasodilation under the influence of progesterone before there has been a compensatory increase in the blood volume.
Management
-Avoid long standing periods.
-Quickly sit or lie down if feels slightly faint,
-Mother should avoid lying on her back except during abdominal examination.

Vericose veins

-Progesterone relaxes smooth muscles of veins and results in sluggish circulation. Varicose veins may occur in legs, anus and vulva.
Management
During pregnancy
-Support tights increase comfort eg stockings.
-Avoid constipation.
-A sanitary pad may give support.
-Use a crepe bandage on affected leg from below upwards before getting out of bed in the
morning and remove it at night.
-The affected leg should be elevated when resting.
-Advise mother to see the doctor if varicose veins appear on the vulva.
-In case of severity, book mother for hospital delivery since they can easily rapture and cause severe bleeding.
During labour
-Inform doctor.
-Take off blood for Hb, grouping and x-matching.
-Be careful when shaving the vulva and when performing an episiotomy.
-Sedatives are given to prevent premature pushing.

Hemorrhoids

These are veins of the vulva or rectum and they usually occur due to constipation. They can be painful, edematous and ulcerative.
Management
-Advise mother on diet to avoid constipation.
-Use cold compress gently on the area.
-Doctor may order analgesic like anusol.

Heart palpitations

This occurs due to increased functioning of the heart to meet the demands of the growing fetus and mother.

NERVOUS SYSTEM
Carpal tunnel syndrome

The mother complains of numbness, pins and needles in her fingers and hands.
It’s caused by fluid retention which causes oedema and pressure on the median nerve by compressing it.
Management
-Wearing a splint at night and rising hands on a pillow at night.
-If it persists, refer to doctor who will give diuretics.

Insomnia

This is failure to get sleep and may be caused by worries, anxiety and it shouldn’t be taken lightly.
Emotional instability
Hating, irritation, loving i.e. willing to stay closer to partner.

GENITAL URINARY SYSTEM
Leucorrhoea

This is increased, non- irritant, vaginal discharge.
Management
-Ensure hygiene if distressing.
-Wear cotton under pants for easy absorption.

Frequency of micturition

This occurs in early pregnancy when the growing fetus is still in the pelvic cavity and late pregnancy when the PP descends and competes for space needed by bladder.

INTEGUMENTARY SYSTEM
Itching of the skin

This can be due to Striae gravidurum, poor hygiene, heat rash and minor skin rashes.
Management
-Wear cotton clothes which are non-irritating.
-Advise on personal hygiene.
-Apply calamine lotion in case of skin rash.

Disorders which require immediate action

  • Vaginal bleeding.
  • Reduced fetal movements.
  • Frontal or recurrent headache.
  • Sudden swelling or oedema.
  • Early rapture of membranes.
  • Premature onset of contractions
  • Maternal exhaustion at whatever extent.
  • Fits.
  • Excessive nausea and vomiting.
  • Epigastric pain.

MINOR DISORDERS OF PREGNANCY Read More »

PHYSIOLOGY OF PREGNANCY

PHYSIOLOGY OF PREGNANCY

PHYSIOLOGY OF PREGNANCY

These are normal natural changes that occur in the body due to pregnancy. These result mainly from alteration of hormones and metabolism.

CHANGES IN THE ENDOCRINE SYSTEM
  1. Hormonal changes:
    The placenta produces several hormones which cause a number of physiological changes.
    Successful physiological adaptation of pregnancy is due to alterations in hormone production by the maternal endocrine system and the trophoblast.
  2.  Human chorionic gonadotrophic hormone.
    It is produced by the trophoblast. H.C.G levels increase rapidly in early pregnancy, maximum levels being attained at 8-10 weeks of gestation. The main function of HCG is to maintain the
    corpus luteum in order to ensure secretion of progesterone and Oestrogen until placental production is adequate after 10-12 weeks after which concentration of HCG gradually decreases until it has completely disappeared 2 weeks after birth.
  3.  Progesterone hormone;
    This is produced mainly in the corpus luteum. Its function is to thicken the decidua in order to receive a fertilized ovum. It helps to increase the glandular tissue, ducts of the breasts and muscle
    fibres of the uterus.
  4.  Oestrogen;
    It causes growth of the uterus and duct system of the breasts in pregnancy. It is excreted in urine and amount present indicates fetal wellbeing.
  5.  Relaxin hormone;
    During the last weeks of pregnancy, it acts on ligaments and joints producing the “give” of the pelvis. It is also produced by decidua and the trophoblast to promote myometrium relaxation and
    may play a role in cervical ripening and rapture of membranes.
  6. HPL ( human placental lactogen): It stimulates the growth of breasts and has lactogenic properties that affect a number of metabolic changes. These changes brought about by HPL ensure that glucose is readily available for body and brain growth in the developing fetus, and protects against nutritional deficiencies.
  7. Pituitary hormones: The follicle stimulating hormone and L.H are suppressed by the high levels of Oestrogen and progesterone. The adrenal gland increases only slightly in size during pregnancy due to hypertrophy and widening in glucocorticoid area which suggests increased secretion of hormones.
  8. Thyroid function: In normal pregnancy, the thyroid gland increases due to hyperplasia of glandular tissue and increased vascularity. There is normally an increased uptake of iodine during pregnancy which may be to compensate for renal clearance of iodine leading to reduced level of plasma iodine.
CHANGES IN THE REPRODUCTIVE SYSTEM
CHANGES IN THE UTERUS:

It stretches and expands to accommodate and nurture the growing fetus. This occurs in the
myometrium. The body grows to provide a nutritive and protective environment in which the fetus will develop and grow.

Uterine muscle layers;
1. Endometrium;
– Menstruation stops.
-It becomes the decidua during pregnancy.
-It becomes thick, soft, spongy and readily supplied with blood.

. Myometrium.

  • The enlargement of the body of the uterus is due to 2 factors.
    1. The actual muscle fibres enlarge increasing in length about 10 times and in width about 3 times.
    This process is called hypertrophy (increase in size).
    2. The new muscle cells make their appearance and grow alongside the original muscle cells. This process is called hyperplasia (increase in number).
    The size; as pregnancy advances, the uterus grows from its normal size. The length being 7.5cm,
    width 5cm and thickness 2.5cm. So it becomes 30cm in length, 23cm in width and 20 cm in
    thickness. The weight increases from 60g to 960g.
    The shape; Health growth of the uterus requires adequate space to accommodate the growing fetus, increasing amount of liquor and placental tissue. After conception, the uterus enlarges
    because of Oestrogen. At the beginning of pregnancy, it is pear shaped organ, at the end of 12 weeks, it is globular, from 12-38weeks its oval shaped and when lightening takes place after 38weeks, it turns back to globular.

Muscle layers of the myometrium;

  1.   Outer most longitudinal layer,
    This layer begins in the anterior wall of the upper uterine segment, passes over the fundus and down the posterior wall. It is by contraction and retraction of this muscle layer that the fetus is expelled from the uterus during labour.
  2. Middle oblique layer,
    In this case, muscles are arranged in criss cross manner; the muscle cells surround the blood vessels in the figure of 8 pattern. After separation and expulsion of the placenta, they compress the blood vessels and help to prevent PPH. They are sometimes referred to as living ligatures.
  3.   Inner circular layer,
    This is the weakest of the 3 layers, the muscle fibres pass transversely around the uterus. They are more developed around the cervix, lower uterine segment and the fallopian tubes. They help in cervical dilatation.

3. The perimetrium;
This is the layer of the peritoneum which does not totally cover the uterus, its deflexed over the bladder anteriorly to form the utero vesicle pouch and posteriorly forming pouch of Douglas. After 12 weeks, the uterus rises out of pelvis and becomes an abdominal organ. It loses its ante-version and ante flexed position and becomes erect and leans on its axis on the right.

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CLINICAL OBSERVATIONS OF THE GROWING UTERUS
  • At 12 weeks

The uterus is out of the pelvis and becomes upright; it is no longer anteverted and ante flexed. The uterus is palpable just above the symphysis pubis and is about the size of a grape fruit.

  • At 16 weeks

Between 12 and 16 weeks, the fundus becomes dome shaped. As it rises, it rotates to the right (dextrorotation) due to the recto sigmoid colon in the left side of the pelvis and exerts tension on the broad and round ligaments.
The conceptus has grown enough to put pressure on the isthmus causing it to open out so that the uterus becomes more globular in shape.

  • At 20 weeks

The fundus of the uterus may be palpated at the level of the umbilicus. The uterus becomes more rounded around the fundus.

  • At 30 weeks

The fundus may be palpated midway between the umbilicus and ximphoid sternum. Enlarging uterus displaces the intestines laterally and superiorly. Abdominal wall supports the uterus and maintains the relationship btn the long axis of the uterus and axis of the pelvic inlet.
In supine position, the uterus falls back to the vertebral column, aorta and inferior venacava.

  • At 36 weeks

By the end of 36 weeks, the enlarged uterus fills the abdominal cavity. The fundus is at the tip of the ximphoid cartilage.

  • At 38 weeks

Between 38 and 40 weeks, there is increase in smoothening and softening of the lower uterine segment. Uterus becomes more rounded with a decrease in fundal height. The reduction in fundal height is known as lightening.

Changes in blood supply: The uterine blood vessels increase in diameter and new vessels develop under the influence of Oestrogen. Blood supply to the uterine and ovarian arteries increases to about 750ml/ min at term to keep pace with its growth and meet the needs of the functioning placenta.

Changes in the fallopian tubes: On either side are more stretched out and are more vascular in pregnancy. Uterine end of the tube is usually closed and fimbriated end remains open.

Changes in the isthmus;
It softens and elongates from 7mm to23mm and forms the lower uterine segment during late pregnancy.

Changes in the ovaries:
The follicle- stimulating hormone {FSH} ceases its activity due to the increased levels of estrogen and progesterone secreted by the ovaries and corpus luteum .This prevents ovulation and menstruation. As the uterus enlarges, the ovaries are raised out of the pelvis. Also both ovaries are enlarged due to increased vascularity and become edematous particularly that containing the corpus luteum.
The corpus luteum enlarges during early pregnancy and may even form a cyst on the ovary. The corpus luteum produces progesterone to help maintain the lining of the endometrium in early pregnancy. It functions until about the 10th and 12th week of pregnancy when the placenta is capable of producing adequate amounts of progesterone and estrogen. It slowly decreases in size and function after the 10th to 12th week.

Changes in the cervix:
It remains tightly closed during pregnancy, providing protection to the fetus and resistance to pressure from above when the woman is in standing position. There is slight growth on the cervix during pregnancy, it becomes softer and this is due to increased vascularity and relaxing effects of hormones.
Under the influence of progesterone racemose glands secrete thicker and more viscous mucus which fills the cervical canal and prevents entry of infection in the uterus. The plug of mucous is called opeculum
Towards the end of pregnancy or at the onset of labour the cervix becomes part of the lower uterine segment, this is called effacement of the cervix. The external os of the cervix also admits a finger. A short softened cervix or os which admits the tip of a figure at term is referred to as ripe cervix.

Changes in the vagina:
The muscle layer hypertrophies and capacity of vagina increases and it becomes more elastic allowing it to dilate during 2 nd stage.
The epithelium becomes thicker with increased desquamation of the superficial cells which increase the amount of normal white virginal discharge known as leucorrhea. The epithelial cells have high glycogen content. The cells interact with Do-derlein’s bacillus and produce a more acidic environment providing extra degree of protection against some organism and increasing susceptibility to others such as candida albicans. The vagina is more vascular and appears violet in colour.

Changes in the vulva:
The vulva appears bluish in colour due to increased vascularity and pelvic congestion.

Breast changes:
-In early pregnancy, breasts may feel full or tingle and increase in size as pregnancy progresses.
-The nipples become more erectile.
– The areolar of the nipples darken and the diameter increases.
– The sebaceous glands become the Montgomery’s tubercles which enlarge and tend to
protrude. They secrete sebum to lubricate the breast throughout pregnancy and breast feeding.
– The surface vessels of the breast become visible due to increased circulation and turns to bluish
tint on the breasts.
-A little clear, sticky fluid(colostrum) may be expressed from the nipples after the 1 st trimester
which later becomes yellowish in colour.

Changes in the cardiovascular system

The heart
Due to increased work load, the heart hypertrophies particularly in the left ventricle. The uterus pushes the heart upwards and to the left. Heart sounds are changed and murmurs are common.
The cardiac output is increased by 40%. The heart rate increases by an average of 15 beats per minute. The stroke volume increases from 64 to about 71mls.

Effect on blood pressure
During the first trimester, blood pressure remains almost constant. BP drops in 2 nd trimester due to hormone progesterone which causes vasodilation. It reaches its lowest level at 16-20 weeks and towards term, it returns to the level of the first trimester. The decrease may lead to fainting.
Supine position should be avoided in pregnancy as it leads to supine hypotensive syndrome due to compression of the inferior venacava thus reducing venous return. Poor venous return in late pregnancy may lead to oedema in lower limbs, varicose veins and hemorrhoids.

Blood flow
Blood flow increases to uterus, kidneys, breasts and skin but not to liver and brain. Utero placental blood flow increases by 10-15% about 75mls per minute at term. Renal blood flow increases by 70-80%.

Blood volume
Increase in blood volume varies according to the size of the woman, number of pregnancies she has had, parity and whether the pregnancy is singleton or multiple.
The total blood volume increases steadily from early pregnancy to reach a maximum of 35 to 45% above the non- pregnant level. A higher circulating volume is required for the following;
-To provide extra blood flow for placental circulation.
-To supply the extra metabolic needs of the fetus.
-To provide extra perfusion of kidneys and other organs.
-To compensate for blood loss at delivery.
-To counterbalance the effects of increased venous and arterial capacity.

Plasma volume
Increases by 40% where the red cell mass decreases by 20%leading to haemodilution (physiological anaemia). These changes begin at 6-8weeks of pregnancy. The acceptable Hb level in pregnancy is 11-12g/dl.

Iron metabolism
Iron of about 1000g is needed. 500g is to increase the red cell mass, 300g to fetus and 200g for daily iron compensation. In normal pregnancy, only 20% of ingested iron is absorbed. The purpose of iron supplementation is to prevent iron deficiency anaemia not to raise Hb level.

Plasma protein
During the 1st 20 weeks of pregnancy, plasma protein concentration reduces due to increased plasma volume. This leads to lowered osmotic pressure leading to oedema of lower limbs seen in late pregnancy. In absence of disease, moderate oedema is termed as physiological oedema.

Clotting factors
Fibrinogen 7,8,9 and 10 increase leading to a change in coagulation time from 12 to 8 minutes.
The capacity of clotting is increased in preparation to prevent PPH after separation of the placenta.

White blood cells.
These are slightly increased during pregnancy, from 700mm to 10500mm during pregnancy and up to 1600mm during labour. The total count cells rises from 8 weeks and reaches a peak at 30 weeks of gestation. This is mainly because of the increase in the number of neutrophils, polymorphs, nucleus, leucocytes, monocytes and granulocytes are active and efficient phagocytes.

Erythrocytes.
They decrease during pregnancy from 4.5million to 3.7million.

HB.
HB concentration falls from 14g/dl; a falling HB is a physiological. The total iron requirements of pregnancy where as a high HB level can be assign of pathology. The total requirements of
pregnancy is averagely 1000g ,about 500gare required to increase the red cells mass and about 300g are transported to the fetus mainly in the last weeks of pregnancy . The remaining 200g are needed to compensate for insensible loss in skin, stool and urine.

RESPIRATORY SYSTEM.

The basal metabolism rate is increased and the volume of air which enters and leaves the lungs during the normal respiration becomes slightly increased. This is because of increased oxygen consumption by the fetus and the work of maternal heart and lungs.
In the late pregnancy the ribs flare out inhibiting the capacity of the thoracic cavity to expand, the enlarging uterus elevates the diaphragm up wards and compresses the lower lobes of the lungs

CHANGES IN THE URINARY SYSTEM

Renal blood flow and glomerular filtration rate increases by 50%.
There is frequency of micturition in early and late pregnancy. Ureters become elongated and kinked due to progesterone hormone and this results into urine stagnation hence increased favor to UTI in pregnancy.

CHANGES IN THE GIT

-The gums become edematous, soft and spongy and may bleed.
-Increased salivation(ptyalism) is common.
-Nausea and vomiting is common in 70% of the cases.
-Changes in taste becoming metallic.
-Craving for abnormal things like soil or plaster known as pica.
-Increased appetite in most women.
-Heart burn due to of stomach content from decreased space by growing uterus.
-There is reduced GIT motility leading to constipation.

Changes in metabolism
– There is increased metabolism to provide nutrients for the mother and fetus.
-Maternal weight, There is continuing weight increase in pregnancy which is an indication of fetal growth.

Weight gain in pregnancy is as follows;-
4kg in the 1 st 20 weeks(0.2kg/week)
8.5kg in the last 20 weeks(0.4kg/week)
12.5kg approximate total.

 

 

  Maternal Weight Gain (kg) Fetal Weight Gain (kg) Total Weight Gain (kg)
Uterus 1 1
Breasts 0.4 0.4
Fat 3.5 3.5
Blood Volume 1.5 1.5
Extracellular Fluid 1.5 1.5
Fetus 3.4 3.4
Placenta 0.6 0.6
Amniotic Fluid 0.6 0.6
Total 7.9 4.6 12.5

The following factors influence weight gain during pregnancy:

  1. Maternal oedema: Edema, or swelling, can affect weight gain as it involves the accumulation of excess fluid in the tissues of the body.

  2. Maternal metabolic rate: The metabolic rate of the mother can impact weight gain. A higher metabolic rate may result in increased energy expenditure and potentially lower weight gain.

  3. Dietary intake: The quantity and quality of the mother\’s dietary intake play a significant role in weight gain during pregnancy. Consuming a balanced and nutritious diet supports healthy weight gain.

  4. Vomiting or diarrhea: Frequent vomiting or diarrhea can lead to weight loss or inadequate weight gain during pregnancy. These conditions can affect nutrient absorption and overall caloric intake.

  5. Amount of amniotic fluid: The volume of amniotic fluid surrounding the fetus can contribute to weight gain. An increased amount of amniotic fluid may contribute to higher weight gain.

  6. Size of the fetus: The size and growth rate of the fetus can impact maternal weight gain. A larger fetus may result in increased weight gain during pregnancy.

  7. Maternal physical activity level: The level of physical activity and exercise undertaken by the mother can influence weight gain. Regular physical activity can help maintain a healthy weight during pregnancy.

  8. Maternal genetics: Genetic factors can influence an individual\’s predisposition to weight gain or weight retention during pregnancy.

CHANGES IN THE MUSCULO-SKELETAL SYSTEM

Progesterone and Relaxin lead to relaxation of pelvic ligaments, joints and muscles. The relaxation allows the pelvis to increase its capacity in readiness to accommodate the presenting part towards term and also during labour. The symphysis pubis and sacroiliac joints soften, the gait of the mother changes as the balance of the body is altered by the weight of the uterus. Allowing the pelvis to increase its capacity towards term is a process known as a give.

SKIN CHANGES

Increased activity of melanin-stimulating hormone from the pituitary causes varying degrees of pigmentation in pregnant women from the end of 2 nd month until term.The areas that are commonly affected are; areolar of the breasts, abdominal mid line, perineum and axilla. This is because of increased sensitivity of the melanocytes to the hormone or because of greater number of melanocytes in these areas.

  • -Linea nigra. This is a dark line that runs from the umbilicus to the symphysis pubis and may extend as high as the sternum. It is hormone induced pigmentation. After delivery, the line begins to fade though it may not ever completely disappear.
  • -Mask of pregnancy(Cloasma). This is the brownish hyper pigmentation of the skin over the face, fore head, nose, cheeks and neck. It gives a bronze look especially in black complexioned women.
  • -Striae gravidurum(stretch marks).
  • -Sweat glands. Activity of the sweat glands usually increases throughout the body which causes the woman to perspire more profusely during pregnancy.
  • – A rise in body temperature of 0.5 and increase in blood supply causes vasodilation and makes woman feel hotter.

PHYSIOLOGY OF PREGNANCY Read More »

NORMAL PREGNANCY

NORMAL PREGNANCY

NORMAL PREGNANCY

Normal Pregnancy refers to growth and development of a fertilized ovum and begins from when the ovum is fertilized until the fetus is expelled from the uterus.

Normally the fetus is expelled at term or 9 months or 40 weeks or 280 days.
If the fetus is expelled before 28 weeks, it is called an abortion and if fetus is expelled after 28 weeks but before 37weeks it’s called premature labour and if born after 42 weeks, the post- mature is used.

Pregnancy is said to be normal when;

  • The fertilized ovum is growing in the cavity of the uterus.
  •  One fetus is forming, one placenta and two membranes.
  •  There is about 1000-1500ml of liquor amnii.
  •  There is vertex presentation.
  •  There is no bleeding until show in first stage of labour.
  •  The mother should remain healthy with no serious disorders of pregnancy.

\"normal

SIGNS AND SYMPTOMS OF PREGNANCY

When a woman misses one or two menstrual periods, she may begin to suspect that she is pregnant, and in most cases, her intuition is correct with an accuracy of about 98%, especially if she has been experiencing regular menstruation.

The signs of pregnancy can be classified into three groups:

  1. Presumptive
  2. Probable
  3. Positive.
Presumptive signs:
  1. Amenorrhea: This refers to the absence of menstruation. A woman may report missing one or two periods, which can be a strong indicator of pregnancy. However, amenorrhea can also be caused by factors such as contraceptive use, changes in environment, prolonged illness, or emotional disturbances.

  2. Breast changes: Many women experience tingling and prickling sensations, as well as breast enlargement and tenderness. These changes are commonly associated with pregnancy.

  3. Morning sickness (nausea and vomiting): Approximately 30-50% of pregnant women experience morning sickness, which typically occurs between the 4th and 14th weeks of pregnancy. While other conditions can also cause nausea and vomiting, the combination of these symptoms with amenorrhea strongly suggests pregnancy. Morning sickness often subsides by the end of the first trimester.

  4. Increased frequency of urination: The growing uterus puts pressure on the bladder, leading to more frequent trips to the bathroom. This symptom is usually experienced before 12 weeks of pregnancy and tends to decrease once the uterus rises out of the pelvis at around 12 weeks.

  5. Skin changes:

    • Striae gravidarum: These stretch marks appear around the 16th week of pregnancy on the abdomen, thighs, and breasts.
    • Chloasma (mask of pregnancy): Some women develop patches of darkened skin on the face.
    • Linea nigra: A dark line may darken and appear both above and below the umbilicus.
    • Darkening of areolas: The primary areolas become darker, and secondary areolas may form. The hormone responsible for these pigmentation changes is called melanin hormone and is produced by the anterior pituitary gland.
  6. Quickening: This refers to the first fetal movements felt by the mother, usually occurring around 18-20 weeks of pregnancy for primigravida (first-time pregnancies) and 16-18 weeks for multigravida (women who have been pregnant before). Quickening can assist a midwife or healthcare provider in estimating the gestational age of a mother who is unsure of her dates.

  7. Fatigue: Pregnant women often experience fatigue due to increased blood production, lower blood sugar levels, and decreased blood pressure influenced by progesterone. Sleep disturbances and nausea can also contribute to feelings of tiredness.

  8. Mood changes: Physical stress, metabolic changes, fatigue, and hormonal fluctuations, particularly progesterone and estrogen, can lead to mood swings in pregnant women.

Probable signs:
  1. Hagar\’s sign: This sign can be detected between the 6th and 12th week of pregnancy. It involves performing a vaginal examination where two fingers are inserted into the anterior fornix of the vagina while the other hand presses the uterus abdominally. When the fingers from both hands meet, a softening of the isthmus can be felt, indicating pregnancy.

  2. Jacquemier\’s sign: This sign refers to the bluish discoloration of the vaginal walls, which becomes noticeable from the 8th week onwards. It is caused by pelvic congestion, a common indication of pregnancy.

  3. Osiander\’s sign: Increased pulsation felt on the lateral vaginal fornices is known as Osiander\’s sign. This sign can be detected from the 8th week onwards and is a result of increased vascularity in the area.

  4. Softening of the cervix (Goodell\’s sign): Starting from the 8th week of pregnancy, the cervix of a pregnant woman becomes noticeably softer. It can be compared to the texture of the lower lip, whereas in a non-pregnant state, it is as firm as the tip of the nose.

  5. Uterine soufflé: This refers to a soft blowing sound heard on auscultation of the abdomen. It typically occurs from the 16th week of pregnancy due to increased vascularity in the uterus.

  6. Abdominal enlargement: The uterus undergoes rapid and progressive enlargement from the 16th week onwards. This enlargement can be observed and felt during abdominal palpation, helping to differentiate it from other causes such as gaseous distension, a full bladder, fibroids, or ascites.

  7. Braxton Hicks contractions: These are painless contractions that usually begin from the 16th week of pregnancy. They can be felt during abdominal palpation and occur approximately every 15 minutes.

  8. Internal ballottement: This technique involves giving the uterus a sharp tap just above the cervix, causing the fetus to float upward in the amniotic fluid. When the fetus sinks back down, the movement can be felt by fixed fingers within the vagina. Internal ballottement can be detected between the 16th and 28th weeks of pregnancy.

  9. Presence of hCG (Human chorionic gonadotropin): The hormone hCG can be detected in the blood as early as 9 days after conception and in urine approximately 14 days after conception. The presence of hCG is a reliable indicator of pregnancy and can also be detected in conditions like hydatidiform mole.

Positive signs:

Positive signs are those that definitively confirm the presence of pregnancy. These signs include:

  1. Fetal heart sounds: The fetal heart begins beating around the 24th week after conception. It can be heard using a Doppler device as early as 10 weeks and with a fetoscope by 24 weeks. It is important to distinguish the fetal heart sounds from the uterine soufflé caused by pulsating maternal arteries. The normal fetal heart rate ranges between 120 and 160 beats per minute.

  2. Ultrasound scanning of the fetus: Using ultrasound technology, the gestation sac can be visualized and photographed. As early as the 4th week, an embryo can be identified, and by the 10th week of gestation, fetal body parts begin to appear on the ultrasound images.

  3. Palpation of the entire fetus: A trained examiner can palpate and feel the various parts of the fetus, including the head, back, and upper and lower body parts. This allows for a comprehensive assessment of the baby\’s position and size.

  4. Palpation of fetal movement: Skilled healthcare providers can feel and detect fetal movements through palpation after the 24th week of gestation. This involves perceiving the baby\’s kicks, rolls, and other movements by gently applying pressure on the mother\’s abdomen.

  5. X-ray: While an X-ray can identify the complete fetal skeleton as early as the 12th week, it is not a recommended method for confirming pregnancy due to the potential risks associated with radiation exposure. Total body radiation from X-rays in utero can have harmful effects on the developing fetus, leading to genetic or gonadal alterations. Therefore, other non-invasive methods, such as ultrasound, are preferred for assessing pregnancy.

  6. Actual delivery of the baby: The ultimate confirmation of pregnancy occurs when the woman delivers the baby. The delivery of a live newborn is the conclusive evidence of pregnancy.

Differential Diagnosis:

Abdominal enlargement can be caused by conditions other than pregnancy, and it is important to consider these possibilities. Some of the potential differential diagnoses include:

  1. Ovarian cysts: Enlargement of the abdomen can occur due to the presence of ovarian cysts. When palpated, the swelling caused by ovarian cysts can be distinguished from the uterus, and pregnancy tests will yield negative results.

  2. Fibroids: Fibroids are noncancerous growths that can develop in the uterus. They can sometimes be mistaken for pregnancy, as they can cause a hard mass to be felt in the abdomen. However, pregnancy tests will be negative in the case of fibroids.

  3. Distended urinary bladder: Abdominal enlargement can also result from a distended urinary bladder due to urine retention. In such cases, a catheter can be inserted to relieve the urine retention, and there will be no other signs indicating pregnancy.

  4. Pseudocyesis: Pseudocyesis, also known as false pregnancy or phantom pregnancy, is a condition in which a woman experiences symptoms that mimic pregnancy, including amenorrhea (absence of menstruation) and other signs suggestive of pregnancy. However, upon examination, the typical signs of pregnancy are absent, and pregnancy tests will be negative. Pseudocyesis often occurs in women who have a strong desire to conceive or who experience high levels of anxiety related to pregnancy.

Multiple Choice Questions:

  1. Which of the following is a presumptive sign of pregnancy?
    a) Fetal heart sounds
    b) Softening of the cervix
    c) Palpation of fetal movement
    d) Morning sickness
  2. Hagar\’s sign is detected by:
    a) Auscultation of fetal heart sounds
    b) Palpation of fetal movement
    c) Vaginal examination
    d) Ultrasound scanning
  3. Which sign is a probable sign of pregnancy?
    a) Fetal heart sounds
    b) Ovarian cysts
    c) Presence of HCG
    d) Pseudocyesis
  4. What is the normal fetal heart rate?
    a) 60-80 beats per minute
    b) 90-120 beats per minute
    c) 120-160 beats per minute
    d) 180-200 beats per minute
  5. Which sign can help in determining the gestational age if the mother is unsure of her dates?
    a) Quickening
    b) Internal ballottement
    c) Jacquemier\’s sign
    d) Amenorrhea
  6. Which diagnostic tool can visualize the gestation sac and fetal parts?
    a) X-ray
    b) Ultrasound scanning
    c) Fetal palpation
    d) HCG test
  7. What is the most accurate method to confirm pregnancy?
    a) Palpation of fetal movement
    b) X-ray
    c) Actual delivery of the baby
    d) Ultrasonography
  8. Which condition can cause abdominal enlargement and yield negative pregnancy test results?
    a) Fibroids
    b) Ovarian cysts
    c) Pseudocyesis
    d) Morning sickness
  9. Osiander\’s sign is characterized by:
    a) Softening of the cervix
    b) Increased pulsation in the vaginal fornices
    c) Bluish discoloration of the vaginal walls
    d) Enlargement of the breasts
  10. Which sign can be detected by both Doppler and fetoscope?
    a) Fetal heart sounds
    b) Uterine soufflé
    c) Internal ballottement
    d) Quickening
  11. What differentiates fibroids from pregnancy?
    a) Positive pregnancy test results
    b) Palpable fetal movements
    c) Presence of uterine soufflé
    d) Hard mass felt on palpation
  12. What is the purpose of X-ray in pregnancy?
    a) To visualize the fetal heart rate
    b) To determine the gestational age
    c) To confirm pregnancy definitively
    d) It is not recommended due to radiation risks
  13. What differentiates pseudocyesis from a true pregnancy?
    a) Amenorrhea
    b) Fetal heart sounds
    c) Palpation of fetal movement
    d) Negative pregnancy test results
  14. What is the primary cause of morning sickness during pregnancy?
    a) Increased blood production
    b) Hormonal changes
    c) Bladder pressure
    d) Emotional upsets
  15. Which sign is considered a positive sign of pregnancy?
    a) Morning sickness
    b) Softening of the cervix
    c) Distended urinary bladder
    d) Palpation of fetal movement

Fill in the Blanks:

  1. ________ is the absence of menstruation and a presumptive sign of pregnancy.
  2. ________ can be detected by performing a vaginal examination and palpating the isthmus.
  3. Increased pulsation in the lateral vaginal fornices is known as ________.
  4. ________ is a condition in which a woman experiences symptoms resembling pregnancy, but pregnancy tests are negative.
  5. Fetal heart sounds can be detected by a ________ or a fetoscope.
  6. The normal fetal heart rate ranges between ________ beats per minute.
  7. Ultrasound scanning can visualize the ________ and identify the fetal parts.
  8. Palpation of ________ is necessary to assess the position and size of the fetus.
  9. X-ray is not recommended for pregnancy confirmation due to potential ________ risks.
  10. The delivery of a live newborn is the ________ evidence of pregnancy.

Multiple Choice Questions:

  1. Answer: d) Morning sickness
  2. Answer: c) Vaginal examination
  3. Answer: b) Ovarian cysts
  4. Answer: c) 120-160 beats per minute
  5. Answer: b) Internal ballottement
  6. Answer: b) Ultrasound scanning
  7. Answer: c) Actual delivery of the baby
  8. Answer: a) Fibroids
  9. Answer: b) Increased pulsation in the vaginal fornices
  10. Answer: a) Fetal heart sounds
  11. Answer: d) Hard mass felt on palpation
  12. Answer: d) It is not recommended due to radiation risks
  13. Answer: d) Negative pregnancy test results
  14. Answer: b) Hormonal changes
  15. Answer: d) Palpation of fetal movement

Fill in the Blanks:

  1. Amenorrhea is the absence of menstruation and a presumptive sign of pregnancy.
  2. Hagar\’s sign can be detected by performing a vaginal examination and palpating the isthmus.
  3. Increased pulsation in the lateral vaginal fornices is known as Osiander\’s sign.
  4. Pseudocyesis is a condition in which a woman experiences symptoms resembling pregnancy, but pregnancy tests are negative.
  5. Fetal heart sounds can be detected by a Doppler or a fetoscope.
  6. The normal fetal heart rate ranges between ________ beats per minute.
  7. Ultrasound scanning can visualize the gestation sac and identify the fetal parts.
  8. Palpation of the entire fetus is necessary to assess the position and size of the fetus.
  9. X-ray is not recommended for pregnancy confirmation due to potential radiation risks.
  10. The delivery of a live newborn is the ultimate evidence of pregnancy.

NORMAL PREGNANCY Read More »

Terminologies

Terminologies

Terminologies

TERMS USED IN MIDWIFERY

Midwifery: It is the profession of providing assistance and medical care to women undergoing labor and childbirth during the antenatal, prenatal, and postnatal periods.

Obstetrics: This is a branch of medicine dealing with pregnancy, labor, and the postpartum period.

Caesarian section: It is an incision made on the uterus through the anterior abdominal wall to remove products of gestation after 28 weeks of gestation.

Cephalic: Refers to the head.

Cervix: It is the neck of the uterus.

Colostrum: This is a fluid found in the breasts from the 16th week of pregnancy up to the 2nd and 3rd day after delivery.

Crowning: This is when the largest transverse diameter of the fetal skull emerges under the subpubic arch and does not recede back between contractions.

Gestation: Pregnancy or the maternal condition of having a developing fetus in the body.

Fetus: Refers to the human conceptus from the 9th week to delivery.

Viability: The capability of the fetus to live outside the womb, usually accepted between 24 and 28 weeks, although survival is rare.

Gravida: A woman who is or has been pregnant, regardless of pregnancy outcome.

Primigravida: A woman pregnant for the first time.

Multigravida: A woman who has been pregnant more than once.

Nullipara: A woman who is not currently pregnant and has never been pregnant.

Parity: The number of children born alive or dead after 28 weeks of gestation.

Vernix caseosa: A greasy substance that covers the baby\’s skin at birth.

Meconium: This is the stool of the neonate that is present in the lower bowel at 16 weeks of gestation and is passed within 3 days following birth. It is greenish-black in color.

Lightening: This refers to the descent of the baby into the pelvis, resulting in a drop in fundal height.

Show: The bloody stained mucoid discharge seen at the onset of labor.

Additional Midwifery Terms 

  1. Lochia: The vaginal discharge that occurs after childbirth, consisting of blood, mucus, and uterine tissue.

  2. Antenatal care: Medical care and monitoring provided to pregnant women before childbirth.

  3. Postpartum: The period following childbirth, typically lasting six weeks, during which the mother\’s body undergoes physical and hormonal changes.

  4. Perineum: The area between the vagina and anus in females, which may stretch or tear during childbirth.

  5. Amniotic fluid: The fluid surrounding the fetus within the amniotic sac, providing protection and cushioning.

  6. Placenta: A temporary organ that develops during pregnancy, providing oxygen and nutrients to the fetus and removing waste products.

  7. Episiotomy: A surgical incision made in the perineum during childbirth to enlarge the vaginal opening and facilitate delivery.

  8. Postpartum depression: A mood disorder characterized by feelings of sadness, anxiety, and exhaustion experienced by some women after giving birth.

  9. Lactation: The production and secretion of breast milk.

  10. Umbilical cord: The flexible cord connecting the fetus to the placenta, through which nutrients and oxygen are transferred.

  11. Neonate: A newborn baby, typically in the first 28 days after birth.

  12. Preterm birth: Delivery of a baby before completing 37 weeks of gestation.

  13. Ectopic pregnancy: A pregnancy that occurs outside the uterus, usually in the fallopian tube.

  14. Intrauterine growth restriction: A condition in which the fetus fails to grow at the expected rate inside the uterus.

  15. Preeclampsia: A pregnancy complication characterized by high blood pressure and damage to organs, usually occurring after 20 weeks of gestation.

  16. Fetal distress: A condition in which the fetus is not receiving adequate oxygen, typically detected through abnormal heart rate patterns.

  17. Postpartum hemorrhage: Excessive bleeding after childbirth, often caused by the uterus not contracting properly.

  18. Neonatal intensive care unit (NICU): A specialized medical unit providing care for newborns with serious health conditions or premature babies.

  19. Midwifery-led care: A model of care in which midwives are the primary providers for pregnant women, providing continuity of care throughout pregnancy, labor, and postpartum.

  20. Birth plan: A written document created by the pregnant woman outlining her preferences and expectations for labor, delivery, and postpartum care.

Terminologies Read More »

Symptoms Control

Symptoms Control

Symptoms Control

Symptom control aims at the primary goal of providing comfort and improving the quality of life for individuals facing serious illness and end-of-life stages.

Symptom control and management play a crucial role in achieving this aim/goal. Palliative care focuses on addressing the physical, emotional, social, and spiritual needs of patients, with a particular emphasis on relieving distressing symptoms.

Common symptoms in Palliative Care

SystemSymptoms
GITDry mouth, painful mouth, nausea and vomiting, dysphagia, indigestion, constipation, diarrhea, intestinal obstruction, ascites
RespiratoryShortness of breath (SOB), cough, death rattle, hemoptysis
Genito-UrinaryDysuria, prostatism, spasms, urinary retention, urinary incontinence, hematuria
SkinFungating wound, pruritus, pressure sores
NeurologicalWeakness, seizures, headache
PsychiatricAdjustment disorders, depression, anxiety, delirium
OtherAnorexia, sleep disturbance

Principles of Symptom Assessment

  1. Accept the patient’s description: It is important to accept the patient’s description of their symptoms, considering the type and severity, as true and valid.
  2. Assess each symptom separately: Since most patients experience multiple symptoms, it is necessary to evaluate and analyze each symptom individually.
  3. Diagnose the possible cause: Determine the potential underlying cause of the symptom or problem through a comprehensive diagnostic process.
  4. Take a detailed history and examination, including:
    a. Onset of symptom: Gather information about when the symptom started, its severity, character, periodicity, precipitating and relieving factors, impact on sleep, mobility, quality of life, and its significance to the patient, particularly in the case of pain.
    b. Medication history: Explore the patient’s past medication usage, including the effectiveness of previous drugs and any failures, as well as the current medications and any complementary or alternative treatments being used for symptom management.
  5. Evaluate associated symptoms: Identify and assess any additional symptoms that may be related to the main symptom, such as constipation and abdominal distension in cases of intestinal obstruction.
  6. Perform a mandatory physical examination: Conduct a focused, thorough, and detailed physical examination that specifically targets the system associated with the presenting symptom.
  7. Proactively ask and observe: Don’t wait for the patient to complain; instead, actively inquire about their symptoms and carefully observe any visible signs or changes.
  8. Use appropriate investigations: Employ suitable investigations to guide clinical decision-making, ensuring that they are not performed unnecessarily or solely for the sake of doing them.
  9. Avoid delaying treatment: Initiate practical management and treatment without undue delay, even if investigation results are pending.
  10. Explain possible causes of symptoms: Provide explanations to the patient and their family regarding the potential reasons behind the symptoms, fostering open and regular communication that is essential for their understanding and involvement in the care process.

Principles of Symptom Management (Woodworth, 2004)

  1. Evaluation: Before initiating treatment, it is important to diagnose each symptom accurately.
  2. Explanation: Prior to treatment, provide clear explanations to the patient about the intended approach and set realistic goals for symptom management.
  3. Management: Tailor the treatment plan to each individual, considering their specific needs and preferences.
  4. Monitoring: Continuously assess and review the impact of the treatment on symptom control, making necessary adjustments as needed.
  5. Attention to details: Avoid making assumptions and ensure that all relevant details are taken into account when managing symptoms.
  6. Utilize both drug and non-drug measures: Incorporate a combination of pharmaceutical and non-pharmaceutical interventions to effectively control and manage symptoms.
  7. Allow sufficient time for interventions: Give interventions an appropriate amount of time to take effect before determining their success or failure.
  8. Adopt a multidisciplinary team approach: Collaborate with a diverse team of healthcare professionals to provide comprehensive symptom management.
  9. Seek consultation: When necessary, consult with a senior or more experienced clinician to gain insights and guidance in complex cases.
  10. Consider referral: In situations where specialized management is required, consider referring the patient to appropriate specialists or healthcare facilities.
  11. Implications of inaccurate assessment: Recognize that inaccurate assessment of the patient’s symptoms can have various implications on the overall management plan.
  12. Treat the underlying cause: Whenever possible, focus on treating the root cause of the symptoms to achieve optimal symptom control and management.

In Summary, Principles of Symptom Control are;

 Holistic assessment
1Careful and detailed history
2Relevant clinical examination
3Appropriate investigations
4Establish diagnosis
5Explain everything to the patient.
1Detailed history: First step in effective management of a patient’s symptoms is undertaking a detailed history.
This enables us to diagnose the possible cause of the symptoms.
We must remember the concept of “Total Care” and resist the temptation to focus on physical aspects of history.
2Physical examination: It should be focused, thorough, and detailed.
Direct examination towards the system of the presenting symptom.
3Investigations: Appropriate investigations to guide clinical decision making.
May not be a realistic option in terms of financial, location, and resources.
Do not delay starting treatment pending investigation results.
4Establish Diagnosis: Cause of symptoms may be due to the disease itself, the treatment for the disease, disease-related debility, or concurrent disorders.
What is the underlying mechanism? E.g., hypercalcemia, raised ICP.
16Explanation to patient: Explain the possible causes of symptoms to the patient and family. A simple explanation of the cause and nature of the symptoms to the patient may help to reduce fears or anxieties. Open and regular communication is essential.

Gastrointestinal Tract Symptoms

Nausea and Vomiting:

Causes:

  1. Pharmaceutical: opioids, digoxin, anti-convulsants, antibiotics.
  2. Toxic: infection, radiotherapy, chemotherapy.
  3. Metabolic: hypercalcemia, ketoacidosis, renal failure.
  4. Intracranial: cerebral tumors, cerebral infections, meningeal metastases, raised ICP, meningitis, cerebral malaria, ear infections.
  5. Gastrointestinal: gastric stasis, intestinal obstruction, constipation, candidiasis, abdominal and pelvic tumors, partial or complete bowel obstruction.

Assessment:

  1. Take a history, including the amount, content, and odor of vomit.
  2. Differentiate between vomiting, expectoration, or regurgitation.
    a. Determine the duration of the problem, including frequency, precipitating factors, type, and consistency.
    b. Review medication history, including antibiotics, ARVs, NSAIDs.
    c. Consider raised intracranial pressure.
    d. Examine the abdomen to rule out pancreatitis, gastritis, and peptic ulcers.

Pharmacological Management:

  1. Choose anti-emetics based on understanding different classes of medications and their mechanisms of action.
  2. Treat the underlying cause, if possible (e.g., constipation with bisacodyl – 5mg nocte, review and possibly change medication).
  3. Select appropriate anti-emetics based on the cause:
    • Depress vomiting center: hyoscine, cyclizine 50mg 6-hourly.
    • Depress chemoreceptors: prochlorperazine (Stemetil) 5-10mg tds, haloperidol 0.5-1mg bd.
    • Normalize upper bowel function: metoclopramide 5-10mg tds.
    • Delayed gastric emptying: metoclopramide 5-10mg tds (contraindicated in obstruction).
    • Vestibular disturbances: prochlorperazine 5-10mg tds, cyclizine 50mg 6-hourly, uraemia – haloperidol 0.5-1mg.

Non-Pharmacological Management:

  1. Provide psychological support, especially for anxiety-related or anticipatory symptoms.
  2. Recommend relaxation techniques.
  3. Suggest dietary modifications, such as increased fluid intake and small, regular meals.
  4. Create a calm environment away from food odors that may induce nausea.

Diarrhea:

Causes:

  1. Imbalance of laxative therapy.
  2. Drugs such as antibiotics, NSAIDs, ARVs.
  3. Fecal impaction – fluid stool leaks past a fecal plug or tumor mass.
  4. Abdominal or pelvic radiotherapy.
  5. Malabsorption.
  6. Colonic or rectal tumors.
  7. Concurrent disease.
  8. Odd dietary habits.
  9. HIV.
  10. Stress.

Assessment:

  1. Identify the cause of diarrhea.
  2. Differentiate between diarrhea and overflow.
  3. Gather history regarding duration, characteristics (volume, frequency, presence of blood), and associated symptoms (abdominal pain, fever).
  4. Review medications.
  5. Perform stool tests for culture and sensitivity.

Pharmacological Management:

  1. Advise increased fluid intake with oral rehydration solution after each episode of diarrhea.
  2. If symptoms persist, administer anti-diarrheal medication such as loperamide 2-4 capsules stat, then 2 capsules after every motion, codeine 30mg tds, or liquid morphine 5mg/5ml 4 hourly, 10ml at night.
  3. Administer antibiotics for infections, e.g., septrin 480mg bd if needed.
  4. Consider IV fluids for severe dehydration.
  5. Review and modify medications if necessary.
  6. Apply barrier cream (e.g., aqueous cream) to protect the skin when necessary.

Non-Pharmacological Management:

  1. Provide nutrition advice.
  2. Encourage plenty of oral fluids.
  3. Offer skin care to prevent breakdown.
  4. Provide appropriate advice for incontinence, including the use of a mackintosh/plastic under-sheet and regular changing/cleaning to prevent bedsores, etc.

Constipation:

Causes: Direct effects of disease:

  1. Intestinal obstruction from tumors in the bowel wall or external compression from abdominal masses.
  2. Damage to the lumbosacral spinal cord. Secondary effects of disease:
  3. Decreased food intake and low-fiber diet.
  4. Dehydration.
  5. General body weakness.
  6. Metabolic abnormalities – hypokalemia, hypercalcemia. Medications:
  7. Opioids such as codeine or morphine.
  8. Anticholinergic drugs such as tricyclic antidepressants.
  9. Diuretics. Concurrent disease:
  10. Diabetes mellitus, hypothyroidism.
  11. Hemorrhoids, anal fissures. (Note: The most common causes are related to the side effects of opioids and the effects of progressive disease.)

Assessment:

  1. Take a history to ascertain the cause of constipation.
  2. Establish the previous and present bowel pattern.
  3. Perform abdominal and rectal examinations.

Pharmacological Management:

  1. Prescribe appropriate laxatives, such as bisacodyl 5-15mg nocte.
  2. Consider the use of pawpaw seeds chewed or crushed in a fruit drink.
  3. Reduce or stop the dose of constipating drugs.

NonPharmacological Management:

  1. Use rectal interventions if required, such as enemas.
  2. Advise on increasing a high-fiber diet and fluid intake.
  3. Ensure privacy and adequate toilet facilities.

Management in Children:

 For children, an osmotically active laxative (e.g., lactulose) is preferable to a stimulant laxative (bisacodyl) as stimulants may cause severe abdominal pain in children. When starting opioids, prevent constipation by adding laxatives (e.g., bisacodyl).

Remember to adjust the dosage based on the child’s age:

  • 6-12 years: Bisacodyl 5-10mg once daily orally.
  • Step 1: Try lactulose, gradually increasing the dose over one week:
    • <1 year: 2.5ml twice daily.
    • 1-5 years: 5mls twice daily.
    • 6-12 years: 10mls twice daily.
  • Step 2: If no improvement, add Senna.
    • 2-6 years: 1 tablet twice daily orally.
    • 6-12 years: 1-2 tablets twice daily orally.
  • Step 3: If already on opioids, use step 2 drugs right away.

Additional Notes:

  • If rectal examination reveals hard stool, try a glycerine suppository. If the stool is soft but not moving, try a bisacodyl or senna suppository. If the rectum is empty, consider using a bisacodyl suppository to bring the stool down or a high-phosphate enema.
  • For severe constipation, consider using a phosphate enema or a bowel prep product (e.g., Movicol) if available.

Mouth Sores and Difficulty Swallowing (Dysphagia)

These sores are commonly caused by oral and esophageal candidiasis. It’s important to note that many mouth-related problems can be prevented by practicing good mouth care, keeping the mouth moist, and promptly treating any infections.

Causes of mouth sores and difficulty swallowing :

  1. Infections such as candidiasis or herpes.
  2. Mucositis resulting from radiotherapy or chemotherapy.
  3. Ulceration.
  4. Poor dental hygiene.
  5. Dry mouth caused by medications, salivary gland damage due to radiotherapy or tumors, or mouth breathing.
  6. Erosion of the buccal mucosa by tumors, possibly leading to fistula formation.
  7. Iron deficiency.
  8. Vitamin C deficiency.

Non-pharmacological management:

  1. Prevention through regular mouth cleaning, maintaining moisture, and promptly treating infections.
  2. Regularly checking the mouth, teeth, tongue, palate, and gums for dryness, inflammation, ulcers, or infection.
  3. Educating the patient and family on proper mouth care using available resources.
  4. Using a soft brush or soft cotton cloth for gentle brushing, avoiding harsh brushing.
  5. Rinsing the mouth with a simple mouthwash made from sodium bicarbonate or saline (a pinch in a glass of water is sufficient) can be effective.
  6. Relieving dry mouth by sucking on ice or pieces of fruit.
  7. Applying petroleum jelly on the lips after cleaning.

Assessment and pharmacological management:

  • Treating pain following the WHO analgesic ladder.
  • Considering oral morphine for severe pain caused by mucositis.
  • Treating oral candidiasis even in the absence of white patches but with inflammation:
    • Nystatin oral drops (1–2mls) every 6 hours after food and at night, holding the dose in the mouth for topical action.
    • Fluconazole (50mg daily for five days), increasing to higher doses (200mg daily for two weeks) if there is difficulty swallowing and suspicion of esophageal candidiasis. Ketoconazole (200mg daily) is an alternative, but caution must be exercised regarding drug interactions.
  • Treating other infections:
    • Applying Gentian Violet three times daily, which is useful for many types of sores.
    • Using metronidazole mouthwash, prepared by mixing crushed oral tablets or liquid for injection with fruit juice, to alleviate discomfort from foul-smelling mouth sores, especially in oral cancer cases. Consider acyclovir (200mg po for five days) for herpes infections. Severe infections may require oral or parenteral medications.
  • Treating inflammation:
    • Considering the use of steroids, such as oral dexamethasone (4–8mg) or prednisolone powder or solution, for ulceration and inflammation. However, it’s important to ensure that any infection is well treated, as steroids can exacerbate them.
Hiccup

 Hiccups are a common occurrence among many patients who are in the dying process. These hiccups can be quite distressing and exhausting for the patient, especially if they persist and do not resolve quickly.

Cause:

  1. The underlying cause of hiccups is typically irritation of the phrenic nerve in the neck of the mediastinum or irritation of the diaphragm from above.
  2. Commonly associated with hiccups are conditions such as tumors that cause stomach distension, lung tumors, esophageal cancer, renal failure, and hepatomegaly.
  3. Additionally, hiccups can also be of central origin, originating from the brain.

Management of hiccups:

Immediate measures:

  1. Pharyngeal stimulation: This can be achieved by having the patient swallow a piece of dry bread or two spoons of sugar.
  2. Correcting uremia if possible.
  3. Simple re-breathing from a paper bag to elevate the level of carbon dioxide (PCO2).
  4. Assisting the patient in a sitting up position.
  5. Medications such as Metoclopramide (10-20 mg every 8 hours), haloperidol (3 mg at night), or chlorpromazine (25-50 mg at night) may be prescribed.

Gastro-esophageal reflux

 Gastro-esophageal reflux commonly occurs when there is pressure on the diaphragm caused by an abdominal tumor or ascites, or in the presence of a neurological disorder.

Management:

  1. It is helpful to position the patient in an upright, sitting position.
  2. Administer medications after meals.
  3. Consider giving the patient milk.
  4. If the patient is currently taking NSAIDs, they may need to discontinue their use.
  5. Simple antacids such as Magnesium trisilicate (10 ml every 8 hours) may be prescribed. If the condition persists, cimetidine (200 mg every 12 hours), ranitidine (300 mg every 12 hours), or omeprazole (20-40 mg once daily) may be prescribed.

Dehydration

Dehydration is a common symptom often observed in patients, and there is a strong desire among both relatives and the medical or nursing team to ensure proper hydration for the patients.

Diagnosis:

The diagnosis and prognosis of dehydration can be influenced by several factors:

  1. Dehydration may occur when a patient experiences an intercurrent illness that is expected to resolve, such as an episode of diarrhea in a patient with lung cancer who has a prognosis of several months or severe diarrhea in an HIV/AIDS patient.
  2. Presence of other symptoms:

    a
    . Dehydration can significantly impair drug excretion, leading to increased side effects, particularly for medications like morphine. It is advisable to discontinue unnecessary medications or reduce the dosage while maintaining symptom control.

    b
    . Supplementary fluids may be administered for a short period to alleviate distressing symptoms like hallucinations or myoclonic jerks.
  3. Presence of a dry mouth rather than thirst:

    a
    . Patients may report feeling thirsty, but they may appear well hydrated, and their symptom could be a dry mouth.

    b
    . If the patient is excessively thirsty, and measures to keep their mouth moist are ineffective, considering supplementary fluids may be appropriate.

    c
    . Assess the patient’s proximity to death:
    • Patients nearing death often struggle with managing oral fluids and may even experience coughing during swallowing.

Assessment and management of dehydration:

  1. A dilemma arises when a patient is critically ill and entering the terminal phase. In most patients approaching death, a reduction in fluid intake is natural and appropriate as they no longer require significant fluid intake. Explaining this to the family can help alleviate concerns and reduce requests for supplementary fluids.
  2. It is crucial to keep the mouth and lips clean and moist, as dry oral mucosa can be more distressing than thirst.
  3. In certain situations, considering artificial hydration may be appropriate. Whenever possible, oral hydration should be attempted, but if necessary, intravenous (IV) or subcutaneous (SC) infusions can be considered. SC infusions are the least invasive and can even be administered in a home setting.
  4. Excessive hydration can lead to fluid overload, requiring venous cannulation, which may become painful and challenging. When deciding to administer supplementary fluids, several factors should be taken into account.
  5. Offering more than sips of oral fluids in this situation risks the complication of aspiration and pneumonia.
  6. Families often worry that the patient will be uncomfortable without hydration. However, it’s important to note that anorexia and cachexia (severe weight loss) are common in advanced cancer, HIV/AIDS, and end-stage organ failure, and forced feeding or hydration will not improve these conditions.

Cachexia and Anorexia

Cachexia refers to weakness, profound weight loss, and poor appetite commonly observed in advanced stages of cancer, HIV/AIDS, and end-stage organ failure. 

It is important to understand that cachexia is not associated with hunger or thirst and cannot be improved by forced feeding or hydration. The underlying mechanisms of cachexia differ among different diseases but involve the release of inflammatory mediators and metabolic alterations that induce a catabolic state, resulting in significant weight loss affecting both fat and skeletal muscle.

General measures for managing cachexia:

  • Ensuring that reversible causes of anorexia or malnutrition are addressed, such as:
    • Lack of available or digestible food.
    • Dysphagia.
    • Sore mouth or altered taste.
    • Dyspepsia, nausea and vomiting, or constipation.
    • Pain.

Management in Children:

  • Corticosteroids should not be used in children if anorexia/cachexia is the sole symptom that may benefit from treatment.
  • A short trial of corticosteroids may be considered in children with associated symptoms like nausea, pain, asthenia, or depressed mood. Dexamethasone is the most appropriate corticosteroid dose in children. Alternatively, prednisone can be used at a dosage of 0.05-2mg/kg divided 1-4 times a day.

Faecal Incontinence

Faecal incontinence is a distressing symptom for the patient and presents a challenging problem for their relatives to manage at home. The causes of faecal incontinence can vary and may include:

  1. Faecal impaction: A blockage in the rectum can lead to involuntary leakage of stool.
  2. Excessive use of laxatives: Overuse of laxatives can cause loose stools and contribute to incontinence.
  3. Frequent and severe diarrhoea in debilitated patients.
  4. Paraplegic patients: Those with paralysis or impaired control of the lower body may experience difficulties in controlling bowel movements.
  5. Relaxed anal sphincters, especially in the elderly: Weakening of the muscles that control bowel movements can result in incontinence.
  6. Ano-rectal tumors: Tumors in the anal or rectal region can disrupt normal bowel function and contribute to incontinence.

Management strategies for faecal incontinence:

  1. Thorough rectal examination: A comprehensive examination should be performed to identify the underlying cause of the incontinence.
  2. Patients with relaxed anal sphincters may benefit from the use of constipating agents such as loperamide or codeine phosphate.
  3. Paraplegic or constipated patients can benefit from regular rectal evacuation and the use of faecal softeners to maintain regular bowel movements.
  4. Patients with ano-rectal carcinoma may find relief through the following measures:
    • Radiotherapy (RT) may be recommended.
    • Rectal steroids, such as prednisolone suppositories twice daily or betamethasone foam twice daily, can provide relief.
    • Metronidazole can be used rectally if there is an offensive discharge.
  5. Practical measures to manage faecal incontinence at home include:
    • Using plastic under sheets, diapers, and promptly changing and washing/drying the patient after each episode.
    • Applying barrier cream to protect the skin.
    • Regularly turning immobile patients to prevent pressure sores.

Neurological Symptoms

Fatigue:

Chronic fatigue is a common symptom in people with advanced disease. It can have multiple causes that are often overshadowed by coexisting disease processes. 

Causes of fatigue:

  1. Anaemia
  2. Pain
  3. Emotional distress
  4. Sleep disturbances
  5. Poor nutrition

General care for managing fatigue:

  •  Adapting lifestyle around periods of greater energy or fatigue. 
  • To address fatigue, it is important to treat the underlying cause if possible. For example, if anaemia is contributing to fatigue, a blood transfusion may be appropriate.
  •  Low doses of psycho-stimulants such as methylphenidate (Ritalin) or antidepressants can also be considered.
  •  Non-pharmacological interventions include energy conservation, physical exercise, stress reduction through relaxation techniques, and meditation.

Insomnia:

Insomnia refers to difficulty initiating or maintaining sleep, early-morning awakening, non-restful sleep, or a combination of these symptoms. It is common in individuals with advanced disease and can be transient or chronic. 

The causes of insomnia:

  1. Transient: Often related to life crises, bereavement, or illness.
  2. Chronic: Associated with medical or psychiatric disorders, drug intake, or maladaptive behavioral patterns. In advanced disease, it can emerge as a psychological or physiological side effect of diagnosis or treatment.

General care for managing insomnia 

  •  Reducing intake of nicotine, caffeine, and other stimulants, as well as avoiding alcohol near bedtime. 
  • Regular exercise earlier in the day can also be helpful. 
  • Benzodiazepines are commonly used hypnotic medications for sleep, offering prompt relief by decreasing time to sleep onset, improving sleep efficiency, and promoting a sense of restful sleep. 
  • Long-acting benzodiazepines like lorazepam and diazepam can be considered, but they are not recommended for long-term treatment due to the risk of tolerance, dependency, and other side effects.

Confusion:

Confusion is a distressing symptom and can be difficult to manage.

 Causes:

  1. Uncontrolled pain
  2. Urinary retention or severe constipation
  3. Changes in environment or transfer from one ward to another
  4. Metabolic disturbances (e.g., uraemia, hypercalcaemia, hyponatraemia)
  5. Infections (e.g., urinary tract infection, cryptococcal meningitis, other opportunistic infections)
  6. Hypoxia
  7. Raised intracranial pressure, strokes
  8. Medication-induced (e.g., opioids, antimuscarinics, corticosteroids)
  9. Withdrawal states (e.g., alcohol, benzodiazepines, opioids)
  10. Dementia, delirium, HIV encephalopathy
  11. Sudden sensory deprivation (blindness, deafness)

General care for managing confusion

  •  Creating a calm and reassuring environment that is as familiar as possible. 
  • Reminding the patient of their surroundings and orientation in time can be helpful. 
  • Physical restraint should be avoided unless necessary for the patient’s safety. 
  • Supporting family members to stay with the patient and express their concerns is important. 

The management of confusion

  •  Addressing underlying causes such as pain, urinary retention, constipation, infections, and organ failure. 
  • Medications can be used to relieve symptoms, but caution should be exercised to avoid excessive sedation. 
  • For mild agitation, diazepam or lorazepam can be given. For severe delirium, haloperidol or chlorpromazine can be considered along with diazepam, but not as a sole treatment for severe delirium as it may worsen confusion.

Depression:

Depression is often misunderstood, under-diagnosed, and under-treated. Assessing and managing depression involves considering key factors such as low mood for more than 50% of each day, loss of enjoyment or interest, excessive or inappropriate guilt, and thoughts of suicide.

 Ongoing support and counseling may be necessary, and antidepressant medications can be considered if depression does not respond to counseling. Amitriptyline and imipramine are examples of antidepressants that may be prescribed.

Anxiety:

Anxiety may be a symptom of depression or can occur independently. Assessment and management of anxiety involve recognizing symptoms such as feelings of panic, irritability, tremor, sweating, sleep disturbances, and lack of concentration. Providing opportunities for the patient to talk about their fears and anxieties can be beneficial. Non-pharmacological interventions like massage, relaxation techniques, and counseling may help. If persistent symptoms significantly affect the patient’s quality of life, medication with benzodiazepines such as diazepam can be considered.

Respiratory Symptoms

Breathlessness:

Difficulty in breathing can be a frightening experience for patients. They often use words such as “suffocating,” “choking,” “could not get enough air,” or “it felt like I was about to die” to describe their experience.

 Causes of breathlessness:

  1. Respiratory causes: Primary or secondary lung cancers, pleural effusion, pulmonary embolism, tracheal tumors, airway collapse, infections, lymphangitis carcinomatosa, and chronic obstructive pulmonary disease (COPD), weak respiratory muscles.

  2. Cardiac causes: Superior vena cava obstruction, anemia, cardiac failure, cardiomyopathy, pericardial effusion.

  3. Other causes: Ascites, and breathlessness secondary to treatments like radiotherapy, chemotherapy, or pneumonectomy.

General care for managing breathlessness:

  1. Adjusting the patient’s position: It is usually best for the patient to sit up. However, in patients with pleural effusion, lying on the affected side with the good lung upwards can help maximize ventilation.
  2. Ensuring good ventilation: This can be achieved by opening windows, using a fan, or even fanning with a newspaper.
  3. Assisting with slow, deep breathing and adjusting activity accordingly.
  4. Gently suctioning any excessive secretions.

Assessment and management of breathlessness:

  1. Taking a careful history: Inquire about the severity, duration, and associated features such as breathlessness worsening when lying down or on exertion, pleuritic chest pain, or hemoptysis.
  2. Treating reversible conditions if possible: This may include addressing anemia, heart failure, infection, pulmonary embolism, or pleural effusion.
  3. Addressing underlying anxiety and panic.
  4. Using medications to relieve symptoms:

  • a. Morphine: 2.5-5mg orally every four hours. If the patient is already taking oral morphine for pain, adjust the dose and advise on taking extra doses as required.
  • b. Diazepam: 2-5mg at night, especially for anxiety and panic.
  • c. Dexamethasone: 8-12mg daily for specific causes such as superior vena cava obstruction or lymphangitis carcinomatosa.
  • d. Consider other medications such as bronchodilators, diuretics, or oxygen, depending on their availability and the cause of breathlessness.

Cough

The incidence of cough in all cancer patients is around 30%, while in patients with lung or bronchus cancer, it is as high as 80%. In patients living with HIV/AIDS, any duration of cough should raise a high suspicion of tuberculosis (TB), and the patient should be referred for investigations such as Gene X-pert.

Causes of cough:

  1. Bronchial obstruction from a primary tumor or enlarged medial sternal glands, which is the most common cause.
  2. TB or pneumonia in immunosuppressed patients.
  3. Left ventricular failure, characterized by dyspnea and cough that wakes the patient.
  4. Vocal cord paralysis due to hilar tumor or lymphadenopathy.
  5. Unrelated causes to cancer, such as smoking, common colds, asthma, or congestive heart failure.

During the assessment, consider the following:

  • Type of cough: Determine if the cough is productive (with phlegm) or dry, and whether the patient is able to cough effectively.
  • Identify factors that precipitate, worsen, or relieve the cough.

Perform a physical examination of the mouth, throat, lungs, and heart.

Management of cough:

  1. Productive cough: Perform gentle postural drainage to aid expectoration and drainage if the patient’s condition allows. Steam inhalations can be helpful if the sputum is thick. Antibiotics are often prescribed to clear infections and facilitate easier expectoration. Bronchodilators, such as salbutamol, can be included in cough mixtures if bronchospasms are present.

  2. Non-productive cough: Sedation at night can be achieved with codeine linctus (1mg/ml, 10mls every 4 hours) or morphine (2.5mg, with an increase in the usual dose by 2.5mg every 4 hours).

Nursing management:

  • Positioning the patient in bed, propped up with 2 or 3 pillows in the most comfortable position.
  • If there is a pleural effusion, the patient should lie on the side of the effusion in a semi-recumbent position.

Urinary Symptoms

Urinary Retention

Urinary retention in terminally ill patients can have various causes, including:

  1. Drug-induced retention, particularly from anti-cholinergic medications, tricyclic antidepressants, and opioids. This is usually temporary and initially only.
  2. Neurological causes, especially spinal cord compression.
  3. Faecal impaction of the rectum, which can be resolved by evacuating the rectum.
  4. Prostatic carcinoma obstructing the bladder neck, which requires managing the underlying cause.

In all of the above causes, catheterization of the patient should be performed while managing the underlying cause.

Dysuria

Causes:

  1. Urinary tract infections (UTIs).
  2. Bladder or prostatic carcinoma, particularly affecting the bladder neck.
  3. Calculi (stones) or retained blood clots in the urinary system.
  4. Infiltration of the bladder by a tumor from adjacent organs such as the rectum, vagina, or cervix.

Management:

Except for UTIs, catheterization is crucial to perform bladder washouts and address incontinence or partial retention.

  1. Generalized bladder pain from bladder carcinoma may be relieved by prostaglandin inhibitors such as Ibuprofen (400mg four times a day), but strong analgesics like opioids are usually necessary and should not be withheld.
  2. If the above measures fail, permanent catheterization may be considered as an option.

Urinary catheterization is very useful for ill patients to prevent dribbling incontinence or recurring retention. When performing catheter care, the following tips are helpful:

  1. Use Foley catheters.
  2. Avoid inflating/deflating the bulb or inserting different sizes of catheters repeatedly.
  3. Bladder washouts are beneficial. Use Chlorhexidine 0.05% daily for infection prevention and weekly for maintenance, and saline for removing debris, deposits, and clots. Carers should be trained to perform bladder washouts using boiled, cooled water at home to remove debris.
  4. To minimize discomfort during catheterization for anxious patients, administer oral or rectal diazepam (2-5mg) or morphine (5mg) 30 minutes before the procedure.
  5. In about 10% of patients nearing the end of life, hematuria (blood in urine) may occur. In severe cases, a bladder washout using a silver nitrate solution can help reduce bleeding.
  6. Reassurance and explanation to family members are crucial.

Skin Related Conditions

Skin disorders can cause significant discomfort and distress to patients, especially as end-of-life approaches. Lack of activity and excessive weight loss can contribute to the development of skin breakdown. Recognizing the potential causes of skin and mucous membrane disorders is crucial because terminally ill patients cannot afford to wait for diagnostic test results before initiating therapy. Treatment planning is based on clinical identification of the most likely diagnosis, and therapy should be started as soon as possible to alleviate discomfort.

Pruritus (Itching)

Near the end of life, the cause of pruritus may be related to the patient’s primary illness, co-morbid conditions, allergies, and infections. 

The causes of pruritus;

  1. HIV/AIDS
  2. Pre-existing skin diseases (such as eczema, psoriasis, or infestations)
  3. Dry skin, particularly senile pruritus
  4. Obstructive jaundice
  5. Anxiety
  6. Allergic reactions

Management:

  1. For HIV/AIDS-related pruritus due to drug eruptions, apply 1% hydrocortisone cream.
  2. In cases of multiple opportunistic skin infections, rinse the skin after bathing with a 0.05% Chlorhexidine solution. This usually provides results within 10 days.
  3. In cases of obstructive jaundice where biliary stenting is unavailable, the following measures can be taken:
    • Administer steroids such as Dexamethasone (2mg twice daily, reducing to 1mg/day) or Prednisolone (15mg reducing to 10mg daily in the morning).
    • Use an antihistamine, such as Chlorpheniramine (4mg three times daily).

Other measures to alleviate pruritus include:

  1. Advising the patient to keep their nails short and to gently rub itching skin to prevent damage.
  2. Using a cold fan on exposed skin.

Hyperhidrosis (Excessive Sweating)

Hyperhidrosis, or excessive sweating, can cause discomfort and anxiety in patients.

Caused by various factors, including:

  1. Intercurrent infections, including tuberculosis (TB)
  2. Toxemia associated with liver metastases
  3. Lymphomas
  4. High doses of morphine

Management:

  • Identify and treat the underlying cause. 
  • If fever is present, administer antipyretics such as Paracetamol, Ibuprofen, or Diclofenac, which may initially increase sweating but eventually bring down the temperature and provide cooling effects. 
  • Steroids like Dexamethasone (2-4mg/day) can also be given. 
  • Frequent sponging and appropriate advice regarding clothing and bedding can help alleviate discomfort.

Oedema and Swelling

Kaposi’s Sarcoma is a common cause of swelling in various parts of the body, particularly the legs and face. The woody hard infiltration of the skin by the tumor leads to areas of distension, blockage of small vessels and lymphatics, and fluid retention.

Management:

  1. Considering starting antiretroviral therapy (ART) to improve the condition.
  2. Chemotherapy, if available.
  3. Pain relief with analgesics.
  4. Managing the underlying cause, if identified.

Bilateral Upper Limb Oedema

Bilateral upper limb edema is mainly caused by superior vena cava obstruction, resulting in venous distension in the area drained by the superior vena cava. Management involves:

  • Prompt radiotherapy (RT)
  • Chemotherapy
  • High-dose Dexamethasone

Unilateral Lower Limb Oedema

The three principal causes of unilateral lower limb edema in terminal care are:

  • Venous and/or lymphatic obstruction caused by a pelvic tumor. Consider radiotherapy (RT) and chemotherapy to shrink the tumor.
  • Deep venous obstruction. Avoid anticoagulants due to the bleeding tendency in terminal diseases.
  • Infection, which can manifest as cellulitis, lymphangitis, or deep tissue infection from a nearby tumor.

Management:

  • Use appropriate antibiotics, specifically broad-spectrum or according to culture and sensitivity results.
  • Advise bed rest.
  • Administer analgesics to control pain.

Bilateral Lower Limb Oedema

The three principal causes of bilateral lower limb edema in terminal care are:

Lymphatic and venous obstruction caused by a pelvic tumor. Management:

  • High-dose Dexamethasone
  • Diuretics, preferably Spironolactone (75-400mg daily) together with Frusemide (40-200mg daily)

Cardiac failure, which should be treated using routine methods.

 

Lypoalbuminemia resulting from dietary deficiency or loss in ascitic fluids. Prolonged periods of sitting with dependent feet can also cause lower limb edema, but it is not an indication for diuretics. Management:
  • Elevate the feet
  • Encourage leg movement through walking or passive movements
  • Treat the contributing factor
  • Provide reassurance to the patient and family members

Ascites

Ascites is the accumulation of excessive fluid in the peritoneal cavity, which is the space within the abdomen. Malignancy, or cancer, accounts for around 10% of all adult cases of ascites.

Clinical features of ascites :

  1. Increasing distension of the abdomen
  2. Abdominal pain
  3. Early satiety (feeling full quickly after eating)
  4. Nausea and vomiting
  5. Shortness of breath
  6. Leg edema (swelling)

Pathogenesis

The pathogenesis of ascites involves an imbalance between fluid influx and efflux in the peritoneal cavity. Increased fluid influx is associated with peritoneal metastasis (spread of cancer to the peritoneum) and increased peritoneal permeability. Reduced efflux is associated with lymphatic vessels blocked by tumor infiltration and liver metastasis causing low albumin levels.

Causes of ascites can include 

  • ovarian carcinoma, 
  • colorectal carcinoma, 
  • pancreatic carcinoma, 
  • gastric carcinoma, 
  • cardiac failure, 
  • renal failure, and liver failure.

Management

  •  Correcting the underlying cause if possible, as successful treatment of the underlying condition can often control ascites. 
  • Non-drug treatment options include paracentesis, which involves the removal of fluid from the peritoneal cavity. However, ascites is likely to reaccumulate after paracentesis.
  • Drug treatment options for ascites include the use of spironolactone, which is a diuretic that helps reduce fluid accumulation, and frusemide may be added if necessary.

Fungating Tumors and Odors

Fungating tumors can cause distress to patients due to embarrassment and isolation from relatives and friends. 

Management:

  1. Regular cleaning of the fungating tumor with saline.
  2. Radiotherapy (RT) may be a good option.
  3. Crushed Metronidazole tablets applied to the fungating area can remove odor and dry up the discharge.
  4. Metronidazole tablets can be inserted into sinuses or orifices leading to smelly growth, particularly in rectal or cervical cancers. It helps with pain relief, hemostasis, and clearing infections caused by anaerobic organisms.
Wound Care

Causes of wounds:

  1. Fungating skin cancers (primary or secondary), such as breast, sarcoma, squamous tumors, or melanoma.
  2. Poor wound healing due to debility, poor nutrition, and illness.
  3. Pressure sores due to debility and immobility.

General Care:

Cleaning wounds:

  1. Use a simple saline solution made by boiling water and adding salt (a pinch for a glass or one teaspoon for 500mls).
  2. Use saltwater baths for perineal wounds.
  3. Avoid caustic cleaning agents like hydrogen peroxide.
  4. Consider leaving a wound exposed to air (while monitoring for maggots).
  5. If necessary, apply clean dressings daily or more frequently if there is discharge.
  6. Consider using locally available materials, such as old cotton cloths washed and cut to size, for simple dressings.
  7. Educate the patient’s family on how to perform daily dressing changes.
  8. Prevent pressure sores by regularly changing the patient’s position.
  9. Keep the skin dry and clean.
  10. Consider using a water-filled surgical glove for pressure relief in critical areas.

Assessment and Management:

Is there pain?

  • Use non-adherent dressings and soak them off before changing.
  • Administer analgesia 30 minutes before changing the dressing.

Is there an unpleasant smell?

  • Sprinkle crushed metronidazole tablets directly onto the wound (avoid enteric-coated tablets) or use metronidazole gel if affordable.
  • Consider using locally available remedies such as natural yogurt, papaya, or tried-and-tested local herbs.
  • Honey or sugar can be temporarily used on a dressing for de-sloughing necrotic wounds. Dressings should be changed twice a day as they become moist, but within a few days, you can revert to dry dressings or metronidazole.

Is there discharge?

  • Use absorbent dressings and change them frequently.

Is there bleeding?

  • In cases of severe bleeding, consider radiotherapy or surgery. Use dark cloths to soak up the blood.
  • Clean the wound carefully to avoid trauma during dressing changes.
  • Consider using crushed topical tranexamic acid (500mg).

Symptoms Control Read More »

Pain Management

Pain Management

Pain Management in Palliative Care

The WHO states that freedom from cancer pain and pain caused by other diseases like HIV/AIDS should be a Basic Human Right. Pain is managed after Assessment, therefore understand Assessment of Pain by clicking here.

Principal of effective pain management

The WHO set out some basic principles for pain management::

PrincipleDescription
By the mouth
  • Always give treatment orally when possible.
By the clock
  • Persistent pain requires regular round the clock dosages (i.e. 4 hourly oral morphine).
  • Give analgesics at regular intervals.
  • Give the net dose of analgesia before the previous one has worn off
  • Titrate the dose against pain.
By the ladder
  • Use the WHO analgesic ladder as a guide to management, you can move stepwise up or down the ladder.
By the patient
  • Dosage is determined on an individual basis as no two patients are the same.
  • The choice of drug for managing pain should be appropriate for the type and severity of pain and a combination of medication should be used as appropriate.
Attention to Detail/Adjuvants
  • Regular laxatives are needed in all patients who receive opiates except those suffering from persistent diarrhea.
  • Antiemetics are usually required with initial morphine use in African patients.
  • Not all pain responds to opiates and the ladder.
  • Opiate semi-responsive: Bone pain-NSAID+/- opiates;
  • Nerve compression-steroid;
  • Increased edema-ICP-steroid;
  • Inflammation-steroid.
  • Opiate resistant:
  • Muscle pain/spasm-muscle relaxant;
  • Neuropathic pain-tricyclic antidepressants e.g. amitriptyline and anticonvulsants.

Types of Pain Management

Non-pharmacological Pain Management

  • Physical: Includes methods like massage, exercise, physiotherapy, and surgery.
  • Psychological: Involves strengthening the patient’s coping mechanisms through counseling and relaxation therapies.
  • Social: Assists the patient in resolving social or cultural problems through community resources, financial and legal support, etc.
  • Spiritual: Includes religious counseling and prayer.

Pharmacological Pain Management

  • Nociceptive Pain (normal) Management:
    • Follow WHO guidelines.
    • Utilize the oral route whenever possible.
    • Administer analgesia at fixed time intervals, giving the next dose before pain recurs.
    • Involve adults and children fully in their care and link doses to their daily routine.
    • Choose analgesics based on the WHO analgesic ladder, which covers mild, moderate, and severe pain.

WHO Analgesic Ladder

The World Health Organization (WHO) created an analgesic ladder as a method for effectively managing pain in cancer patients (WHO, 1996).

The ladder consists of three steps.

  • If a particular drug becomes ineffective, a stronger drug should be prescribed, and the treatment should progress to the next step on the ladder.
  • The management of pain should follow a step-wise approach, moving both upward and downward on the ladder as necessary.

The WHO Analgesic Ladder has proven successful in providing pain relief to approximately 90% of cancer patients.

WHO Analgesic Ladder

Step 1: Mild Pain(Non-Opioids)

  • Paracetamol:
    • Adult dose: 500mg-1g orally every 6 hours, with a maximum daily dose of 4g.
    • Can be combined with a non-steroidal anti-inflammatory drug (NSAID).
  • Ibuprofen (NSAID):
    • Adult dose: 400mg orally every 6-8 hours, with a maximum daily dose of 1.2g.
    • Give with food and avoid in asthmatic patients.
    • Effective for bone and soft tissue pains.

Step 2: Moderate Pain (Weak opioids)

  • Codeine:
    • Adult dose: 30-60mg orally every 4 hours, with a maximum daily dose of 180-240mg.
    • Often combined with Step 1 analgesics.
    • Laxatives should be given to prevent constipation, unless the patient has diarrhea.
  • Tramadol:
    • Adult dose: 50-100mg orally every 4-6 hours.
    • Start with a small dose and increase if needed, with a maximum daily dose of 400mg.
    • Use with caution in epileptic cases.

Step 3: Severe Pain (Strong analgesics)

  • Morphine:
    • Considered the “gold standard” of opioid analgesics.
    • No maximum dose; the right dose is the one that provides pain relief without side effects.  (In Uganda 30mg /24hrs is most common dose)
    • Starting dose varies based on factors such as age and previous use of opioids.
    • Starting dose: 5—10mg orally 4hrly depending on age, previous use of opiates, etc.
    • Gradually increase the dose as needed.
    • Frail/elderly patients may start with a lower dose( 2.5mg orally 6—8hrly,) due to impaired renal function.

Pharmacology of the Drugs used in the WHO Analgesic Ladder

MORPHINE

Morphine is a commonly used analgesic medication available in liquid form. It comes in different strengths, including weak (green) with a concentration of 5mg/5ml, strong (red) with a concentration of 50mg/5ml, and very strong (blue) with a concentration of 100mg/5ml. Liquid morphine is widely accessible and used for pain management purposes.  

Mode of Action
  • Morphine exerts its action by binding to opioid receptors in the brain and spinal cord, resulting in pain relief. (Morphine binds to both mu and kappa receptor sites, resulting in profound analgesia.)
  • It acts on the spinal cord to modify the transmission of pain signals and activates inhibitory pathways from the brain stem and basal ganglia.
  • Morphine also affects the limbic system and higher brain centers, influencing the emotional response to pain.
  • Additionally, its effects on the gastrointestinal and respiratory systems are partly mediated by the autonomic nervous system and direct interaction with opioid receptors in peripheral tissues.
Indications of Morphine
  •  Primarily indicated for moderate to severe pain
  • It is also employed in the treatment of acute myocardial infarction (heart attack) to alleviate chest pain and reduce anxiety.
  • It is used for the symptomatic relief of severe acute and chronic pain when nonnarcotic analgesics have proven ineffective.
  • Morphine is administered as preanesthetic medication.
  • It helps relieve shortness of breath associated with heart failure and pulmonary edema.
  • Morphine is employed for the management of acute chest pain associated with myocardial infarction (MI).
  • Morphine can be utilized to treat symptoms such as diarrhea, cough, and dyspnea.
Common Side Effects
  1. Constipation: Laxatives should be administered alongside morphine, unless the individual has diarrhea. For example, Bisacodyl 5mg at night, increasing the dose to 15mg if necessary.
  2. Nausea and Vomiting: If these symptoms occur, anti-emetics can be given. For instance, Plasil 10mg every 8 hours or Haloperidol 0.5mg once a day.
  3. Drowsiness: Some individuals may experience drowsiness during the initial days of morphine treatment. If drowsiness persists beyond three days, reducing the morphine dose is recommended.
  4. Itching: Although uncommon, itching may occur as a side effect of morphine. In such cases, reducing the morphine dose can help alleviate the itching sensation.
Contraindications
  • Acute or Severe Asthma: Morphine should be avoided in patients with acute or severe asthma due to the potential risk of exacerbating respiratory symptoms.
  • Gallbladder Disease: Morphine may intensify or mask the pain associated with gallbladder disease, specifically due to biliary tract spasms. Caution should be exercised when considering morphine use in these cases.
  • Gastrointestinal (GI) Obstruction: Morphine should be avoided in patients with known or suspected GI obstruction as it may worsen the condition or lead to complications.
  • Severe Hepatic Impairment: Morphine should be used with caution in patients with severe hepatic impairment, as the metabolism and elimination of the drug may be altered.
  • Severe Renal Impairment: Morphine should be used with caution in patients with severe renal impairment, as clearance of the drug may be reduced, potentially leading to drug accumulation and increased risk of adverse effects.
  • Caution: Elderly patients and those who are debilitated or cachectic should be initially treated with reduced doses of morphine.
Adverse Effects of Morphine
  • Dysphoria: Morphine can lead to feelings of restlessness, depression, and anxiety.
  • Hallucinations: Some individuals may experience hallucinations while taking morphine.
  • Nausea: Morphine can cause nausea.
  • Constipation: One of the common side effects of morphine is constipation.
  • Dizziness: Morphine may cause dizziness.
  • Itching: Some individuals may experience an itching sensation.
  • Overdose: Taking an excessive amount of morphine can result in severe respiratory depression or cardiac arrest.
  • Tolerance: Tolerance can develop to the sedative, nausea-producing, and euphoric effects of morphine.
Drug Interactions of Morphine
  1. CNS Depressants: Concurrent use of morphine with other central nervous system (CNS) depressants, such as alcohol, other opioids, general anesthetics, sedatives, and certain antidepressants (e.g., monoamine oxidase inhibitors and tricyclics), can potentiate the effects of opiates. This increases the risk of severe respiratory depression and the potential for life-threatening complications.
  2. Monoamine Oxidase (MAO) Inhibitors: Combining morphine with MAO inhibitors, a type of antidepressant medication, can lead to increased opioid effects and the risk of serotonin syndrome. Serotonin syndrome is a potentially life-threatening condition characterized by symptoms such as agitation, hallucinations, rapid heartbeat, elevated body temperature, and changes in blood pressure.
  3. Tricyclic Antidepressants: Concurrent use of morphine with tricyclic antidepressants can enhance the analgesic effects of morphine but also increase the risk of adverse effects, such as sedation and respiratory depression.
Black Box Warning:
  • When morphine is administered as an epidural drug, patients must be closely monitored in a fully equipped and staffed environment for at least 24 hours due to the risk of adverse effects.
  • Extended-release tablets of morphine have a potential for abuse similar to other opioid analgesics.
  • Morphine is classified as a Schedule II controlled substance and should be used strictly according to dispensing instructions. Tablets or capsules should be taken whole and should not be broken, chewed, dissolved, or crushed.
  • Alcohol consumption should be avoided when taking morphine products.
  • Failure to adhere to these warnings could result in fatal respiratory depression.
Morphine prescription
Date25/3/2014
PatientBaluku John
IP No123/14
Age68 years
SexMale
DiagnosisCa penis
MedicationLiquid morphine 5mg in 5ml
InstructionsTake 5ml every 4 hours and 10ml at night
Supply250ml
Signature…………………………..
Treatment of Morphine Overdose
  1. Naloxone Administration: Naloxone is an opioid receptor antagonist that can reverse the effects of morphine overdose. It is typically administered intravenously (IV) and acts quickly to restore normal respiration and consciousness. Multiple doses of naloxone may be required depending on the severity of the overdose.
  2. Activated Charcoal: Activated charcoal may be given orally or through a nasogastric tube to help prevent further absorption of morphine from the gastrointestinal tract. It works by binding to the drug and reducing its availability for systemic circulation.
  3. Laxative: A laxative may be administered to promote bowel movement and eliminate the morphine from the digestive system. This helps to reduce the absorption of the drug and enhance its elimination.
  4. Narcotic Antagonist: Along with naloxone, other narcotic antagonists such as naltrexone may be used to counteract the effects of morphine overdose. These medications compete with morphine for opioid receptors and can help reverse respiratory depression and other opioid-related symptoms.
About Naloxone.

Actions and Uses of Naloxone

  • Naloxone is a pure opioid antagonist
  • Blocks both mu and kappa receptors I.

Used for:

  • Reversal of opioid effects in emergency situations of suspected opioid overdose
  • Postoperative opioid depression treatment
  • Adjunctive therapy to reverse hypotension caused by septic shock

II. Administration Alerts

  • Administer for a respiratory rate of fewer than 10 breaths/minute
  • Keep resuscitative equipment accessible
  • Pregnancy category B

III. Adverse Effects of Naloxone

  • Minimal toxicity
  • Reversal of opioid effects may result in: 1. Rapid loss of analgesia 2. Increased blood pressure 3. Tremors 4. Hyperventilation 5. Nausea and vomiting 6. Drowsiness

IV. Contraindications

  • Naloxone should not be used for respiratory depression caused by nonopioid medications

About Dependence

I. Opioid Dependence

Dependence refers to the state where a patient feels that they cannot function without the drug.

  1. Psychological dependence (addiction):

    • Involves experiencing cravings and engaging in compulsive drug-seeking behavior.
  2. Physiological dependence:

    • If the drug is abruptly discontinued, patients may develop withdrawal symptoms.
    • The likelihood of physiological dependence is reduced due to the use of low doses and the shorter lifespan of cancer patients.
  3. Therapeutic dependence:

    • Occurs when the underlying cause of pain is not resolved, leading to ongoing reliance on morphine.
    • If the cause of pain is resolved, the dosage of morphine needs to be adjusted accordingly.
  • Opioids have a high risk for dependence
  • Tolerance develops quickly, leading to escalated doses and increased frequency of drug use
  • Physical dependence occurs with higher and more frequent doses
  • Discontinuation of drug use leads to uncomfortable withdrawal symptoms
  • Psychological dependence and intense craving may persist even after overcoming physical dependence
  • Support groups are important to prevent relapse

II. Treatment Options for Opioid Dependence

Methadone Maintenance

  • Switching from illegal IV and inhalation drugs to oral methadone
  • Methadone does not cause euphoria and allows patients to function normally
  • Methadone maintenance requires continued drug use to avoid withdrawal symptoms
  • Provides physical, emotional, and legal benefits compared to illegal drug use

Buprenorphine Therapy

  • Administered sublingually or transdermally
  • Used early in opioid abuse therapy to prevent withdrawal symptoms
  • Suboxone (buprenorphine and naloxone) used for maintenance of opioid addiction

Adjuvant Medication

Adjuvant medications are drugs that are typically used for other purposes but can be effective in relieving pain under certain circumstances. They can be used alone or in combination with other medications on the analgesic ladder. Adjuvant medication plays a crucial role in pain management, especially for non-opioid responsive pain.

Examples of adjuvant medications include:

  1. Antidepressants (e.g., Amitriptyline):
    • Used to treat pain caused by nerve damage.
    • Cancer pain may require the addition of opioids as well.
    • Full benefits may take several weeks to achieve, although some effects may be noticed within one week.
    • Commonly used antidepressants are Amitriptyline (12.5-50mg at night) and Imipramine (10-50mg at night).
    • Given at night to potentially aid in sleep.
    • Side effects may include drowsiness, dry mouth, and urinary retention.
  2. Anticonvulsants (e.g., Phenytoin, Carbamazepine):
    • Used to treat neuropathic pain.
    • Can be used as an alternative or in combination with antidepressants or opioids.
    • Mechanism of action involves blocking sodium channels and enhancing GABA-mediated synaptic inhibition.
    • Examples of anticonvulsants include Phenytoin, Sodium valproate, Clonazepam, and Gabapentin.
  3. Corticosteroids (e.g., Dexamethasone):
    • Have various uses in palliative care.
    • Useful for pain caused by tumor pressure and inflammation.
    • Best used as a short-term measure due to potential side effects with long-term use.
    • Indicated for conditions such as nerve compression, superior vena caval obstruction, raised intracranial pressure (headache), and bone pain.
    • Side effects may include gastric irritation, oral candidiasis, fluid retention (ankle edema), proximal myopathy, steroid-induced diabetes mellitus, and psychosis.
  4. Smooth Muscle Relaxants (e.g., Buscopan, Diazepam):

    • Used for specific types of pain, such as biliary colic, bowel obstruction, ureteric colic, contractures, or spastic paraparesis.
    • Examples include Hyoscine butylbromide (Buscopan), Oxybutynin, Diazepam, and Clonazepam.
    • Side effects may include drowsiness.

Other interventions in pain management

  • Antibiotics for fungating wounds
  • Use of frangipani petals for post-herpetic neuralgia (neuropathic pain)
  • Capsaicin cream for neuropathic pain
  • Massage therapy, and reflexology.

Myths surrounding the use of opioids:

Morphine is offered to patients only when death is imminent:

  • The degree of pain, not the stage of a life-threatening illness, determines the need for medication.
  • Morphine is prescribed based on pain levels, and some patients may require it for an extended period.
  • Patients can lead active lives while managing pain with morphine.

Healthcare providers do an adequate job of providing pain control:

  • Barriers exist for healthcare providers in achieving optimal pain control.
  • Doctors may overlook assessing pain and assume disease-oriented treatment will suffice.
  • Nurses may administer lower doses than prescribed, resulting in under-treatment of acute pain.

Pain medications always lead to addiction:

  • Appropriate use of opioids for short-term acute pain management does not lead to addiction.
  • Reluctance to prescribe opioids due to addiction fears can deny patients freedom from pain.

People on morphine die sooner because of respiratory depression:

  • Respiratory depression is rare, especially in patients started on oral morphine with careful titration.
  • Low doses of morphine can safely relieve dyspnea in patients with COPD or lung cancer.

Pain medications always cause heavy sedation:

  • Initial sedation may occur due to chronic pain-induced sleep deprivation.
  • Adequate opioid doses allow patients to regain normal mental alertness and orientation.

People should not take morphine before their pain is severe, lest it lose its effect:

  • There is no upper dose limit for morphine. The dose can be increased as pain increases.
  • Early use of opioids does not diminish their effectiveness later in a terminal illness.

Some kinds of pain cannot be relieved:

  • Different pain medications have varying effects, and a combination approach may be necessary.
  • Thorough pain assessment helps in prescribing a regimen to manage pain effectively.

Effective pain management can be achieved on an ‘as needed’ basis:

  • Prophylactic, around-the-clock medication administration is necessary for effective pain management.
  • Scheduled opioid administration reduces side effects and provides continuous pain relief.

Opioid analgesics should be avoided in older patients:

  • Elderly patients with chronic moderate-to-severe pain may require strong opioids.
  • Caution is needed in dosing and titration due to pharmacokinetic and physiological changes.

Other myths about managing pain:

  1. Morphine does not hasten death in terminally ill patients.
  2. Injectable morphine is not necessarily more effective than other routes.
  3. Strong analgesics should not be withheld until death is imminent.
  4. Patients can experience pain even while sleeping.
  5. Pain can be present in patients who are engaged in activities like watching television or laughing.
  6. Infants and children experience pain similarly to adults.
  7. The dose of pain medications does not always need to be increased continuously.
  8. Vital signs alone are not reliable indicators of pain in patients.

Myths and Fears about Morphine:

Myths:

  1. Tolerance (Myth):

    • Some patients and physicians believe that increasing the dose of morphine to control pain indicates tolerance.
    • In palliative care, the ceiling dose of morphine is the dose that effectively controls the pain for each individual patient.
    • The need for an increased dose of morphine does not mean the patient is developing an addiction.
  2. Physical dependence (Myth):

    • Abrupt discontinuation of an opioid typically leads to withdrawal symptoms.
    • Gradual withdrawal over 2-3 days can alleviate these symptoms.
    • This is not physical dependence.
  3. Addiction (Psychological dependence) (Myth):

    • Addiction to morphine is very rare and primarily associated with non-medical use of opioids.
    • It is not a common problem in medical settings.
  4. Cognitive impairment (Myth):

    • When initiating morphine therapy, some sedation and temporary attention deficits may occur, including reduced recent memory.
    • These effects generally disappear after three to five days.
    • This is not addiction.
  5. Lethality (Myth):

    • Properly prescribed morphine, with gradual dose adjustments based on need, does not cause death.
    • In the event of an overdose, Naloxone can help control the situation.
Fears:
  1. A last resort before death? (Fear):

    • Some people fear that morphine is only prescribed as a last resort when the patient is close to death.
    • In reality, morphine is used to relieve pain at various stages of illness, not solely in end-of-life care.
  2. Hastening death (Fear):

    • There is a fear that morphine might speed up the dying process.
    • When used appropriately, morphine does not affect the timing of death.
    • Patients pass away due to the effects of advanced cancer or AIDS, not as a direct result of morphine.
    • Morphine allows pain relief, enabling patients to function more effectively.
  3. Morphine is reserved until the end (Fear):

    • Some individuals mistakenly believe that morphine should only be used as a last resort.
    • They fear that if morphine is taken early in the illness, it may not be effective when pain becomes more severe.
    • However, morphine can be used at various stages of illness to alleviate pain.
  4. Respiratory distress (Fear):

    • Some people believe that morphine can cause breathing problems, especially if the person has a lung condition.
    • Breathing difficulties can occur due to morphine overdose.
    • Starting with low doses and gradually increasing can help avoid this issue.
    • Morphine can actually be used to reduce distress caused by severe cough or breathlessness.
  5. The elderly should not be given morphine (Fear):

    • Elderly patients with cancer pain respond as well to morphine as younger patients.
    • However, they may be more prone to side effects.
    • Smaller doses and gradual increments are recommended for the elderly.
  6. Injection morphine is better than oral morphine (Fear):

    • Morphine is well absorbed when taken orally.
    • Oral (liquid) morphine is cost-effective compared to tablets or injectable forms.
    • Injection morphine should only be used when oral administration is not possible, such as in cases of severe vomiting.

Laws governing narcotics

International Regulation:

  • Opioids are regulated under the 1961 convention, amended by the 1972 protocol.
  • Uganda is a party to this convention, aiming to ensure the availability of opioids for medical and research purposes while preventing abuse.
  • The following aspects are considered under the enacted laws:
    • Production (cultivation)
    • Manufacturers
    • Distribution
    • Registration of all handlers
  • The international board oversees countries’ compliance with the convention.
  • The government estimates the annual quantity of opioids needed, which is confirmed by the International Board before manufacturing or importation.
  • Quarterly reports on imported, manufactured, and distributed opioids are required, necessitating accurate record-keeping.
  • Communication regarding regulations is done through the Ministry of Health (MOH) and the National Drug Authority (NDA), with the NDA regulating drug handling.

Restricted or Class A Drugs:

  • Class A drugs include opioids like morphine and pethidine.
  • Specific procedures, storage requirements, and records are in place to prevent diversion.
  • Records must be kept for two years for inspection purposes.
  • Loss of class A drugs must be reported to the Chief Inspector of Drugs (NDA) within seven days.

Expired, Rejected, or Returned Class A Drugs:

  • Unused drugs should be returned to the prescriber or dispenser.
  • Expired or rejected drugs should be returned to the pharmacy in charge, who contacts the drug inspector.
  • Expired drugs should be destroyed by the pharmacy in charge, witnessed by the drug inspector, following WHO guidelines.
  • Details of the quantity destroyed and the reason must be recorded in the Class A register.

Importation of Class A Drugs:

  • Manufacturing and wholesale of class A drugs require an annual import license.
  • Currently, only the National Medical Stores (government) and Joint Medical Stores (NGO) are allowed to import narcotics.
  • Private retail pharmacies and hospitals can access narcotics through these licensed agencies.

Storage:

  • Powdered morphine and finished morphine should be stored in a separate, immovable cupboard.
  • The cupboard should be double-locked and restricted from public access.
  • The key should be kept by the pharmacist or dispenser.

Disposal:

  • Drug disposal follows WI-TO guidelines (NDA).
  • Details of the quantity destroyed and the reason for destruction must be recorded in the Class A register.

Transport:

  • All individuals and enterprises involved in the distribution system should be licensed and authorized.
  • An anti-narcotic drug squad ensures drugs do not fall into the hands of drug traffickers.

Prescription:

  • Only registered medical doctors, dentists, veterinary doctors, specialized palliative care nurses or clinical officers, and midwives are allowed to prescribe class A drugs.
  • Prescription forms must contain all necessary details as it is a legal document.
  • Prescription is valid for 14 days, and supply must not exceed one month. Duplicate copies are required.

Prescription Requirements:

  • The prescription must include:
    • Name, age, sex, and address of the patient
    • Total dose of drugs prescribed in words and figures
    • Specific form of drug (e.g., tablets, injections, oral solution)
    • Specific strength where possible (e.g., 5mg/5ml or 50mg/5ml of oral morphine)

Penalties:

  • Unlawful possession of classified drugs can result in:
    • A fine not exceeding 2 million Ugandan shillings
    • Imprisonment for a term not exceeding 2 years
    • Both penalties may be applied.

Pain Management Read More »

Assessment OF Pain

Assessment OF Pain

Assessment OF Pain

Assessment Introduction.

To effectively manage pain, it is important to begin with a thorough assessment. This includes conducting a comprehensive physical examination and considering other factors that may influence the pain, such as psychological, social, cultural, and spiritual aspects. We covered Pain already, incase you want to view Pain Introduction, Click Here.

Here are some key points to keep in mind during the pain assessment process:

Physical Assessment: Perform a detailed physical examination and document the findings in writing and on a body chart. Limit further investigations to those that will significantly impact treatment decisions. Also, evaluate the extent of the patient’s disease.

Assessment of Influencing Factors: In addition to the physical assessment, assess other factors that may contribute to the pain experience, such as psychological, social, cultural, and spiritual aspects.

Specific Questions to Ask: To gather important information about the pain, ask specific questions, including:

  1. Onset of Pain: When did the pain start?
  2. Nature of Pain: What does the pain feel like?
  3. Site and Radiation of Pain: Where is the pain located and does it spread to other areas?
  4. Type of Pain: What type of pain is it?
  5. Duration of Pain and Changes: How long has the pain been present and has it changed over time?
  6. Precipitating/Aggravating or Relieving Factors: What triggers or worsens the pain? Are there any factors that provide relief? Also, consider how the pain affects the patient’s functional ability, mood, and sleep.
  7. Effect of Previous Medications: Assess the effectiveness and any side effects of previous pain medications.
  8. Meaning of Pain to the Patient: Understand the patient’s perspective on the pain and its significance, especially if it relates to their deterioration or end-of-life concerns.

PQRST Pain Assessment 

  1. Precipitating and relieving factors: What makes your pain better or worse?
  2. Quality of pain: How would you describe your pain? What does it feel like?
  3. Radiation of pain: Does the pain stay in one place or move around your body?
  4. Site and severity of pain: Where is your pain? (Use a body chart) How bad is it? (Use a pain rating scale)
  5. Timing and previous treatment for pain: How often do you experience the pain? Does it occur at specific times? Have you received any previous pain treatments?

PQRST Pain Assessment

PQRSTQuestions
P – Position
  • – Where is the pain?
  • – Can you point to where the pain is?
  • – Does the pain spread?
  • – Put an X where it hurts the most.
P – Precipitating Factors
  • – Does anything worsen the pain, such as eating, bowel movements, or movement in general?
  • – Does anything alleviate or improve the pain?
  • – Does the pain get better when staying still?
  • – Does it improve after having a bowel movement?
  • – Does it improve after wound discharge?
  • – Does using hot or cold compresses help?
  • – Does praying or being with friends provide relief?
  • – Have you tried any medications, painkillers, or herbs? Do they help?
  • – Did any treatment reduce or eliminate the pain?
  
Q – Quality
  • – What does the pain feel like to you?
  • – How would you describe your pain using words like nociceptive, somatic pain, etc.?
R – Radiation
  • – Where does the pain start?
  • – Does the pain radiate to any other areas?
S – Severity
  • – On a scale of 0 to 5, how severe is the pain?
  • – How does the pain affect your daily life?
  • – Does it prevent you from engaging in normal activities, sleeping, moving, sitting, or eating?
T – Timing
  • – How long have you had the pain?
  • – Is the pain constant or does it come and go?
  • – Does the pain worsen at a specific time of day or night?
Meaning of Pain, this is to help to understand the patient’s thinking about the pain.
  1. – What are your fears about the pain?
  2. – What do you think is causing the pain?
  3. – What does the pain mean to you?
  4. Some possible answers: “I’m being punished,”
  5. “I’m going to die,”
  6. “There is no hope,”
  7. “I have to suffer; it is my destiny,”
  8. “I’m being eaten away.”

In a PQRST pain assessment, these questions help gather important information about the pain, its location, factors that worsen or alleviate it, the quality of the pain, any radiation or spread, its severity and impact on daily life, timing patterns, and the patient’s thoughts and fears related to the pain.

Pain Assessment Tools

Pain assessment tools are helpful in evaluating and monitoring a patient’s pain. These tools provide a way to measure and track the severity of pain over time. They are particularly useful for:

  • Determining the intensity of the patient’s pain.
  • Monitoring changes in pain levels as treatment progresses.
  • Assessing the effectiveness of interventions.

It is important to use simple techniques during pain assessment. 

Initially, 

  • Identifying the location of the pain and whether it is present in multiple areas of the body is crucial
  • Regular pain measurements should be conducted, typically every 6 or 4 hours, or more frequently in severe cases.
  •  It is important to note that most measurement tools do not consider the presence of anxiety, which can lead to inaccurate high or low pain scores. Anxiety and pain can exhibit similar behavioral indicators, so it is possible to measure anxiety instead of pain.

There are various pain measurement tools available for both adults and children. One useful tool is a body chart, where individuals can mark the areas where they experience pain.

Types of pain assessment tools.

The Numerical Rating Scale

 

  • The Numerical Rating Scale

One common type of pain assessment tool is the Numerical Rating Scale. The patient is asked to rate their pain intensity on a numerical scale, typically ranging from 0 (indicating no pain) to 10 (indicating the worst pain imaginable). Alternatively, a simplified version of the scale may use a range of 0-5. Another variation is the verbal-descriptor scale, which includes descriptive terms such as “mild pain,” “mild-to-moderate pain,” and “moderate pain.”

hand scale for pain assessment
  • Hand Scale

This scale uses a hand gesture to represent the level of pain. A clenched hand indicates no pain or “no hurt,” while fully extended fingers represent the worst possible pain or “hurts worst.”

 It’s important to note that cultural interpretations may vary, so it’s necessary to explain the scale clearly to the patient. For example, you can ask the patient to rate their pain on a scale of 0 to 5, where 0 means no pain at all, 1 is a little pain, 2 is a bit more pain, 3 is quite some pain, 4 is a significant amount of pain, and 5 is overwhelming pain—the worst pain imaginable

  • The Faces Pain Scale  (Wong-Baker Faces Pain Rating Scale)

This scale consists of six cartoon faces, each depicting a different expression. The faces range from a broad smile, representing “no hurt,” to a very sad face, representing “hurts worst.”

 It’s important to provide proper training to the patient on how to use this tool accurately. Make sure they understand that they are rating their pain level and not their emotions. It’s worth noting that experiences with the Faces Scale in Africa have varied, with many individuals preferring the hand scale for pain assessment.

Pain assessment in children 

Pain management in children is complex. Although there are similarities with pain management in adults, there are specific considerations for children.

Myths and Facts about Pain in Children
MythsFacts
Newborns do not feel painNewborns have the ability to perceive pain
Young children cannot process or remember painChildren of all ages can experience and remember pain
Children become accustomed to repeated painful proceduresRepeated painful procedures can still cause distress and pain
Children are unable to tell where it hurtsChildren can indicate the location of their pain
Opioids should be avoided due to addiction riskPsychological addiction to opioids is rare in children
Incomplete myelination or immature pain cortex means children don’t feel painProper nociception (pain perception) is possible without complete myelination
Younger children have higher pain sensitivityPain tolerance generally increases with age
Children always communicate when they have painChildren may not always express pain due to fear or inadequate communication skills
Children are not aware they have chronic painChildren may not recognize or understand chronic pain

Goals of pain measurement in children:

  1. Assess the intensity/severity of pain.
  2. Identify the location of pain.
  3. Evaluate the effectiveness of treatment.

Barriers to pain assessment and measurement in children::

  1. Limited availability of age-appropriate and validated pain assessment tools.
  2. Lack of knowledge regarding appropriate tools for different age groups in children.
  3. Insufficient training in the use and implementation of pain assessment tools.
  4. Difficulty in interpreting pain scores.
  5. Challenges in distinguishing between anxiety and psychological pain.
  6. Limited understanding of children’s pain experiences.
  7. Factors that may inhibit children from reporting their pain, such as fear of doctors or nurses, fear of illness, reluctance to bother caregivers, avoidance of injections, and eagerness to leave the hospital

Assessment Process of Pain in Children

To effectively assess pain in children, a standardized tool or guideline can be valuable in tracking changes in pain over time. One such tool is the QUESTT tool, which stands for:

  • Q – Question the child (if able to respond) or the parent/caregiver (if the child is unable to communicate).
  • U – Use pain rating scales, if appropriate, to quantify the child’s pain.
  • E – Evaluate the child’s behavior and physiological changes that may indicate pain.
  • S – Secure the involvement of parents in assessing and managing the child’s pain.
  • T – Take into account the cause or source of the pain.
  • T – Take necessary action based on the assessment findings and continuously evaluate the effectiveness of interventions.
StepQuestions/Tools
Question the child1. Do you have any hurt/pain?
 2. Can you show me where it hurts?
 3. Does it hurt anywhere else?
 4. When did the pain/hurt start?
 5. Do you know what might have caused the pain?
 6. How much does it hurt? (Use a pain rating scale)
 7. What helps to take away the pain or make it better?
U – Use of pain rating scales– Eland Body scale: This tool helps to assess multiple sites and differing intensities. Get the child to assign colors to the different categories e.g. no pain – green. Little pain – yellow, moderate pain – orange and severe pain – red. Ask them to colour in the bodies where their pain is, using the different colors to depict different levels of pain in different areas.
 – Faces Scale
 – Hand Scale
Evaluate behavior and physiological changesObserve behavioral and physiological responses to pain
Secure the caregivers involvement1. Listen to mothers, fathers, and caregivers
 2. Include them in decision-making
 3. Consider their insights into subtle changes in behavior
 4. Seek their input on comforting strategies for the child
Take the cause of pain into account1. Consider the underlying problem/pathophysiology
 2. Obtain descriptions of the type of pain to determine its cause
Take action and evaluate results1. Assess pain, develop a treatment plan
 2. Reassess using pain rating scales
 3. Adjust the treatment plan accordingly
 4. Utilize pain diaries for continuous re-evaluation in chronic pain cases

Assessment OF Pain Read More »

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