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conjunctivitis

Conjunctivitis

Conjunctivitis Lecture Notes

Conjunctivitis is medically defined as the inflammation of the conjunctiva. It is commonly known as "pink eye" or "red eye" due to the characteristic redness that often accompanies the condition.

  • Inflammation: This refers to the body's protective response to injury or irritation, involving increased blood flow, swelling, and often pain and redness. In the case of conjunctivitis, this response is localized to the conjunctiva.
  • Conjunctiva: This is the key anatomical structure involved.
Anatomy: The Conjunctiva

The conjunctiva is a thin, transparent mucous membrane that lines the inner surface of the eyelids (palpebral conjunctiva) and covers the anterior surface of the eyeball, extending from the limbus (the junction between the cornea and sclera) to the inner surface of the eyelids (bulbar conjunctiva).

1. Structure:
  • Palpebral (Tarsal) Conjunctiva: This portion lines the inner surface of the upper and lower eyelids. It is firmly adherent to the tarsal plates (which give the eyelids their stiffness).
  • Bulbar (Ocular) Conjunctiva: This portion covers the anterior sclera (the white outer layer of the eyeball) but does not cover the cornea (the clear front part of the eye). It is loosely attached to the sclera, allowing for free movement of the eyeball.
  • Fornix (Conjunctival Fornices): This is the loose fold of conjunctiva that connects the palpebral and bulbar conjunctivas. It acts as a cul-de-sac and is where the tear film collects and where topical medications can pool.
2. Key Features and Functions:
  • Transparency: The conjunctiva is normally transparent, allowing the white sclera underneath to be visible.
  • Blood Vessels: It is richly supplied with small blood vessels. When these vessels become dilated due to inflammation, they give the eye its characteristic red or pink appearance.
  • Mucous-Secreting Goblet Cells: These cells are scattered throughout the conjunctiva and produce mucin, a component of the tear film. Mucin helps to spread tears evenly over the ocular surface, moisten the eye, and trap foreign particles.
  • Accessory Lacrimal Glands (Glands of Krause and Wolfring): These small glands, located in the conjunctival fornices, contribute to the aqueous layer of the tear film.
  • Lymphoid Tissue: The conjunctiva contains lymphoid follicles (especially in the fornices), which are part of the ocular immune system and play a role in defending against pathogens.
  • Protection: The conjunctiva helps protect the eyeball from foreign bodies and pathogens, and its smooth, moist surface facilitates easy movement of the eyelids over the globe.
3. Susceptibility to Inflammation:

The conjunctiva's exposed location and rich vascularity make it particularly vulnerable to various insults:

  • Direct Exposure: It is directly exposed to the external environment, making it susceptible to pathogens (bacteria, viruses), allergens (pollen, dust), and irritants (smoke, chemicals).
  • Vascularity: Its extensive blood supply means that inflammatory responses (vasodilation, increased permeability) quickly become evident as redness and swelling.
  • Immune Response: Its lymphoid tissue readily mounts an immune response, leading to the characteristic cellular infiltrates and exudates seen in different types of conjunctivitis.
I. BACTERIAL CONJUNCTIVITIS

This category involves conjunctivitis caused by bacteria. It is typically contagious.

1. Etiology and Causes
  • Common (non-gonococcal, non-chlamydial): Caused by bacteria such as Staphylococcus aureus (most common), Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
    • Streptococcus pyogenes (haemolyticus) is virulent and usually produces pseudomembranous conjunctivitis.
    • Pseudomonas pyocyanea is a virulent organism, which readily invades the cornea.
    • Corynebacterium diphtheriae causes acute membranous conjunctivitis.
  • Hyperacute (Gonococcal): Caused by Neisseria gonorrhoeae. A severe, rapidly progressive form that can lead to corneal perforation and vision loss if not treated urgently. Often seen in neonates (ophthalmia neonatorum) or sexually active adults.
  • Neisseria meningitidis: May produce muco-purulent conjunctivitis.
  • Chlamydial (Inclusion) Conjunctivitis: Caused by Chlamydia trachomatis. Can be acquired by neonates during passage through the birth canal or in adults through sexual contact. Can become chronic if untreated.
  • Trachoma: A chronic form of chlamydial conjunctivitis (serovars A, B, C) that is a leading cause of preventable blindness worldwide.
Predisposing Factors:
  • Flies (vector transmission)
  • Poor hygienic conditions and poor sanitation
  • Hot dry climate
  • Dirty habits
Mode of Infection:
  1. Exogenous infections: Spread directly through close contact, vector transmission (e.g., flies), or material transfer (e.g., infected fingers of health workers, common towels, handkerchiefs, tonometers).
  2. Local spread: From neighbouring structures such as infected lacrimal sac, lids, and nasopharynx.
  3. Endogenous infections: Very rare spread through blood (e.g., gonococcal and meningococcal infections).
2. Pathophysiology

Pathological changes of bacterial conjunctivitis consist of:

  1. Vascular response: Characterized by congestion and increased permeability of the conjunctival vessels associated with proliferation of capillaries.
  2. Cellular response: Exudation of polymorphonuclear cells (Neutrophils) and other inflammatory cells into the substantia propria of conjunctiva as well as in the conjunctival sac.
  3. Conjunctival tissue response: Conjunctiva becomes edematous. Superficial epithelial cells degenerate, become loose and even desquamate. Proliferation of basal layers of conjunctival epithelium and increase in the number of mucin-secreting goblet cells.
    • Papillae Formation: Hypertrophy of the conjunctival epithelium with a central vascular core, often seen in bacterial conjunctivitis, especially on the tarsal conjunctiva. These appear as small, elevated bumps.
  4. Conjunctival discharge: Consists of tears, mucus, inflammatory cells, desquamated epithelial cells, fibrin and bacteria. If the inflammation is very severe, diapedesis of red blood cells may occur and discharge may become blood stained.
    • Gonococcal Specifics: Rapid and aggressive bacterial proliferation, profound neutrophilic response, massive purulent discharge, and a high risk of corneal ulceration due to bacterial enzymes.
3. Clinical Presentation
  • Onset: Can be sudden, often starts unilaterally but can spread to the other eye. (Mucopurulent usually bilateral, although one eye may become affected 1–2 days before the other).
  • Discharge: Copious, thick, purulent (pus-like) or mucopurulent discharge (white, yellow, or green). Eyelids often "stuck together" upon waking.
  • Itching: Mild.
  • Appearance:
    • Typically there is conjunctival infection (hyperemia), especially in the fornices where the blood supply is rich.
    • Eyelids may be red and inflamed.
    • Flakes of mucopus seen in the fornices, canthi and lid margins is a critical sign.
  • Sensation: The patient may complain of a gritty or foreign body sensation, some discomfort, and very occasionally very mild photophobia. Vision is always unaffected (unless corneal involvement), though there may be slight blurring due to mucous flakes.
  • Specific Types:
    • Acute Bacterial Conjunctivitis: Marked conjunctival hyperemia and mucopurulent discharge.
    • Hyperacute (Gonococcal): Extremely copious, thick, green-yellow purulent discharge, severe chemosis, painful, rapid progression.
    • Chronic Bacterial (Chronic Catarrhal): Characterized by mild catarrhal inflammation.
  • Infectious Period: The time during which the eye discharge is present.
4. Management and Nursing Care
Medical Management:
  • Topical Antibiotics: Treatment may be started with chloramphenicol (1%), gentamicin (0.3%), tobramycin (0.3%), or framycetin (0.3%).
    • Regimen: Eye drops 3–4 hourly in day and ointment used at night (provides antibiotic cover and reduces morning stickiness).
    • Severe Cases: Quinolone antibiotic drops such as ciprofloxacin (0.3%), ofloxacin (0.3%), gatifloxacin (0.3%) or moxifloxacin (0.5%) may be used.
    • Note: Bacterial conjunctivitis usually resolves without treatment; antibiotics may be needed only if no improvement after 3 days.
  • Systemic Antibiotics: Required for severe cases (e.g., gonococcal, chlamydial) or in neonates.
Nursing Interventions (Bacterial Specific):
  • Clean the eyes: Remove crusts and discharge before applying medication.
  • Apply Topical Antibiotics: Emphasize compliance with the full course.
  • Dark Goggles: Use to prevent photophobia.
  • NO Bandage: No bandage should be applied in patients with mucopurulent conjunctivitis. Exposure to air keeps the temperature of conjunctival cul-de-sac low which inhibits bacterial growth.
  • NO Steroids: No steroids should be applied, otherwise infection will flare up and bacterial corneal ulcer may develop.
  • Infection Control: Rigorous hand hygiene, do not share towels/pillows, wash linens in hot water. Exclude from school/work until 24 hours after antibiotics started.
II. VIRAL CONJUNCTIVITIS

This category is highly contagious and often associated with systemic viral infections.

1. Etiology and Subtypes
  • Adenovirus: Most common cause.
    • Pharyngoconjunctival Fever (PCF): Types 3, 4, 7. Characterized by fever, pharyngitis (sore throat), and conjunctivitis.
    • Epidemic Keratoconjunctivitis (EKC): Types 8, 19, 37, 54. More severe, can involve the cornea, and is highly contagious.
  • Herpes Simplex Virus (HSV): Less common, but can lead to corneal involvement and vision loss.
  • Acute Hemorrhagic Conjunctivitis (AHC): Caused by Enterovirus 70 or Coxsackievirus A24. Characterized by sudden onset, pain, and subconjunctival hemorrhage.
  • Other causes: Varicella-zoster, Poxvirus, Mycovirus, Paramyxovirus.
2. Pathophysiology
  • Entry: Virus replicates in conjunctival epithelial cells.
  • Immune Response: Primarily a lymphocytic response. Lymphocytes and plasma cells infiltrate the conjunctiva.
  • Tissue Response:
    • Follicle Formation: Small, avascular mounds of lymphoid tissue (aggregates of lymphocytes), typically seen in the inferior fornix.
    • Pseudomembranes: Can occur in severe cases.
  • Corneal Involvement: The virus can infect corneal epithelial cells leading to epithelial keratitis (punctate lesions) and subepithelial infiltrates.
3. Clinical Presentation
  • Onset: Often sudden, typically unilateral initially but frequently spreads to the other eye within days.
  • Discharge: Watery, serous, or scant mucoid discharge. Not thick or purulent.
  • Itching: Mild.
  • Signs: Red/pink eye, Chemosis (if severe), Follicles on palpebral conjunctiva. Bleeding from conjunctival vessels in severe adenoviral cases.
  • Associated Symptoms:
    • Recent Upper Respiratory Tract Infection (URTI).
    • Preauricular Lymphadenopathy: Swelling/tenderness of the lymph node in front of the ear (Key diagnostic sign).
4. Management and Nursing Care
Medical Management:
  • Supportive Treatment: This is the only treatment required for adenovirus.
    • Cold compresses.
    • Dark glasses for photophobia.
    • Artificial lubricants for comfort.
  • Antivirals: NOT beneficial for adenoviral conjunctivitis. Used ONLY for HSV (e.g., topical ganciclovir/trifluridine or oral acyclovir) to prevent corneal scarring.
  • Antibiotics: Topical antibiotics help only to prevent superadded bacterial infections.
  • Steroids: Topical steroids should not be used during active inflammation as they may enhance viral replication and extend infectivity. (Exception: Weak steroids for severe subepithelial infiltrates or membrane formation).
Nursing Interventions (Viral Specific):
  • Strict Isolation/Hygiene: Highly contagious. Rigorous hand washing. Advise patients not to share towels or pillows.
  • School/Work Exclusion: Generally 5-7 days depending on severity.
  • Comfort Measures: Cool compresses to reduce swelling.
III. ALLERGIC CONJUNCTIVITIS

Non-infectious, generally not contagious.

1. Etiology and Subtypes

Etiology: An immune-mediated hypersensitivity reaction (Type I) to airborne allergens.

  • Simple Allergic Conjunctivitis:
    • Seasonal Allergic Conjunctivitis (SAC): Triggered by seasonal allergens (tree/grass pollen). Associated with allergic rhinitis.
    • Perennial Allergic Conjunctivitis (PAC): Triggered by year-round allergens (dust mites, pet dander). Onset is subacute/chronic.
  • Vernal Keratoconjunctivitis (VKC): Severe, chronic, often in children/young adults, associated with atopy (asthma/eczema). Can involve the cornea (shield ulcers).
  • Atopic Keratoconjunctivitis (AKC): Similar to VKC but in adults with atopy. Potentially vision-threatening.
  • Giant Papillary Conjunctivitis (GPC): Associated with contact lens wear or ocular prosthetics due to chronic mechanical irritation and protein deposits.
2. Pathophysiology
  • Mechanism: Type I (IgE-mediated) immediate hypersensitivity reaction.
  • Process: Allergen binds to IgE on Mast Cells → Degranulation → Release of mediators (Histamine, prostaglandins, etc.).
  • Effects:
    • Histamine: Causes intense itching, vasodilation, and increased permeability.
    • Cellular Infiltration: Eosinophils are predominant (abundant in discharge).
    • Papillae: Large/Giant papillae form in chronic cases (cobblestone appearance in VKC/GPC).
3. Clinical Presentation
  • Symptom: Intense itching (hallmark), burning sensation, watery mucus, mild photophobia.
  • Signs: Hyperemia, Chemosis (swollen juicy appearance of conjunctiva), Edema of lids.
  • Discharge: Watery, clear, or stringy/ropy mucoid.
  • Onset: Acute (SAC/PAC) or chronic. usually bilateral.
  • Associated: Allergic shiners (dark circles), rhinitis symptoms.
4. Management and Nursing Care
Medical Management:
  • Elimination: Avoidance of allergens.
  • Topical Agents:
    • Vasoconstrictors: Naphazoline, antizoline (immediate decongestion).
    • Antihistamines/Mast Cell Stabilizers: Olopatadine, azelastine, sodium cromoglycate (effective for prevention).
    • NSAIDs: Ketorolac.
    • Steroids: Only if severe (risk of side effects).
  • Systemic: Oral antihistamines.
Nursing Interventions (Allergic Specific):
  • Cool Compresses: Reduce itching and swelling.
  • Cool Water: Poured over face with head inclined downward constricts capillaries.
  • Artificial Tears: Wash away allergens.
  • Contact Lens Management: Discontinue during flare-ups.
IV. IRRITANT / CHEMICAL CONJUNCTIVITIS
1. Etiology and Features
  • Etiology: Direct exposure to chemicals (smoke, chlorine, acid/alkali) or foreign bodies.
  • Pathophysiology: Direct damage to epithelial cells. Alkalis cause liquefactive necrosis (penetrate deep); Acids cause coagulative necrosis.
  • Symptoms: Immediate onset, burning/stinging, watery discharge. No itching, no lymphadenopathy.
2. Management
  • Immediate Irrigation: Copious irrigation with sterile saline or water for 15-30 minutes is the most critical first step.
  • Remove Irritant: Carefully remove foreign body.
  • Artificial Tears: Lubricate and flush.
Differentiating Features (Summary)
Feature Viral Bacterial Allergic Irritant/Chemical
Discharge Watery, serous, scant mucoid Copious, thick, purulent/mucopurulent Watery, clear, stringy/ropy mucoid Watery, minimal
Itching Mild Mild Intense Absent (burning/stinging)
Lymphadenopathy Preauricular (common) Absent (except Chlamydia) Absent Absent
Onset Sudden, often unilateral spreading Sudden, unilateral spreading Acute/chronic, usually bilateral Immediate, history of exposure
Eyelids "stuck" Mild Prominent (especially in morning) Mild Absent
Associated Sx URTI, sore throat, fever None (except STI for specific types) Rhinitis, asthma, eczema (atopy) History of exposure (smoke, chemicals, FB)
Key Ocular Signs Follicles, punctate keratitis Papillae, (hyperacute: rapid progression) Chemosis, giant papillae (VKC/AKC/GPC) Redness proportional to exposure/severity
Contagious Highly Yes No No
DIAGNOSTIC METHODS

Diagnosing conjunctivitis primarily relies on a thorough history and physical examination. However, in certain cases, laboratory tests may be necessary to confirm the etiology, especially for severe, recurrent, or atypical presentations.

I. History Taking (Key Questions)

A detailed patient history provides crucial clues:

  • Onset and Duration: Acute vs. chronic, sudden vs. gradual.
  • Unilateral vs. Bilateral: Does it affect one or both eyes? Does it spread?
  • Nature of Symptoms:
    • Discharge: Watery, purulent, mucopurulent, ropy.
    • Itching: Absent, mild, severe.
    • Pain/Grittiness/Foreign Body Sensation: Severity.
    • Photophobia: Presence and severity.
  • Associated Systemic Symptoms:
    • Upper Respiratory Tract Infection (URTI) symptoms: Cold, cough, sore throat, fever (suggests viral).
    • Allergic symptoms: Sneezing, runny nose, asthma, eczema (suggests allergic).
    • Genitourinary symptoms: Urethritis, cervicitis (suggests chlamydial or gonococcal).
    • Recent Illness/Exposure: Contact with sick individuals.
  • History of Exposure:
    • Allergens: Pollen, dust, pet dander.
    • Irritants/Chemicals: Smoke, chlorine, workplace chemicals.
    • Contact Lens Wear: Type, duration, hygiene, solutions.
  • Medical History:
    • Atopy: History of allergies, asthma, eczema.
    • Immunocompromised state.
    • Sexually Transmitted Infections (STIs).
    • Previous episodes of conjunctivitis.
  • Medications:
    • Eye drops used.
    • Anticoagulants (can increase bleeding risk).
  • II. Physical Examination (Ocular and Systemic)
  • Visual Acuity: Always assess, as a significant decrease may indicate corneal involvement or a more serious condition.
  • External Examination:
    • Eyelids: Edema, erythema, crusting.
    • Periorbital area: Allergic shiners, skin changes.
    • Preauricular Lymph Node Palpation: Tenderness and enlargement are highly suggestive of viral conjunctivitis (especially adenoviral) or chlamydial conjunctivitis.
  • Slit Lamp Examination (by an Ophthalmologist/Optometrist) or Penlight Examination:
    • Conjunctival Injection: Diffuse redness.
    • Discharge Character: As described in Objective 5.
    • Conjunctival Reaction:
      • Follicles: Small, round, avascular lymphatic aggregates, typically on the inferior palpebral conjunctiva (classic for viral, chlamydial, toxic conjunctivitis).
      • Papillae: Small, raised mounds with a central vascular core, typically on the superior palpebral conjunctiva (classic for bacterial, allergic conjunctivitis; giant papillae in VKC, AKC, GPC).
      • Chemosis: Swelling of the conjunctiva.
      • Pseudomembranes/True Membranes: Can be peeled off in severe viral or bacterial cases.
    • Cornea: Check for epithelial defects, infiltrates, ulcers (using fluorescein staining).
    • Anterior Chamber: Look for cells/flare (indicating uveitis, which can mimic conjunctivitis but is more serious).
    • Iris/Pupil: Check for abnormalities.
  • III. Laboratory Investigations (When Indicated)

    Laboratory tests are not always necessary for routine conjunctivitis, as many cases are mild and resolve spontaneously or with empirical treatment. However, they are crucial for:

    • Severe, persistent, or recurrent cases.
    • Cases unresponsive to initial therapy.
    • Hyperacute conjunctivitis (suspected gonococcal).
    • Neonatal conjunctivitis.
    • Suspected chlamydial conjunctivitis.
    • Corneal involvement (ulceration, severe keratitis).
    • Immunocompromised patients.
    1. Conjunctival Swabs/Scrapings:
    • Gram Stain: Rapid identification of bacteria (gram-positive cocci, gram-negative rods, etc.) and presence of inflammatory cells (neutrophils in bacterial, lymphocytes in viral/chlamydial, eosinophils in allergic). Crucial for suspected gonococcal conjunctivitis.
    • Bacterial Culture and Sensitivity: Identifies the specific bacterial pathogen and its antibiotic susceptibility. Essential for severe bacterial cases, non-responsive cases, and hyperacute forms.
    • Chlamydia Testing:
      • Direct Fluorescent Antibody (DFA): Detects C. trachomatis antigens.
      • PCR (Polymerase Chain Reaction): Highly sensitive and specific for detecting chlamydial DNA.
      • Giemsa Stain: Can reveal intracytoplasmic inclusions in epithelial cells (pathognomonic for chlamydia).
    • Viral Culture/PCR: Detects specific viral pathogens (e.g., adenovirus, HSV). Typically reserved for severe, recurrent, or atypical viral cases, or when HSV is suspected.
    • Cytology: Microscopic examination of stained conjunctival scrapings.
      • Neutrophils: Predominant in bacterial conjunctivitis.
      • Lymphocytes/Monocytes: Predominant in viral conjunctivitis.
      • Basophilic cytoplasmic inclusion bodies: Classic for chlamydia.
      • Eosinophils/Mast Cells: Predominant in allergic conjunctivitis.
    2. Allergy Testing:
    • Skin Prick Test or Blood Test (RAST/ImmunoCAP): To identify specific environmental allergens, especially in chronic or severe allergic conjunctivitis.
    3. Other Tests:
    • Fluorescein Staining: To detect corneal abrasions, epithelial defects, or ulcers.
    • Schirmer Test: May be used if dry eye is suspected as a contributing factor.
    NURSING DIAGNOSES
    1. Acute Pain related to inflammation of the conjunctiva, as evidenced by patient reports of burning, grittiness, foreign body sensation, and grimacing.
      • Rationale: The inflammatory process (vasodilation, edema, cellular infiltration) directly causes discomfort and pain, which is a primary concern for patients.
    2. Disrupted Sensory Perception (Visual) related to ocular discharge, eyelid edema, and photophobia, as evidenced by patient reports of blurred vision, difficulty reading, and avoidance of bright lights.
      • Rationale: Swelling and exudate can temporarily obscure vision, while inflammation can increase light sensitivity, impacting the patient's ability to perceive their environment clearly.
    3. Risk for Infection Transmission related to contagious nature of viral/bacterial conjunctivitis and lack of knowledge regarding proper hygiene, as evidenced by patient's expression of concern about spreading it to family members or observed ineffective hand hygiene.
      • Rationale: Viral and bacterial conjunctivitis are highly contagious. Patients and their families need clear guidance on preventing spread. This diagnosis is not applicable to allergic or irritant conjunctivitis.
    4. Inadequate health Knowledge related to disease process, treatment regimen, and prevention of transmission, as evidenced by patient questions about the cause of symptoms, how to use eye drops, or concern about infecting others.
      • Rationale: Patients often lack comprehensive understanding of their condition, its management, and infection control, which can lead to non-adherence and continued spread or discomfort.
    5. Impaired Comfort related to ocular irritation, discharge, and eyelid crusting, as evidenced by patient reports of "sticky eyes," constant need to wipe eyes, and desire for relief.
      • Rationale: The physical manifestations of conjunctivitis directly interfere with the patient's comfort and can be quite distressing.
    6. Excessive Anxiety related to changes in vision, fear of permanent eye damage, or concern about social activities/work, as evidenced by patient expressing worries about their condition and asking repeated questions.
      • Rationale: Any eye condition can cause significant anxiety, particularly if vision is affected or if the condition is perceived as unsightly or highly contagious, impacting daily life.
    7. Ineffective Health Maintenance related to insufficient knowledge about managing chronic allergic conjunctivitis or contact lens hygiene, as evidenced by recurrent episodes of allergic conjunctivitis or contact lens-related infections.
      • Rationale: For patients with chronic forms (like allergic) or those with modifiable risk factors (like contact lens use), ongoing education and support are needed to prevent recurrence.
    8. Risk for Impaired Skin Integrity related to frequent wiping of periorbital area and irritation from discharge.
      • Rationale: Constant rubbing or wiping to remove discharge can irritate the delicate skin around the eyes, leading to redness, dryness, or even breakdown.
    NURSING INTERVENTIONS
    I. General Nursing Interventions
  • Assess and Monitor:
    • Continuously monitor visual acuity, comfort level, type and amount of discharge, eyelid swelling, and conjunctival redness.
    • Assess effectiveness of prescribed treatments and document any adverse reactions.
    • Monitor for signs of worsening infection or corneal involvement (increased pain, photophobia, decreased vision).
  • Comfort Measures:
    • Warm or Cool Compresses: Apply warm compresses for bacterial conjunctivitis to help loosen crusts and reduce discomfort. Use cool compresses for allergic or viral conjunctivitis to reduce itching and swelling.
    • Lid Hygiene: Gently clean eyelids with a clean, warm, moist cloth to remove discharge and crusting. Always use a fresh cloth for each eye or discard after single use.
    • Artificial Tears: Encourage the use of preservative-free artificial tears to soothe irritation and wash away irritants/allergens.
    • Dark Glasses: Advise wearing sunglasses to reduce photophobia.
  • Patient Education (Crucial for all types):
    • Medication Administration: Provide clear, step-by-step instructions on how to correctly instill eye drops or apply ointment. Emphasize hand hygiene before and after, avoiding touching the eye with the dropper tip, and proper spacing of different drops.
    • Expected Course: Explain the typical duration and expected resolution of symptoms.
    • When to Seek Further Medical Attention: Educate on warning signs of complications (e.g., sudden vision changes, severe pain, inability to open eye, increasing redness after treatment).
    • Avoid Eye Rubbing: Explain that rubbing can worsen irritation and spread infection.
  • II. Type-Specific Nursing Interventions
    A. For Infectious Conjunctivitis (Viral and Bacterial)
  • Pharmacological Interventions (Administer as Prescribed):
  • Bacterial:
    • Topical Antibiotics: Administer antibiotic eye drops (e.g., erythromycin, azithromycin, fluoroquinolones) or ointment as prescribed. Emphasize compliance with the full course, even if symptoms improve.
    • Systemic Antibiotics: For severe cases (e.g., gonococcal, chlamydial) or in neonates, systemic antibiotics will be prescribed and administered.
  • Viral:
    • Antivirals: If HSV conjunctivitis is diagnosed or strongly suspected, administer topical (e.g., ganciclovir, trifluridine) or oral (e.g., acyclovir, valacyclovir) antiviral medications as prescribed. This is critical to prevent corneal scarring.
    • No specific antiviral for adenovirus: Treatment is generally supportive.
  • Topical Corticosteroids: Generally avoided in infectious conjunctivitis unless prescribed by an ophthalmologist, as they can worsen viral infections (especially HSV) and prolong bacterial infections.
  • Non-Pharmacological & Infection Control Interventions:
    • Rigorous Hand Hygiene: Teach and reinforce frequent and thorough hand washing with soap and water for at least 20 seconds, especially after touching the eyes, before and after medication administration, and after contact with other people. Alcohol-based hand sanitizers can be used if soap and water are unavailable.
    • Avoid Sharing: Emphasize not sharing towels, pillows, makeup, eye drops, or any personal items.
    • Disinfection: Advise disinfecting frequently touched surfaces (doorknobs, phones, remote controls).
    • Laundry: Wash pillowcases, towels, and clothes in hot water and detergent.
    • School/Work Exclusion: Advise patients (especially children) to stay home from school/work until symptoms improve or they are no longer contagious (e.g., after 24 hours on antibiotics for bacterial, or for 5-7 days for viral depending on severity).
    • Contact Lens Avoidance: Instruct contact lens wearers to discontinue lens use until the infection resolves and to discard current lenses and cases. Replace with new, sterile lenses and cases after recovery.
  • B. For Allergic Conjunctivitis
  • Pharmacological Interventions (Administer as Prescribed):
    • Topical Antihistamines/Mast Cell Stabilizers: Administer dual-acting agents (e.g., olopatadine, azelastine) or separate antihistamine (e.g., levocabastine) and mast cell stabilizer (e.g., cromolyn sodium) eye drops.
    • Topical NSAIDs: May be prescribed for mild to moderate cases (e.g., ketorolac).
    • Topical Corticosteroids: For severe, refractory cases (e.g., VKC, AKC), an ophthalmologist may prescribe short courses of topical steroids (e.g., loteprednol, fluorometholone) with careful monitoring for side effects (IOP elevation, cataract formation).
    • Oral Antihistamines: May be used for systemic allergic symptoms.
    • Immunotherapy (Allergy Shots/Sublingual Tablets): For chronic, severe cases, referral to an allergist may be considered.
  • Non-Pharmacological & Environmental Control Interventions:
    • Allergen Avoidance: Identify and advise on avoiding specific triggers (e.g., staying indoors when pollen counts are high, using air purifiers, frequent dusting, vacuuming, pet management).
    • Cool Compresses: Effective for reducing itching and swelling.
    • Artificial Tears: To wash away allergens and soothe the eyes.
    • Contact Lens Management: Advise against contact lens wear during acute flare-ups. Consider daily disposable lenses or re-evaluate lens hygiene and type if GPC is present.
  • C. For Irritant/Chemical Conjunctivitis
  • Pharmacological Interventions:
    • Topical Antibiotics: May be used prophylactically if there is significant epithelial damage to prevent secondary bacterial infection.
    • Topical Corticosteroids: May be used in some chemical burns under ophthalmological guidance to reduce inflammation and scarring, but their use is complex and depends on the specific chemical and severity.
  • Non-Pharmacological Interventions:
    • Immediate Irrigation: For chemical exposures, immediate and copious irrigation with sterile saline or water is the most critical first step. Continue for at least 15-30 minutes and seek emergency medical attention.
    • Remove Irritant: If a foreign body is present, attempt to remove it carefully if superficial, or refer for removal by an ophthalmologist.
    • Avoid Further Exposure: Educate on protective eyewear in occupational or recreational settings.
    • Artificial Tears: To lubricate and flush out remaining irritants.
  • EXPECTED OUTCOMES

    Evaluating expected outcomes allows nurses to determine if interventions were successful, if the patient's condition is improving, and if the established goals of care have been met.

    I. General Expected Outcomes (Common to All Types)
    • Resolution of Symptoms:
      • Patient reports decreased or absence of eye redness within [specific timeframe, e.g., 3-7 days].
      • Patient reports decreased or absence of foreign body sensation, burning, or grittiness within [specific timeframe].
      • Patient reports improved comfort level (e.g., verbalizes less discomfort, less rubbing of eyes).
      • Patient demonstrates improved visual acuity (if initially impaired).
    • Effective Medication Management:
      • Patient correctly demonstrates proper instillation technique for eye drops/ointment.
      • Patient verbalizes understanding of the medication regimen, including dosage, frequency, duration, and potential side effects.
      • Patient adheres to the prescribed treatment plan for the entire duration.
    • Prevention of Complications:
      • Patient's eyes show no signs of corneal involvement (e.g., no ulcers, infiltrates, or significant keratitis).
      • Patient experiences no secondary bacterial infections (if the initial conjunctivitis was viral or allergic).
    II. Type-Specific Expected Outcomes
    A. For Infectious Conjunctivitis (Viral and Bacterial)
    • Resolution of Infection:
      • Patient's eyes exhibit decreased or absence of purulent/mucopurulent discharge (bacterial) or watery discharge (viral) within [specific timeframe, e.g., 24-48 hours for bacterial after starting antibiotics, 5-7 days for viral].
      • Patient reports no eyelid matting upon waking.
      • Preauricular lymphadenopathy (if present) is resolved or significantly reduced.
      • Cultures (if taken) are negative for bacterial growth after treatment, or viral load significantly decreased.
    • Prevention of Transmission:
      • Patient and family members correctly verbalize and demonstrate appropriate infection control measures (e.g., hand hygiene, avoiding sharing personal items).
      • Patient verbalizes understanding of the contagious nature of their condition.
      • There is no evidence of spread of infection to household contacts or others.
    B. For Allergic Conjunctivitis
    • Symptom Control and Allergen Management:
      • Patient reports significantly reduced or absence of intense itching within [specific timeframe, e.g., hours to days with effective medication].
      • Patient demonstrates ability to identify and implement strategies for allergen avoidance.
      • Patient experiences decreased chemosis and eyelid edema.
      • Patient verbalizes a reduction in associated allergic symptoms (e.g., sneezing, nasal congestion).
      • Patient with chronic allergic conjunctivitis (e.g., VKC, AKC, GPC) reports fewer flare-ups or less severe symptoms due to ongoing management.
    C. For Irritant/Chemical Conjunctivitis
    • Resolution of Irritation and Protection:
      • Patient reports cessation of burning or stinging sensation within [specific timeframe, e.g., immediately after irrigation for chemical exposure, or within hours for mild irritants].
      • Patient's eyes show no residual signs of chemical injury (e.g., corneal opacification, persistent redness) or foreign body presence.
      • Patient verbalizes understanding of preventative measures to avoid future exposure (e.g., wearing protective eyewear, safe handling of chemicals).
    III. Patient-Centered Outcomes
    • Improved Quality of Life:
      • Patient reports resumption of normal daily activities, including work, school, and social interactions, without significant discomfort or visual impairment.
      • Patient verbalizes reduced anxiety related to their eye condition.

    Conjunctivitis Read More »

    eye anatomy and physiology

    Eye Anatomy and Physiology

    Eye Anatomy.

     Eye  is the organ for sight. The globe-shaped eyeball occupies the anterior part of the orbit/eye socket. The eyeball is embedded in the orbital cavity.  

    The eye contains the receptors for vision and a refracting system that focuses light rays on the receptors in the retina.

    Diagram Showing the structure of the Eye.

     

    The Structure of the Eye

    • The eye is spherical in shape and the diameter of an adult eye is approximately 2.5cm.   
    • Internally, the eye is divided into 2 chambers.  
    • The lens, suspensory ligaments and ciliary body separate the 2 chambers; 

    Anterior and posterior chamber 

    Anterior chamber. It is filled with a clear watery fluid called aqueous humour.  

    • This chamber is in front of the lens.  
    • It is further divided into 2 cavities ie anterior and posterior cavities. 

    Posterior chamber. It is filled with a jelly like substance called vitreous humour (vitreous body).  This chamber is behind the lens. 

    There are three main layers of tissue in the walls of the eye: 

    • The outer fibrous layer consisting of sclera and cornea 
    • The middle vascular layer or uveal tract consisting of the choroid, ciliary body and iris 
    • The inner nervous tissue layer consisting of the retina. 

    The outer fibrous layer

    • This consists of sclera and cornea.  

    The sclera or white of the eye forms the outermost layer of the posterior and lateral aspects of the eyeball.  

    • It is continuous anteriorly with a clear transparent epithelial membrane, the cornea.  

    The cornea is transparent due to its vascularity and the regular arrangement of its fibres.  

    • Its surface is lined by the conjunctiva.  
    • It is well supplied with nerve endings from the trigeminal nerve. 
    • It consists of a firm fibrous membrane that maintains the shape of the eye.  
    • This membrane gives attachment to the extrinsic muscles of the eye. 
    • Light rays pass through the cornea to reach the retina.  
    • The cornea is convex anteriorly. 
    • It is involved in refracting (bending) light rays to focus them on the retina. 

    The middle vascular layer

    • The middle vascular layer is also known as the uveal tract
    • This layer consists of the choroid, ciliary body and iris. 

    The choroid lines sclera in the posterior compartment of the eye.  

    • The choroid is rich in blood supply and is chocolate brown in colour.  

    The ciliary body is an anterior continuation of the choroid which is inserted into suspensory ligaments.  

    • These ligaments extend to the lens and hold it in position.   
    • The ciliary body is supplied by the 3rd cranial nerve (Oculomotor).  
    • The ciliary body also consists of;  
    • Ciliary muscles. Contraction and relaxation of these smooth muscles determine the size and thickness of the lens. 
    • Secretory epithelial cells (Ciliary glands). These secrete aqueous humour which nourishes structures in the anterior chamber. 

    The iris is the visible coloured ring at the front of the eye. 

    • The iris extends anteriorly from the ciliary body lying behind the cornea and in front of the lens.  
    • It divides the anterior chamber of the eye into anterior and posterior cavities.  
    • It contains both circular and radiating muscle fibres which control the size of the pupil.  
    • The colour of iris is genetically determined and depends on the number of pigment cells present. 
    • NB: The Oculomotor nerve supplies the muscles of the iris and ciliary body (intrinsic eye muscles).  

    The inner nervous tissue layer

    • The inner layer of the eye ball is the retina.  
    • It is the light sensitive (photosensitive) part of the eye.  
    • It contains several millions of sensory photo receptor cells. 
    • These cells are responsible for converting light into nerve impulses.  

    The retina consists of two layers;  

    • The pigmented outer layer which lines choroid. 
    • The inner most neural layer which is in contact with the vitreous humour.  
    • The light sensitive layer consists of sensory receptor cells ie rods and cones. 
    • These contain photosensitive pigments that convert light rays into nerve impulses. 
    • Rod cells pre-dominate in the periphery and function best in dim light.  These cells are much more numerous. 
    • Cone cells pre-dominate near the centre of the retina. These are adapted for bright light and colour vision. 
    • Near the posterior of the retina is a part called macula lutea or yellow spot.  
    • The greatest concentration of cone cells is at a small area in the yellow spot called the fovea centralis.  
    • It is the most vital part of retina for high definition or vision.  
    • The optic disc or blind spot is a small area where the optic nerve leaves the eye.  
    • The blind spot does not have light sensitive cells. 
    eye anatomy
    Parts of the Eye and functions.

    Eyebrows-protect eyeball from sweat, dust and other foreign bodies.

    Eyelids –movable folds acting as curtains, preventing injuries. Meet at palpebral fissure(both eyelids meet). It contains sebaceous glands, sweat glands and accessory lacrimal glands all aligned with conjuctival material.

    Conjunctiva-clear, delicate mucous membrane. it lines the eyelids and is highly vascularised. It protects the eye against infections. It also acts as a physical barrier, and produces mucin (goblet cells)which lubricates the eye ball.

    Sclera-is a fibrous tissue of the eye(white),is tough and contains collagen fibres, and covers 5/6 of the eyeball. It protects inner structures maintains the shape of the eyeball. It also acts as a passage of blood vessels and nerves

    Cornea-covers 1/6 of the eyeball. Its clear, transparent and has 5 layers.

    Its functions include;

    • protection of the eye as it’s very
    • Refractive media of the and
    • Prevents aqueous from coming out of the eye Anterior chamber

    Is just behind the cornea and its functions include;

    • Refractive media
    • Maintains shape and structure of the eyeball
    • Bathes/nourishes the

    Production and flow of aqueous humor.

    Aqueous Humor is secreted by the epithelial cells of the ciliary body. it passes through suspensory ligaments into the posterior chamber, then flow through the pupil into the anterior chamber. From anterior chamber it drains through trabecular meshwork into the canal of schlemm (scleral venous sinus) then goes to the general circulation

    Iris-is the thin visible, contractile, and coloured part of the eye, with a central aperture known as the pupil. It divides the anterior segment of the eye into anterior and posterior chambers. It controls amount of light entering the eye and plays a role in accommodation.

    Ciliary body-Is continuous with choroid(middle layer of eyeball). It suspends the lens which is important during accommodation, and produces aqueous.

    Choroid-Is the soft brown part behind the eye. Is most vascularized, and nourishes the retina.

    Lens-is the transparent, highly elastic biconvex body, that lies immediately behind the pupil/front of the vitreous body. Its thickness is controlled by ciliary muscle through the suspensory ligaments.

    Its functions include:

    • Refractive media
    • Absorbs ultra violet rays

    Retina-Innermost layer of eyeball where images are formed. It has macula, optic disk, rods and cones. It consists of 2 layers.

    • Epithelial
    • Nervous layer
    • It absorbs
    • Stores and releases vitamin

    Vitreous body-is transparent, jelly like media.

    • It maintains the shape of eyeball and acts as refractive
    blood and nerve supply of the eye

    Blood and Nerve supply to the eye

    • The blood supply of the eye is from the ciliary and central retinal arteries. 
    • These are branches of ophthalmic artery which is also a branch of the internal carotid artery.  
    • Venous drainage is by the central retinal vein.  
    • These vessels run alongside the optic nerve. 
    • Nerve supply is by the optic nerve which is the 2nd cranial nerve.  
    • The retinal nerve fibres originate in the retina. 
    • These fibres converge to form the optic nerve at the optic disc. 

    Physiology of Sight 

    • Light rays from objects are bent (refracted) as they pass through varying densities of the clear media of the eye to focus onto the retina.  
    • In the eye, the biconvex shape of the lens refracts and focuses light rays on the retina.  
    • Before reaching the retina, the light rays pass through the cornea. 

    Physiology of vision - Online Biology Notes

    • The cornea also plays a role in the refractive power of the eyes. 
    • The lens is elastic thus has ability to change shape. Change in shape varies the amount of refraction for clarity of focus.  This is known as accommodation.  
    • Accommodation is necessary in order for objects at different distances to be visualized with equal clarity. 
    • The normal eye in its relaxed state brings rays of light from distant objects into sharp focus.  
    • However for clear focusing on near objects, an autonomic reflex comes into play.  
    • The reflex involves accommodation, miosis and convergence as follows; 

    Accommodation. This refers to the increase in the refractive power of the lens in order to focus light rays from near objects on the retina.  The ciliary muscle contracts and changes shape of the lens to bulge increasing its convexity and refractive power. 

    Miosis. This is also known as constriction of pupils. 

    • It accompanies accommodation.  
    • It ensures that light rays are concentrated to pass through the centre of the lens and focus on the retina. 

    Convergence (movement of the eyeballs). This refers to bilateral movement of the eyes at the same time in order to focus on a nearby object eg focusing the tip of one’s nose.   

    • The light sensitive layer in the retina containing sensory photo receptor cells (rods and cones) convert light rays into nerve impulses.  
    • These are transmitted through the visual pathways to the visual area in occipital lobe of cerebrum. 
    • Here, they are interpreted as sensation of light form. 
    • They are processed into images of objects which are given meaning by other cerebral areas. 
    • This process involves interaction with information stored as memory in the association areas of the brain. 

    NB: The images refracted on the retina are upside down. 

    • The brain adapts to this early in life so that objects are perceived as upside/upright. 

    Anatomy and Physiology of Human Eye - GeeksforGeeks

    Accessory Organs of the Eye

    • The eye is a delicate organ on the body and it is protected by several structures.  

    These include; 

    (1).  The eye brows:

    • These are numerous hairs that project from the skin at the supra orbital margins of the frontal bone. 
    • These protect the eye from sweat, dust and other foreign bodies. 

    (2). Eyelids and eyelashes: 

    • These are two movable folds of tissue above and below the front of each eye.  
    • There are sebaceous glands, some open into the hair follicles of the eye lids. 

    The eyelids contain two muscles. 

    • These include;  
    •  Levator palpebrae superioris which raises the upper eyelid
    •  Orbicularis oculi which closes the eyelids. 
    • The hair on the eye lid is called eye lashes. 
    • The eyelids have a lining (mucous membrane) of the conjunctiva. 
    • This lining is a fine transparent membrane that is on the inner surface of the eyelid.  
    • This layer also covers the eyeball.  Where it lines the eyelids, there is a highly vascularized columnar epithelium  The corneal conjunctiva has avascular stratified epithelium.  
    • This means that the conjunctiva has epithelium without blood vessels at the cornea.  
    • The medial and lateral angles where the eyelids come together are called medial and lateral canthus respectively. 
    • At the edges of the eyelids, are eyelid margins that have numerous sebaceous glands.  
    • These are modified and secrete an oily material (meibum) spread over the conjunctiva by blinking.  
    • The material delays evaporation of the tears. 
      • Protect the eye from injury  
      • Blinking at about 3 to 7 seconds interval spreads tears and oily secretions over the cornea.  This prevents drying of the eyeball. 
        • Function of the eyelids and eyelashes 

    (3). Lacrimal apparatus: 

    • The lacrimal apparatus consists of the structures that secrete tears and drain them from the front of the eyeball.  
    • These include;  
    • 1 lacrimal gland and its ducts 
    • 2 lacrimal canaliculi ie superior and inferior to the caruncle of the eye. 
    • 1 lacrimal sac 
    • 1 nasolacrimal duct 
    • Each eye has a lacrimal gland behind the supra orbital margin.  
    • Lacrimal glands are exocrine glands.  
    • They secrete tears which are composed of water, mineral salts, antibodies and bactericidal enzymes. 
    • The tears leave the lacrimal glands by several small ducts. 
    • They then pass over to the front of the eye under the eyelids towards the medial canthus where they drain into two lacrimal canaliculi.  
    • The opening of canaliculi on each side is called punctum.  
    • The canaliculi lie above one another separated by a red body called caruncle. 
    • The tears then drain into the lacrimal sac which is the upper expanded part of the nasolacrimal duct
    • When foreign bodies or other irritants enter the eye, secretion of tears is greatly increased and the conjunctival blood vessels dilate.  
    • Secretion of tears is also increased in emotional states like crying and laughing. 
    • Excess tears are drained from the eye via the lacrimal apparatus into the lacrimal sac and then into the nasolacrimal duct. 
    • Functions of the lacrimal apparatus.
    • It has a fluid which is filled into the conjunctival sac. 
    • This fluid consists of tears and oily (meibum) secretions of meibomian/tarsal glands. 
    • The fluid is spread over the cornea by blinking. 
    • This mixture washes away irritants eg dust. 
    • It provides oxygen and nutrients to the avascular corneal conjunctiva and drains off wastes. 
    • Bactericidal enzyme lysozyme protects the eye by preventing microbial infection. 
    • The oiliness nature of the fluid delays its evaporation and prevents drying/friction of the conjunctiva. 
    • The fluid also prevents the eyelids from sticking together while sleeping. 
    • Main function of tears / tear fluid
    • To lubricate the eye to facilitate oxygen and carbon dioxide exchange. 
    • To produce an optically smooth cornea surface. 
    • To cleanse the eye with a bactericidal enzyme lysozyme.
    • To prevent the conjunctiva from drying. 

     

    (4). Extrinsic muscles :

    • These are also called extrinsic muscles.  
    • They are 6 in number and include the following; 
    • Medial rectus which rotates the eyeball inwards. 
    • Lateral rectus which rotates the eyeball outwards 
    • Superior rectus which rotates the eyeball upwards 
    • Inferior rectus which rotates the eyeball downwards 

    Function of the muscles 

    • They protect the eye through the flexible movement of the types of muscles.  
    • These movements help us to see in all directions of the eyeball movement.  
    • Hence they also play a protective function ie protecting the eye and the whole body. 

    Eye Anatomy and Physiology Read More »

    Intracranial Hemorrhage

    Intracranial Hemorrhage

    INTRACRANIAL HEMORRHAGE

    An intracranial hemorrhage is a type of bleeding that occurs inside the skull (cranium).

    Bleeding around or within the brain itself is known as a cerebral hemorrhage (or intracerebral hemorrhage).

    Bleeding caused by a blood vessel in the brain that has leaked or ruptured is called a hemorrhagic stroke.

    All bleeding within the skull is referred to as intracranial hemorrhage.

    Causes of Intracranial Hemorrhage.

    1. Head Trauma: Injury to the head from falls, car accidents, sports incidents, or seizures.
    2. Hypertension: High blood pressure leading to damage in blood vessel walls, causing leakage or rupture.
    3. Blood Clot: Blockage of a brain artery by a clot formed in the brain or traveling from another body part.
    4. Cerebral Aneurysm: Rupture of a weak spot in a blood vessel wall, forming a balloon-like bulge that bursts.
    5. Malformed Arteries or Veins: Leaking of improperly formed arteries or veins.
    6. Bleeding Tumors: Hemorrhage from tumors causing bleeding.
    7. Pregnancy-Related Conditions: Conditions linked to pregnancy or childbirth, including eclampsia, difficult delivery, and assisted delivery.
    8. Coagulopathy or Anticoagulation Medicine: Blood clotting disorders, use of anticoagulants like warfarin or heparin, or bleeding disorders like hemophilia and thrombocytopenia.
    9. Child Abuse Syndrome: Shaken baby syndrome as a result of child abuse.
    10. Postsurgical Causes: Hemorrhage occurring after surgeries like craniotomy or shunting.

    Pathophysiology:

    The brain relies on a network of blood vessels to supply oxygen and nutrients. Intracranial hemorrhage disrupts this supply, preventing oxygen from reaching brain tissue. The pooled blood from the hemorrhage increases pressure on the brain, further limiting oxygen delivery.

    During a hemorrhage or stroke, if oxygen deprivation persists for more than three or four minutes, brain cells begin to die. This results in damage to affected nerve cells and the related functions they control. The interruption of blood flow around or inside the brain is a critical factor leading to cellular damage and dysfunction.

    Types of Intracranial Hemorrhage

    • Epidural hematoma
    • Subdural hematoma
    • Subarachnoid hemorrhage
    • Intra cerebral hemorrhage
    Types of intracranial hemorrhage

    Epidural Hematoma (Subgalea hemorrhage.

    Subgaleal hemorrhage occurs when emissary veins between the skull and intracranial venous sinuses tear, leading to blood collection between the dura/apo-neurosis and periosteum of the skull.

    High-pressure bleeding is a prominent feature. An epidural hematoma, may briefly lead to lose consciousness and then consciousness is regained latter.

    Epidural hematoma is accumulation of blood between the Dura and the skull following fracture of the skull

    • Most commonly from rupture of middle meningeal artery.
    • The hematoma expands rapidly since accumulating blood is arterial in origin and causes compression of the Dura and flattening of underlying gyri
    •  The patient develops progressive loss of consciousness if hematoma is not drained early.

    Signs and symptoms

    • Swelling of the ears
    • Increasing head circumference as bleeding expands into this space. (hydrocephalus)
    • Hypovolemic shock,
    • Tachycardia,
    • Hypotension

    Diagnosis

    • Subgaleal hemorrhage may present as a large, boggy fluid collection palpable on the head’s surface. Characteristic of a subgaleal hemorrhage is that it is not restricted by suture lines and may shift with movement. This is in contrast to the more common cephalohematoma, a superficial collection of blood restricted to the space between the periosteum and skull, which is contained along suture lines.
    • Neonates with subgaleal hemorrhage are at high risk for rapid decompensation; the subgaleal space can expand to collect a newborn’s entire intravascular blood volume if bleeding continues unrecognized.

    Subdural hematoma (SDH)

    Subdural hematoma (SDH)

    A subdural hemorrhage occurs when bridging veins carrying blood through the dura mater to the arachnoid mater of the meninges are torn.

     This causes bleeding, with blood collecting below the dura and brain.

    Presence of blood on the surface of the brain beneath its outer covering.

    SDH is a collection of blood below the inner layer of the dura mater but external to the arachnoid membrane.

    • Subdural hematoma is accumulation of blood between the Dura and subarachnoid.
    • Develops most often from rupture of veins which cross the surface convexities of the cerebral hemispheres.

    Subdural hematoma may be acute or chronic.

    • Acute subdural hematoma; develops following trauma and consists of clotted blood, often in the front parietal region. There is no significant compression of gyri. Since the accumulated blood is of venous origin, symptoms appear slowly and may become chronic with passage of time if not fatal.
    • Chronic subdural hematoma; occurs often with brain atrophy. Chronic subdural hematoma is composed of liquid blood. Separating the hematoma from underlying brain is a membrane composed of granulation tissue.

    Diagnosis

    • Because subdural bleeders are located within the skull, there is often no physical sign on the scalp that reflects injury. Instead, the presence of hemorrhage may initially be unrecognized. For most neonates, subdural hemorrhage remains asymptomatic and resolves without consequence.
    • Clinical problems can arise in case of large volume hemorrhage or if bleeding slowly continues over hours or even days, as in cases of bleeding disorders.
    • Symptomatic neonates often present 24–48 hours after birth with nonspecific signs such as apnea, respiratory distress, altered neurologic state, or seizures.

    Subarachnoid hemorrhage

    Subarachnoid hemorrhage occurs when the veins of the subarachnoid villi are torn, leading to a collection of blood in the subarachnoid space

    There’s bleeding between the brain and the thin tissues that cover the brain. These tissues are called meninges.

    A sudden, sharp headache usually comes before a subarachnoid hemorrhage. Typical symptoms also include loss of consciousness and vomiting.

    • Hemorrhage into the subarachnoid space is most common, caused by;
    •  rupture of an aneurysm,  and rarely, rupture of a vascular malformation.
    • Of the three types of aneurysms affecting the larger intracranial arteries—berry, mycotic and fusiform, berry aneurysms are most important and most common.
    • Berry aneurysms are saccular in appearance with rounded or lobulated bulge arising at the bifurcation of intracranial arteries and varying in size from 2 mm to 2 cm or more.
    • They account for 95% of aneurysms which are liable to rupture.
    •  Berry aneurysms are rare in childhood but increase in frequency in young adults and middle life.
    • They are, therefore, not congenital anomalies but develop over the years from developmental defect of the media of the arterial wall at the bifurcation of arteries forming thin-walled saccular bulges.
    •  Although most berry aneurysms are sporadic in occurrence, there is an increased incidence of their presence in association with congenital polycystic kidney disease and coarctation of the aorta.
    • In more than 85% cases of subarachnoid hemorrhage, the cause is massive and sudden bleeding from a berry aneurysm on or near the circle of Willis.

    The four most common sites are;

    1. In relation to anterior communicating artery.
    2. At the origin of the posterior communicating artery from the stem of the internal carotid artery.
    3. At the first major bifurcation of the middle cerebral artery.
    4. At the bifurcation of the internal carotid into the middle and anterior cerebral arteries

    Intracerebral hemorrhage

    An intracerebral brain hemorrhage (ICH) is bleeding in the brain caused by the rupture of a damaged blood vessel in the head.

    As the amount of blood increases, the build-up of pressure can lead to brain damage, unconsciousness or even death.

    Intra cerebral hemorrhage is when there’s bleeding inside the brain.

    This is bleeding into the brain’s ventricular system, where the cerebrospinal fluid is produced and circulates through towards the subarachnoid space. It can result from physical trauma or from hemorrhaging in stroke ( HTN). This is the most common type of ICH that occurs with a stroke. It’s not usually the result of injury.

    • Spontaneous intracerebral hemorrhage occurs mostly in patients of hypertension. Children with systemic diseases that manifest with HTN are at risk because they have micro aneurysms in very small cerebral arteries in the brain tissue.
    • Rupture of one of the numerous micro aneurysms is believed to be the cause of intracerebral hemorrhage
    • Not common to have recurrent intracerebral hemorrhages like is the case of subarachnoid hemorrhages
    •  The common sites of hypertensive intracerebral hemorrhage are the region of the basal ganglia (particularly the putamen and the internal capsule), pons and the cerebellar cortex

    Diagnosis

    • There are very few clinical symptoms of IcH. When present, signs may include an acute drop in hematocrit, new-onset hypotension, and lethargy.
    • However, these symptoms are often present in extremely low birth weight and prematures

    Signs and Symptoms

    A prominent warning sign is the sudden onset of neurological deficit. This is a problem with the brain’s functioning. The symptoms progress over minutes to hours and they include:

    • Headache accompanied by neck stiffness
    • Drowsiness
    • Difficulty speaking/crying
    • Nausea
    • Vomiting
    • Decreased consciousness
    • Seizure
    • Coma
    • Weakness in one part of the body
    • Elevated blood pressure
    • Cognitive dysfunction or memory loss
    • Sudden tingling, weakness, numbness, or paralysis of the face, arm or leg, particularly on one side of the body
    • Loss of balance or coordination in older children
    • Babies less than 12 months old may develop a swollen fontanel, or soft spot

    Diagnosis

    • History taking
    • Computed temography (CT- scan) of head
    • MRI of head
    • CBC
    • Coagulation profile e.g. INR, PT
    • Physical examination e.g. glasgow coma scale (GCS):

      • Eye Opening
      • Verbal response
      • Best motor response

    GLASGOW COMA SCALE

    Management

    • Admission in icu or surgical ward
    • Resuscitation (ABC); All patients with GCS < 8 should be intubated for airway protection
    • Surgical management

    ICH is a medical emergency. Survival depends on getting treatment right away. It may be necessary to operate to relieve the pressure on the skull (craniotomy)

    • Craniotomy; to evacuate blood
    • Endovascular treatment; to occlude parent artery
    • Aneurysm coiling; obstruct aneurysm site with coil

    MEDICAL MANAGEMENT

    1. Steroids to Reduce Swelling: Steroids help reduce inflammation and swelling in the brain. Minimizing swelling is important to prevent further damage to delicate brain tissue.
    2. Anticoagulants: Reduces clotting to prevent the formation of blood clots. Clots can exacerbate the existing hemorrhage and lead to complications like stroke.
    3. Anti-Seizure Medications: Controls and prevents seizures. Seizures can further damage the brain and hinder the recovery process.
    4. Medications to Counteract Anticoagulants: Reverses the effects of any blood thinners previously taken. Prevents excessive bleeding and facilitates clotting.
    5. Blood Pressure Management: Maintain mean arterial pressure below 130 mm Hg. Helps control bleeding, but excessive hypotension should be avoided to ensure adequate blood flow to the brain.
    6. Avoiding Hyperthermia: Prevents elevated body temperature. Elevated temperature can worsen brain damage; controlling it is essential for recovery.
    7. Correction of Coagulopathy: Using interventions like fresh frozen plasma, vitamin K, or platelet transfusions. Correcting coagulation issues ensures proper blood clotting and reduces the risk of complications.
    8. Anticonvulsant Initiation: Controls seizures. Seizures can cause additional harm to the brain and hinder recovery.
    9. Transfer to Operating Room or ICU: Facilitates specialized care and monitoring. Swift transfer ensures prompt and appropriate management of the patient’s condition.
    10. Consideration of Nonsurgical Management: For patients with minimal neurological deficits. Nonsurgical approaches may be appropriate in less severe cases, avoiding unnecessary interventions.
    11. Dietary Measures: Initiating enteral feedings, possibly via nasogastric tube or percutaneous device. Ensures proper nutrition and supports the patient’s recovery.
    12. Activity Management: Bed rest initially, followed by a progressive increase in activity. Balancing rest and activity promotes recovery without causing undue stress on the healing brain.

    Nursing Concerns Intracranial Hemorrhage:

    1. Risk for Increased Intracranial Pressure: Bleeding within the brain can lead to increased intracranial pressure, which can damage brain tissue.
    2. Risk for Neurological Deficits: The hemorrhage can cause permanent neurological damage, such as paralysis, speech impairment, or cognitive decline.
    3. Risk for Seizures: The hemorrhage can trigger seizures.
    4. Risk for Complications of Immobility: The patient may be bedridden, increasing the risk of complications such as pneumonia, deep vein thrombosis, and pressure ulcers.
    5. Risk for Anxiety and Fear: The patient and family may experience anxiety and fear about the diagnosis and prognosis.
    6. Risk for Family Dysfunction: The patient’s illness can put a strain on family relationships.
    7. Risk for Post-Traumatic Stress Disorder: The patient may experience PTSD after a traumatic brain injury.

    Complications to Monitor:

    • Seizures: Can occur and require prompt management.
    • Paralysis: Possible impairment of motor functions.
    • Memory Loss: Cognitive deficits may arise.
    • Stroke: Hemorrhage can lead to a secondary stroke.
    • Permanent Brain Damage: A risk, especially if complications are not managed effectively.
    • Cerebral Coning: Herniation of brain tissue, a serious complication.
    • Depression: Emotional and psychological impact.
    • Bedsore: Potential complication due to immobility, requiring preventive measures.

    Intracranial Hemorrhage Read More »

    Congenital toxoplasmosis

    Congenital Toxoplasmosis

    Congenital Toxoplasmosis Lecture Notes
    Congenital Toxoplasmosis

    Congenital toxoplasmosis is a disease that occurs in fetuses or new-borns infected with Toxoplasma gondii, a protozoan parasite, which is transmitted from mother to fetus.

    Congenital Toxoplasmosis is an infection of a fetus or newborn baby with the parasite Toxoplasma gondii, acquired in utero from an infected mother.

    Etiological Agent: Toxoplasma gondii
    • Toxoplasma gondii is an obligate intracellular protozoan parasite. This means it can only reproduce inside the cells of a host.
    • It belongs to the phylum Apicomplexa, a group of parasites that includes other well-known pathogens like Plasmodium (malaria) and Cryptosporidium.
    Infectious Forms of Congenital Toxoplasmosis

    Congenital toxoplasmosis occurs when Toxoplasma gondii is transmitted from a pregnant woman to her fetus through the placenta, resulting from a primary maternal infection during or shortly before pregnancy. While the infection in the mother can be acquired via three different forms, the parasite reaches the fetus primarily as tachyzoites.

    The infectious forms of T. gondii that initiate the maternal infection (leading to the subsequent vertical transmission) are:

    1. Tachyzoites (The Acute/Invasive Form):
    • This is the fast-dividing, crescent-shaped, actively multiplying form.
    • In the context of congenital toxoplasmosis, the parasite multiplies in the mother's placenta and enters the fetal circulation in this stage.
    • Tachyzoites are responsible for direct, acute tissue damage.
    • They are the form typically transmitted across the placenta to the fetus.
    2. Bradyzoites (The Chronic/Cyst Form):
    • These are slow-multiplying organisms found within tissue cysts in the meat of intermediate hosts.
    • Ingestion of undercooked or raw meat (especially pork, lamb, or venison) containing these cysts is a primary way pregnant women become infected.
    • Once ingested, the cyst walls are broken down by stomach acid, releasing the bradyzoites, which then transform into tachyzoites.
    3. Sporozoites (The Environmental Form):
    • These are contained within oocysts that are produced in the intestines of cats (the definitive host) and excreted in their feces.
    • The oocysts require 1–5 days to sporulate and become infectious in the environment.
    • Ingestion of food, water, or soil contaminated with sporulated oocysts (e.g., via unwashed vegetables or handling contaminated cat litter) causes infection in humans.
    Life Cycle
    • Toxoplasma gondii has a complex life cycle involving definitive hosts (domestic and wild cats) and intermediate hosts (virtually all warm-blooded animals, including humans, birds, and other mammals).
    • In cats (definitive host): The parasite undergoes sexual reproduction in the feline intestine, producing oocysts that are shed in the cat's feces. These oocysts sporulate and become infective in the environment within 1-5 days.
    • In intermediate hosts (including humans):
      • When an intermediate host ingests sporulated oocysts (e.g., from contaminated soil, water, unwashed vegetables) or tissue cysts (e.g., from undercooked meat of infected animals), the parasites are released.
      • They rapidly multiply as tachyzoites (the rapidly multiplying, invasive form) which disseminate throughout the body via the bloodstream and lymphatic system.
      • The immune system eventually controls the tachyzoites, which then transform into slower-growing bradyzoites contained within tissue cysts, primarily in muscle, brain, and eye tissues. These tissue cysts can persist for the life of the host and are responsible for chronic, latent infection.
    Modes of Human Infection
  • Ingestion of contaminated food or water:
    • Eating undercooked or raw meat (especially pork, lamb, venison) containing Toxoplasma tissue cysts. This is a very common route.
    • Ingesting sporulated oocysts from contaminated sources (e.g., unwashed fruits/vegetables from contaminated soil, contaminated water).
  • Contact with contaminated cat feces:
    • Changing cat litter boxes without proper hygiene.
    • Gardening or playing in areas contaminated with cat feces.
  • Vertical Transmission (Mother-to-Child): Vertical transmission refers to the passage of an infection from a mother to her unborn child during pregnancy or childbirth. In the congenital toxoplasmosis, it specifically means transplacental transmission.
    • This is the focus of congenital toxoplasmosis. A pregnant woman who acquires a primary infection with Toxoplasma gondii during pregnancy can transmit the parasite transplacentally to her fetus.
  • Horizontal Transmission:
    • Foodborne: Humans can contract toxoplasmosis by eating undercooked meat containing infective tissue forms of the parasite T. gondii. It can also be transferred to food and therefore to humans through contaminated utensils and cutting boards. Also, drinking unpasteurized goat’s milk can cause toxoplasmosis infection.
    • Zoonotic transmission: Zoonotic transmission refers to animal to human transfer of the infection. Cats play a major role in this type of transmission. Cats serve as hosts to T. gondii. They shed their oocysts through their feces, and these oocysts are microscopic and can be transferred to humans through accidental ingestion by not washing hands after cleaning the cat’s litter box, drinking water infected with oocysts, or not using gloves when gardening.
    • Rare means of transmission: In very rare occasions, toxoplasmosis can be transmitted through organ donation and transplant, as well as in blood transfusion.
  • Risk Factors for Maternal Acquisition of Toxoplasma gondii:
  • Dietary Habits:
    • Consumption of raw or undercooked meat (especially pork, lamb, venison) containing tissue cysts is a major risk factor.
    • Eating unwashed fruits or vegetables contaminated with oocysts.
  • Environmental Exposure:
    • Contact with soil contaminated with cat feces (e.g., gardening without gloves, playing in sandboxes where cats defecate).
    • Cleaning cat litter boxes (especially if done frequently, without gloves, and without proper hand hygiene).
  • Occupation: Farmers, veterinarians, butchers, and those who handle raw meat frequently may have higher exposure.
  • Travel: Visiting or living in areas with high prevalence and poor hygiene.
  • Lack of Prior Immunity: Women who are seronegative (have no antibodies) for Toxoplasma at the beginning of pregnancy are susceptible to primary infection and thus at risk for transmitting it to their fetus.
  • Pathophysiology of Fetal Infection and its Impact on Organ Systems

    The pathophysiology of congenital toxoplasmosis is complex, involving direct parasitic invasion, host inflammatory responses, and disruption of fetal development.

    Mechanisms of Damage to Fetal Tissues

    Once in the fetal circulation, tachyzoites disseminate throughout the body and can infect virtually any nucleated cell. The primary mechanisms of damage include:

    1. Direct Cellular Lysis: Tachyzoites rapidly multiply within host cells, forming vacuoles. As they multiply, they eventually cause the host cell to rupture, releasing more tachyzoites to infect neighboring cells. This direct destruction of cells contributes significantly to tissue damage.
    2. Host Inflammatory Response: The presence of the parasite triggers a robust fetal immune and inflammatory response. While intended to clear the infection, this inflammation can also cause significant collateral damage to delicate developing fetal tissues. This immune response involves cytokines and immune cells that can contribute to tissue destruction and fibrosis.
    3. Cyst Formation: As the fetal immune system attempts to control the acute infection, tachyzoites differentiate into bradyzoites, which form dormant tissue cysts within cells. These cysts can persist for the lifetime of the host, primarily in the brain, eyes, and muscles. While dormant, they can reactivate later in life (e.g., due to immunosuppression), leading to recurrent disease, particularly in the eyes.
    4. Disruption of Organogenesis: If infection occurs early in pregnancy (first trimester), when vital organs are undergoing rapid formation and differentiation, the cellular destruction and inflammation can severely disrupt normal organogenesis, leading to severe malformations or even fetal demise.
    Impact on Specific Organ Systems

    The tropism of Toxoplasma gondii for neural and retinal tissue, combined with the vulnerability of the developing fetus, leads to characteristic patterns of damage:

  • Central Nervous System (CNS): This is the most commonly and severely affected organ system.
    • Hydrocephalus: Caused by obstruction of cerebrospinal fluid (CSF) flow, often due to ependymitis (inflammation of the lining of the brain ventricles) or aqueductal stenosis, resulting from inflammation and scarring.
    • Intracranial Calcifications: These are characteristic findings, often scattered throughout the brain parenchyma, particularly periventricularly. They represent areas of necrosis and inflammation that have healed with calcification.
    • Microcephaly: May occur due to extensive brain destruction.
    • Developmental Delay/Intellectual Disability: Resulting from direct neuronal damage, inflammation, and altered brain development.
    • Seizures: Due to brain lesions and scarring.
  • Eyes: Ocular involvement is almost universal in congenital toxoplasmosis, even in cases that appear subclinical at birth.
    • Chorioretinitis: This is the hallmark ocular lesion. It involves inflammation and scarring of the choroid (vascular layer) and retina. Lesions can be active (inflamed) or inactive (scarred) at birth. Active lesions can cause pain and vision loss. Inactive scars can reactivate later in life, leading to recurrent inflammation and progressive vision loss.
    • Microphthalmia: Abnormally small eyes.
    • Strabismus (crossed eyes): Due to visual impairment.
    • Nystagmus (involuntary eye movements): Due to visual impairment.
    • Blindness: Can result from severe, bilateral chorioretinitis or optic nerve involvement.
  • Other Organ Systems: While CNS and ocular involvement are most prominent, other systems can be affected:
    • Liver and Spleen: Hepatosplenomegaly (enlarged liver and spleen) is common due to generalized infection and inflammation.
    • Lymphatic System: Lymphadenopathy (enlarged lymph nodes) can occur.
    • Hematological: Anemia and thrombocytopenia (low platelet count) can be present.
    • Skin: Petechiae, purpura, or rash (generalized macular papular rash) may be seen.
    • Lungs: Pneumonitis (inflammation of the lungs).
    • Heart: Myocarditis (inflammation of the heart muscle) can occur but is less common.
  • Clinical Manifestations
    Manifestations at Birth (Acute Phase)

    Only a minority (10-20%) of congenitally infected infants show overt signs of disease at birth. These infants typically experienced maternal infection earlier in pregnancy.

    1. The "Classic Triad" of Congenital Toxoplasmosis:

    This severe form is characterized by the combination of:

    • Chorioretinitis: Inflammation and scarring of the retina and choroid, often leading to vision impairment. This can be active (inflamed) or inactive (scarred) at birth.
    • Hydrocephalus: Abnormal accumulation of cerebrospinal fluid (CSF) within the brain, leading to an enlarged head circumference (macrocephaly), increased intracranial pressure, and potential brain damage.
    • Intracranial Calcifications: Characteristic deposits of calcium within the brain tissue, often scattered and periventricular, indicative of previous tissue destruction and healing.
    2. Other Common Systemic Signs and Symptoms:
  • General:
    • Prematurity: Higher incidence in infected infants.
    • Intrauterine Growth Restriction (IUGR): Small for gestational age.
    • Hepatosplenomegaly: Enlargement of the liver and spleen, due to generalized infection.
    • Jaundice: Yellow discoloration of the skin and eyes, indicating liver dysfunction or hemolysis.
    • Fever: Although less common at birth, can be present.
  • Neurological:
    • Seizures: Due to brain lesions and inflammation.
    • Microcephaly: Abnormally small head, in contrast to hydrocephalus which causes macrocephaly. This indicates significant brain tissue destruction.
    • Poor feeding, lethargy, hypotonia (poor muscle tone).
  • Ocular:
    • Microphthalmia: Abnormally small eyes.
    • Strabismus, Nystagmus: Often secondary to vision impairment from chorioretinitis.
  • Hematological:
    • Anemia: Low red blood cell count.
    • Thrombocytopenia: Low platelet count, potentially leading to petechiae (small red spots) or purpura (larger purple patches) due to bleeding under the skin.
  • Skin:
    • Rash: Non-specific macular, papular, or petechial rash.
  • Delayed Manifestations (Chronic Phase and Sequelae)

    This is where the majority of issues arise, particularly in infants who were asymptomatic at birth. These sequelae can appear weeks, months, or even years after birth, highlighting the importance of long-term follow-up.

    1. Ocular Sequelae (Most Common Delayed Manifestation):
    • Recurrent Chorioretinitis: The most frequent and significant long-term complication. Dormant tissue cysts in the retina can reactivate, causing new inflammatory lesions or exacerbating existing scars. This leads to progressive vision loss, pain, photophobia (light sensitivity), and floaters. It can occur at any age, often into adolescence and adulthood.
    • Strabismus, Nystagmus, Amblyopia ("lazy eye"): Resulting from long-standing vision impairment.
    • Glaucoma, Cataracts: Less common, but can develop.
    • Blindness: Can be a devastating outcome of severe or recurrent chorioretinitis.
    2. Neurological Sequelae:
    • Developmental Delays: Ranging from mild learning disabilities to severe intellectual disability, motor delays, and speech delays.
    • Seizures: Can emerge or persist despite initial treatment.
    • Hearing Loss: Sensorineural hearing loss can occur.
    • Spasticity: Increased muscle tone and stiffness.
    • Visual Impairment/Cortical Blindness: Even without direct eye damage, brain damage can impair visual processing.
    3. Endocrine/Other:
    • Precocious Puberty: Early onset of puberty in girls, potentially related to hypothalamic damage.
    • Learning Disabilities and Behavioral Problems: Even with subtle brain involvement.
    Diagnostic Approaches for Congenital Toxoplasmosis
    I. Maternal Diagnosis

    The primary method for diagnosing maternal Toxoplasma infection is serological testing. The interpretation of these tests is crucial as it determines whether a woman has a past infection (immune), is currently acutely infected, or is susceptible.

    1. Serological Screening (Antibody Detection):
  • IgG Antibodies:
    • Presence (positive): Indicates past or current infection. A rising IgG titer over several weeks (paired sera) suggests a recent infection.
    • Absence (negative): Indicates susceptibility to infection.
  • IgM Antibodies:
    • Presence (positive): Often indicates a recent or acute infection. However, IgM can persist for months to over a year after acute infection, so a positive IgM alone is not definitive for acute infection during pregnancy. It warrants further investigation.
    • Absence (negative): Rules out recent infection in most cases, especially if accompanied by negative IgG.
  • IgA Antibodies:
    • Similar to IgM, IgA antibodies usually appear shortly after infection and decline within a few months. They can aid in diagnosing recent infection, particularly when IgM results are equivocal.
  • IgG Avidity Testing: This is a critical test for differentiating recent from remote infection.
    • Low IgG Avidity: Suggests a recent infection (typically within the last 3-4 months). This is because in the early stages of infection, IgG antibodies bind weakly to the parasite antigen.
    • High IgG Avidity: Suggests an infection acquired more than 3-4 months ago (i.e., remote infection). In later stages, IgG antibodies bind more strongly.
    • Clinical Utility: A high IgG avidity in the first trimester of pregnancy usually rules out an infection acquired during the current pregnancy, thus reducing anxiety and potentially avoiding unnecessary interventions.
  • 2. Interpretation Algorithm:
    • IgG negative, IgM negative: Susceptible. Counsel on prevention. Re-test if symptoms develop or exposure occurs.
    • IgG positive, IgM negative (High Avidity): Past infection, immune. No risk to fetus.
    • IgG positive, IgM positive (Low Avidity): Recent infection (likely during pregnancy). High risk for fetal transmission. Further fetal diagnostic testing is indicated.
    • IgG positive, IgM positive (High Avidity): Infection likely occurred several months ago (before or early in pregnancy). Lower risk for current pregnancy, but further evaluation may be considered.
    • IgG negative, IgM positive: Possible very early acute infection, or false positive IgM. Repeat testing, consider confirmatory tests.
    II. Fetal Diagnosis (In Utero)

    If maternal serology suggests a primary infection during pregnancy, fetal diagnostic procedures are offered to confirm (or rule out) fetal infection.

  • Amniocentesis:
    • Timing: Typically performed after 18 weeks of gestation and at least 4 weeks after the estimated time of maternal infection to allow for parasite multiplication in fetal fluids.
    • Procedure: Fetal amniotic fluid is collected.
    • Analysis:
      • PCR (Polymerase Chain Reaction): This is the most sensitive and specific method for detecting Toxoplasma gondii DNA in amniotic fluid. A positive PCR confirms fetal infection.
      • Fetal Serology: Less reliable as the fetal immune response might not be robust enough to produce antibodies at this stage.
  • Fetal Ultrasound:
    • Purpose: To look for sonographic signs of fetal infection and damage.
    • Findings: Hydrocephalus, microcephaly, intracranial calcifications, hepatosplenomegaly, ascites (fluid in abdomen), fetal growth restriction, abnormal cardiac findings.
    • Limitations: Ultrasound findings may be absent even in infected fetuses, especially early in infection or with milder forms. Its main role is to assess the severity of damage if infection is present.
  • Fetal Blood Sampling (Cordocentesis):
    • Purpose: To test fetal blood directly.
    • Analysis: Fetal IgM, IgA, or PCR for Toxoplasma.
    • Limitations: Invasive, higher risk than amniocentesis, and often replaced by amniotic fluid PCR due to its accuracy.
  • III. Neonatal Diagnosis (At Birth)

    Diagnosis in the neonate confirms that the baby is infected and guides treatment.

    1. Neonatal Serology:
      • IgM and IgA: A positive specific IgM or IgA in the newborn's blood definitively indicates congenital infection, as maternal IgM/IgA do not cross the placenta.
      • IgG: All infants born to IgG-positive mothers will have maternal IgG antibodies. Therefore, the presence of IgG alone is not diagnostic of congenital infection. Serial IgG titers are used:
        • Persistently positive or rising IgG titers beyond 12 months of age: Indicates active congenital infection.
        • Declining IgG titers that become negative by 12 months: Indicates passive transfer of maternal antibodies, and the infant is not infected.
    2. PCR (Polymerase Chain Reaction): Detection of Toxoplasma gondii DNA in neonatal blood, CSF, or urine. Highly sensitive and specific.
    3. Cerebrospinal Fluid (CSF) Examination: Analysis includes elevated protein, pleocytosis (increased cell count), and sometimes Toxoplasma DNA by PCR. Essential for assessing CNS involvement.
    4. Ophthalmological Examination: Findings are mandatory for all suspected cases. Dilated funduscopic examination can reveal active chorioretinitis or healed scars, even in asymptomatic infants.
    5. Neuroimaging:
      • Cranial Ultrasound (for open fontanelle): Can detect hydrocephalus, ventriculomegaly, and intracranial calcifications.
      • CT Scan or MRI of the Brain: Provides more detailed imaging of brain pathology, including calcifications, hydrocephalus, and other lesions.
    6. Other Investigations:
      • Complete Blood Count (CBC): To check for anemia, thrombocytopenia.
      • Liver Function Tests: To check for jaundice and hepatosplenomegaly.
    Medical Management and Treatment Strategies

    The medical management of congenital toxoplasmosis involves specific drug regimens for pregnant women, neonates, and infants, with the goals of reducing vertical transmission, preventing or minimizing disease severity, and managing complications.

    I. Treatment for Infected Pregnant Women

    The goal is to prevent or reduce the risk of transmission to the fetus and to mitigate fetal damage if transmission has already occurred. The choice of medication depends on whether fetal infection has been confirmed.

    1. If Fetal Infection is NOT Confirmed (i.e., amniocentesis negative or not yet performed):
    • Drug: Spiramycin
    • Mechanism: Spiramycin is a macrolide antibiotic that concentrates in the placenta. It is thought to reduce the rate of vertical transmission from mother to fetus, but it does not treat the fetus once infected.
    • Regimen: Typically given as 1 g orally three times daily throughout the remainder of the pregnancy, or until fetal infection is confirmed.
    • Side Effects: Generally well-tolerated, with mild gastrointestinal upset being most common.
    2. If Fetal Infection IS Confirmed (e.g., by positive amniotic fluid PCR) OR high suspicion of fetal infection:
  • Drug Combination: Pyrimethamine + Sulfadiazine + Leucovorin
  • Mechanism:
    • Pyrimethamine: A dihydrofolate reductase inhibitor, blocking folic acid synthesis in the parasite. It can cross the placenta. Pyrimethamine when given in high doses may cause haemolytic anaemia therefore monitor closely. Dose: 50-75mg OD PO for 2-3weeks then 25-37.5mg OD PO for 4-5 weeks
    • Sulfadiazine: A sulfonamide antibiotic that inhibits dihydropteroate synthase, another enzyme in the parasite's folic acid pathway. It also crosses the placenta. Dose: 1-1.5g QID for 3-4 weeks or 100mg/kg/day in 2DD
    • Leucovorin (Folnic Acid): Given to the mother (and later to the infant) to counteract the bone marrow suppressive effects (myelosuppression) of pyrimethamine, which can lead to thrombocytopenia and neutropenia by interfering with human folate metabolism. It is crucial to give leucovorin whenever pyrimethamine is used.
  • Regimen: initiated after the first trimester (due to potential teratogenicity of pyrimethamine, though risks are debated). The regimen is often cyclical or continuous.
  • Side Effects: Significant, requiring close monitoring. Pyrimethamine can cause myelosuppression, rash, and gastrointestinal upset. Sulfadiazine can cause rash, crystalluria, and bone marrow suppression.
  • II. Treatment for Infected Neonates and Infants (After Birth)

    All infants with confirmed congenital toxoplasmosis (symptomatic or asymptomatic) should receive prolonged anti-parasitic treatment to prevent or minimize the development of long-term sequelae, particularly ocular and neurological damage.

    1. Drug Combination: Pyrimethamine + Sulfadiazine + Leucovorin
  • Regimen: This is the cornerstone of treatment.
    • Pyrimethamine: Given daily or three times a week.
    • Sulfadiazine: Given twice daily.
    • Leucovorin: Given daily to mitigate pyrimethamine's side effects.
  • Duration: Treatment is typically continued for at least 12 months (one year) after birth. In some cases, treatment may be extended, particularly if there is active chorioretinitis.
  • 2. Corticosteroids (e.g., Prednisone 1mg/kg/day) till they resolve
  • Indications: Used to control severe inflammation.
    • Active chorioretinitis: Especially if threatening the macula or optic nerve.
    • Significant inflammation in the CNS: Such as severe hydrocephalus with high protein in CSF.
  • Regimen: Given concurrently with anti-parasitic drugs and tapered as inflammation subsides.
  • III. Monitoring During Treatment

    Due to the potential side effects of the medications, especially pyrimethamine and sulfadiazine, close monitoring is essential.

    • Hematological Monitoring: Regular (e.g., weekly or bi-weekly) complete blood counts (CBC) with differential and platelet counts to detect myelosuppression (anemia, neutropenia, thrombocytopenia). Doses may need adjustment or temporary interruption if severe myelosuppression occurs.
    • Renal Function: Monitoring of BUN and creatinine, especially with sulfadiazine, to prevent crystalluria.
    • Liver Function: Monitoring of liver enzymes.
    • Clinical Monitoring: Regular assessment for drug rashes, gastrointestinal upset, and signs of disease progression.
    IV. Management of Specific Complications
    1. Hydrocephalus: May require neurosurgical intervention, such as placement of a ventriculoperitoneal (VP) shunt to drain excess CSF and relieve intracranial pressure.
    2. Chorioretinitis: In addition to anti-parasitic treatment and corticosteroids, ophthalmological follow-up is critical. Regular eye exams are needed to monitor for active lesions, assess visual acuity, and manage complications.
    3. Developmental Delays: Referrals for early intervention programs including physical therapy, occupational therapy, speech therapy, and special education services are crucial to optimize developmental outcomes.
    V. Long-Term Follow-up

    Even after completing the initial 12 months of treatment, long-term follow-up is essential, often extending into adolescence and adulthood, due to the risk of delayed sequelae (especially recurrent chorioretinitis).

    • Regular ophthalmological examinations.
    • Neurological assessments.
    • Developmental evaluations.
    Prevention Strategies for Congenital Toxoplasmosis

    Prevention is paramount in congenital toxoplasmosis, as timely identification and avoidance of exposure in susceptible pregnant women can entirely avert fetal infection and its associated morbidities.

    I. Public Health Recommendations for Pregnant Women (Primary Prevention)

    These recommendations focus on reducing exposure to Toxoplasma gondii from food and environmental sources. Education of pregnant women (and women of childbearing age) is key.

    1. Food Safety Practices:
    • Cook Meat Thoroughly: Ensure all meat, especially pork, lamb, and venison, is cooked to safe internal temperatures (e.g., 160°F/71°C for ground meat, 145°F/63°C for whole cuts with a 3-minute rest time) until no pink remains and juices run clear. Freezing meat to -4°F (-20°C) for several days can also kill tissue cysts.
    • Wash Fruits and Vegetables: Thoroughly wash all raw fruits and vegetables before consumption, especially those grown in gardens where cats might roam.
    • Avoid Raw/Undercooked Meat: Refrain from eating raw or undercooked meat, including cured meats unless they have been previously frozen.
    • Prevent Cross-Contamination: Use separate cutting boards and utensils for raw meat and produce. Wash hands, cutting boards, and all utensils thoroughly with hot, soapy water after contact with raw meat.
    2. Environmental Hygiene:
  • Cat Litter Box Management:
    • Avoid Cleaning: Ideally, pregnant women should avoid changing cat litter boxes. If unavoidable, wear gloves and wash hands thoroughly afterwards.
    • Daily Cleaning: Have someone else clean the litter box daily, as Toxoplasma oocysts do not become infective until 1-5 days after being shed in feces.
    • Dispose Safely: Dispose of cat feces carefully, ideally by flushing or bagging and placing in sealed waste.
  • Gardening and Soil Contact:
    • Wear Gloves: Wear gloves when gardening or handling soil, sand, or anything that might be contaminated with cat feces.
    • Wash Hands: Wash hands thoroughly with soap and water after outdoor activities.
  • Sandboxes: Cover children's sandboxes when not in use to prevent cats from using them as litter boxes.
  • 3. Cat Care:
    • Keep Cats Indoors: This prevents them from hunting and eating infected rodents or birds, which are sources of Toxoplasma.
    • Avoid Feeding Raw Meat: Do not feed raw or undercooked meat to cats.
    • No New Cats During Pregnancy: Avoid acquiring new cats during pregnancy, especially stray or feral cats, unless they have been tested for Toxoplasma.
    II. Screening Programs
  • Maternal Serological Screening:
    • Universal Screening: Some countries (e.g., France, Austria) implement universal serological screening for Toxoplasma at the beginning of pregnancy (first trimester).
    • Targeted Screening: In other regions (e.g., USA), screening is often targeted only to women who develop symptoms suggestive of infection or have known exposure.
    • Benefits of Screening: Early detection of maternal seroconversion allows for prompt initiation of spiramycin, which can significantly reduce the risk of vertical transmission.
  • Neonatal Screening (Controversial/Not Universal): Some regions implement universal neonatal screening using cord blood or dried blood spots to detect Toxoplasma antibodies (e.g., IgM, IgA, or IgG avidity patterns) or PCR. Benefits include identifying congenitally infected infants (including asymptomatic ones) who can then receive treatment.
  • III. Primary Prevention Measures (Beyond Personal Hygiene)
    • Animal Control: Efforts to control feral cat populations in certain areas.
    • Water Treatment: Ensuring safe drinking water to prevent oocyst ingestion.
    • Public Education Campaigns: Raising awareness about Toxoplasma and its prevention methods among the general population, especially women of childbearing age.
    Key Nursing Diagnoses
    • Risk for Infection, related to compromised immune system and presence of parasitic infection.
    • Inadequate protein energy nutritional intake, related to increased metabolic demands, poor feeding, or gastrointestinal disturbances (e.g., jaundice, hepatosplenomegaly).
    • Risk for Delayed Development, related to neurological damage, visual impairment, or hearing deficits.
    • Impaired Physical Mobility, related to neurological damage (e.g., hydrocephalus, spasticity) and developmental delays.
    • Acute Pain, related to inflammation (e.g., active chorioretinitis, CNS inflammation) or surgical interventions (e.g., shunt placement).
    • Compromised Family Coping, related to chronic illness, uncertain prognosis, and demands of prolonged treatment and care.
    • Inadequate health Knowledge (Parents), related to disease process, treatment regimen, potential complications, and long-term care needs.
    • Risk for Caregiver Role Strain, related to complexity of care, financial burden, emotional stress, and lack of support systems.
    • Excessive Anxiety (Parents), related to diagnosis, prognosis, potential for sequelae, and future care needs.
    SPECIFIC NURSING MANAGEMENT
    Intervention Category Action & Rationale
    1. Infection Control & Medication Management
    • Administer Anti-parasitic Medications: Ensure timely and accurate administration of pyrimethamine, sulfadiazine, and leucovorin as prescribed. Educate parents on adherence.
    • Monitor Side Effects:
      • Hematological: Monitor CBC results (anemia, neutropenia, thrombocytopenia). Educate parents on signs of bleeding/infection.
      • Renal/Hepatic: Monitor renal/liver function tests. Educate on signs of jaundice, dark urine.
      • Skin: Assess for rash (sulfadiazine side effect).
    • Leucovorin Administration: Critical for preventing myelosuppression from pyrimethamine.
    • Infection Prevention: Implement standard precautions. Teach hand hygiene to protect infant from environmental infections (especially if neutropenic).
    2. Nutritional Support
    • Assess Feeding Patterns: Observe for difficulties with sucking/swallowing or aspiration.
    • Optimize Feeding: Small, frequent feedings. Specialized nipples if needed. Gavage/gastrostomy if oral intake insufficient.
    • Monitor Growth: Weigh regularly, plot growth, monitor intake/output.
    • Manage Jaundice: Monitor bilirubin, assist with phototherapy if prescribed.
    3. Developmental and Sensory Support
    • Early Intervention Referrals: Physical, occupational, speech therapy.
    • Sensory Stimulation: Age-appropriate stimulation (visual tracking, tactile).
    • Promote Mobility: Position to prevent contractures, promote normal development.
    • Ophthalmological Care: Ensure regular dilated eye exams. Educate parents on signs of active chorioretinitis (redness, photophobia).
    • Hearing Screening: Advocate for regular screenings.
    4. Pain Management
    • Assess Pain: Use age-appropriate scales.
    • Administer Meds: Analgesics/Corticosteroids as prescribed.
    • Comfort Measures: Swaddling, gentle handling, reduced environmental stimuli.
    5. Psychosocial & Educational Support
    • Educate Comprehensively: Clear info on disease, prognosis, treatment, complications. Use written materials.
    • Emotional Support: Allow expression of fears/grief. Provide empathetic listening.
    • Connect to Resources: Support groups, social workers, financial aid.
    • Promote Self-Care: Encourage parents to maintain their own well-being.
    • Advocacy: Ensure access to specialists/services.
    • Empowerment: Involve parents in care planning.
    • Prevention Education: For future pregnancies.
    6. Long-Term Follow-up Coordination
    • Schedule Appointments: Help organize appointments with multiple specialists (infectious disease, ophthalmology, neurology).
    • Maintain Records: Encourage parents to keep comprehensive records.

    Congenital Toxoplasmosis Read More »

    Mental Health Assessment

    Assessment of the Mentally Ill

    Mental Health Assessment

    The psychiatric interview is the most important tool in psychiatry. It is the primary tool used to understand a patient’s problems, elicit signs and symptoms, uncover etiologies, and identify complications. This process is essential to making an accurate diagnosis, initiating treatment, and predicting outcomes.

    A mental health assessment is a comprehensive evaluation of a person’s emotional, cognitive, and behavioral functioning. It’s a process used to diagnose mental health conditions, understand a person’s strengths and challenges, and develop a treatment plan.

    Overview of the Assessment Process

    The mental health assessment involves several key steps:

    1. History Taking: Gathering information from the patient and, when possible, collateral sources (family, friends, or other close contacts).
    2. Psychiatric Interview and Assessment: A comprehensive exploration of the patient’s mental state using structured interviews and observations.
    3. Physical Examination: Evaluating physical health, which may influence or mimic psychiatric conditions.
    4. Investigations: Requesting relevant investigations including biological tests (blood, urine, X-rays), psychological testing, social evaluations (home visits, environmental assessments), and any other assessments deemed necessary.

    Conditions for an Effective Consultation

    For the consultation to yield high-quality information, several environmental and practical factors must be met:

    Factor

    Details/Considerations

    Adequate Time

    Ensure that sufficient time is allocated so that the patient does not feel rushed.

    Privacy

    Conduct the interview in a private setting to encourage openness and honesty.

    Tidy Environment

    A neat and organized consultation room can positively influence the patient’s mood and level of comfort.

    Minimized Interference

    Avoid interruptions (e.g., answering phone calls) to maintain the focus of the consultation.

    Professional Appearance

    The appearance and grooming (e.g., well-kept nails, eyebrows, lips, and hair) of the health worker can affect the patient’s willingness to share personal details.

    Establishing a Therapeutic Relationship

    The quality of information gathered in a psychiatric interview greatly depends on the level of trust and confidentiality the patient perceives. A strong rapport encourages the patient to share personal and diagnostically important details. The following elements are essential to establishing an effective therapeutic relationship:

    1. Respect: Treat the patient with respect regardless of appearance or socioeconomic status. This respect is often immediately sensed by the patient.
    2. Compassion: Display genuine concern and empathy for the patient’s suffering and distress.
    3. Genuineness and Non-Judgment: Approach the patient with a sincere, non-judgmental attitude. This helps build trust, making it easier for patients to open up about sensitive issues.
    4. Cultural Sensitivity: Be aware of and respect cultural differences. For example, when taking a sexual history or discussing personal matters, consider cultural norms (such as attire or communication styles).
    5. Flexibility with Accompaniment: If a patient prefers to have a relative or friend present, allow this unless confidentiality is required for certain parts of the discussion.

    Essential Must-Do’s for the Interview

    • Explain the Purpose: Clearly inform the patient about the reasons for the interview.
    • Reassurance: Provide reassurance regarding the need and benefits of the interview.

    General Principles of the Psychiatric Interview

    A successful interview involves active participation from both the clinician and the patient. Key principles include:

    • Active Observation: Notice behavioral cues such as gait, physical appearance, and facial expressions.
    • Two-Way Assessment: Recognize that the patient is also evaluating you. Show genuine attention, listen carefully, and engage with empathy.
    • Acceptance: Understand that every behavior has meaning. Avoid making premature assumptions and strive to fully comprehend the patient’s perspective.
    • Avoiding Arguments: Maintain assertiveness without engaging in confrontations. Focus on understanding rather than debating.
    • Emphasis on Feelings: Encourage the patient to express their emotions (for example, allow space for tears and exploration of emotionally charged topics).
    • Interpersonal Focus: Nurture a sense of connection and trust during the interaction.
    • Tolerance of Silence: Recognize that pauses can be valuable, allowing the patient time to reflect and respond.

    Psychiatric History Components

    A comprehensive psychiatric history is gathered from the patient and, when possible, from family members or close contacts. It includes the following sections:

    1. Identifying Data

    Name

    Patient’s full name

    Age

    Chronological age

    Tribe/Ethnicity

    Cultural or ethnic background

    Occupation

    Employment status and type of work

    Religion

    Religious affiliation

    Next of Kin

    Primary contact or emergency contact

    Marital Status

    Current relationship status

    Education

    Highest level of education achieved

    2. Referral System

    Source of Referral

    Who referred the patient (e.g., health worker, family member, police)

    Reason for Referral

    The main concerns or symptoms prompting the referral

    Chief Complaints

    Primary issues as reported by the patient, along with the duration of symptoms

    3. History of Present Illness

    Exploration of Problems

    Detailed discussion of the current issues and emotional state.

    Diagnostic Focus

    Information should guide differential diagnoses, identify stressors, and note any complications.

    4. Past Psychiatric and Medical History

    Previous Illnesses

    Past physical and emotional health issues

    Investigations and Results

    Relevant tests (including HIV tests) and their outcomes

    Previous Diagnoses

    Prior psychiatric diagnoses

    Treatment History

    Treatments received and their outcomes

    5. Family History(Information to Gather)

    Family Members

    Note each member’s relationship with the patient

    Current Health Conditions

    Health status of family members

    Dependency Issues

    Whether any relative is dependent on the patient and how that affects the patient emotionally

    Presence of Mental Illness

    Any history of mental illness among nuclear or extended family

    6. Personal and Developmental History

    Early Development

    Details about pregnancy, birth, and early childhood (up to 6 years, particularly important in children).

    Childhood to Adolescence

    School performance, peer group activities, and early social experiences.

    Adolescence to Young Adulthood (up to 19 years)

    Sexual history, personal interests, and identity formation.

    7. Occupational and Marital History

    Occupational History

    Details

    Nature of Work

    Type of job and job description

    Job Satisfaction and Issues

    Level of satisfaction and any workplace challenges

    Marital History

    Details

    Age at Marriage

    The age when the patient got married

    Spouse’s Occupation

    Occupation and background of the spouse

    Family Health

    Health status of the spouse and children

    Marital Relationship

    Quality and dynamics of the marital relationship

    8. Forensic History

    • Legal Encounters: Document any previous problems with the law or involvement in legal matters.

    Mental Status Examination (MSE)

    The Mental Status Examination (MSE) is the psychiatric equivalent of a physical examination in medical assessments. It provides a structured way to evaluate a patient’s mental health by systematically observing and documenting their psychological and cognitive functioning.

    MSE observations begin the moment the clinician meets the patient and continue throughout the interaction until the patient leaves.

    The MSE is a systematic appraisal of the patient’s appearance, behavior, mental functioning, and overall demeanor.

    It is divided into several components:

    The main elements of the MSE can be remembered with the mnemonic ASEPTIC:

    • A: Appearance and Behavior
    • S: Speech
    • E: Emotion (Mood and Affect)
    • P: Perception
    • T: Thought Content and Process
    • I: Insight and Judgment
    • C: Cognition
    1. Appearance and Behavior

    Observation

    Examples/Observations

    Sample Questions/Comments

    Apparent Age

    Compare stated age vs. observed appearance (Does the patient look younger or older than stated?)

    “Can you confirm your age?” (This also helps compare self-report with observation.)

    Dress

    Clothing style and condition (casual, formal, disheveled, poorly maintained)

    “How do you decide what to wear each day?” (Or simply note your observations.)

    Grooming & Hygiene

    Overall grooming, cleanliness, and personal care (well-groomed vs. disheveled; good vs. poor hygiene)

    “Have you been taking care of yourself recently?” (Observation is usually key.)

    Gait

    The way a person walks (brisk, slow, intoxicated, ataxic, rigid, shuffling, staggering, uncoordinated)

    “I’ve noticed a certain way you move—have you felt any changes in your energy or balance?”

    Psychomotor Activity

    Overall motor activity (normal, reduced, or excessive movements)

    “Do you feel more or less energetic in your movements than usual?”

    Abnormal Movements

    Involuntary movements (grimaces, tics, tardive dyskinesias, foot tapping, ritualistic behaviors)

    “Have you experienced any involuntary movements or twitches?”

    Eye Contact

    Level and quality of eye contact (good or poor)

    “Do you feel comfortable maintaining eye contact during conversations?”

    Attitude

    Interpersonal stance (cooperative, belligerent, oppositional, submissive, etc.)

    “How are you feeling about discussing your current situation today?”

    2. Speech

    Observation

    Examples/Observations

    Sample Questions/Comments

    Speech Rate

    Speed of speaking (rapid, pressured, or slowed)

    “Do you feel you speak more quickly or more slowly than you normally do?”

    Speech Rhythm

    Flow of speech (hesitant, rambling, halting, stuttering, jerky, with long pauses)

    “Do you ever feel that your thoughts are hard to get out in order?”

    Tone of Voice

    Quality of tone (appropriate or inappropriate for the context)

    (Often observed; you may comment, “Your tone seems different today.”)

    Volume

    Loudness of speech (loud, soft, whispered, yelling, inaudible)

    “Have you noticed any changes in how loudly or softly you speak?”

    Clarity & Quantity

    Articulation, pronunciation, and amount of speech (clear, accented, slurred; responds only when asked, overly repetitive, verbose)

    “Do you think people understand you easily when you speak?”

    3. Emotion (Mood and Affect)

    Observation

    Examples/Observations

    Sample Questions/Comments

    Mood

    The patient’s subjective report of their emotional state (e.g., “good,” “depressed,” “anxious”)

    “How have you been feeling emotionally lately?”

    Affect

    The observable expression of emotion (e.g., appears down, euphoric, blunted) and whether it matches the reported mood (congruent vs. incongruent)

    “Does the way you feel inside match how you’re expressing yourself now?”

    Range & Stability

    Range: Broad versus restricted emotional expression; Stability: Fixed versus labile (rapid changes)

    “Have you noticed any sudden changes in your mood during the day?”

    4. Perception

    Observation

    Examples/Observations

    Sample Questions/Comments

    Hallucinations

    Sensory experiences without external stimuli (auditory – hearing voices; visual – seeing things; olfactory – unusual smells)

    “Have you experienced any sensations, like hearing voices or seeing things that others do not?”

    Illusions

    Misinterpretations of real sensory stimuli (e.g., mistaking a shadow for a person)

    “Do you sometimes perceive things differently from others around you?”

    Depersonalization/Derealization

    Feelings of unreality regarding self (depersonalization) or surroundings (derealization)

    “Do you ever feel as if you’re not real, or that the world around you isn’t real?”

    5. Thought Content and Process

    A. Thought Process

    Observation

    Examples/Observations

    Sample Questions/Comments

    Coherence & Organization

    How well thoughts are connected (logical, coherent, relevant) versus disorganized (circumstantial, tangential, flight of ideas, loosening of associations)

    “Do you find it easy to organize your thoughts when you speak?”

    Specific Abnormalities

    Instances of thought blocking (sudden stops), word salad (incoherent jumble), echolalia (repeating others’ words), or neologisms (making up new words)

    “Have you noticed moments where your thoughts seem to just stop or jumble together?”

    B. Thought Content

    Observation

    Examples/Observations

    Sample Questions/Comments

    Delusions

    Fixed false beliefs (paranoid delusions: e.g., “people are watching you”; delusions of grandeur: e.g., “I have special powers”)

    “Have you had any strong or unusual beliefs recently—such as feeling that people are out to get you or that you possess extraordinary abilities?”

    Suicidal Ideation

    Thoughts about life not being worth living or ending one’s life

    “When things get overwhelming, have you ever felt that life isn’t worth living? Can you tell me more about those thoughts?”

    Homicidal Ideation

    Thoughts about hurting others

    “Have you ever had thoughts about hurting someone else?”

    6. Insight and Judgment

    Observation

    Examples/Observations

    Sample Questions/Comments

    Insight

    Awareness of one’s own mental health (good insight: recognizes illness and need for treatment; partial: acknowledges a problem but is reluctant; poor: denies issues)

    “What do you think is contributing to your current difficulties?”

    Judgment

    The ability to make sound decisions (good, fair, or impaired based on the patient’s reasoning and decision-making skills)

    “Can you walk me through how you make decisions when faced with a difficult situation?”

    7. Cognition

    Observation

    Examples/Observations

    Sample Questions/Comments

    Level of Consciousness

    Overall alertness (alert, confused, lethargic, stuporous)

    (Generally observed, but you might ask, “How aware do you feel right now?” if needed.)

    Orientation

    Awareness of person, place, and time (e.g., “What is your name? Where are you right now? What is the date today?”)

    “Can you tell me your full name, your current location, and today’s date?”

    Attention/Concentration

    Ability to focus (good vs. poor concentration)

    “Do you feel that you have any difficulty staying focused on tasks?”

    Memory

    Short-term memory (recalling recent events) and long-term memory (recalling distant events)

    “What did you have for breakfast this morning?” (for short-term) and “Can you describe an important memory from your past?”

    Intellectual Functioning

    Overall cognitive abilities as inferred from speech and comprehension (below average, average, or above average)

    “How do you solve everyday problems? Could you explain your thought process when faced with a challenge?”

    Developing the Nursing Care Plan

    Based on the findings from the interview, history, MSE, and physical examination, a nursing care plan is developed. This plan should include:

    1. Assessment: Group findings into objective (observable) and subjective (reported) data.
    2. Nursing Diagnosis: Identify the patient’s needs and formulate clear nursing diagnoses.
    3. Goal Setting:  Establish realistic, measurable goals for the patient’s treatment and recovery.
    4. Planning and Implementation: Identify the methods, resources, and interventions required. Implement the care plan with a focus on holistic recovery.
    5. Evaluation: Continuously assess and adjust the care plan based on the patient’s progress and feedback.

    Assessment of the Mentally Ill Read More »

    mental health

    Mental Health

    Introduction to Mental Health & Symptomatology
    Introduction to Mental Health

    Mental health is a state of balance between the individual and the surrounding world.

    Mental health is a state of harmony between oneself and others.

    Mental health is a co-existence between the realities of the self and that of other people and that of the environment.

    HEALTH is a state of well being of an individual, socially, physically, mentally, not merely the absence of a disease or infirmity. (WHO)

    PSYCHIATRY is a branch of medicine which deals with assessment, diagnosis and treatment of mental disorders.

    "Mental health is a state of well-being in which an individual realizes his or her own abilities, can cope with the normal stresses of life, can work productively and fruitfully, and is able to make a contribution to his or her community."
    To break down:
    1. A State of Well-being: This means that mental health is about feeling good, having a sense of purpose, and experiencing overall life satisfaction. It's not static but dynamic, fluctuating as we navigate life's challenges.
    2. Realizes His or Her Own Abilities: A mentally healthy person has a realistic understanding of their strengths and weaknesses. They can recognize their potential and strive to achieve it, fostering self-esteem and self-efficacy.
    3. Cope with the Normal Stresses of Life: Life inevitably brings challenges, disappointments, and pressures. Mental health equips us with resilience – the ability to adapt, recover, and grow stronger in the face of adversity. This doesn't mean being stress-free, but rather having effective strategies to manage stress.
    4. Can Work Productively and Fruitfully: This refers to the ability to engage in meaningful activities, whether it's employment, education, caregiving, or creative pursuits. It encompasses concentration, motivation, problem-solving, and a sense of accomplishment.
    5. Is Able to Make a Contribution to His or Her Community: Mental health enables individuals to form meaningful relationships, participate in social life, and contribute positively to their families, friendships, and broader society. It's about a sense of belonging and connectedness.
    Distinguishing Mental Health from Mental Illness
    • Mental Health: As discussed, this is a state of optimal psychological and emotional well-being. Someone can have good mental health even if they experience occasional stress, sadness, or anxiety, as long as they can cope effectively and maintain overall functioning.
    • Mental Illness (or Mental Disorder): This refers to a wide range of conditions that affect mood, thinking, and behavior. Mental illnesses are characterized by significant distress, impairment in daily functioning, and often require diagnosis and treatment. They are not merely temporary reactions to stress or personal weaknesses.
    Key Differences:
    Feature Mental Health Mental Illness
    State State of well-being, thriving Diagnosable condition affecting thinking, mood, or behavior
    Coping Effective coping with life's stresses Difficulty coping, significant distress
    Functioning Productive, fruitful, contributes to community Significant impairment in social, occupational, or other important areas of functioning
    Presence of Symptoms May experience normal fluctuations in mood/stress Presence of persistent, often distressing symptoms (e.g., hallucinations, severe depression, extreme anxiety)
    Duration Dynamic, but generally stable functioning Prolonged or recurrent, often requires professional intervention
    Characteristics of a Mentally Healthy Person

    Building on the WHO definition, a mentally healthy individual typically exhibits several key characteristics:

    1. Positive Self-Concept: Possesses a realistic and generally positive view of themselves, including their strengths and limitations.
    2. Sense of Identity: Has a clear understanding of who they are, their values, and their purpose.
    3. Autonomy and Independence: Capable of making their own decisions and taking responsibility for their actions, while also recognizing the importance of interdependence.
    4. Resilience: Ability to bounce back from adversity, adapt to change, and learn from difficult experiences.
    5. Emotional Regulation: Can recognize, understand, and appropriately express emotions (both positive and negative) without being overwhelmed by them.
    6. Effective Coping Strategies: Has a repertoire of healthy ways to manage stress, problem-solve, and deal with challenges.
    7. Meaningful Relationships: Capable of forming and maintaining healthy, reciprocal relationships based on trust, empathy, and respect.
    8. Purpose and Direction: Finds meaning in life, sets goals, and works towards achieving them, contributing to a sense of fulfillment.
    9. Adaptability: Can adjust to new situations, unexpected events, and changing circumstances.
    10. Realistic Perception of Reality: Able to differentiate between reality and fantasy, and make sound judgments.
    Stress in Mental Health

    Stress is a natural and often unavoidable part of life. It's essentially your body's way of responding to any kind of demand or threat. When you perceive a threat – whether it's physical (like a near-miss car accident) or psychological (like a looming deadline or a difficult conversation) – your body initiates a "fight-or-flight" response.

    • Stress: Is a stimulus or demand that generates disruption in homeostasis or produces a reaction.
    • Stress: Is a state of disequilibrium that occurs when there is a disharmony between demands occurring within an individual’s internal and external environment and his or her ability to cope with those demands.
    • Stressor: a demand from within an individual’s internal and external environment that elicits a physiological and or psychological response.
    • Stressor: is a source of stress.

    Stress can produce adaptive and maladaptive responses.

    This physiological reaction involves:
    • Release of hormones: Adrenaline and cortisol flood your system.
    • Increased heart rate and blood pressure.
    • Rapid breathing.
    • Muscle tension.
    • Sharpened senses.

    Historically, this response was necessary for survival, enabling our ancestors to react quickly to danger. In modern life, however, many of our stressors are not physical threats but ongoing psychological pressures.

    Eustress vs. Distress:
    1. Eustress (Good Stress): This is positive, short-term stress that can motivate us, enhance performance, and help us achieve goals. Examples include the excitement of a new job, the challenge of learning a new skill, or the anticipation of a big event. Eustress is invigorating and can lead to personal growth.
    2. Distress (Bad Stress): This is negative stress that can be overwhelming, prolonged, and detrimental to health. It occurs when demands exceed our perceived ability to cope. Examples include chronic work pressure, relationship problems, financial difficulties, or major life changes (e.g., loss of a loved one). Distress can lead to burnout, anxiety, depression, and various physical health problems.
    Impact of Stress on Mental Well-being:

    While short-term stress can be adaptive, chronic or overwhelming distress can significantly impair mental well-being. It can lead to:

    • Emotional Symptoms: Irritability, mood swings, anxiety, depression, feelings of being overwhelmed, difficulty relaxing, low self-esteem.
    • Cognitive Symptoms: Difficulty concentrating, memory problems, negative thinking, impaired judgment, excessive worry.
    • Behavioral Symptoms: Social withdrawal, changes in eating habits (overeating or undereating), sleep disturbances (insomnia or hypersomnia), increased use of substances (alcohol, drugs), procrastination, fidgeting.
    • Physical Symptoms (linked to mental impact): Headaches, muscle tension, digestive problems, fatigue, weakened immune system.
    Responses to Stress

    Individuals react to stress in a myriad of ways, influenced by their unique genetic makeup, past experiences, coping mechanisms, and the nature of the stressor. Responses can be categorized broadly:

    1. Physiological Responses:
      • Fight-or-Flight: The immediate, automatic response involving the sympathetic nervous system (increased heart rate, blood pressure, muscle tension, rapid breathing).
      • General Adaptation Syndrome (GAS) - Hans Selye: A three-stage model describing the body's long-term response to stress:
        • Alarm Reaction: Initial shock, fight-or-flight response.
        • Stage of Resistance: The body tries to cope with the stressor, maintaining elevated physiological responses but attempting to return to normal. Resources are gradually depleted.
        • Stage of Exhaustion: If stress is prolonged, the body's resources are depleted, leading to weakened immunity, fatigue, and increased vulnerability to illness and disease (both physical and mental).
    2. Emotional Responses:
      • Anxiety: Feelings of unease, worry, nervousness, apprehension.
      • Anger/Irritability: Frustration, resentment, short temper.
      • Sadness/Depression: Feelings of hopelessness, helplessness, loss of interest.
      • Fear: Response to perceived danger or threat.
      • Overwhelm: Feeling swamped, unable to cope.
    3. Cognitive Responses:
      • Negative self-talk: "I can't do this," "I'm not good enough."
      • Rumination: Repetitive thinking about a stressor.
      • Catastrophizing: Blowing problems out of proportion.
      • Difficulty concentrating or making decisions.
      • Memory impairment.
    4. Behavioral Responses:
      • Adaptive/Healthy: Exercise, seeking social support, engaging in hobbies, problem-solving, relaxation techniques (meditation, deep breathing), healthy diet, adequate sleep.
      • Maladaptive/Unhealthy: Social withdrawal, aggression, substance abuse, excessive eating or undereating, procrastination, avoidance, excessive sleeping, lashing out at others.
    Determinants of Response to Stress

    Why do some people thrive under pressure while others crumble? The way an individual responds to stress is determined by a complex interplay of factors:

    1. Perception of the Stressor (Appraisal):
      • Primary Appraisal: Is this event a threat, a challenge, or irrelevant?
      • Secondary Appraisal: Do I have the resources to cope with this threat/challenge?
      • If a situation is appraised as highly threatening and resources are perceived as insufficient, the stress response will be more intense and negative.
    2. Coping Mechanisms:
      • Problem-focused coping: Directly addressing the source of stress (e.g., studying for an exam, creating a budget).
      • Emotion-focused coping: Managing the emotional reaction to stress (e.g., meditation, talking to a friend, exercise).
      • The effectiveness and healthiness of coping strategies significantly influence outcomes.
    3. Individual Differences:
      • Genetics: Some individuals may be genetically predisposed to higher stress reactivity.
      • Personality:
        • Resilience: The ability to adapt and recover from adversity.
        • Hardiness: Commitment, control, and challenge (seeing stressors as opportunities).
        • Optimism vs. Pessimism.
        • Self-efficacy: Belief in one's ability to succeed.
      • Temperament: Innate behavioral and emotional patterns.
    4. Social Support:
      • A strong network of family, friends, and community provides emotional, informational, and practical support, acting as a buffer against stress.
      • Lack of social support can exacerbate the negative effects of stress.
    5. Past Experiences and Learning:
      • Previous encounters with similar stressors, and how they were handled, shape current responses.
      • Traumatic experiences can lead to heightened stress responses.
    6. Physical Health Status:
      • Underlying chronic illnesses, poor nutrition, lack of sleep, or substance abuse can deplete energy reserves and reduce the body's ability to cope with stress.
    7. Environmental Factors:
      • Socioeconomic status, living conditions, access to resources, cultural background, and exposure to chronic environmental stressors (e.g., noise, pollution, violence) can all impact stress levels and coping abilities.
    MENTAL ILLNESS

    Mental illness is the maladjustment in living. The inability to cope with stress and environment.

    It produces a disharmony in the person’s ability to meet human needs comfortably or effectively and function with culture

    Mentally ill person loses his ability to respond according to the expectations he has for himself and the demands that society has for him

    In general an individual may be considered to be mentally ill if

    • The personal behavior is causing distress to self and others
    • The person’s behavior is causing disturbance in his day-to-day activities, job and interpersonal relationships
    Key aspects of mental illness include:
    1. Significant Distress: The individual experiences profound emotional pain, discomfort, or suffering that is disproportionate to circumstances or is persistent over time. This distress can manifest as sadness, anxiety, anger, confusion, or other intense negative emotions.
    2. Impairment in Functioning: The condition significantly interferes with one or more major life activities. This could include:
      • Social Functioning: Difficulty maintaining relationships, social withdrawal, inability to interact appropriately.
      • Occupational/Academic Functioning: Inability to work, perform daily tasks, attend school, or maintain employment.
      • Self-Care: Neglect of personal hygiene, eating, or other basic needs.
      • Role Performance: Inability to fulfill roles as a parent, spouse, student, or employee.
    3. Deviation from Norms: The thoughts, feelings, or behaviors are significantly outside of what is culturally expected or considered typical. This deviation must be considered within a cultural context, as what is "normal" can vary.
    4. Duration and Persistence: Unlike transient mood changes or reactions to stress, the symptoms of mental illness are usually persistent over a certain period, not just a brief episode.
    Common Signs and Symptoms of Mental Illness

    It's important to remember that experiencing one or two of these symptoms does not necessarily mean a person has a mental illness.

    1. Changes in Mood:
      • Persistent sadness or irritability: Lasting for weeks or months, not just a day or two.
      • Loss of interest or pleasure: In activities once enjoyed (anhedonia).
      • Extreme mood swings: Rapid shifts from extreme happiness to extreme sadness or anger.
      • Feelings of hopelessness or helplessness.
      • Elevated mood, euphoria, or grandiosity: Unusually high energy, racing thoughts, reduced need for sleep (can indicate mania).
    2. Changes in Thinking and Perception:
      • Difficulty concentrating or focusing: Problems paying attention or easily distracted.
      • Memory problems: Significant, unexplainable forgetfulness.
      • Confused thinking: Disorganized thoughts, difficulty following conversations.
      • Paranoia: Unreasonable suspicion or distrust of others.
      • Delusions: False beliefs not based in reality (e.g., belief that one is being persecuted or has special powers).
      • Hallucinations: Hearing, seeing, smelling, tasting, or feeling things that are not there (e.g., hearing voices).
      • Obsessive thoughts: Repetitive, intrusive, unwanted thoughts.
    3. Changes in Behavior:
      • Social withdrawal: Avoiding friends, family, or social activities.
      • Changes in sleep patterns: Insomnia (difficulty sleeping), hypersomnia (sleeping too much), or disturbed sleep.
      • Changes in appetite or weight: Significant weight loss or gain.
      • Decreased energy or fatigue: Feeling constantly tired and lacking motivation.
      • Increased agitation or restlessness: Inability to sit still, pacing.
      • Neglect of personal hygiene: Not showering, grooming, or changing clothes.
      • Impulsive or risky behavior: Excessive spending, reckless driving, substance abuse.
      • Aggression or violence.
      • Suicidal thoughts or self-harm behaviors.
    4. Physical Symptoms (without a clear medical cause):
      • Unexplained aches and pains: Headaches, stomach aches, muscle tension.
      • Digestive problems: Nausea, diarrhea, constipation.
      • Fatigue.
    PROBLEMS ASSOCIATED WITH MENTAL DISODERS
  • Profound Impairments in Daily Functioning:
    • Self-care limitations: Individuals may struggle with basic hygiene, nutrition, and personal upkeep.
    • Impaired functioning: This can manifest as difficulty maintaining employment, managing finances, or fulfilling household responsibilities.
    • Significant deficits in biological, emotional, and cognitive functioning: These can include disruptions in sleep patterns, appetite, mood regulation, memory, attention, and problem-solving abilities.
  • Disability and Life-Process Changes:
    • Mental disorders can lead to long-term disability, preventing individuals from engaging in typical life activities.
    • They can alter major life trajectories, impacting educational attainment, career progression, and the formation of meaningful relationships.
  • Intense Emotional Distress and Dysregulation:
    • Pervasive emotional problems: These include chronic anxiety, overwhelming sadness, debilitating anger, profound loneliness, and prolonged grief that can be disproportionate to life events.
    • Emotional lability: Rapid and intense shifts in mood can make daily life unpredictable and challenging.
  • Co-occurring Physical Health Issues:
    • Somatization: Mental distress can manifest as physical symptoms, such as chronic pain, fatigue, headaches, and digestive problems, often without clear medical explanation.
    • Increased risk of physical illnesses: Individuals with mental disorders are at a higher risk for cardiovascular disease, diabetes, and other chronic conditions, partly due to lifestyle factors, medication side effects, and physiological stress responses.
  • Distortions in Perception, Thought, and Communication:
    • Alterations in thinking: This can include delusional beliefs, disorganized thought processes, and difficulty with abstract reasoning.
    • Distorted perception: Hallucinations (auditory, visual, etc.) can significantly impact an individual's reality.
    • Communication difficulties: Disorganized speech, reduced verbal output, or an inability to express thoughts coherently can hinder social interaction.
    • Impaired decision-making: Cognitive deficits can make it challenging to make sound judgments and plan for the future.
  • Challenges in Interpersonal Relationships:
    • Difficulties relating to others: Mental illness can strain existing relationships and make it hard to form new ones due to social withdrawal, paranoia, irritability, or communication barriers.
    • Social isolation and stigma: The misunderstanding and prejudice surrounding mental illness can lead to ostracization and loneliness.
  • Risk to Self and Others:
    • Dangerous behaviors: In some cases, mental disorders can lead to self-harm, suicidal ideation, or, rarely, aggression towards others, particularly when psychosis or severe mood disturbances are present.
  • Widespread Adverse Effects:
    • Individual well-being: Mental illness significantly diminishes an individual's quality of life, sense of purpose, and overall happiness.
    • Family burden: Families often experience immense emotional, financial, and logistical strain as they try to support a loved one with a mental disorder.
    • Community impact: Untreated mental illness can contribute to homelessness, crime, and a reduced workforce productivity, impacting societal well-being and economic stability.
  • Significant Life Domain Problems:
    • Financial problems: Loss of employment, healthcare costs, and inability to manage finances can lead to severe financial hardship.
    • Marital and family discord: Mental illness can be a major source of conflict, divorce, and family breakdown.
    • Academic and occupational setbacks: Difficulty concentrating, maintaining attendance, and performing tasks can lead to school dropout and job loss.
  • Etiology of Mental Illness

    Many factors are responsible for the causation of mental illness. These factors may predispose an individual to mental illness, precipitate or perpetuate the mental illness

    1. Predisposing Factors: These are long-term, underlying vulnerabilities that increase an individual's susceptibility to developing a mental illness. They set the stage, often present for extended periods or even from birth.
      Examples:
      • Genetic make-up: Inherited predispositions, not the illness itself, but a heightened vulnerability. Studies highlight the significant role of heredity in mental health conditions (e.g., three-fourths of mental defectives and one-third of psychotic individuals owing their condition mainly to unfavorable heredity).
      • Physical damage to the central nervous system: Chronic or congenital neurological impairments.
      • Adverse psychological influences: Early childhood trauma, developmental issues, or chronic maladaptive learned behaviors.
    2. Precipitating Factors: These are acute, immediate stressors or events that trigger the onset of a mental illness in a vulnerable individual. They often occur shortly before the symptoms emerge.
      Examples:
      • Physical stress: Acute illness, injury, or other physical demands on the body.
      • Psychosocial stress: Significant life events such as bereavement, job loss, relationship breakdown, academic failure, or trauma.
    3. Perpetuating Factors: These are factors that maintain, aggravate, or prolong a mental illness once it has developed. They make it harder for the individual to recover or can lead to symptom exacerbation.
      Examples:
      • Psychological stress: Ongoing, unresolved stress can prevent recovery and worsen existing symptoms.
      • Other examples could include lack of social support, financial difficulties, substance abuse, stigma, or inadequate treatment.
    OTHER FACTORS;
    A. Biological Factors

    These involve genetic, neurochemical, structural, and physiological aspects of the body, particularly the brain.

    1. Heredity (Genetic Make-up):
      • Mental illnesses are not typically inherited directly, but a predisposition or vulnerability can be passed down through genes. This means an individual might inherit a higher risk, but whether the illness develops often depends on the interaction with environmental and psychological factors.
      • As you noted, studies indicate a significant genetic component in conditions like intellectual disability ("mental defectives") and psychoses.
    2. Biochemical Factors (Neurotransmitters):
      • Disturbances in the balance or functioning of neurotransmitters (chemical messengers in the brain) are strongly implicated in various psychiatric disorders.
      • Examples include:
        • Dopamine: Linked to schizophrenia (excess) and Parkinson's disease (deficiency), also involved in reward pathways.
        • Serotonin: Associated with depression and anxiety (deficiency).
        • Norepinephrine (Noradrenaline): Involved in mood, arousal, and attention (imbalances linked to depression and anxiety).
        • GABA: The primary inhibitory neurotransmitter (deficiency linked to anxiety disorders).
    3. Brain Damage / Structural and Functional Alterations:
      • Any insult or damage to the brain can affect its structure and function, leading to mental health symptoms.
      • Causes include:
        • Infection: Neurosyphilis, encephalitis, HIV infection (can lead to neurocognitive disorders).
        • Injury: Traumatic Brain Injury (TBI) from head injury, leading to cognitive, emotional, and behavioral changes.
        • Intoxication: Damage from toxins like alcohol, barbiturates, lead, recreational drugs, or even certain medications.
        • Vascular Issues: Poor blood supply (ischemia), bleeding (intracranial hemorrhage), or stroke, which can impair brain function.
        • Alteration in Brain Function: Changes in blood chemistry (e.g., severe hypoglycemia, hypoxia/anoxia, electrolyte imbalances) that directly interfere with neuronal activity.
        • Tumors: Brain tumors can cause a range of psychiatric symptoms depending on their location and size.
        • Nutritional Deficiencies: In particular, B-complex vitamin deficiencies (e.g., B1, B3, B12) can lead to neurological and psychiatric symptoms (e.g., Wernicke-Korsakoff syndrome from thiamine deficiency).
        • Degenerative Diseases: Conditions like Alzheimer's disease and other dementias involve progressive brain cell death, leading to cognitive and behavioral decline.
    4. Endocrine Disturbances:
      • Hormonal imbalances can profoundly affect mood and cognition.
      • Examples: Hypothyroidism (can mimic depression), hyperthyroidism (can cause anxiety, irritability), adrenal gland disorders.
    5. Physical Defects and Illnesses:
      • Both acute and chronic physical illnesses can lead to mental health issues through various mechanisms:
        • Direct physiological impact: The illness itself affecting brain function.
        • Psychological distress: Coping with pain, disability, loss of function, or life-threatening diagnoses.
        • Medication side effects.
    6. Physiological Changes at Critical Life Periods:
      • Periods of significant hormonal flux and physiological change can increase vulnerability to mental illness due to their impact on neurochemistry and the added psychological demands.
      • Examples: Puberty, menstruation (PMDD), pregnancy, delivery, puerperium (postpartum depression/psychosis), and climacteric (menopause).
    B. Psychological Factors

    These factors relate to an individual's thoughts, feelings, learning experiences, personality, and coping styles.

    1. Personality Types and Vulnerability:
      • Certain personality traits or types may increase susceptibility to specific disorders under stress.
      • Example: Individuals with schizoid personality traits (unsocial, reserved) may be more vulnerable to schizophrenia when facing significant adverse situations and psychosocial stress. Other examples include obsessive-compulsive traits leading to OCD, or anxious traits predisposing to anxiety disorders.
    2. Strained Interpersonal Relationships:
      • Ongoing conflict and negativity in significant relationships can be a major source of psychological distress.
      • Examples: Strained relationships at home, work, school, or college can erode self-esteem and lead to feelings of isolation and anxiety.
    3. Significant Life Events and Loss:
      • Bereavement: The death of a loved one.
      • Loss of prestige or social standing.
      • Loss of employment/job: Can lead to financial stress, loss of identity, and purpose.
    4. Childhood Insecurities and Developmental Trauma:
      • Early life experiences play a crucial role in shaping mental health.
      • Examples:
        • Parental psychopathology: Parents with their own mental health issues or maladaptive coping.
        • Faulty parenting styles: Over-strictness, over-leniency, inconsistent discipline.
        • Abnormal parent-child relationships: Over-protection (hinders independence), rejection (leads to feelings of worthlessness), unhealthy comparisons between siblings.
        • Deprivation of essential needs: Lack of love, security, stimulation, or consistent care.
        • Childhood abuse (physical, emotional, sexual) and neglect are profound risk factors for nearly all mental health disorders.
    5. Social and Recreational Deprivations:
      • Lack of engaging activities, social connection, and opportunities for enjoyment can lead to boredom, isolation, loneliness, and feelings of alienation, contributing to depression and anxiety.
    6. Marriage Problems:
      • Marital discord, forced relationships, disharmony due to incompatibility (physical, emotional, social, educational, financial), and issues like childlessness or having too many children can be significant stressors.
    7. Sexual Difficulties:
      • Problems arising from improper sex education, unhealthy attitudes towards sexual functions, guilt feelings (e.g., about masturbation), pre- and extramarital sexual relations, and worries about sexual identity or "perversions" can lead to significant psychological distress and contribute to mental health issues.
    8. Stress, Frustration, and Environmental Variations:
      • Chronic psychological stress and frustration deplete coping resources.
      • Climatic conditions and seasonal variations: Conditions like Seasonal Affective Disorder (SAD) demonstrate how environmental factors can trigger mood disturbances.
    C. Social Factors

    These are broad societal and cultural influences that affect an individual's mental health.

    1. Socioeconomic Disadvantage:
      • Poverty: Associated with chronic stress, lack of resources, poor nutrition, and limited access to healthcare.
      • Unemployment: Leads to financial strain, loss of purpose, social isolation, and reduced self-esteem.
      • Injustice and Inequality: Experiences of discrimination, systemic oppression, and lack of fairness.
    2. Environmental and Community Stressors:
      • Insecurity: Living in unstable or unsafe environments (e.g., high crime areas).
      • Migration: The stress of adapting to a new culture, language barriers, and loss of social networks.
      • Urbanization: Can lead to overcrowding, social isolation despite proximity, and increased sensory stimulation.
    3. Social Disruptions and Deviance:
      • Gambling, Alcoholism, Prostitution: These are often both symptoms of underlying distress and factors that perpetuate mental health problems.
      • Broken homes, Divorce: Disruption of family structure, leading to instability and emotional distress, especially for children.
      • Very big family: Can mean stretched resources, less individual attention, and increased stress for caregivers.
    4. Cultural and Political Influences:
      • Religion and traditions: Can be sources of support or, in some cases, conflict and guilt.
      • Political upheavals and other social crises: Wars, natural disasters, economic depressions create widespread trauma and stress.
    CLASSIFICATION OF MENTAL ILLNESS

    It’s important to classify mental illness because it serves as a guide to Diagnosis and prognosis (outcome). In psychiatry classification is based on clinical description of disease.

    I. Classification Systems for Mental Disorders

    To ensure consistent diagnosis, facilitate research, and guide treatment, mental health professionals rely on standardized classification systems. The two most widely used internationally are:

    1. Diagnostic and Statistical Manual of Mental Disorders (DSM):
      • Published by the American Psychiatric Association (APA).
      • Currently in its fifth edition, revised text (DSM-5-TR).
      • Primarily used in the United States and heavily influences psychiatric practice globally.
      • Provides explicit diagnostic criteria for hundreds of mental disorders, along with descriptive text, prevalence rates, and risk factors.
      • It is atheoretical regarding etiology, meaning it describes disorders based on observable symptoms rather than endorsing a particular theory of causation.
      Key Classifications in DSM-5:
      • Neurodevelopmental Disorders: Autism spectrum disorder, ADHD, intellectual disabilities.
      • Schizophrenia Spectrum & Other Psychotic Disorders: Delusional disorder, schizophrenia, brief psychotic disorder.
      • Bipolar & Related Disorders: Bipolar I and II, cyclothymic disorder.
      • Depressive Disorders: Major depressive disorder, disruptive mood dysregulation disorder, premenstrual dysphoric disorder.
      • Anxiety Disorders: Generalized anxiety disorder, panic disorder, social anxiety.
      • Obsessive-Compulsive & Related Disorders: OCD, hoarding disorder, body dysmorphic disorder.
      • Trauma- & Stressor-Related Disorders: PTSD, acute stress disorder, adjustment disorders.
      • Dissociative Disorders: Dissociative identity disorder, depersonalization/derealization.
      • Somatic Symptom & Related Disorders: Somatic symptom disorder, illness anxiety disorder, conversion disorder.
      • Feeding & Eating Disorders: Anorexia nervosa, bulimia nervosa, binge-eating.
      • Disruptive, Impulse-Control, & Conduct Disorders: Oppositional defiant disorder, conduct disorder.
      • Substance-Related & Addictive Disorders: Alcohol, cannabis, stimulant-related disorders.
      • Personality Disorders: Antisocial, borderline, narcissistic personality disorders.
    2. International Classification of Diseases (ICD):
      • Published by the World Health Organization (WHO).
      • Currently in its 11th revision (ICD-11).
      • Covers all health conditions, including mental and behavioral disorders.
      • Used globally for health statistics, epidemiology, and clinical purposes, especially outside the U.S.
      • While there are differences, the DSM and ICD systems are increasingly harmonized to allow for better international comparability of diagnostic data.
    II. General Classifications of Mental Illness

    Historically, and sometimes still colloquially, mental illnesses have been broadly grouped. While modern classification systems offer more nuance, understanding these general categories can be helpful:

    1. Organic vs. Functional Mental Disorders:
      • Organic Mental Disorders: These are conditions where a clear physical or physiological cause (e.g., brain injury, infection, substance intoxication, neurological disease) can be identified as directly causing the mental symptoms. Examples: Delirium, Dementia (e.g., Alzheimer's type), Substance-Induced Psychotic Disorder.
      • Functional Mental Disorders: These are conditions where no clear organic or physical cause has been identified, and symptoms are believed to arise primarily from psychological, social, and genetic vulnerabilities. Most major psychiatric disorders (e.g., Schizophrenia, Major Depressive Disorder, Anxiety Disorders) traditionally fall into this category, though growing research often reveals subtle biological underpinnings.
    2. Neurosis vs. Psychosis: This is a historical distinction that is less used in formal diagnosis today but remains useful in understanding the severity and nature of impairment.
      • Neurosis (Neurotic Disorders):
        • Core Characteristics: Characterized by significant distress, anxiety, fear, and/or maladaptive behaviors, but the individual generally retains a grasp on reality. They understand that their thoughts or feelings are problematic, and their personality remains largely intact.
        • Common Examples: Most anxiety disorders (e.g., Generalized Anxiety Disorder, Panic Disorder, Phobias), Obsessive-Compulsive Disorder (OCD), Post-Traumatic Stress Disorder (PTSD), and mild to moderate depressive disorders.
        • Impact: Can cause significant impairment and suffering, but the individual usually maintains some level of social and occupational functioning, and there is no loss of contact with reality.
      • Psychosis (Psychotic Disorders):
        • Core Characteristics: Defined by a significant loss of contact with reality. Individuals experiencing psychosis have difficulty distinguishing between what is real and what is not. This often involves profound disturbances in thought, perception, emotion, and behavior.
        • Key Symptoms:
          • Delusions: Fixed, false beliefs not amenable to change in light of conflicting evidence (e.g., believing one is being persecuted, or that one has special powers).
          • Hallucinations: Sensory experiences that occur in the absence of an external stimulus (e.g., hearing voices, seeing things that aren't there).
          • Disorganized Thinking (Speech): Inferred from speech, which may be illogical, incoherent, or derail from topic to topic.
          • Grossly Disorganized or Abnormal Motor Behavior: Catatonia (ranging from stupor to agitation) or other unusual movements.
          • Negative Symptoms: Absence of normal mental functions (e.g., diminished emotional expression, avolition - decrease in motivated self-initiated purposeful activities).
        • Common Examples: Schizophrenia, Bipolar Disorder (during manic or depressive episodes with psychotic features), Severe Depressive Disorder with Psychotic Features, Substance-Induced Psychotic Disorder.
        • Impact: Can lead to severe functional impairment, often requiring hospitalization and significant support.
    General Symptomatology of Mental Disorders

    Mental disorders often manifest as exaggerated, distorted, or significantly atypical patterns of normal behavior and experience that cause distress or impair functioning. These deviations can occur across various domains, including mood, beliefs, perception, awareness, memory, and physical presentation.

    Individuals experiencing mental disorders may sometimes present with non-specific physical complaints, such as persistent, unexplained headaches, or a general sense of malaise and poor health that lacks a clear medical explanation. There might also be a noticeable change in their typical engagement with work, school, or other gainful economic activities.

    The signs and symptoms of mental disorders can be observed through various lenses, including a person's appearance, behavior, patterns of movement, and speech.

    I. Observable Signs
    1. Appearance: A person's physical appearance can offer significant clues about their mental state. Individuals with certain mental disorders may exhibit:
      • Poor grooming and hygiene: This can range from disheveled hair, unkempt clothing, and dirty nails to a complete neglect of personal care.
        • Example: A person with severe depression might stop showering or changing clothes for days; someone experiencing psychosis might wear multiple layers of inappropriate clothing regardless of the weather.
      • Unusual attire: Clothing that is mismatched, inappropriate for the weather, or bizarre in style.
    2. Behavior: Behavior refers to how an individual acts and reacts to their environment and social situations. Deviations from typical behavior can include:
      • Social Withdrawal: Avoiding interaction with others, isolating oneself.
        • Example: A person with social anxiety disorder might consistently decline invitations, or someone with depression might stay in bed all day.
      • Hostility or Aggression: Verbal or physical aggression, irritability, or an argumentative demeanor.
        • Example: A person experiencing a manic episode might become easily enraged or lash out at others with little provocation.
      • Uncommunicativeness: Reluctance or inability to engage in conversation, providing minimal responses.
      • Guardedness/Suspiciousness: Being overly cautious, distrustful of others, or secretive.
        • Example: Someone with paranoid delusions might believe others are conspiring against them and refuse to share personal information.
      • Disinhibition: Lack of impulse control, acting without considering consequences.
        • Example: A person in a manic state might engage in reckless spending or inappropriate sexual behavior.
      • Agitation: Restlessness, inability to sit still, increased motor activity.
    3. Disorders of Movement: These symptoms relate to the way individuals move their limbs and body, and can indicate underlying neurological or psychiatric conditions.
      • Psychomotor Retardation: A noticeable slowing of movement and speech, appearing sluggish and lethargic.
        • Example: Common in severe depression, where even simple tasks feel effortful.
      • Akathisia (Restlessness): An inner sense of restlessness that compels continuous movement; the person cannot sit still. This is different from general restlessness in that it's a specific, often distressing, motor symptom.
        • Example: A side effect of certain antipsychotic medications, where the person constantly shifts position, taps their feet, or paces.
      • Echopraxia: Involuntarily imitating the movements or gestures of another person.
        • Example: A symptom seen in some psychotic disorders, where the person mirrors the interviewer's actions.
      • Stereotypies: Repetitive, seemingly purposeless movements (e.g., body rocking, head banging) that don't serve a goal.
      • Pacing: Repeatedly walking back and forth in a confined space.
      • Involuntary Movements:
        • Tremors: Rhythmic, involuntary muscle contractions, causing shaking.
        • Tics: Sudden, rapid, recurrent, non-rhythmic motor movements or vocalizations (e.g., eye blinking, head jerking, throat clearing).
      • Bizarre Posturing/Mannerisms: Involuntarily maintaining an abnormal or exaggerated body position for an extended period, or performing idiosyncratic, stylized movements.
        • Example: Catatonia, where a person might hold an unusual pose for hours; grimacing, or odd gestures that seem out of context.
    II. Disturbances in Speech

    Speech patterns are crucial indicators of mental state, reflecting thought processes, mood, and cognitive function. Disturbances can affect the speed, volume, appropriateness, and coherence of verbal communication.

    1. Speed of Speech:
      • Pressured Speech (Extremely Rapid): Speaking excessively quickly, often loudly, and sometimes unintelligibly, as if words are being forced out. The person may interrupt frequently and be difficult to interrupt.
        • Example: A classic sign of mania, where thoughts are racing.
      • Slowed Speech (Bradyarthria/Slurred Speech): Speaking unusually slowly, sometimes with reduced articulation or volume.
        • Example: Common in depression or in conditions affecting motor control like Parkinson's disease.
    2. Volume of Speech:
      • Hypophonia (Low Volume/Whispered): Speech that is unusually quiet or whispered, even in normal conversational settings.
        • Example: Can be seen in severe depression or sometimes in schizophrenia.
      • Inappropriately Loud Speech: Speaking at a volume that is much louder than warranted by the situation.
        • Example: A person in a manic episode might shout or talk very loudly without realizing it.
    3. Absence of Speech:
      • Mutism: Complete absence of speech, despite being physically capable of speaking.
        • Example: Can occur in severe depression, catatonic states, or some anxiety disorders (selective mutism).
    4. Appropriateness of Speech:
      • Irrelevant/Inappropriate Content: Speech that deviates significantly from the topic, or is logically disconnected from the conversation.
        • Example: Responding to a question about their day with a detailed account of a conspiracy theory unrelated to the conversation.
    5. Specific Speech Disturbances:
      • Echolalia: Involuntarily repeating words or phrases spoken by another person (like an echo).
        • Example: A symptom seen in some individuals with autism spectrum disorder or psychotic disorders.
      • Latency of Response: Taking an unusually long time to answer questions or respond to conversation.
        • Example: Characteristic of slowed thinking in depression.
      • Word Salad (Incoherence): A jumble of seemingly random words and phrases that have no logical connection, making the speech unintelligible.
        • Example: "The sun is blue, and apples fly on the carousel, purple elephants sing." Often seen in disorganized schizophrenia.
      • Neologisms: Inventing new words or phrases that have meaning only to the individual, and are not understandable by others.
        • Example: A person might refer to their phone as a "thought-box" or a "mind-squeezer." Also common in psychotic disorders.
      • Clang Associations: Speech driven by the sound of words rather than their meaning, often rhyming or alliterative.
        • Example: "The train pain, it went in the rain, on the plain."
    III. Mood and Affect

    Mood refers to a person's sustained, pervasive internal emotional state, which colors their perception of the world and influences their behavior. It's often described by the individual themselves (e.g., "I feel sad" or "I feel joyful").

    In mental disorders, mood can be significantly dysregulated:

    • Elevated/Elated Mood: Characterized by extreme happiness, euphoria, or an exaggerated sense of well-being, often out of proportion to circumstances.
      • Example: The persistent, elevated mood experienced during a manic episode in Bipolar Disorder.
    • Depressed Mood: Characterized by extreme sadness, hopelessness, anhedonia (loss of pleasure), or a general feeling of misery.
      • Example: The pervasive sadness and lack of interest in activities common in Major Depressive Disorder.
    • Irritable Mood: Easily annoyed, frustrated, or prone to anger, often disproportionately so.
      • Example: A person in a manic or hypomanic episode might become irritable when their plans are thwarted.

    Affect is the external, observable expression of emotion. It's the way a person's mood appears to others. Clinicians assess affect based on its range, intensity, appropriateness, and stability.

    Affective presentations in mental disorders can include:

    • Normal (Euthymic) Affect: A wide range of emotional expression that is appropriate to the situation and content of speech.
    • Elevated Affect: An expression of extreme cheerfulness or euphoria.
    • Depressed Affect: An expression of sadness, gloom, or despondency.
    • Labile Affect: Rapid, often abrupt, shifts in emotional expression, alternating quickly between extremes (e.g., crying one moment, laughing the next).
      • Example: Seen in Borderline Personality Disorder or some neurological conditions.
    • Inappropriate Affect: Emotional expression that is incongruent with the situation or the person's thoughts.
      • Example: Laughing when describing a tragic event, often seen in psychotic disorders.
    • Constricted/Restricted Affect: A mild reduction in the range and intensity of emotional expression.
    • Blunted Affect: A significant reduction in the intensity of emotional expression; emotions are present but dulled.
    • Flat Affect: A near or total absence of emotional expression, with a monotone voice and immobile facial features.
      • Example: A common negative symptom of schizophrenia, where the person shows little to no emotional response.
    IV. Perception

    Perception is the process through which we interpret sensory information from our environment via our five senses (touch, taste, hearing, smell, sight). Mental disorders can distort these processes, leading to experiences that deviate from reality.

    Key perceptual disturbances include:

    1. Illusions:
      • A misinterpretation or distortion of an actual external sensory stimulus. The stimulus is real, but the interpretation is incorrect.
      • Example: Mistaking a shadow for an intruder in a dimly lit room, or perceiving patterns in wallpaper as faces. Illusions can occur in normal individuals under certain conditions (e.g., fatigue, fear) but are more frequent and persistent in some mental disorders (e.g., delirium, psychosis). When associated with other symptoms, they can be indicative of a mental disorder.
    2. Hallucinations:
      • A perception-like experience that occurs without an external stimulus. They are vivid and clear, with the full force and impact of normal perceptions, and are not under voluntary control.
      • Hallucinations can occur in any sensory modality:
        • Auditory Hallucinations: Hearing voices, sounds, or noises that no one else can hear. This is the most common type of hallucination in psychotic disorders.
          • Example: Hearing critical, commanding, or conversing voices when no one is present.
        • Visual Hallucinations: Seeing things (people, objects, patterns) that are not actually there.
          • Example: Seeing deceased relatives, flashing lights, or distorted figures.
        • Tactile Hallucinations: Feeling sensations on or under the skin without any physical cause.
          • Example: Feeling insects crawling on the skin (formication) or a burning sensation.
        • Olfactory Hallucinations: Smelling odors that are not present.
          • Example: Smelling smoke, rotten food, or pleasant fragrances when there is no source.
        • Gustatory Hallucinations: Experiencing a taste in the mouth without any food or drink.
          • Example: A persistent bitter, metallic, or unpleasant taste.
    V. Thinking

    Thinking encompasses the mental processes involved in acquiring, processing, storing, and using information. Disturbances in thinking are central to many mental disorders and can affect the stream, form, and content of thoughts.

    1. Stream of Thought (Pace and Quantity): Refers to the amount and speed of thoughts an individual experiences and reports.
      • Pressure of Thought: Thoughts come so rapidly and abundantly that the individual feels overwhelmed and unable to keep up or express them coherently.
        • Example: Often accompanies pressured speech in mania.
      • Flight of Ideas: Rapid, continuous flow of accelerated speech with abrupt changes from topic to topic, usually based on understandable associations, distracting stimuli, or plays on words. The connections are discernible, but the goal is not reached.
        • Example: "I went to the store for milk. Milk is white. White clouds are in the sky. The sky is blue. Blue birds sing."
      • Poverty of Thought: A reduction in the quantity of thoughts; the individual reports difficulty generating or sustaining thoughts.
        • Example: A person with severe depression might feel their mind is empty, or struggle to elaborate on topics.
      • Thought Blocking: A sudden interruption in the middle of a thought or sentence, leaving the individual unable to recall what they were saying. They may report that their thoughts have been "stolen" or "taken out of their head."
        • Example: While talking, a person suddenly stops mid-sentence, appears blank, and then changes the topic or says they forgot what they were talking about. This is often associated with psychotic disorders.
    2. Form of Thought (Logic and Coherence): Refers to the logical connections between ideas and how thoughts are structured.
      • Perseveration: Persistent, inappropriate repetition of the same words, ideas, or themes in response to different questions or topics.
        • Example: If asked "How are you?" and then "What did you have for breakfast?", the person repeatedly answers with the first response, "I'm fine, I'm fine, I'm fine."
      • Tangentiality: Digressing from the main topic, introducing irrelevant details, and never returning to the original point.
        • Example: Asked "How was your day?", the person replies, "Well, the weather was nice, and the birds were singing, and I saw a squirrel, and my neighbor has a red car..." never answering about their day.
      • Circumstantiality: Speech that is indirect and delayed in reaching its goal, due to the inclusion of excessive or irrelevant details. Unlike tangentiality, the person eventually returns to the original point.
      • Loosening of Associations / Derailment: A disturbance in the logical progression of thoughts, where ideas shift from one subject to another in a way that is unrelated or only superficially connected.
        • Example: "I like to eat at the restaurant. It has a nice window. Windows are made of glass. My friend broke a glass yesterday. He was very sad." The connections are increasingly difficult to follow.
      • Abstract Thinking: The ability to understand concepts that are not concrete or directly observable, to generalize, and to interpret metaphors or proverbs. Impaired abstract thinking means thinking is excessively concrete.
        • Example: When asked to interpret "People who live in glass houses shouldn't throw stones," a person with concrete thinking might say, "Because the glass would break," rather than understanding the metaphorical meaning about hypocrisy.
    3. Content of Thought (What one is thinking about): Refers to the themes, beliefs, and preoccupations that dominate an individual's thoughts.
      • Delusions: Fixed, false beliefs that are firmly held despite clear evidence to the contrary, and are not consistent with the person's cultural or religious background.
      • Types of Delusions:
        • Grandiose Delusions: The belief that one is exceptionally important, famous, wealthy, powerful, or possesses special abilities or knowledge, often beyond what is realistic.
          • Example: A patient believing they are a secret agent with a mission to save the world, or that they have invented a cure for all diseases.
        • Delusions of Guilt or Worthlessness: Intense feelings of self-blame, remorse, or belief that one is deserving of punishment, has committed unforgivable sins, or is utterly worthless, even without any objective reason.
          • Example: A patient believing they are responsible for all the suffering in the world or that they are a terrible person who doesn't deserve to live.
        • Delusions of Jealousy (Morbid Jealousy or Othello Syndrome): The unfounded belief that one's spouse or partner is being unfaithful, despite a lack of evidence.
          • Example: A person constantly accusing their partner of infidelity, checking their phone, or following them, without any basis for suspicion.
        • Delusions of Persecution (Paranoid Delusions): The belief that one is being deliberately harmed, harassed, tormented, conspired against, spied upon, or otherwise ill-treated by others (individuals or agencies).
          • Example: A patient believing the government is monitoring their thoughts, or that their neighbors are poisoning their food.
        • Religious Delusions: Beliefs that are extreme or idiosyncratic interpretations of religious themes, outside the bounds of what is accepted by their religious community. These differ from culturally normative strong religious faith.
          • Example: A patient believing they are a prophet chosen by God for a specific, often bizarre, mission, or that they are the reincarnation of a divine figure.
        • Delusions of Control, Influence, or Passivity: The belief that one's thoughts, feelings, or actions are being controlled, imposed, or influenced by an external force or agency. This can manifest in several ways:
          • Thought Insertion: The belief that alien thoughts are being placed into one's mind by an external source.
            • Example: A patient stating, "These aren't my thoughts; the aliens are putting them in my head."
          • Thought Withdrawal: The belief that thoughts are being removed or stolen from one's mind by an external force.
            • Example: A patient explaining why they stopped mid-sentence: "My thoughts were just taken out of my head by the FBI."
          • Thought Broadcasting: The belief that one's thoughts are being transmitted aloud or broadcasted to others, or that others can hear their thoughts.
            • Example: A patient covering their head, saying, "Everyone can hear what I'm thinking, it's on the radio."
        • Somatic Delusions: False beliefs about one's body, health, or bodily functions.
          • Example: A patient believing their organs are rotting inside them, or that they are infested with parasites despite medical reassurance.
      • Obsessions: Recurrent and persistent thoughts, urges, or images that are experienced as intrusive and unwanted, causing marked anxiety or distress. The individual attempts to ignore or suppress them, or to neutralize them with some other thought or action (compulsion).
        • Example: Persistent intrusive thoughts about contamination, doubts about having locked the door, or aggressive impulses.
      • Phobias: Persistent, irrational, and excessive fear of a specific object, situation, or activity, leading to avoidance or intense distress when exposed to the feared stimulus.
        • Example: Arachnophobia (fear of spiders), Acrophobia (fear of heights), Social Phobia (fear of social situations).
      • Suicidal or Homicidal Ideation: Thoughts about ending one's own life or harming others. These are serious symptoms requiring immediate assessment and intervention.
      • Ideas of Reference: Belief that unrelated external events have a special, personal meaning for them (less fixed and bizarre than delusions of reference).
    VI. Awareness and Cognitive Functions

    These symptoms relate to an individual's fundamental mental capacities, which can be significantly impacted by mental disorders.

    1. Level of Consciousness: Refers to the state of alertness and wakefulness. Disturbances can range from mild alterations to complete unconsciousness.
      • Clouding of Consciousness: A mild form of altered consciousness, characterized by reduced alertness, poor attention, and a lack of clear-mindedness in perception and comprehension. The person may appear dull or listless.
      • Delirium: An acute state of mental confusion characterized by fluctuating awareness, disorientation, inattention, disorganized thinking, and often perceptual disturbances (e.g., hallucinations). The individual appears bewildered, restless, and confused.
      • Stupor: A state of near-unconsciousness or profound unresponsiveness, characterized by a significant reduction in reaction to external stimuli. Despite appearing motionless, the person may still be aware of their surroundings. Can occur in severe depression, catatonia, or neurological conditions.
      • Coma: A profound state of unconsciousness from which the person cannot be aroused, even with vigorous stimulation.
    2. Orientation: The ability to know one's current place in time, space, and person. A person is considered fully oriented if they can accurately identify:
      • Time: Day, date, month, year, season.
      • Place: Current location (hospital, home, city).
      • Person: Who they are and who significant others around them are.
      • Example: Disorientation is common in delirium, dementia, and states of acute confusion.
    3. Attention and Concentration:
      • Attention: The ability to focus one's mental resources on a specific task or stimulus, selecting relevant information while ignoring distractions.
      • Concentration: The ability to sustain that focus over a period.
      • Assessment: Often assessed by tasks like serial sevens (subtracting 7 from 100 repeatedly), reciting months of the year backward, or spelling words backward.
      • Impact: Impaired attention and concentration can significantly affect the ability to learn new information (poor registration) and immediate/short-term memory.
        • Example: A person with ADHD struggles to maintain attention on schoolwork; someone in a manic state may have highly distractible attention.
    4. Memory: The ability to register, retain, and recall past and present events and general knowledge. Memory disturbances manifest as forgetfulness or an inability to remember important information.
      • Immediate Memory: Ability to recall information just presented (e.g., repeating a short list of numbers).
      • Short-Term Memory (Recent Memory): Ability to recall events from minutes to days ago.
        • Example: Forgetting what one had for breakfast that morning, or misplacing keys frequently.
      • Long-Term Memory (Remote Memory): Ability to recall events from months or years ago, or personal history.
        • Example: Forgetting one's childhood home or significant life events.
      • Amnesia: Partial or complete loss of memory.
      • Confabulation: Fabricating imaginary experiences to fill in gaps in memory, often without conscious intent to deceive.
    5. Intellect: The overall ability to process, interpret, and use information, to learn from experience, and to adapt to new situations. It includes reasoning, problem-solving, and critical thinking.
      • Assessment: While IQ tests are formal measures, clinical assessment involves observing the person's vocabulary, general knowledge, judgment, and ability to handle complex information.
      • Example: Asking hypothetical questions like, "What would you do if you found a child playing with a sharp razor blade?" to assess judgment. Impaired intellect is characteristic of intellectual disability and neurocognitive disorders.
    6. Abstract Thought: The ability to understand concepts that are not concrete or directly observable, to generalize, and to interpret metaphors or proverbs. Impaired abstract thought (concrete thinking) means interpreting things literally.
      • Example: If asked the meaning of "Don't cry over spilled milk," a person with concrete thinking might say, "Because it makes a mess," rather than the abstract meaning of not dwelling on past misfortunes.
    VI. Sense of Self and Reality

    These involve disruptions in the fundamental experience of one's own self and the reality of the external world.

    1. Depersonalization: A sense of detachment from one's own body, thoughts, feelings, or actions, as if observing oneself from outside or feeling unreal. The body may feel changed, distorted, or not truly one's own.
      • Example: "I feel like I'm watching myself in a movie," or "My hand doesn't feel like it belongs to me." It is a change in the awareness of the self, often accompanied by emotional numbness.
    2. Derealization: A sense of detachment from one's surroundings, where the external world feels unreal, dreamlike, foggy, or distorted. Objects or people may appear strange, lifeless, or distant.
      • Example: "The room looks flat, like a painting," or "People around me seem like robots." This can occur in anxiety, stress, fatigue, affective disorders, or hyperventilation.
    VII. Insight and Judgment
    1. Insight: An individual's awareness and understanding of their own mental state, symptoms, and the nature of their illness, including the need for treatment.
      • Degrees of Insight: Can range from complete denial of illness to full intellectual and emotional appreciation of the condition.
      • Impact: Lack of insight is a significant barrier to treatment adherence, as individuals may not recognize the need for help.
        • Example: A person with schizophrenia experiencing delusions may firmly believe they are not ill and refuse medication.
    2. Judgment: The ability to make sound decisions, understand the consequences of one's actions, and behave appropriately in social situations.
      • Example: Poor judgment might be evident if a person in a manic episode makes impulsive financial decisions, or if someone with impaired reality testing walks into traffic without looking.
    VII. Other Common Presenting Symptoms
    1. Relationship Problems: Mental disorders often impair an individual's ability to form and maintain healthy interpersonal relationships.
      • Social Withdrawal: A pervasive avoidance of social interactions or activities, leading to isolation.
        • Example: A person with depression or social anxiety might stop seeing friends and family, staying home all the time.
      • Isolation: Keeping to oneself even when in a social environment; feeling disconnected from others.
      • Poor Interpersonal Relations: Frequent conflicts, arguments, or difficulty empathizing and connecting with others.
        • Example: Someone with Borderline Personality Disorder may experience intense, unstable relationships characterized by rapid shifts from idealization to devaluation.
    2. Appetite and Weight Disturbances: Significant changes in eating patterns and body weight are common symptoms across various mental disorders.
      • Increased Appetite/Weight Gain:
        • Example: Seen in atypical depression, or as a side effect of certain psychotropic medications.
      • Decreased Appetite/Weight Loss:
        • Example: A prominent symptom in major depressive disorder, anorexia nervosa, or anxiety.
      • Specific Eating Disorder Symptoms: Such as refusing to eat, hiding food, excessive worry about weight and body image (as in anorexia nervosa or bulimia nervosa).
    3. Sleep Disturbances: Disrupted sleep patterns are nearly universal in mental disorders and can range from insomnia to hypersomnia.
      • Altered Sleep-Wake Cycle: Disruption of the natural circadian rhythm, leading to being awake at night and drowsy during the day.
        • Example: Common in bipolar disorder during manic or depressive episodes.
      • Initial Insomnia: Difficulty falling asleep at the beginning of the night.
        • Example: Often associated with anxiety disorders.
      • Middle Insomnia: Waking up frequently during the night and having difficulty returning to sleep.
      • Terminal Insomnia (Early Morning Awakening): Waking up much earlier than desired (e.g., 3 AM to dawn) and being unable to return to sleep.
        • Example: A classic symptom of major depressive disorder.
      • Hypersomnia: Excessive sleepiness, or prolonged sleep duration.
        • Example: Can occur in atypical depression or some neurological conditions.
      • Disturbed Sleep Quality: Sleeping for a sufficient duration but waking up feeling unrefreshed, often due to nightmares, night terrors, or fragmented sleep.

    Mental Health Read More »

    midwifery pregnancy

    Normal Midwifery Questions and answers

    Normal Midwifery

    Abdominal examination; do systematically from the head to toes to find out the lie, presentation, position, level of descent, nature of contractions and fetal heart moulding if any.

      1. Hygiene given; bath and a clean gown provided.
      2. Records: All the information about the mother is charted on the record sheet.
      3. Position: Mother is allowed to adopt any comfortable position especially sitting up position.
      4. Ambulation: In early 1st SOL mother is allowed to move about where the midwife can observe her.
      5. Nutrition: Mother is allowed to eat alight diet like porridge, but later in established 1st SOL she is given hot sweetened tea.
      6. Care of the bladder: Mother is encouraged to empty the bladder after every 2hours and urine should be tested for any abnormality.
      7. Rest and sleep: assist the mother by dimming off lights and control noise and visitors.
      8. Prevention of infections: Ensure aseptic techniques and proper hygiene of the ward to prevent infections.
      9. Bowel actions: Mother is encouraged to empty the bowel, move frequently and clean the bed pan if offered.
    1.  

    Write short notes on the following

      1. Causes of pain in labour.
      2. Factors that affect pain perception during
      3. Observation done during fourth stage of Labour indicating importance of each.
      4. List indications of ultra sound scan during

    SOLUTIONS

    LABOUR

    Is the physiological process by which the fetus, placenta and membranes are expelled through the birth canal by the help of the mother‘s effort after 28 weeks of gestation and there are four stages of labour that is to say; first, second, third and fourth stage and there are two types of labour and that is normal and abnormal labour.

    PAIN

    Is a sensory /emotional experience of what the patient feels and there are two types of pain; somatic and visceral pain.

    CAUSES OF PAIN

    There are two major causes of pain;

    • Hormonal factors
    • Mechanical factors

    Hormonal factors

    These include;

    • Oxytocin stimulation. This increases the strength, intensity, duration and frequency of the contractions leading to pain.
    • Progesterone withdrawal. The reduced levels of progesterone lead to an increase in estrogen levels which stimulates the muscles of the deciduae muscles of the uterus to produce prostaglandin which stimulates the smooth muscles of the uterus to contract.

    Mechanical factors

    These include;

    • Strength and frequency of Braxton hick‘s contractions occurring in late pregnancy which leads to over stretching of the uterus which irritates the uterine muscles to contract leading to pain.
    • Pressure of the presenting part on the sacra-nerves and lumbar nerves which has pain receptor.
    • Pressure of the presenting part on the cervix. The presenting part exerts pressure on the cervix muscles hence leading to pain.
    • Displacement of the pelvic floor muscles. The advancing presenting part distends the vagina and displaces the pelvic floor muscles which are over stretched and the nerves are compressed leading to pain.

    PART (B)

    PERCEPTION.

    Is the process of becoming aware of the environment through the five senses.

    Factors that affect pain perception during labour

    These factors are emotional experience involving physical and psychological mechanism and can be contributed by the mother, fetus, health workers and structural environment.

    Mother

    • Maternal medical; conditions like pre-eclampsia and eclampsia, cardiac conditions which can affect pain perception.
    • Compromised immunity due to chronic conditions like HIV and cancer which can affect pain perception.
    • Size of the pelvis. Any pelvic deviation from normal leading to cephalous pelvic disproportion which can affect pain perception.
    • Age. Young prime gravidae below 18years their pelvic bones are not fully developed and the mother above 35years their pelvic bones are contracted and this hinders normal progress of labour and affects pain.
    • Parity. Prime gravidae‘s their muscles are still intact and sensitive to pain which leads to strong contractions. The multipara mothers their muscles are laced which leads to uterine itial.
    • Past obstetrical history like caesarian section which increases the risks of uterine rapture and affects normal labour
    • Social economic factors for example lack of support which can affect pain perception.
    • Cultural factors like use of native drugs can affect pain perception.
    • Past experience can also affect pain perception
    • Level of education, occupation, religion can also affect pain perception.

    Fetus

    • Fetal abnormalities like hydrocephalous, macrosomic babies can lead to cephalopelvic disproportion hence affecting pain.
    • Lie, position and presenting pain can affect pain perception during labour
    • Size of the fetus that is to say big babies which cannot pass through the pelvis hence affecting pain perception
    • Gestation age. In past maturity the sutures and the fontanels are closing and molding can hot take place hence affecting pain perception.

    Health workers

    1. Poor screening of mothers during antenatal Poor management during labour
    2. Poor attitude towards the mother

    Structural environment

    • Hospital setting where there is no privacy for mothers, all stages of labour in one room which can affect pain perception.
    • Lack of recreation in labour rooms like newspapers, television to occupy the mothers.

    PART (C)

    Forth stage of labour

    Is the 1-2 hours following third stage of labour. Observations done during the fourth stage of labour

    To the mother

    • Per vagina

    Perineum to inspect for perineal tears, episiotomy and other injuries Bleeding to rule out anemia and post partner hemorrhage

    • Per abdominal

    Fundal height estimation to rule out the retained products of conception State of the uterus whether it has contracted

    Bladder encourages the mother to pass urine to prevent PPH

    • Vital observations like blood pressure, temperature, pulse, and respiration for consciousness of the mother to rule out pre –eclampsia and eclampsia, dehydration and
    • Breast examination – to rule out abnormalities of the nipple which can hinder breast feeding like inverted nipples.
    • Observe the bowel action if the bowel movements are present and able to pass out stool
    • Observe the legs for varicose veins

    To the baby

    • Assessment of the baby after five minutes for example APGAR scoring the baby General examination of the baby to rule out abnormalities
    • Observation of the cord for bleeding and well ligatured
    • Bowel for passage of meconium to rule out anal impaction
    • Observe if the baby is breast feeding for the presence of the sucking reflex.

    PART (D)

    Ultra- sound scan

    Is a tool used in pregnancy and obstetrics generally for diagnosis. The system uses waves of sound that create images by bounding off and td safe to the developing fetus.

    Methods

    • Trans abdominal
    • Trans vaginal

    INDICATIONS

    • To determine the gestation age
    • To detect the sex of the baby
    • To detect the fetal abnormalities
    • To know the site of the placenta
    • To determine the maturity where the dates are not accurate
    • To rule out intra- uterine fetal death
    • To rule out intra- fetal growth retardation
    • To confirm pregnancy
    • To asses amniotic fluid amount an order to rule out polyhydrominous and oligohydrominous
    • To determine the causes of bleeding in pregnancy
    • For detection of multiple pregnancies
    • To determine the size of the baby
    • For diagnostic purposes
    • Improves the woman‘s pregnancy experience

    For pelvic assessment.

        • Vital observations. Vital observations like blood pressure is taken to rule out conditions like pre-eclampsia that will necessitate referral.

        • Physical examination. This is done to exclude conditions like anaemia, jundice, dehydration, oedema, malnutrition.
        • External pelvic assessment. This is done especially from 36 weeks of gestation those mothers who have not delivered vaginally and prime gravidas by considering gait, stature, height and weight.

        • Blood tests. Blood test like complete blood count(CBC),blood grouping and rhesus factor, venereal disease research laboratory test(VDRL),Random blood sugar (RBS),Routine counseling and testing(RCT) to rule out conditions like anaemia, rhesus incompatibility, syphilis, diabetes, HIV &Aids respectively that will necessitate referral.
        • Urine test. Urinalysis is done at every visit to exclude the presence of glucose, protein and ketones in the urine which indicates conditions like diabetes, hypertensive disorders, urinary tract infection and unmet fetal demand respectively which necessitate referral.

          • Breast examination. It is done to exclude conditions like breast abscess ,breast cancer and any abnormality of the breast that will necessitate referral.

        Abdominal examination

        On inspection. Observe the size and shape of the abdomen and previous scars that indicates condition like polyhydrominous and oligohydrominous and fresh previous scars that will necessitate referral.

        On palpation. It is done to ascertain any abnormality like; Height of fundus not corresponding with gestational weeks, oblique and transverse lie, breech presentation at term especially prime gravidas and absence of fetal movement that will necessitate referral.

        Auscultation. This is to exclude abnormal fetal heart tone, regularity, rhythm and absence of fetal heart that will necessitate referral.

          1. Define a partograph.
          2. What information is recorded on the partograph?
          3. List the observations/ nursing care that can be done for a woman in first stage of labour but cannot be plotted on the partograph.

          1.  

          1.  

          SOLUTIONS

          A partograph is a tool used to monitor the progress of labour, condition of the fetus and the mother.

          OR

          Is the chart used to record all information and observations of a woman in labour/its a partogram before plotting and becomes a partograph after plotting.

           A PARTOGRAPH IS STARTED

              • When a woman is in active phase of labour that is 4cm or more of cervical opening.

              • When the pregnancy of at least 30 completed weeks.

              • When the presenting part is cephalic or breech.

              • When there is no complication that needs immediate action.

            THE INFORMATION RECORDED ON A PARTOGRAPH.

            The following information is recorded on a partograph;

              • Mothers demographic data.
              • Fetal conditions
              • Labour progress.
              • Maternal condition.
              • Outcome of labour.

              MOTHERS DEMOGRAPHIC DATA

              This is the first information entered on a partograph, this is essential as it helps a midwife to easily identify the mother she is following to know the weeks of Amenorrhoea and any risk factor etc. It includes name of the health facility, in patient‘s number, name, and data of admission on the partograph, time of admission of the partograph, LNMP, EDD, WOA risk factors and time of rapture of membranes.

              FETAL CONDITION.

              This part of the graph is used to monitor and assess fetal condition.

              It consists of the following; fetal heart, membranes, liquor, molding and caporal.

              • Fetal heart; Listening to and recording feta heart is safe and reliable away of knowing that the fetus is well. It‘s recorded after every 30 minutes when a mother is active phase of labour .The normal range is between 120b/m to 160b/m.

              • Membranes; Liquor can assist in assessing the fetal condition.

                • If membranes are intact record 1 on the partograph.

                • If ruptured record R.

              • Liquor; The following are recorded about the color of liquor when membranes have ruptured;

                • If membranes rapture and liquor is clear: C
                • If membranes rupture and liquor is blood stained: B
                • If membranes rupture and liquor is Meconium stained: M
                • If membranes rupture and; liquor is absent: A
                • If membranes rupture and liquor is brown: B

                • Moulding; This indicates how well the cervix will accommodate the fetal head.

                    • Bones separatable, sutures can be felt easily. O
                    • Bones are flit fast touching each other. +
                    • Bones are overlapping but can be easily separated with pressure from your fingers ++
                    • Bones are overlapping but can not be separated easily with pressure from your fingers +++
                    • In ++ and +++ refer a mother if in a maternity centre or lower health facility in a hospital inform a Doctor.

                  •  

                  •  

                  •  

                  The labour progress.

                  Cervical dilation;

                  First stage of labour is divided into two; latent phase and active phase;-

                      1. Latent phase; This is a slow period of cervical dilation 0.3cm with gradual shortening of the cervix. It should not exceed 8hours.

                      1. Active phase; This is the faster period of cervical dilation from 4-10cm.

                    The cervix dilates at a rate of at least 1cm/hr.

                    Cervical dilation is plotted with letter X and vaginal examination is done every 4 hours from 4cm to 6cm.Then from 7cm after 3 hours, 8cm after 2hours, 9cm hourly.

                    If the progress of labour is satisfactory plotting of cervical dilation will remain on the left of the alertline. It should not cross the right of the action line. If cervical dilation is going towards or is on action line the mother is referred from the health centre, in the hospital and Dr is informed.

                    Desent of the head;

                    For labour to progress well, dilation of the cervix should be accompanied by desent of the head. For desent to occur at an expected rate the head should be well flexed. This is assessed abdominally.

                    Desent is plotted with O on the partograph.

                    Uterine contractions;

                    Good uterine contractions are necessary for progress of labour; normally contractions become more frequent and last longer as labour progresses and contraction are observed after every 30mins for frequency, strength and duration.

                    Maternal conditions;

                    All observations for a mother‘s condition are recorded at the bottom of the partograph e.g. temperature 4hours, pulse ½ hourly. B.P 2hourly, urine output 2hourly.

                    Drug, rehydration fluids, Oxytocin, if labour is augmented and analysis of proteins, sugar and acetones are cleared.

                    Out comes of labour;

                    This information is entered in a partograph after the mother has delivered e.g. Date of delivery, type of delivery, duration of 1st SOL and 2nd SOL, post delivery vitals, time of delivery of the placenta and membranes Oxytocin given, amount of blood loss, state of the

                    perineum whether intact has sustained a tear or episiotomy was made immediate post, partum care and treatment.

                    Only the baby;

                    Involves weight, sex, time of delivery, APGAR score, treatment given at birth, any physical abnormality and immediate care.

                    Observation / Nursing care;

                    Observation while the mother is coming; the gait whether normal stature, short indicates risk mothers.

                    General examination from head to toe to examine Anaemia, jaundice and oedema.

                    Abdominal examination; do systematically from the head to toes to find out the lie, presentation, position, level of descent, nature of contractions and fetal heart moulding if any.

                      1. Hygiene given; bath and a clean gown provided.
                      2. Records: All the information about the mother is charted on the record sheet.
                      3. Position: Mother is allowed to adopt any comfortable position especially sitting up position.
                      4. Ambulation: In early 1st SOL mother is allowed to move about where the midwife can observe her.
                      5. Nutrition: Mother is allowed to eat alight diet like porridge, but later in established 1st SOL she is given hot sweetened tea.
                      6. Care of the bladder: Mother is encouraged to empty the bladder after every 2hours and urine should be tested for any abnormality.
                      7. Rest and sleep: assist the mother by dimming off lights and control noise and visitors.
                      8. Prevention of infections: Ensure aseptic techniques and proper hygiene of the ward to prevent infections.
                      9. Bowel actions: Mother is encouraged to empty the bowel, move frequently and clean the bed pan if offered.
                    1.  

                    Write short notes on the following

                      1. Causes of pain in labour.
                      2. Factors that affect pain perception during
                      3. Observation done during fourth stage of Labour indicating importance of each.
                      4. List indications of ultra sound scan during

                    SOLUTIONS

                    LABOUR

                    Is the physiological process by which the fetus, placenta and membranes are expelled through the birth canal by the help of the mother‘s effort after 28 weeks of gestation and there are four stages of labour that is to say; first, second, third and fourth stage and there are two types of labour and that is normal and abnormal labour.

                    PAIN

                    Is a sensory /emotional experience of what the patient feels and there are two types of pain; somatic and visceral pain.

                    CAUSES OF PAIN

                    There are two major causes of pain;

                    • Hormonal factors
                    • Mechanical factors

                    Hormonal factors

                    These include;

                    • Oxytocin stimulation. This increases the strength, intensity, duration and frequency of the contractions leading to pain.
                    • Progesterone withdrawal. The reduced levels of progesterone lead to an increase in estrogen levels which stimulates the muscles of the deciduae muscles of the uterus to produce prostaglandin which stimulates the smooth muscles of the uterus to contract.

                    Mechanical factors

                    These include;

                    • Strength and frequency of Braxton hick‘s contractions occurring in late pregnancy which leads to over stretching of the uterus which irritates the uterine muscles to contract leading to pain.
                    • Pressure of the presenting part on the sacra-nerves and lumbar nerves which has pain receptor.
                    • Pressure of the presenting part on the cervix. The presenting part exerts pressure on the cervix muscles hence leading to pain.
                    • Displacement of the pelvic floor muscles. The advancing presenting part distends the vagina and displaces the pelvic floor muscles which are over stretched and the nerves are compressed leading to pain.

                    PART (B)

                    PERCEPTION.

                    Is the process of becoming aware of the environment through the five senses.

                    Factors that affect pain perception during labour

                    These factors are emotional experience involving physical and psychological mechanism and can be contributed by the mother, fetus, health workers and structural environment.

                    Mother

                    • Maternal medical; conditions like pre-eclampsia and eclampsia, cardiac conditions which can affect pain perception.
                    • Compromised immunity due to chronic conditions like HIV and cancer which can affect pain perception.
                    • Size of the pelvis. Any pelvic deviation from normal leading to cephalous pelvic disproportion which can affect pain perception.
                    • Age. Young prime gravidae below 18years their pelvic bones are not fully developed and the mother above 35years their pelvic bones are contracted and this hinders normal progress of labour and affects pain.
                    • Parity. Prime gravidae‘s their muscles are still intact and sensitive to pain which leads to strong contractions. The multipara mothers their muscles are laced which leads to uterine itial.
                    • Past obstetrical history like caesarian section which increases the risks of uterine rapture and affects normal labour
                    • Social economic factors for example lack of support which can affect pain perception.
                    • Cultural factors like use of native drugs can affect pain perception.
                    • Past experience can also affect pain perception
                    • Level of education, occupation, religion can also affect pain perception.

                    Fetus

                    • Fetal abnormalities like hydrocephalous, macrosomic babies can lead to cephalopelvic disproportion hence affecting pain.
                    • Lie, position and presenting pain can affect pain perception during labour
                    • Size of the fetus that is to say big babies which cannot pass through the pelvis hence affecting pain perception
                    • Gestation age. In past maturity the sutures and the fontanels are closing and molding can hot take place hence affecting pain perception.

                    Health workers

                    1. Poor screening of mothers during antenatal Poor management during labour
                    2. Poor attitude towards the mother

                    Structural environment

                    • Hospital setting where there is no privacy for mothers, all stages of labour in one room which can affect pain perception.
                    • Lack of recreation in labour rooms like newspapers, television to occupy the mothers.

                    PART (C)

                    Forth stage of labour

                    Is the 1-2 hours following third stage of labour. Observations done during the fourth stage of labour

                    To the mother

                    • Per vagina

                    Perineum to inspect for perineal tears, episiotomy and other injuries Bleeding to rule out anemia and post partner hemorrhage

                    • Per abdominal

                    Fundal height estimation to rule out the retained products of conception State of the uterus whether it has contracted

                    Bladder encourages the mother to pass urine to prevent PPH

                    • Vital observations like blood pressure, temperature, pulse, and respiration for consciousness of the mother to rule out pre –eclampsia and eclampsia, dehydration and
                    • Breast examination – to rule out abnormalities of the nipple which can hinder breast feeding like inverted nipples.
                    • Observe the bowel action if the bowel movements are present and able to pass out stool
                    • Observe the legs for varicose veins

                    To the baby

                    • Assessment of the baby after five minutes for example APGAR scoring the baby General examination of the baby to rule out abnormalities
                    • Observation of the cord for bleeding and well ligatured
                    • Bowel for passage of meconium to rule out anal impaction
                    • Observe if the baby is breast feeding for the presence of the sucking reflex.

                    PART (D)

                    Ultra- sound scan

                    Is a tool used in pregnancy and obstetrics generally for diagnosis. The system uses waves of sound that create images by bounding off and td safe to the developing fetus.

                    Methods

                    • Trans abdominal
                    • Trans vaginal

                    INDICATIONS

                    • To determine the gestation age
                    • To detect the sex of the baby
                    • To detect the fetal abnormalities
                    • To know the site of the placenta
                    • To determine the maturity where the dates are not accurate
                    • To rule out intra- uterine fetal death
                    • To rule out intra- fetal growth retardation
                    • To confirm pregnancy
                    • To asses amniotic fluid amount an order to rule out polyhydrominous and oligohydrominous
                    • To determine the causes of bleeding in pregnancy
                    • For detection of multiple pregnancies
                    • To determine the size of the baby
                    • For diagnostic purposes
                    • Improves the woman‘s pregnancy experience

                    For pelvic assessment.

                      • Plasma volume increase by 30% this results into hydraemia.
                      • Increased blood flow to the uterus to aid placental circulation by 10-15% or about 750mls per minute, kidneys for excretion of extra waste product of metabolism.

                      Identification of abnormalities that necessitate referral.

                        • History taking. A comprehensive history is taken on medical, surgical, past and present obstetrical, social and family history that may complicate or be complicated by pregnancy, labour and pueperium like diabetes, hypertension, epilepsy, sickle cell disease and accident involving the spine, pelvis and the lower limbs that will necessitate referral.

                        • Vital observations. Vital observations like blood pressure is taken to rule out conditions like pre-eclampsia that will necessitate referral.

                        • Physical examination. This is done to exclude conditions like anaemia, jundice, dehydration, oedema, malnutrition.
                        • External pelvic assessment. This is done especially from 36 weeks of gestation those mothers who have not delivered vaginally and prime gravidas by considering gait, stature, height and weight.

                        • Blood tests. Blood test like complete blood count(CBC),blood grouping and rhesus factor, venereal disease research laboratory test(VDRL),Random blood sugar (RBS),Routine counseling and testing(RCT) to rule out conditions like anaemia, rhesus incompatibility, syphilis, diabetes, HIV &Aids respectively that will necessitate referral.
                        • Urine test. Urinalysis is done at every visit to exclude the presence of glucose, protein and ketones in the urine which indicates conditions like diabetes, hypertensive disorders, urinary tract infection and unmet fetal demand respectively which necessitate referral.

                        • Breast examination. It is done to exclude conditions like breast abscess ,breast cancer and any abnormality of the breast that will necessitate referral.

                      Abdominal examination

                      On inspection. Observe the size and shape of the abdomen and previous scars that indicates condition like polyhydrominous and oligohydrominous and fresh previous scars that will necessitate referral.

                      On palpation. It is done to ascertain any abnormality like; Height of fundus not corresponding with gestational weeks, oblique and transverse lie, breech presentation at term especially prime gravidas and absence of fetal movement that will necessitate referral.

                      Auscultation. This is to exclude abnormal fetal heart tone, regularity, rhythm and absence of fetal heart that will necessitate referral.

                      1. Define a partograph.
                      2. What information is recorded on the partograph?
                      3. List the observations/ nursing care that can be done for a woman in first stage of labour but cannot be plotted on the partograph.

                      1.  

                      1.  

                      SOLUTIONS

                      A partograph is a tool used to monitor the progress of labour, condition of the fetus and the mother.

                      OR

                      Is the chart used to record all information and observations of a woman in labour/its a partogram before plotting and becomes a partograph after plotting.

                       A PARTOGRAPH IS STARTED

                        • When a woman is in active phase of labour that is 4cm or more of cervical opening.

                        • When the pregnancy of at least 30 completed weeks.

                        • When the presenting part is cephalic or breech.

                        • When there is no complication that needs immediate action.

                      THE INFORMATION RECORDED ON A PARTOGRAPH.

                      The following information is recorded on a partograph;

                      • Mothers demographic data.
                      • Fetal conditions
                      • Labour progress.
                      • Maternal condition.
                      • Outcome of labour.

                      MOTHERS DEMOGRAPHIC DATA

                      This is the first information entered on a partograph, this is essential as it helps a midwife to easily identify the mother she is following to know the weeks of Amenorrhoea and any risk factor etc. It includes name of the health facility, in patient‘s number, name, and data of admission on the partograph, time of admission of the partograph, LNMP, EDD, WOA risk factors and time of rapture of membranes.

                      FETAL CONDITION.

                      This part of the graph is used to monitor and assess fetal condition.

                      It consists of the following; fetal heart, membranes, liquor, molding and caporal.

                      • Fetal heart; Listening to and recording feta heart is safe and reliable away of knowing that the fetus is well. It‘s recorded after every 30 minutes when a mother is active phase of labour .The normal range is between 120b/m to 160b/m.

                      • Membranes; Liquor can assist in assessing the fetal condition.

                        • If membranes are intact record 1 on the partograph.

                        • If ruptured record R.

                      • Liquor; The following are recorded about the color of liquor when membranes have ruptured;

                      • If membranes rapture and liquor is clear: C
                      • If membranes rupture and liquor is blood stained: B
                      • If membranes rupture and liquor is Meconium stained: M
                      • If membranes rupture and; liquor is absent: A
                      • If membranes rupture and liquor is brown: B

                      • Moulding; This indicates how well the cervix will accommodate the fetal head.

                        • Bones separatable, sutures can be felt easily. O
                        • Bones are flit fast touching each other. +
                        • Bones are overlapping but can be easily separated with pressure from your fingers ++
                        • Bones are overlapping but can not be separated easily with pressure from your fingers +++
                        • In ++ and +++ refer a mother if in a maternity centre or lower health facility in a hospital inform a Doctor.

                      •  

                      •  

                      •  

                      The labour progress.

                      Cervical dilation;

                      First stage of labour is divided into two; latent phase and active phase;-

                        1. Latent phase; This is a slow period of cervical dilation 0.3cm with gradual shortening of the cervix. It should not exceed 8hours.

                        1. Active phase; This is the faster period of cervical dilation from 4-10cm.

                      The cervix dilates at a rate of at least 1cm/hr.

                      Cervical dilation is plotted with letter X and vaginal examination is done every 4 hours from 4cm to 6cm.Then from 7cm after 3 hours, 8cm after 2hours, 9cm hourly.

                      If the progress of labour is satisfactory plotting of cervical dilation will remain on the left of the alertline. It should not cross the right of the action line. If cervical dilation is going towards or is on action line the mother is referred from the health centre, in the hospital and Dr is informed.

                      Desent of the head;

                      For labour to progress well, dilation of the cervix should be accompanied by desent of the head. For desent to occur at an expected rate the head should be well flexed. This is assessed abdominally.

                      Desent is plotted with O on the partograph.

                      Uterine contractions;

                      Good uterine contractions are necessary for progress of labour; normally contractions become more frequent and last longer as labour progresses and contraction are observed after every 30mins for frequency, strength and duration.

                      Maternal conditions;

                      All observations for a mother‘s condition are recorded at the bottom of the partograph e.g. temperature 4hours, pulse ½ hourly. B.P 2hourly, urine output 2hourly.

                      Drug, rehydration fluids, Oxytocin, if labour is augmented and analysis of proteins, sugar and acetones are cleared.

                      Out comes of labour;

                      This information is entered in a partograph after the mother has delivered e.g. Date of delivery, type of delivery, duration of 1st SOL and 2nd SOL, post delivery vitals, time of delivery of the placenta and membranes Oxytocin given, amount of blood loss, state of the

                      perineum whether intact has sustained a tear or episiotomy was made immediate post, partum care and treatment.

                      Only the baby;

                      Involves weight, sex, time of delivery, APGAR score, treatment given at birth, any physical abnormality and immediate care.

                      Observation / Nursing care;

                      Observation while the mother is coming; the gait whether normal stature, short indicates risk mothers.

                      General examination from head to toe to examine Anaemia, jaundice and oedema.

                      Abdominal examination; do systematically from the head to toes to find out the lie, presentation, position, level of descent, nature of contractions and fetal heart moulding if any.

                        1. Hygiene given; bath and a clean gown provided.
                        2. Records: All the information about the mother is charted on the record sheet.
                        3. Position: Mother is allowed to adopt any comfortable position especially sitting up position.
                        4. Ambulation: In early 1st SOL mother is allowed to move about where the midwife can observe her.
                        5. Nutrition: Mother is allowed to eat alight diet like porridge, but later in established 1st SOL she is given hot sweetened tea.
                        6. Care of the bladder: Mother is encouraged to empty the bladder after every 2hours and urine should be tested for any abnormality.
                        7. Rest and sleep: assist the mother by dimming off lights and control noise and visitors.
                        8. Prevention of infections: Ensure aseptic techniques and proper hygiene of the ward to prevent infections.
                        9. Bowel actions: Mother is encouraged to empty the bowel, move frequently and clean the bed pan if offered.
                      1.  

                      Write short notes on the following

                        1. Causes of pain in labour.
                        2. Factors that affect pain perception during
                        3. Observation done during fourth stage of Labour indicating importance of each.
                        4. List indications of ultra sound scan during

                      SOLUTIONS

                      LABOUR

                      Is the physiological process by which the fetus, placenta and membranes are expelled through the birth canal by the help of the mother‘s effort after 28 weeks of gestation and there are four stages of labour that is to say; first, second, third and fourth stage and there are two types of labour and that is normal and abnormal labour.

                      PAIN

                      Is a sensory /emotional experience of what the patient feels and there are two types of pain; somatic and visceral pain.

                      CAUSES OF PAIN

                      There are two major causes of pain;

                      • Hormonal factors
                      • Mechanical factors

                      Hormonal factors

                      These include;

                      • Oxytocin stimulation. This increases the strength, intensity, duration and frequency of the contractions leading to pain.
                      • Progesterone withdrawal. The reduced levels of progesterone lead to an increase in estrogen levels which stimulates the muscles of the deciduae muscles of the uterus to produce prostaglandin which stimulates the smooth muscles of the uterus to contract.

                      Mechanical factors

                      These include;

                      • Strength and frequency of Braxton hick‘s contractions occurring in late pregnancy which leads to over stretching of the uterus which irritates the uterine muscles to contract leading to pain.
                      • Pressure of the presenting part on the sacra-nerves and lumbar nerves which has pain receptor.
                      • Pressure of the presenting part on the cervix. The presenting part exerts pressure on the cervix muscles hence leading to pain.
                      • Displacement of the pelvic floor muscles. The advancing presenting part distends the vagina and displaces the pelvic floor muscles which are over stretched and the nerves are compressed leading to pain.

                      PART (B)

                      PERCEPTION.

                      Is the process of becoming aware of the environment through the five senses.

                      Factors that affect pain perception during labour

                      These factors are emotional experience involving physical and psychological mechanism and can be contributed by the mother, fetus, health workers and structural environment.

                      Mother

                      • Maternal medical; conditions like pre-eclampsia and eclampsia, cardiac conditions which can affect pain perception.
                      • Compromised immunity due to chronic conditions like HIV and cancer which can affect pain perception.
                      • Size of the pelvis. Any pelvic deviation from normal leading to cephalous pelvic disproportion which can affect pain perception.
                      • Age. Young prime gravidae below 18years their pelvic bones are not fully developed and the mother above 35years their pelvic bones are contracted and this hinders normal progress of labour and affects pain.
                      • Parity. Prime gravidae‘s their muscles are still intact and sensitive to pain which leads to strong contractions. The multipara mothers their muscles are laced which leads to uterine itial.
                      • Past obstetrical history like caesarian section which increases the risks of uterine rapture and affects normal labour
                      • Social economic factors for example lack of support which can affect pain perception.
                      • Cultural factors like use of native drugs can affect pain perception.
                      • Past experience can also affect pain perception
                      • Level of education, occupation, religion can also affect pain perception.

                      Fetus

                      • Fetal abnormalities like hydrocephalous, macrosomic babies can lead to cephalopelvic disproportion hence affecting pain.
                      • Lie, position and presenting pain can affect pain perception during labour
                      • Size of the fetus that is to say big babies which cannot pass through the pelvis hence affecting pain perception
                      • Gestation age. In past maturity the sutures and the fontanels are closing and molding can hot take place hence affecting pain perception.

                      Health workers

                      1. Poor screening of mothers during antenatal Poor management during labour
                      2. Poor attitude towards the mother

                      Structural environment

                      • Hospital setting where there is no privacy for mothers, all stages of labour in one room which can affect pain perception.
                      • Lack of recreation in labour rooms like newspapers, television to occupy the mothers.

                      PART (C)

                      Forth stage of labour

                      Is the 1-2 hours following third stage of labour. Observations done during the fourth stage of labour

                      To the mother

                      • Per vagina

                      Perineum to inspect for perineal tears, episiotomy and other injuries Bleeding to rule out anemia and post partner hemorrhage

                      • Per abdominal

                      Fundal height estimation to rule out the retained products of conception State of the uterus whether it has contracted

                      Bladder encourages the mother to pass urine to prevent PPH

                      • Vital observations like blood pressure, temperature, pulse, and respiration for consciousness of the mother to rule out pre –eclampsia and eclampsia, dehydration and
                      • Breast examination – to rule out abnormalities of the nipple which can hinder breast feeding like inverted nipples.
                      • Observe the bowel action if the bowel movements are present and able to pass out stool
                      • Observe the legs for varicose veins

                      To the baby

                      • Assessment of the baby after five minutes for example APGAR scoring the baby General examination of the baby to rule out abnormalities
                      • Observation of the cord for bleeding and well ligatured
                      • Bowel for passage of meconium to rule out anal impaction
                      • Observe if the baby is breast feeding for the presence of the sucking reflex.

                      PART (D)

                      Ultra- sound scan

                      Is a tool used in pregnancy and obstetrics generally for diagnosis. The system uses waves of sound that create images by bounding off and td safe to the developing fetus.

                      Methods

                      • Trans abdominal
                      • Trans vaginal

                      INDICATIONS

                      • To determine the gestation age
                      • To detect the sex of the baby
                      • To detect the fetal abnormalities
                      • To know the site of the placenta
                      • To determine the maturity where the dates are not accurate
                      • To rule out intra- uterine fetal death
                      • To rule out intra- fetal growth retardation
                      • To confirm pregnancy
                      • To asses amniotic fluid amount an order to rule out polyhydrominous and oligohydrominous
                      • To determine the causes of bleeding in pregnancy
                      • For detection of multiple pregnancies
                      • To determine the size of the baby
                      • For diagnostic purposes
                      • Improves the woman‘s pregnancy experience

                      For pelvic assessment.

                      Identification of abnormalities that necessitate referral.

                      Abdominal examination

                      On inspection. Observe the size and shape of the abdomen and previous scars that indicates condition like polyhydrominous and oligohydrominous and fresh previous scars that will necessitate referral.

                      On palpation. It is done to ascertain any abnormality like; Height of fundus not corresponding with gestational weeks, oblique and transverse lie, breech presentation at term especially prime gravidas and absence of fetal movement that will necessitate referral.

                      Auscultation. This is to exclude abnormal fetal heart tone, regularity, rhythm and absence of fetal heart that will necessitate referral.

                      1. Define a partograph.
                      2. What information is recorded on the partograph?
                      3. List the observations/ nursing care that can be done for a woman in first stage of labour but cannot be plotted on the partograph.

                      1.  

                      1.  

                      SOLUTIONS

                      A partograph is a tool used to monitor the progress of labour, condition of the fetus and the mother.

                      OR

                      Is the chart used to record all information and observations of a woman in labour/its a partogram before plotting and becomes a partograph after plotting.

                       A PARTOGRAPH IS STARTED

                        • When a woman is in active phase of labour that is 4cm or more of cervical opening.

                        • When the pregnancy of at least 30 completed weeks.

                        • When the presenting part is cephalic or breech.

                        • When there is no complication that needs immediate action.

                      THE INFORMATION RECORDED ON A PARTOGRAPH.

                      The following information is recorded on a partograph;

                      • Mothers demographic data.
                      • Fetal conditions
                      • Labour progress.
                      • Maternal condition.
                      • Outcome of labour.

                      MOTHERS DEMOGRAPHIC DATA

                      This is the first information entered on a partograph, this is essential as it helps a midwife to easily identify the mother she is following to know the weeks of Amenorrhoea and any risk factor etc. It includes name of the health facility, in patient‘s number, name, and data of admission on the partograph, time of admission of the partograph, LNMP, EDD, WOA risk factors and time of rapture of membranes.

                      FETAL CONDITION.

                      This part of the graph is used to monitor and assess fetal condition.

                      It consists of the following; fetal heart, membranes, liquor, molding and caporal.

                      • Fetal heart; Listening to and recording feta heart is safe and reliable away of knowing that the fetus is well. It‘s recorded after every 30 minutes when a mother is active phase of labour .The normal range is between 120b/m to 160b/m.

                      • Membranes; Liquor can assist in assessing the fetal condition.

                        • If membranes are intact record 1 on the partograph.

                        • If ruptured record R.

                      • Liquor; The following are recorded about the color of liquor when membranes have ruptured;

                      • If membranes rapture and liquor is clear: C
                      • If membranes rupture and liquor is blood stained: B
                      • If membranes rupture and liquor is Meconium stained: M
                      • If membranes rupture and; liquor is absent: A
                      • If membranes rupture and liquor is brown: B

                      • Moulding; This indicates how well the cervix will accommodate the fetal head.

                        • Bones separatable, sutures can be felt easily. O
                        • Bones are flit fast touching each other. +
                        • Bones are overlapping but can be easily separated with pressure from your fingers ++
                        • Bones are overlapping but can not be separated easily with pressure from your fingers +++
                        • In ++ and +++ refer a mother if in a maternity centre or lower health facility in a hospital inform a Doctor.

                      •  

                      •  

                      •  

                      The labour progress.

                      Cervical dilation;

                      First stage of labour is divided into two; latent phase and active phase;-

                        1. Latent phase; This is a slow period of cervical dilation 0.3cm with gradual shortening of the cervix. It should not exceed 8hours.

                        1. Active phase; This is the faster period of cervical dilation from 4-10cm.

                      The cervix dilates at a rate of at least 1cm/hr.

                      Cervical dilation is plotted with letter X and vaginal examination is done every 4 hours from 4cm to 6cm.Then from 7cm after 3 hours, 8cm after 2hours, 9cm hourly.

                      If the progress of labour is satisfactory plotting of cervical dilation will remain on the left of the alertline. It should not cross the right of the action line. If cervical dilation is going towards or is on action line the mother is referred from the health centre, in the hospital and Dr is informed.

                      Desent of the head;

                      For labour to progress well, dilation of the cervix should be accompanied by desent of the head. For desent to occur at an expected rate the head should be well flexed. This is assessed abdominally.

                      Desent is plotted with O on the partograph.

                      Uterine contractions;

                      Good uterine contractions are necessary for progress of labour; normally contractions become more frequent and last longer as labour progresses and contraction are observed after every 30mins for frequency, strength and duration.

                      Maternal conditions;

                      All observations for a mother‘s condition are recorded at the bottom of the partograph e.g. temperature 4hours, pulse ½ hourly. B.P 2hourly, urine output 2hourly.

                      Drug, rehydration fluids, Oxytocin, if labour is augmented and analysis of proteins, sugar and acetones are cleared.

                      Out comes of labour;

                      This information is entered in a partograph after the mother has delivered e.g. Date of delivery, type of delivery, duration of 1st SOL and 2nd SOL, post delivery vitals, time of delivery of the placenta and membranes Oxytocin given, amount of blood loss, state of the

                      perineum whether intact has sustained a tear or episiotomy was made immediate post, partum care and treatment.

                      Only the baby;

                      Involves weight, sex, time of delivery, APGAR score, treatment given at birth, any physical abnormality and immediate care.

                      Observation / Nursing care;

                      Observation while the mother is coming; the gait whether normal stature, short indicates risk mothers.

                      General examination from head to toe to examine Anaemia, jaundice and oedema.

                      Abdominal examination; do systematically from the head to toes to find out the lie, presentation, position, level of descent, nature of contractions and fetal heart moulding if any.

                        1. Hygiene given; bath and a clean gown provided.
                        2. Records: All the information about the mother is charted on the record sheet.
                        3. Position: Mother is allowed to adopt any comfortable position especially sitting up position.
                        4. Ambulation: In early 1st SOL mother is allowed to move about where the midwife can observe her.
                        5. Nutrition: Mother is allowed to eat alight diet like porridge, but later in established 1st SOL she is given hot sweetened tea.
                        6. Care of the bladder: Mother is encouraged to empty the bladder after every 2hours and urine should be tested for any abnormality.
                        7. Rest and sleep: assist the mother by dimming off lights and control noise and visitors.
                        8. Prevention of infections: Ensure aseptic techniques and proper hygiene of the ward to prevent infections.
                        9. Bowel actions: Mother is encouraged to empty the bowel, move frequently and clean the bed pan if offered.
                      1.  

                      Write short notes on the following

                        1. Causes of pain in labour.
                        2. Factors that affect pain perception during
                        3. Observation done during fourth stage of Labour indicating importance of each.
                        4. List indications of ultra sound scan during

                      SOLUTIONS

                      LABOUR

                      Is the physiological process by which the fetus, placenta and membranes are expelled through the birth canal by the help of the mother‘s effort after 28 weeks of gestation and there are four stages of labour that is to say; first, second, third and fourth stage and there are two types of labour and that is normal and abnormal labour.

                      PAIN

                      Is a sensory /emotional experience of what the patient feels and there are two types of pain; somatic and visceral pain.

                      CAUSES OF PAIN

                      There are two major causes of pain;

                      • Hormonal factors
                      • Mechanical factors

                      Hormonal factors

                      These include;

                      • Oxytocin stimulation. This increases the strength, intensity, duration and frequency of the contractions leading to pain.
                      • Progesterone withdrawal. The reduced levels of progesterone lead to an increase in estrogen levels which stimulates the muscles of the deciduae muscles of the uterus to produce prostaglandin which stimulates the smooth muscles of the uterus to contract.

                      Mechanical factors

                      These include;

                      • Strength and frequency of Braxton hick‘s contractions occurring in late pregnancy which leads to over stretching of the uterus which irritates the uterine muscles to contract leading to pain.
                      • Pressure of the presenting part on the sacra-nerves and lumbar nerves which has pain receptor.
                      • Pressure of the presenting part on the cervix. The presenting part exerts pressure on the cervix muscles hence leading to pain.
                      • Displacement of the pelvic floor muscles. The advancing presenting part distends the vagina and displaces the pelvic floor muscles which are over stretched and the nerves are compressed leading to pain.

                      PART (B)

                      PERCEPTION.

                      Is the process of becoming aware of the environment through the five senses.

                      Factors that affect pain perception during labour

                      These factors are emotional experience involving physical and psychological mechanism and can be contributed by the mother, fetus, health workers and structural environment.

                      Mother

                      • Maternal medical; conditions like pre-eclampsia and eclampsia, cardiac conditions which can affect pain perception.
                      • Compromised immunity due to chronic conditions like HIV and cancer which can affect pain perception.
                      • Size of the pelvis. Any pelvic deviation from normal leading to cephalous pelvic disproportion which can affect pain perception.
                      • Age. Young prime gravidae below 18years their pelvic bones are not fully developed and the mother above 35years their pelvic bones are contracted and this hinders normal progress of labour and affects pain.
                      • Parity. Prime gravidae‘s their muscles are still intact and sensitive to pain which leads to strong contractions. The multipara mothers their muscles are laced which leads to uterine itial.
                      • Past obstetrical history like caesarian section which increases the risks of uterine rapture and affects normal labour
                      • Social economic factors for example lack of support which can affect pain perception.
                      • Cultural factors like use of native drugs can affect pain perception.
                      • Past experience can also affect pain perception
                      • Level of education, occupation, religion can also affect pain perception.

                      Fetus

                      • Fetal abnormalities like hydrocephalous, macrosomic babies can lead to cephalopelvic disproportion hence affecting pain.
                      • Lie, position and presenting pain can affect pain perception during labour
                      • Size of the fetus that is to say big babies which cannot pass through the pelvis hence affecting pain perception
                      • Gestation age. In past maturity the sutures and the fontanels are closing and molding can hot take place hence affecting pain perception.

                      Health workers

                      1. Poor screening of mothers during antenatal Poor management during labour
                      2. Poor attitude towards the mother

                      Structural environment

                      • Hospital setting where there is no privacy for mothers, all stages of labour in one room which can affect pain perception.
                      • Lack of recreation in labour rooms like newspapers, television to occupy the mothers.

                      PART (C)

                      Forth stage of labour

                      Is the 1-2 hours following third stage of labour. Observations done during the fourth stage of labour

                      To the mother

                      • Per vagina

                      Perineum to inspect for perineal tears, episiotomy and other injuries Bleeding to rule out anemia and post partner hemorrhage

                      • Per abdominal

                      Fundal height estimation to rule out the retained products of conception State of the uterus whether it has contracted

                      Bladder encourages the mother to pass urine to prevent PPH

                      • Vital observations like blood pressure, temperature, pulse, and respiration for consciousness of the mother to rule out pre –eclampsia and eclampsia, dehydration and
                      • Breast examination – to rule out abnormalities of the nipple which can hinder breast feeding like inverted nipples.
                      • Observe the bowel action if the bowel movements are present and able to pass out stool
                      • Observe the legs for varicose veins

                      To the baby

                      • Assessment of the baby after five minutes for example APGAR scoring the baby General examination of the baby to rule out abnormalities
                      • Observation of the cord for bleeding and well ligatured
                      • Bowel for passage of meconium to rule out anal impaction
                      • Observe if the baby is breast feeding for the presence of the sucking reflex.

                      PART (D)

                      Ultra- sound scan

                      Is a tool used in pregnancy and obstetrics generally for diagnosis. The system uses waves of sound that create images by bounding off and td safe to the developing fetus.

                      Methods

                      • Trans abdominal
                      • Trans vaginal

                      INDICATIONS

                      • To determine the gestation age
                      • To detect the sex of the baby
                      • To detect the fetal abnormalities
                      • To know the site of the placenta
                      • To determine the maturity where the dates are not accurate
                      • To rule out intra- uterine fetal death
                      • To rule out intra- fetal growth retardation
                      • To confirm pregnancy
                      • To asses amniotic fluid amount an order to rule out polyhydrominous and oligohydrominous
                      • To determine the causes of bleeding in pregnancy
                      • For detection of multiple pregnancies
                      • To determine the size of the baby
                      • For diagnostic purposes
                      • Improves the woman‘s pregnancy experience

                      For pelvic assessment.

                        1.  

                        Normal pregnancy

                        Is the growth and development of the fetus into the uterine cavity without any complication.

                        Pregnancy: Refers to growth and development of the fetus into the body.

                        Circulatory system: Is the transport system that deals with movement of nutrients, hormones, gases and waste products of metabolism into and out of the body cells and tissues.

                        Referral: This is the process of transferring or forwarding clients or patients from a lower health unit to a higher unit for further management.

                        Characteristics of normal pregnancy

                        Changes that takes place in the circulatory system during pregnancy.

                        Heart

                        Blood vessels

                        Blood

                        Identification of abnormalities that necessitate referral.

                        Abdominal examination

                        On inspection. Observe the size and shape of the abdomen and previous scars that indicates condition like polyhydrominous and oligohydrominous and fresh previous scars that will necessitate referral.

                        On palpation. It is done to ascertain any abnormality like; Height of fundus not corresponding with gestational weeks, oblique and transverse lie, breech presentation at term especially prime gravidas and absence of fetal movement that will necessitate referral.

                        Auscultation. This is to exclude abnormal fetal heart tone, regularity, rhythm and absence of fetal heart that will necessitate referral.

                        1. Define a partograph.
                        2. What information is recorded on the partograph?
                        3. List the observations/ nursing care that can be done for a woman in first stage of labour but cannot be plotted on the partograph.

                        1.  

                        1.  

                        SOLUTIONS

                        A partograph is a tool used to monitor the progress of labour, condition of the fetus and the mother.

                        OR

                        Is the chart used to record all information and observations of a woman in labour/its a partogram before plotting and becomes a partograph after plotting.

                         A PARTOGRAPH IS STARTED

                          • When a woman is in active phase of labour that is 4cm or more of cervical opening.

                          • When the pregnancy of at least 30 completed weeks.

                          • When the presenting part is cephalic or breech.

                          • When there is no complication that needs immediate action.

                        THE INFORMATION RECORDED ON A PARTOGRAPH.

                        The following information is recorded on a partograph;

                        • Mothers demographic data.
                        • Fetal conditions
                        • Labour progress.
                        • Maternal condition.
                        • Outcome of labour.

                        MOTHERS DEMOGRAPHIC DATA

                        This is the first information entered on a partograph, this is essential as it helps a midwife to easily identify the mother she is following to know the weeks of Amenorrhoea and any risk factor etc. It includes name of the health facility, in patient‘s number, name, and data of admission on the partograph, time of admission of the partograph, LNMP, EDD, WOA risk factors and time of rapture of membranes.

                        FETAL CONDITION.

                        This part of the graph is used to monitor and assess fetal condition.

                        It consists of the following; fetal heart, membranes, liquor, molding and caporal.

                        • Fetal heart; Listening to and recording feta heart is safe and reliable away of knowing that the fetus is well. It‘s recorded after every 30 minutes when a mother is active phase of labour .The normal range is between 120b/m to 160b/m.

                        • Membranes; Liquor can assist in assessing the fetal condition.

                          • If membranes are intact record 1 on the partograph.

                          • If ruptured record R.

                        • Liquor; The following are recorded about the color of liquor when membranes have ruptured;

                        • If membranes rapture and liquor is clear: C
                        • If membranes rupture and liquor is blood stained: B
                        • If membranes rupture and liquor is Meconium stained: M
                        • If membranes rupture and; liquor is absent: A
                        • If membranes rupture and liquor is brown: B

                        • Moulding; This indicates how well the cervix will accommodate the fetal head.

                          • Bones separatable, sutures can be felt easily. O
                          • Bones are flit fast touching each other. +
                          • Bones are overlapping but can be easily separated with pressure from your fingers ++
                          • Bones are overlapping but can not be separated easily with pressure from your fingers +++
                          • In ++ and +++ refer a mother if in a maternity centre or lower health facility in a hospital inform a Doctor.

                        •  

                        •  

                        •  

                        The labour progress.

                        Cervical dilation;

                        First stage of labour is divided into two; latent phase and active phase;-

                          1. Latent phase; This is a slow period of cervical dilation 0.3cm with gradual shortening of the cervix. It should not exceed 8hours.

                          1. Active phase; This is the faster period of cervical dilation from 4-10cm.

                        The cervix dilates at a rate of at least 1cm/hr.

                        Cervical dilation is plotted with letter X and vaginal examination is done every 4 hours from 4cm to 6cm.Then from 7cm after 3 hours, 8cm after 2hours, 9cm hourly.

                        If the progress of labour is satisfactory plotting of cervical dilation will remain on the left of the alertline. It should not cross the right of the action line. If cervical dilation is going towards or is on action line the mother is referred from the health centre, in the hospital and Dr is informed.

                        Desent of the head;

                        For labour to progress well, dilation of the cervix should be accompanied by desent of the head. For desent to occur at an expected rate the head should be well flexed. This is assessed abdominally.

                        Desent is plotted with O on the partograph.

                        Uterine contractions;

                        Good uterine contractions are necessary for progress of labour; normally contractions become more frequent and last longer as labour progresses and contraction are observed after every 30mins for frequency, strength and duration.

                        Maternal conditions;

                        All observations for a mother‘s condition are recorded at the bottom of the partograph e.g. temperature 4hours, pulse ½ hourly. B.P 2hourly, urine output 2hourly.

                        Drug, rehydration fluids, Oxytocin, if labour is augmented and analysis of proteins, sugar and acetones are cleared.

                        Out comes of labour;

                        This information is entered in a partograph after the mother has delivered e.g. Date of delivery, type of delivery, duration of 1st SOL and 2nd SOL, post delivery vitals, time of delivery of the placenta and membranes Oxytocin given, amount of blood loss, state of the

                        perineum whether intact has sustained a tear or episiotomy was made immediate post, partum care and treatment.

                        Only the baby;

                        Involves weight, sex, time of delivery, APGAR score, treatment given at birth, any physical abnormality and immediate care.

                        Observation / Nursing care;

                        Observation while the mother is coming; the gait whether normal stature, short indicates risk mothers.

                        General examination from head to toe to examine Anaemia, jaundice and oedema.

                        Abdominal examination; do systematically from the head to toes to find out the lie, presentation, position, level of descent, nature of contractions and fetal heart moulding if any.

                          1. Hygiene given; bath and a clean gown provided.
                          2. Records: All the information about the mother is charted on the record sheet.
                          3. Position: Mother is allowed to adopt any comfortable position especially sitting up position.
                          4. Ambulation: In early 1st SOL mother is allowed to move about where the midwife can observe her.
                          5. Nutrition: Mother is allowed to eat alight diet like porridge, but later in established 1st SOL she is given hot sweetened tea.
                          6. Care of the bladder: Mother is encouraged to empty the bladder after every 2hours and urine should be tested for any abnormality.
                          7. Rest and sleep: assist the mother by dimming off lights and control noise and visitors.
                          8. Prevention of infections: Ensure aseptic techniques and proper hygiene of the ward to prevent infections.
                          9. Bowel actions: Mother is encouraged to empty the bowel, move frequently and clean the bed pan if offered.
                        1.  

                        Write short notes on the following

                          1. Causes of pain in labour.
                          2. Factors that affect pain perception during
                          3. Observation done during fourth stage of Labour indicating importance of each.
                          4. List indications of ultra sound scan during

                        SOLUTIONS

                        LABOUR

                        Is the physiological process by which the fetus, placenta and membranes are expelled through the birth canal by the help of the mother‘s effort after 28 weeks of gestation and there are four stages of labour that is to say; first, second, third and fourth stage and there are two types of labour and that is normal and abnormal labour.

                        PAIN

                        Is a sensory /emotional experience of what the patient feels and there are two types of pain; somatic and visceral pain.

                        CAUSES OF PAIN

                        There are two major causes of pain;

                        • Hormonal factors
                        • Mechanical factors

                        Hormonal factors

                        These include;

                        • Oxytocin stimulation. This increases the strength, intensity, duration and frequency of the contractions leading to pain.
                        • Progesterone withdrawal. The reduced levels of progesterone lead to an increase in estrogen levels which stimulates the muscles of the deciduae muscles of the uterus to produce prostaglandin which stimulates the smooth muscles of the uterus to contract.

                        Mechanical factors

                        These include;

                        • Strength and frequency of Braxton hick‘s contractions occurring in late pregnancy which leads to over stretching of the uterus which irritates the uterine muscles to contract leading to pain.
                        • Pressure of the presenting part on the sacra-nerves and lumbar nerves which has pain receptor.
                        • Pressure of the presenting part on the cervix. The presenting part exerts pressure on the cervix muscles hence leading to pain.
                        • Displacement of the pelvic floor muscles. The advancing presenting part distends the vagina and displaces the pelvic floor muscles which are over stretched and the nerves are compressed leading to pain.

                        PART (B)

                        PERCEPTION.

                        Is the process of becoming aware of the environment through the five senses.

                        Factors that affect pain perception during labour

                        These factors are emotional experience involving physical and psychological mechanism and can be contributed by the mother, fetus, health workers and structural environment.

                        Mother

                        • Maternal medical; conditions like pre-eclampsia and eclampsia, cardiac conditions which can affect pain perception.
                        • Compromised immunity due to chronic conditions like HIV and cancer which can affect pain perception.
                        • Size of the pelvis. Any pelvic deviation from normal leading to cephalous pelvic disproportion which can affect pain perception.
                        • Age. Young prime gravidae below 18years their pelvic bones are not fully developed and the mother above 35years their pelvic bones are contracted and this hinders normal progress of labour and affects pain.
                        • Parity. Prime gravidae‘s their muscles are still intact and sensitive to pain which leads to strong contractions. The multipara mothers their muscles are laced which leads to uterine itial.
                        • Past obstetrical history like caesarian section which increases the risks of uterine rapture and affects normal labour
                        • Social economic factors for example lack of support which can affect pain perception.
                        • Cultural factors like use of native drugs can affect pain perception.
                        • Past experience can also affect pain perception
                        • Level of education, occupation, religion can also affect pain perception.

                        Fetus

                        • Fetal abnormalities like hydrocephalous, macrosomic babies can lead to cephalopelvic disproportion hence affecting pain.
                        • Lie, position and presenting pain can affect pain perception during labour
                        • Size of the fetus that is to say big babies which cannot pass through the pelvis hence affecting pain perception
                        • Gestation age. In past maturity the sutures and the fontanels are closing and molding can hot take place hence affecting pain perception.

                        Health workers

                        1. Poor screening of mothers during antenatal Poor management during labour
                        2. Poor attitude towards the mother

                        Structural environment

                        • Hospital setting where there is no privacy for mothers, all stages of labour in one room which can affect pain perception.
                        • Lack of recreation in labour rooms like newspapers, television to occupy the mothers.

                        PART (C)

                        Forth stage of labour

                        Is the 1-2 hours following third stage of labour. Observations done during the fourth stage of labour

                        To the mother

                        • Per vagina

                        Perineum to inspect for perineal tears, episiotomy and other injuries Bleeding to rule out anemia and post partner hemorrhage

                        • Per abdominal

                        Fundal height estimation to rule out the retained products of conception State of the uterus whether it has contracted

                        Bladder encourages the mother to pass urine to prevent PPH

                        • Vital observations like blood pressure, temperature, pulse, and respiration for consciousness of the mother to rule out pre –eclampsia and eclampsia, dehydration and
                        • Breast examination – to rule out abnormalities of the nipple which can hinder breast feeding like inverted nipples.
                        • Observe the bowel action if the bowel movements are present and able to pass out stool
                        • Observe the legs for varicose veins

                        To the baby

                        • Assessment of the baby after five minutes for example APGAR scoring the baby General examination of the baby to rule out abnormalities
                        • Observation of the cord for bleeding and well ligatured
                        • Bowel for passage of meconium to rule out anal impaction
                        • Observe if the baby is breast feeding for the presence of the sucking reflex.

                        PART (D)

                        Ultra- sound scan

                        Is a tool used in pregnancy and obstetrics generally for diagnosis. The system uses waves of sound that create images by bounding off and td safe to the developing fetus.

                        Methods

                        • Trans abdominal
                        • Trans vaginal

                        INDICATIONS

                        • To determine the gestation age
                        • To detect the sex of the baby
                        • To detect the fetal abnormalities
                        • To know the site of the placenta
                        • To determine the maturity where the dates are not accurate
                        • To rule out intra- uterine fetal death
                        • To rule out intra- fetal growth retardation
                        • To confirm pregnancy
                        • To asses amniotic fluid amount an order to rule out polyhydrominous and oligohydrominous
                        • To determine the causes of bleeding in pregnancy
                        • For detection of multiple pregnancies
                        • To determine the size of the baby
                        • For diagnostic purposes
                        • Improves the woman‘s pregnancy experience

                        For pelvic assessment.

                          1. What may make you refer this mother to hospital during first stage of labour? 
                          2. Outline the changes that take place in the uterus during the first stage of labour.
                          3. Explain how you would admit a mother who has reported in active phase of first stage.

                            SOLUTIONS

                            During the first stage of labour the following occurs:

                                1. Effacement or take up of the cervix: this is made possible by the work of muscle fibres surrounding the internal OS which are drawn upward by the retracted upper segment.
                                2. Pacemaker / Fundal dominance: each contraction begins from the pace maker situated at the cornua of the uterus. From the fundal region it spreads downwards being stronger and persisting longer in the upper region on reaching the lower region, the wave of contraction weakens and allows the cervix to dilate.
                                3. Dilatation of the cervix: this is the opening of the external OS to allow the passage of the fetal head; it occurs as a result of uterine action and the pressure from fore bag of waters and the well fitting presenting part
                                4. Contraction and Retraction: is the special ability of the uterine muscle where the contraction does not pass off completely and the muscle fibres retaining some of the contractions do not become completely relaxed instead they become gradually shorter and thicker.
                                5. Polarity: is the term used to define the coordination between two poles of uterus throughout labour
                                6. Development of upper and lower segment: the upper uterine segment is the thicker muscular contractile part. The lower part segment is the firm distensible are of 7.5cm – 10cm in length developed from isthmus to the uterus.
                                7. Development of retraction ring: is the ridge formed between the upper and the lower uterine segment. It‘s present in labour and normal as long as it‘s not marked enough to be visible above the symphysis pubis.   NB: It is called bandl‘s ring in obstructed labour
                                8. Show: is the blood stained mucoid discharge seen a few hours within or a few hours after when labour has started
                                9. General fluid pressure: while the membranes remain intact, the pressure of the uterine contraction is exerted on the fluid as the fluid is not compressible the pressure is equalized throughout the uterus.
                                10. Rupture of membranes: rupture of membranes may be early or later during the second stage of labour due to the malpresentation and pressure from the presenting part.
                                11. Fetal axis pressure: this is when the force of contractions from the uterus is transmitted via the long axis of the canal; this becomes more significant after the rupture of membranes and during second stage.
                              1.  
                              2. B. Explain how you would admit a mother who has reported in active phase of first stage

                              If she has not been attending ANC, a full antenatal history is taken, which involves the mother‘s name, address, tribe, religion, husband‘s name and address, her gravida and parity, obstetrical, surgical, social, and medical history, the time and date of admission are entered in the admission forms of the mother.

                              Then, history of labour under the following headings is recorded:

                              C. What will make you refer this mother to hospital during first stage of labour?

                               

                              1. What are the characteristics of normal pregnancy?
                              2. Outline changes that take place in the circulatory system during pregnancy.
                              3. How can a midwife identify abnormalities that will necessitate referral during pregnancy?

                              1.  

                              SOLUTIONS

                              1.  

                              Normal pregnancy

                              Is the growth and development of the fetus into the uterine cavity without any complication.

                              Pregnancy: Refers to growth and development of the fetus into the body.

                              Circulatory system: Is the transport system that deals with movement of nutrients, hormones, gases and waste products of metabolism into and out of the body cells and tissues.

                              Referral: This is the process of transferring or forwarding clients or patients from a lower health unit to a higher unit for further management.

                              Characteristics of normal pregnancy

                              • It takes 40 weeks or 280 days.

                              • There is a single fetus growing in the uterine cavity.
                              • Amount of liquor amnii should be 500-1500ml.
                              • The lie is longitudinal.
                              • The fetus present by vertex.
                              • The height of fundus corresponds to the weeks of gestation.
                              • Maternal weight gain is by 12kg .
                              • Mother is healthy with no complications.

                              Changes that takes place in the circulatory system during pregnancy.

                              Heart

                                • Enlargement of the heart due to increased workload as a result of hypertrophy of the muscles especially the left ventricle .

                                • The growing uterus pushes the heart upwards and to the left.

                                • Cardiac output is increased by 40% due to increased blood volume and oxygen requirement.

                                • There is no physiological rise in blood pressure because of the relaxing effects of progesterone on the smooth muscles, but the diastolic pressure drops slightly due to peripheral vasodilation hence lower blood pressure during pregnancy

                                • Increased in pulse rate by 15 beats per minutes.

                              Blood vessels

                                • Relaxation of the plain muscles due to effects of progesterone hence vasodilation of the blood vessels.

                                • Poor venous return in late pregnancy results into varicose vein, hemorrhoids and Oedema.

                              Blood

                                • Increase in red cell volume by 20-30% due to increased oxygen requirements for the fetus and the mother.

                                • Slight increase in the level of white cell count to about 10-15,000mls but with low immunity due to the presents of human chorionic gonadotrophin(HCG).

                                • Platelet levels remains unchanged but clotting and fibrinolytic system undergo alteration to arrest bleeding during delivery.

                                • Plasma volume increase by 30% this results into hydraemia.
                                • Increased blood flow to the uterus to aid placental circulation by 10-15% or about 750mls per minute, kidneys for excretion of extra waste product of metabolism.

                              Identification of abnormalities that necessitate referral.

                                • History taking. A comprehensive history is taken on medical, surgical, past and present obstetrical, social and family history that may complicate or be complicated by pregnancy, labour and pueperium like diabetes, hypertension, epilepsy, sickle cell disease and accident involving the spine, pelvis and the lower limbs that will necessitate referral.

                                • Vital observations. Vital observations like blood pressure is taken to rule out conditions like pre-eclampsia that will necessitate referral.

                                • Physical examination. This is done to exclude conditions like anaemia, jundice, dehydration, oedema, malnutrition.
                                • External pelvic assessment. This is done especially from 36 weeks of gestation those mothers who have not delivered vaginally and prime gravidas by considering gait, stature, height and weight.

                                • Blood tests. Blood test like complete blood count(CBC),blood grouping and rhesus factor, venereal disease research laboratory test(VDRL),Random blood sugar (RBS),Routine counseling and testing(RCT) to rule out conditions like anaemia, rhesus incompatibility, syphilis, diabetes, HIV &Aids respectively that will necessitate referral.
                                • Urine test. Urinalysis is done at every visit to exclude the presence of glucose, protein and ketones in the urine which indicates conditions like diabetes, hypertensive disorders, urinary tract infection and unmet fetal demand respectively which necessitate referral.

                                • Breast examination. It is done to exclude conditions like breast abscess ,breast cancer and any abnormality of the breast that will necessitate referral.

                              Abdominal examination

                              On inspection. Observe the size and shape of the abdomen and previous scars that indicates condition like polyhydrominous and oligohydrominous and fresh previous scars that will necessitate referral.

                              On palpation. It is done to ascertain any abnormality like; Height of fundus not corresponding with gestational weeks, oblique and transverse lie, breech presentation at term especially prime gravidas and absence of fetal movement that will necessitate referral.

                              Auscultation. This is to exclude abnormal fetal heart tone, regularity, rhythm and absence of fetal heart that will necessitate referral.

                              1. Define a partograph.
                              2. What information is recorded on the partograph?
                              3. List the observations/ nursing care that can be done for a woman in first stage of labour but cannot be plotted on the partograph.

                              1.  

                              1.  

                              SOLUTIONS

                              A partograph is a tool used to monitor the progress of labour, condition of the fetus and the mother.

                              OR

                              Is the chart used to record all information and observations of a woman in labour/its a partogram before plotting and becomes a partograph after plotting.

                               A PARTOGRAPH IS STARTED

                                • When a woman is in active phase of labour that is 4cm or more of cervical opening.

                                • When the pregnancy of at least 30 completed weeks.

                                • When the presenting part is cephalic or breech.

                                • When there is no complication that needs immediate action.

                              THE INFORMATION RECORDED ON A PARTOGRAPH.

                              The following information is recorded on a partograph;

                              • Mothers demographic data.
                              • Fetal conditions
                              • Labour progress.
                              • Maternal condition.
                              • Outcome of labour.

                              MOTHERS DEMOGRAPHIC DATA

                              This is the first information entered on a partograph, this is essential as it helps a midwife to easily identify the mother she is following to know the weeks of Amenorrhoea and any risk factor etc. It includes name of the health facility, in patient‘s number, name, and data of admission on the partograph, time of admission of the partograph, LNMP, EDD, WOA risk factors and time of rapture of membranes.

                              FETAL CONDITION.

                              This part of the graph is used to monitor and assess fetal condition.

                              It consists of the following; fetal heart, membranes, liquor, molding and caporal.

                              • Fetal heart; Listening to and recording feta heart is safe and reliable away of knowing that the fetus is well. It‘s recorded after every 30 minutes when a mother is active phase of labour .The normal range is between 120b/m to 160b/m.

                              • Membranes; Liquor can assist in assessing the fetal condition.

                                • If membranes are intact record 1 on the partograph.

                                • If ruptured record R.

                              • Liquor; The following are recorded about the color of liquor when membranes have ruptured;

                              • If membranes rapture and liquor is clear: C
                              • If membranes rupture and liquor is blood stained: B
                              • If membranes rupture and liquor is Meconium stained: M
                              • If membranes rupture and; liquor is absent: A
                              • If membranes rupture and liquor is brown: B

                              • Moulding; This indicates how well the cervix will accommodate the fetal head.

                                • Bones separatable, sutures can be felt easily. O
                                • Bones are flit fast touching each other. +
                                • Bones are overlapping but can be easily separated with pressure from your fingers ++
                                • Bones are overlapping but can not be separated easily with pressure from your fingers +++
                                • In ++ and +++ refer a mother if in a maternity centre or lower health facility in a hospital inform a Doctor.

                              •  

                              •  

                              •  

                              The labour progress.

                              Cervical dilation;

                              First stage of labour is divided into two; latent phase and active phase;-

                                1. Latent phase; This is a slow period of cervical dilation 0.3cm with gradual shortening of the cervix. It should not exceed 8hours.

                                1. Active phase; This is the faster period of cervical dilation from 4-10cm.

                              The cervix dilates at a rate of at least 1cm/hr.

                              Cervical dilation is plotted with letter X and vaginal examination is done every 4 hours from 4cm to 6cm.Then from 7cm after 3 hours, 8cm after 2hours, 9cm hourly.

                              If the progress of labour is satisfactory plotting of cervical dilation will remain on the left of the alertline. It should not cross the right of the action line. If cervical dilation is going towards or is on action line the mother is referred from the health centre, in the hospital and Dr is informed.

                              Desent of the head;

                              For labour to progress well, dilation of the cervix should be accompanied by desent of the head. For desent to occur at an expected rate the head should be well flexed. This is assessed abdominally.

                              Desent is plotted with O on the partograph.

                              Uterine contractions;

                              Good uterine contractions are necessary for progress of labour; normally contractions become more frequent and last longer as labour progresses and contraction are observed after every 30mins for frequency, strength and duration.

                              Maternal conditions;

                              All observations for a mother‘s condition are recorded at the bottom of the partograph e.g. temperature 4hours, pulse ½ hourly. B.P 2hourly, urine output 2hourly.

                              Drug, rehydration fluids, Oxytocin, if labour is augmented and analysis of proteins, sugar and acetones are cleared.

                              Out comes of labour;

                              This information is entered in a partograph after the mother has delivered e.g. Date of delivery, type of delivery, duration of 1st SOL and 2nd SOL, post delivery vitals, time of delivery of the placenta and membranes Oxytocin given, amount of blood loss, state of the

                              perineum whether intact has sustained a tear or episiotomy was made immediate post, partum care and treatment.

                              Only the baby;

                              Involves weight, sex, time of delivery, APGAR score, treatment given at birth, any physical abnormality and immediate care.

                              Observation / Nursing care;

                              Observation while the mother is coming; the gait whether normal stature, short indicates risk mothers.

                              General examination from head to toe to examine Anaemia, jaundice and oedema.

                              Abdominal examination; do systematically from the head to toes to find out the lie, presentation, position, level of descent, nature of contractions and fetal heart moulding if any.

                                1. Hygiene given; bath and a clean gown provided.
                                2. Records: All the information about the mother is charted on the record sheet.
                                3. Position: Mother is allowed to adopt any comfortable position especially sitting up position.
                                4. Ambulation: In early 1st SOL mother is allowed to move about where the midwife can observe her.
                                5. Nutrition: Mother is allowed to eat alight diet like porridge, but later in established 1st SOL she is given hot sweetened tea.
                                6. Care of the bladder: Mother is encouraged to empty the bladder after every 2hours and urine should be tested for any abnormality.
                                7. Rest and sleep: assist the mother by dimming off lights and control noise and visitors.
                                8. Prevention of infections: Ensure aseptic techniques and proper hygiene of the ward to prevent infections.
                                9. Bowel actions: Mother is encouraged to empty the bowel, move frequently and clean the bed pan if offered.
                              1.  

                              Write short notes on the following

                                1. Causes of pain in labour.
                                2. Factors that affect pain perception during
                                3. Observation done during fourth stage of Labour indicating importance of each.
                                4. List indications of ultra sound scan during

                              SOLUTIONS

                              LABOUR

                              Is the physiological process by which the fetus, placenta and membranes are expelled through the birth canal by the help of the mother‘s effort after 28 weeks of gestation and there are four stages of labour that is to say; first, second, third and fourth stage and there are two types of labour and that is normal and abnormal labour.

                              PAIN

                              Is a sensory /emotional experience of what the patient feels and there are two types of pain; somatic and visceral pain.

                              CAUSES OF PAIN

                              There are two major causes of pain;

                              • Hormonal factors
                              • Mechanical factors

                              Hormonal factors

                              These include;

                              • Oxytocin stimulation. This increases the strength, intensity, duration and frequency of the contractions leading to pain.
                              • Progesterone withdrawal. The reduced levels of progesterone lead to an increase in estrogen levels which stimulates the muscles of the deciduae muscles of the uterus to produce prostaglandin which stimulates the smooth muscles of the uterus to contract.

                              Mechanical factors

                              These include;

                              • Strength and frequency of Braxton hick‘s contractions occurring in late pregnancy which leads to over stretching of the uterus which irritates the uterine muscles to contract leading to pain.
                              • Pressure of the presenting part on the sacra-nerves and lumbar nerves which has pain receptor.
                              • Pressure of the presenting part on the cervix. The presenting part exerts pressure on the cervix muscles hence leading to pain.
                              • Displacement of the pelvic floor muscles. The advancing presenting part distends the vagina and displaces the pelvic floor muscles which are over stretched and the nerves are compressed leading to pain.

                              PART (B)

                              PERCEPTION.

                              Is the process of becoming aware of the environment through the five senses.

                              Factors that affect pain perception during labour

                              These factors are emotional experience involving physical and psychological mechanism and can be contributed by the mother, fetus, health workers and structural environment.

                              Mother

                              • Maternal medical; conditions like pre-eclampsia and eclampsia, cardiac conditions which can affect pain perception.
                              • Compromised immunity due to chronic conditions like HIV and cancer which can affect pain perception.
                              • Size of the pelvis. Any pelvic deviation from normal leading to cephalous pelvic disproportion which can affect pain perception.
                              • Age. Young prime gravidae below 18years their pelvic bones are not fully developed and the mother above 35years their pelvic bones are contracted and this hinders normal progress of labour and affects pain.
                              • Parity. Prime gravidae‘s their muscles are still intact and sensitive to pain which leads to strong contractions. The multipara mothers their muscles are laced which leads to uterine itial.
                              • Past obstetrical history like caesarian section which increases the risks of uterine rapture and affects normal labour
                              • Social economic factors for example lack of support which can affect pain perception.
                              • Cultural factors like use of native drugs can affect pain perception.
                              • Past experience can also affect pain perception
                              • Level of education, occupation, religion can also affect pain perception.

                              Fetus

                              • Fetal abnormalities like hydrocephalous, macrosomic babies can lead to cephalopelvic disproportion hence affecting pain.
                              • Lie, position and presenting pain can affect pain perception during labour
                              • Size of the fetus that is to say big babies which cannot pass through the pelvis hence affecting pain perception
                              • Gestation age. In past maturity the sutures and the fontanels are closing and molding can hot take place hence affecting pain perception.

                              Health workers

                              1. Poor screening of mothers during antenatal Poor management during labour
                              2. Poor attitude towards the mother

                              Structural environment

                              • Hospital setting where there is no privacy for mothers, all stages of labour in one room which can affect pain perception.
                              • Lack of recreation in labour rooms like newspapers, television to occupy the mothers.

                              PART (C)

                              Forth stage of labour

                              Is the 1-2 hours following third stage of labour. Observations done during the fourth stage of labour

                              To the mother

                              • Per vagina

                              Perineum to inspect for perineal tears, episiotomy and other injuries Bleeding to rule out anemia and post partner hemorrhage

                              • Per abdominal

                              Fundal height estimation to rule out the retained products of conception State of the uterus whether it has contracted

                              Bladder encourages the mother to pass urine to prevent PPH

                              • Vital observations like blood pressure, temperature, pulse, and respiration for consciousness of the mother to rule out pre –eclampsia and eclampsia, dehydration and
                              • Breast examination – to rule out abnormalities of the nipple which can hinder breast feeding like inverted nipples.
                              • Observe the bowel action if the bowel movements are present and able to pass out stool
                              • Observe the legs for varicose veins

                              To the baby

                              • Assessment of the baby after five minutes for example APGAR scoring the baby General examination of the baby to rule out abnormalities
                              • Observation of the cord for bleeding and well ligatured
                              • Bowel for passage of meconium to rule out anal impaction
                              • Observe if the baby is breast feeding for the presence of the sucking reflex.

                              PART (D)

                              Ultra- sound scan

                              Is a tool used in pregnancy and obstetrics generally for diagnosis. The system uses waves of sound that create images by bounding off and td safe to the developing fetus.

                              Methods

                              • Trans abdominal
                              • Trans vaginal

                              INDICATIONS

                              • To determine the gestation age
                              • To detect the sex of the baby
                              • To detect the fetal abnormalities
                              • To know the site of the placenta
                              • To determine the maturity where the dates are not accurate
                              • To rule out intra- uterine fetal death
                              • To rule out intra- fetal growth retardation
                              • To confirm pregnancy
                              • To asses amniotic fluid amount an order to rule out polyhydrominous and oligohydrominous
                              • To determine the causes of bleeding in pregnancy
                              • For detection of multiple pregnancies
                              • To determine the size of the baby
                              • For diagnostic purposes
                              • Improves the woman‘s pregnancy experience

                              For pelvic assessment.

                              1. What may make you refer this mother to hospital during first stage of labour? 
                              2. Outline the changes that take place in the uterus during the first stage of labour.
                              3. Explain how you would admit a mother who has reported in active phase of first stage.

                              SOLUTIONS

                              During the first stage of labour the following occurs:

                                1. Effacement or take up of the cervix: this is made possible by the work of muscle fibres surrounding the internal OS which are drawn upward by the retracted upper segment.
                                2. Pacemaker / Fundal dominance: each contraction begins from the pace maker situated at the cornua of the uterus. From the fundal region it spreads downwards being stronger and persisting longer in the upper region on reaching the lower region, the wave of contraction weakens and allows the cervix to dilate.
                                3. Dilatation of the cervix: this is the opening of the external OS to allow the passage of the fetal head; it occurs as a result of uterine action and the pressure from fore bag of waters and the well fitting presenting part
                                4. Contraction and Retraction: is the special ability of the uterine muscle where the contraction does not pass off completely and the muscle fibres retaining some of the contractions do not become completely relaxed instead they become gradually shorter and thicker.
                                5. Polarity: is the term used to define the coordination between two poles of uterus throughout labour
                                6. Development of upper and lower segment: the upper uterine segment is the thicker muscular contractile part. The lower part segment is the firm distensible are of 7.5cm – 10cm in length developed from isthmus to the uterus.
                                7. Development of retraction ring: is the ridge formed between the upper and the lower uterine segment. It‘s present in labour and normal as long as it‘s not marked enough to be visible above the symphysis pubis.   NB: It is called bandl‘s ring in obstructed labour
                                8. Show: is the blood stained mucoid discharge seen a few hours within or a few hours after when labour has started
                                9. General fluid pressure: while the membranes remain intact, the pressure of the uterine contraction is exerted on the fluid as the fluid is not compressible the pressure is equalized throughout the uterus.
                                10. Rupture of membranes: rupture of membranes may be early or later during the second stage of labour due to the malpresentation and pressure from the presenting part.
                                11. Fetal axis pressure: this is when the force of contractions from the uterus is transmitted via the long axis of the canal; this becomes more significant after the rupture of membranes and during second stage.
                              1.  
                              2. B. Explain how you would admit a mother who has reported in active phase of first stage

                              If she has not been attending ANC, a full antenatal history is taken, which involves the mother‘s name, address, tribe, religion, husband‘s name and address, her gravida and parity, obstetrical, surgical, social, and medical history, the time and date of admission are entered in the admission forms of the mother.

                              Then, history of labour under the following headings is recorded:

                              C. What will make you refer this mother to hospital during first stage of labour?

                               

                              1. What are the characteristics of normal pregnancy?
                              2. Outline changes that take place in the circulatory system during pregnancy.
                              3. How can a midwife identify abnormalities that will necessitate referral during pregnancy?

                              1.  

                              SOLUTIONS

                              1.  

                              Normal pregnancy

                              Is the growth and development of the fetus into the uterine cavity without any complication.

                              Pregnancy: Refers to growth and development of the fetus into the body.

                              Circulatory system: Is the transport system that deals with movement of nutrients, hormones, gases and waste products of metabolism into and out of the body cells and tissues.

                              Referral: This is the process of transferring or forwarding clients or patients from a lower health unit to a higher unit for further management.

                              Characteristics of normal pregnancy

                              • It takes 40 weeks or 280 days.

                              • There is a single fetus growing in the uterine cavity.
                              • Amount of liquor amnii should be 500-1500ml.
                              • The lie is longitudinal.
                              • The fetus present by vertex.
                              • The height of fundus corresponds to the weeks of gestation.
                              • Maternal weight gain is by 12kg .
                              • Mother is healthy with no complications.

                              Changes that takes place in the circulatory system during pregnancy.

                              Heart

                                • Enlargement of the heart due to increased workload as a result of hypertrophy of the muscles especially the left ventricle .

                                • The growing uterus pushes the heart upwards and to the left.

                                • Cardiac output is increased by 40% due to increased blood volume and oxygen requirement.

                                • There is no physiological rise in blood pressure because of the relaxing effects of progesterone on the smooth muscles, but the diastolic pressure drops slightly due to peripheral vasodilation hence lower blood pressure during pregnancy

                                • Increased in pulse rate by 15 beats per minutes.

                              Blood vessels

                                • Relaxation of the plain muscles due to effects of progesterone hence vasodilation of the blood vessels.

                                • Poor venous return in late pregnancy results into varicose vein, hemorrhoids and Oedema.

                              Blood

                                • Increase in red cell volume by 20-30% due to increased oxygen requirements for the fetus and the mother.

                                • Slight increase in the level of white cell count to about 10-15,000mls but with low immunity due to the presents of human chorionic gonadotrophin(HCG).

                                • Platelet levels remains unchanged but clotting and fibrinolytic system undergo alteration to arrest bleeding during delivery.

                                • Plasma volume increase by 30% this results into hydraemia.
                                • Increased blood flow to the uterus to aid placental circulation by 10-15% or about 750mls per minute, kidneys for excretion of extra waste product of metabolism.

                              Identification of abnormalities that necessitate referral.

                                • History taking. A comprehensive history is taken on medical, surgical, past and present obstetrical, social and family history that may complicate or be complicated by pregnancy, labour and pueperium like diabetes, hypertension, epilepsy, sickle cell disease and accident involving the spine, pelvis and the lower limbs that will necessitate referral.

                                • Vital observations. Vital observations like blood pressure is taken to rule out conditions like pre-eclampsia that will necessitate referral.

                                • Physical examination. This is done to exclude conditions like anaemia, jundice, dehydration, oedema, malnutrition.
                                • External pelvic assessment. This is done especially from 36 weeks of gestation those mothers who have not delivered vaginally and prime gravidas by considering gait, stature, height and weight.

                                • Blood tests. Blood test like complete blood count(CBC),blood grouping and rhesus factor, venereal disease research laboratory test(VDRL),Random blood sugar (RBS),Routine counseling and testing(RCT) to rule out conditions like anaemia, rhesus incompatibility, syphilis, diabetes, HIV &Aids respectively that will necessitate referral.
                                • Urine test. Urinalysis is done at every visit to exclude the presence of glucose, protein and ketones in the urine which indicates conditions like diabetes, hypertensive disorders, urinary tract infection and unmet fetal demand respectively which necessitate referral.

                                • Breast examination. It is done to exclude conditions like breast abscess ,breast cancer and any abnormality of the breast that will necessitate referral.

                              Abdominal examination

                              On inspection. Observe the size and shape of the abdomen and previous scars that indicates condition like polyhydrominous and oligohydrominous and fresh previous scars that will necessitate referral.

                              On palpation. It is done to ascertain any abnormality like; Height of fundus not corresponding with gestational weeks, oblique and transverse lie, breech presentation at term especially prime gravidas and absence of fetal movement that will necessitate referral.

                              Auscultation. This is to exclude abnormal fetal heart tone, regularity, rhythm and absence of fetal heart that will necessitate referral.

                              1. Define a partograph.
                              2. What information is recorded on the partograph?
                              3. List the observations/ nursing care that can be done for a woman in first stage of labour but cannot be plotted on the partograph.

                              1.  

                              1.  

                              SOLUTIONS

                              A partograph is a tool used to monitor the progress of labour, condition of the fetus and the mother.

                              OR

                              Is the chart used to record all information and observations of a woman in labour/its a partogram before plotting and becomes a partograph after plotting.

                               A PARTOGRAPH IS STARTED

                                • When a woman is in active phase of labour that is 4cm or more of cervical opening.

                                • When the pregnancy of at least 30 completed weeks.

                                • When the presenting part is cephalic or breech.

                                • When there is no complication that needs immediate action.

                              THE INFORMATION RECORDED ON A PARTOGRAPH.

                              The following information is recorded on a partograph;

                              • Mothers demographic data.
                              • Fetal conditions
                              • Labour progress.
                              • Maternal condition.
                              • Outcome of labour.

                              MOTHERS DEMOGRAPHIC DATA

                              This is the first information entered on a partograph, this is essential as it helps a midwife to easily identify the mother she is following to know the weeks of Amenorrhoea and any risk factor etc. It includes name of the health facility, in patient‘s number, name, and data of admission on the partograph, time of admission of the partograph, LNMP, EDD, WOA risk factors and time of rapture of membranes.

                              FETAL CONDITION.

                              This part of the graph is used to monitor and assess fetal condition.

                              It consists of the following; fetal heart, membranes, liquor, molding and caporal.

                              • Fetal heart; Listening to and recording feta heart is safe and reliable away of knowing that the fetus is well. It‘s recorded after every 30 minutes when a mother is active phase of labour .The normal range is between 120b/m to 160b/m.

                              • Membranes; Liquor can assist in assessing the fetal condition.

                                • If membranes are intact record 1 on the partograph.

                                • If ruptured record R.

                              • Liquor; The following are recorded about the color of liquor when membranes have ruptured;

                              • If membranes rapture and liquor is clear: C
                              • If membranes rupture and liquor is blood stained: B
                              • If membranes rupture and liquor is Meconium stained: M
                              • If membranes rupture and; liquor is absent: A
                              • If membranes rupture and liquor is brown: B

                              • Moulding; This indicates how well the cervix will accommodate the fetal head.

                                • Bones separatable, sutures can be felt easily. O
                                • Bones are flit fast touching each other. +
                                • Bones are overlapping but can be easily separated with pressure from your fingers ++
                                • Bones are overlapping but can not be separated easily with pressure from your fingers +++
                                • In ++ and +++ refer a mother if in a maternity centre or lower health facility in a hospital inform a Doctor.

                              •  

                              •  

                              •  

                              The labour progress.

                              Cervical dilation;

                              First stage of labour is divided into two; latent phase and active phase;-

                                1. Latent phase; This is a slow period of cervical dilation 0.3cm with gradual shortening of the cervix. It should not exceed 8hours.

                                1. Active phase; This is the faster period of cervical dilation from 4-10cm.

                              The cervix dilates at a rate of at least 1cm/hr.

                              Cervical dilation is plotted with letter X and vaginal examination is done every 4 hours from 4cm to 6cm.Then from 7cm after 3 hours, 8cm after 2hours, 9cm hourly.

                              If the progress of labour is satisfactory plotting of cervical dilation will remain on the left of the alertline. It should not cross the right of the action line. If cervical dilation is going towards or is on action line the mother is referred from the health centre, in the hospital and Dr is informed.

                              Desent of the head;

                              For labour to progress well, dilation of the cervix should be accompanied by desent of the head. For desent to occur at an expected rate the head should be well flexed. This is assessed abdominally.

                              Desent is plotted with O on the partograph.

                              Uterine contractions;

                              Good uterine contractions are necessary for progress of labour; normally contractions become more frequent and last longer as labour progresses and contraction are observed after every 30mins for frequency, strength and duration.

                              Maternal conditions;

                              All observations for a mother‘s condition are recorded at the bottom of the partograph e.g. temperature 4hours, pulse ½ hourly. B.P 2hourly, urine output 2hourly.

                              Drug, rehydration fluids, Oxytocin, if labour is augmented and analysis of proteins, sugar and acetones are cleared.

                              Out comes of labour;

                              This information is entered in a partograph after the mother has delivered e.g. Date of delivery, type of delivery, duration of 1st SOL and 2nd SOL, post delivery vitals, time of delivery of the placenta and membranes Oxytocin given, amount of blood loss, state of the

                              perineum whether intact has sustained a tear or episiotomy was made immediate post, partum care and treatment.

                              Only the baby;

                              Involves weight, sex, time of delivery, APGAR score, treatment given at birth, any physical abnormality and immediate care.

                              Observation / Nursing care;

                              Observation while the mother is coming; the gait whether normal stature, short indicates risk mothers.

                              General examination from head to toe to examine Anaemia, jaundice and oedema.

                              Abdominal examination; do systematically from the head to toes to find out the lie, presentation, position, level of descent, nature of contractions and fetal heart moulding if any.

                                1. Hygiene given; bath and a clean gown provided.
                                2. Records: All the information about the mother is charted on the record sheet.
                                3. Position: Mother is allowed to adopt any comfortable position especially sitting up position.
                                4. Ambulation: In early 1st SOL mother is allowed to move about where the midwife can observe her.
                                5. Nutrition: Mother is allowed to eat alight diet like porridge, but later in established 1st SOL she is given hot sweetened tea.
                                6. Care of the bladder: Mother is encouraged to empty the bladder after every 2hours and urine should be tested for any abnormality.
                                7. Rest and sleep: assist the mother by dimming off lights and control noise and visitors.
                                8. Prevention of infections: Ensure aseptic techniques and proper hygiene of the ward to prevent infections.
                                9. Bowel actions: Mother is encouraged to empty the bowel, move frequently and clean the bed pan if offered.
                              1.  

                              Write short notes on the following

                                1. Causes of pain in labour.
                                2. Factors that affect pain perception during
                                3. Observation done during fourth stage of Labour indicating importance of each.
                                4. List indications of ultra sound scan during

                              SOLUTIONS

                              LABOUR

                              Is the physiological process by which the fetus, placenta and membranes are expelled through the birth canal by the help of the mother‘s effort after 28 weeks of gestation and there are four stages of labour that is to say; first, second, third and fourth stage and there are two types of labour and that is normal and abnormal labour.

                              PAIN

                              Is a sensory /emotional experience of what the patient feels and there are two types of pain; somatic and visceral pain.

                              CAUSES OF PAIN

                              There are two major causes of pain;

                              • Hormonal factors
                              • Mechanical factors

                              Hormonal factors

                              These include;

                              • Oxytocin stimulation. This increases the strength, intensity, duration and frequency of the contractions leading to pain.
                              • Progesterone withdrawal. The reduced levels of progesterone lead to an increase in estrogen levels which stimulates the muscles of the deciduae muscles of the uterus to produce prostaglandin which stimulates the smooth muscles of the uterus to contract.

                              Mechanical factors

                              These include;

                              • Strength and frequency of Braxton hick‘s contractions occurring in late pregnancy which leads to over stretching of the uterus which irritates the uterine muscles to contract leading to pain.
                              • Pressure of the presenting part on the sacra-nerves and lumbar nerves which has pain receptor.
                              • Pressure of the presenting part on the cervix. The presenting part exerts pressure on the cervix muscles hence leading to pain.
                              • Displacement of the pelvic floor muscles. The advancing presenting part distends the vagina and displaces the pelvic floor muscles which are over stretched and the nerves are compressed leading to pain.

                              PART (B)

                              PERCEPTION.

                              Is the process of becoming aware of the environment through the five senses.

                              Factors that affect pain perception during labour

                              These factors are emotional experience involving physical and psychological mechanism and can be contributed by the mother, fetus, health workers and structural environment.

                              Mother

                              • Maternal medical; conditions like pre-eclampsia and eclampsia, cardiac conditions which can affect pain perception.
                              • Compromised immunity due to chronic conditions like HIV and cancer which can affect pain perception.
                              • Size of the pelvis. Any pelvic deviation from normal leading to cephalous pelvic disproportion which can affect pain perception.
                              • Age. Young prime gravidae below 18years their pelvic bones are not fully developed and the mother above 35years their pelvic bones are contracted and this hinders normal progress of labour and affects pain.
                              • Parity. Prime gravidae‘s their muscles are still intact and sensitive to pain which leads to strong contractions. The multipara mothers their muscles are laced which leads to uterine itial.
                              • Past obstetrical history like caesarian section which increases the risks of uterine rapture and affects normal labour
                              • Social economic factors for example lack of support which can affect pain perception.
                              • Cultural factors like use of native drugs can affect pain perception.
                              • Past experience can also affect pain perception
                              • Level of education, occupation, religion can also affect pain perception.

                              Fetus

                              • Fetal abnormalities like hydrocephalous, macrosomic babies can lead to cephalopelvic disproportion hence affecting pain.
                              • Lie, position and presenting pain can affect pain perception during labour
                              • Size of the fetus that is to say big babies which cannot pass through the pelvis hence affecting pain perception
                              • Gestation age. In past maturity the sutures and the fontanels are closing and molding can hot take place hence affecting pain perception.

                              Health workers

                              1. Poor screening of mothers during antenatal Poor management during labour
                              2. Poor attitude towards the mother

                              Structural environment

                              • Hospital setting where there is no privacy for mothers, all stages of labour in one room which can affect pain perception.
                              • Lack of recreation in labour rooms like newspapers, television to occupy the mothers.

                              PART (C)

                              Forth stage of labour

                              Is the 1-2 hours following third stage of labour. Observations done during the fourth stage of labour

                              To the mother

                              • Per vagina

                              Perineum to inspect for perineal tears, episiotomy and other injuries Bleeding to rule out anemia and post partner hemorrhage

                              • Per abdominal

                              Fundal height estimation to rule out the retained products of conception State of the uterus whether it has contracted

                              Bladder encourages the mother to pass urine to prevent PPH

                              • Vital observations like blood pressure, temperature, pulse, and respiration for consciousness of the mother to rule out pre –eclampsia and eclampsia, dehydration and
                              • Breast examination – to rule out abnormalities of the nipple which can hinder breast feeding like inverted nipples.
                              • Observe the bowel action if the bowel movements are present and able to pass out stool
                              • Observe the legs for varicose veins

                              To the baby

                              • Assessment of the baby after five minutes for example APGAR scoring the baby General examination of the baby to rule out abnormalities
                              • Observation of the cord for bleeding and well ligatured
                              • Bowel for passage of meconium to rule out anal impaction
                              • Observe if the baby is breast feeding for the presence of the sucking reflex.

                              PART (D)

                              Ultra- sound scan

                              Is a tool used in pregnancy and obstetrics generally for diagnosis. The system uses waves of sound that create images by bounding off and td safe to the developing fetus.

                              Methods

                              • Trans abdominal
                              • Trans vaginal

                              INDICATIONS

                              • To determine the gestation age
                              • To detect the sex of the baby
                              • To detect the fetal abnormalities
                              • To know the site of the placenta
                              • To determine the maturity where the dates are not accurate
                              • To rule out intra- uterine fetal death
                              • To rule out intra- fetal growth retardation
                              • To confirm pregnancy
                              • To asses amniotic fluid amount an order to rule out polyhydrominous and oligohydrominous
                              • To determine the causes of bleeding in pregnancy
                              • For detection of multiple pregnancies
                              • To determine the size of the baby
                              • For diagnostic purposes
                              • Improves the woman‘s pregnancy experience

                              For pelvic assessment.

                              Normal Midwifery Questions and answers Read More »

                               Blood and its composition

                              Module Unit CN-111: Anatomy and Physiology (I)

                              Contact Hours: 60

                              Module Unit Description: Introduces students to the anatomy and physiology of the human body, covering the structure and function of different body parts and systems, specifically skeletal, muscular, circulatory, and digestive systems.

                              Learning Outcomes for this Unit:

                              By the end of this unit, the student shall be able to:

                              • Identify various parts of the human body and their functions.
                              • Differentiate the normal structure and functioning of various systems from that of abnormal conditions of the skeletal, muscular, cardiovascular and digestive systems.

                              Topic: Structures and functions of various body systems - Blood

                              Blood

                              Blood is a vital connective tissue that circulates throughout the body, acting as a transport system and playing roles in defense and maintaining balance. About 7% of your body weight is blood.

                              Blood is a fluid connective tissue. It circulates continually around the body, allowing constant communication between tissues distant from each other.

                              It transports:

                              • oxygen from the lungs to the tissues, and carbon dioxide from the tissues to the lungs for excretion,
                              • nutrients from the alimentary tract to the tissues, and cell wastes to the excretory organs, principally the kidneys,
                              • hormones secreted by endocrine glands to their target glands and tissues,
                              • heat produced in active tissues to other less active tissues,
                              • protective substances, e.g. antibodies, to areas of infection
                              • clotting factors that coagulate blood, minimizing bleeding from ruptured blood vessels

                              Composition of Blood

                              Blood is composed of a clear, straw-coloured, watery fluid called plasma in which several different types of blood cell are suspended. Plasma normally constitutes 55% of the volume of blood. The remaining 45% is accounted for by the cellular fraction of blood. The two fractions of blood, blood cells and plasma, can be separated by centrifugation (spinning) or by gravity when blood is allowed to stand (See the picture below). Because the cells are heavier than plasma, they sink to the bottom of any sample.

                              Blood makes up about 7% of body weight (about 5.6 litres in a 70 kg man). This proportion is less in women and considerably greater in children, gradually decreasing until the adult level is reached.

                              Blood in the blood vessels is always in motion because of the pumping action of the heart. The continual flow maintains a fairly constant environment for body cells. Blood volume and the concentration of its many constituents are kept within narrow limits by homeostatic mechanisms.

                              Plasma

                              The constituents of plasma are water (90 to 92%) and dissolved and suspended substances, including:

                              • plasma proteins
                              • inorganic salts
                              • nutrients, principally from digested foods
                              • waste materials
                              • hormones
                              • gases.

                              Plasma proteins

                              Plasma proteins, which make up about 7% of plasma, are normally retained within the blood, because they are too big to escape through the capillary pores into the tissues. They are largely responsible for creating the osmotic pressure of blood, which keeps plasma fluid within the circulation. If plasma protein levels fall, because of either reduced production or loss from the blood vessels, osmotic pressure is also reduced, and fluid moves into the tissues (oedema) and body cavities.

                              Plasma viscosity (thickness) is due to plasma proteins, mainly albumin and fibrinogen. Plasma proteins, with the exception of immunoglobulins, are formed in the liver.

                              Albumins

                              These are the most abundant plasma proteins (about 60% of total) and their main function is to maintain normal plasma osmotic pressure. Albumins also act as carrier molecules for free fatty acids, some drugs and steroid hormones.

                              Globulins

                              Their main functions are:

                              • as antibodies (immunoglobulins), which are complex proteins produced by lymphocytes that play an important part in immunity. They bind to, and neutralize, foreign materials (antigens) such as microorganisms.
                              • transportation of some hormones and mineral salts, e.g. thyroglobulin carries the hormone thyroxine and transferrin carries the mineral iron.
                              • inhibition of some proteolytic enzymes, e.g. α2 macroglobulin inhibits trypsin activity.

                              Clotting factors

                              These are responsible for coagulation of blood. Serum is plasma from which clotting factors have been removed. The most abundant clotting factor is fibrinogen.

                              Electrolytes

                              These have a range of functions, including;

                              • muscle contraction (e.g. Ca2+),
                              • transmission of nerve impulses (e.g. Ca2+and Na+),
                              • maintenance of acid–base balance (e.g. phosphate, ).

                              The pH of blood is maintained between 7.35 and 7.45 (slightly alkaline) by an ongoing complicated series of chemical activities, involving buffering systems.

                              Nutrients

                              The products of digestion, e.g. glucose, amino acids, fatty acids and glycerol, are absorbed from the alimentary tract.

                              Together with mineral salts and vitamins they are used by body cells for

                              • energy,
                              • heat,
                              • repair and replacement, and for the
                              • synthesis of other blood components and body secretions.

                              Waste products

                              Urea, creatinine and uric acid are the waste products of protein metabolism. They are formed in the liver and carried in blood to the kidneys for excretion.

                              Hormones

                              These are chemical messengers synthesized by endocrine glands.

                              Hormones pass directly from the endocrine cells into the blood, which transports them to their target tissues and organs elsewhere in the body, where they influence cellular activity.

                              Gases

                              Oxygen, carbon dioxide and nitrogen are transported round the body dissolved in plasma. Oxygen and carbon dioxide are also transported in combination with haemoglobin in red blood cells.

                              Most oxygen is carried in combination with haemoglobin and most carbon dioxide as bicarbonate ions dissolved in plasma. Atmospheric nitrogen enters the body in the same way as other gases and is present in plasma but it has no physiological function.

                              Cellular Contents of Blood

                              There are three types of blood cell.

                              • erythrocytes (red blood cells)
                              • platelets (thrombocytes)
                              • leukocytes (white blood cells).

                              Blood cells are synthesized mainly in red bone marrow. Some lymphocytes, additionally, are produced in lymphoid tissue.

                              In the bone marrow, all blood cells originate from pluripotent stem cells (i.e. capable of developing into one of a number of cell types) and go through several developmental stages before entering the blood. Different types of blood cell follow separate lines of development. The process of blood cell formation is called haemopoiesis.

                              Stages in the development of blood cells diagramImage Placeholder - Stages in the development of blood cells diagram

                              Red Blood Cells

                              Red blood cells are biconcave discs; they have no nucleus, and their diameter is about 7.5 micrometres.

                              Their main function is in gas transport, mainly of oxygen, but they also carry some carbon dioxide. Their characteristic shape is suited to their purpose; the biconcavity increases their surface area for gas exchange, and the thinness of the central portion allows fast entry and exit of gases. The cells are flexible so they can squeeze through narrow capillaries, and contain no intracellular organelles, leaving more room for haemoglobin, the large pigmented protein responsible for gas transport.

                              Life span and function of erythrocytes

                              Erythrocytes or red blood cells are produced in red bone marrow, which is present in the ends of long bones and in flat and irregular bones. They pass through several stages of development before entering the blood.

                              Their life span in the circulation is about 120 days.

                              The process of development of red blood cells from stem cells takes about 7 days and is called erythropoiesis. The immature cells are released into the bloodstream as reticulocytes, and then mature into erythrocytes over a day or two within the circulation. During this time, they lose their nucleus and therefore become incapable of division.

                              Maturation of red blood cell diagram

                              Both vitamin B12 and folic acid are required for red blood cell synthesis. They are absorbed in the intestines, although vitamin B12 must be bound to intrinsic factor to allow absorption to take place. Both vitamins are present in dairy products, meat and green vegetables. The liver usually contains substantial stores of vitamin B12, several years’ worth, but signs of folic acid deficiency appear within a few months.

                              Haemoglobin

                              Haemoglobin is a large, complex protein containing a globular protein (globin) and a pigmented iron containing complex called haem.

                              Each haemoglobin molecule contains four globin chains and four haem units, each with one atom of iron. As each atom of iron can combine with an oxygen molecule, this means that a single haemoglobin molecule can carry up to four molecules of oxygen.

                              An average red blood cell carries about 280 million haemoglobin molecules, giving each cell a theoretical oxygen-carrying capacity of over a billion oxygen molecules.

                              Iron is carried in the bloodstream bound to its transport protein, transferrin, and stored in the liver. Normal red cell production requires a steady supply of iron. Iron absorption from the alimentary canal is very slow, even if the diet is rich in iron, meaning that iron deficiency can occur readily if losses exceed intake.

                              Blood haemoglobin molecule diagram

                              Control of Erythropoiesis

                              The rate of red blood cell production (erythropoiesis) is controlled by the body's demand for oxygen. The hormone erythropoietin, produced mainly by the kidneys, stimulates the bone marrow to produce more red blood cells when oxygen levels in the blood are low (hypoxia). This is a negative feedback mechanism that helps maintain homeostasis of oxygen carrying capacity in the blood.

                              Revision Questions for Blood and its Composition:

                              1. Describe the main functions of blood.

                              2. What are the two main components of blood by volume, and what percentage does each constitute?

                              3. List at least three types of substances transported by plasma.

                              4. Name the three main types of blood cells and briefly state the primary function of each.

                              5. Where are blood cells mainly synthesized?

                              6. What is the main function of erythrocytes? How is their shape suited to this function?

                              7. What is haemoglobin, and what is its key component for oxygen transport?

                              8. What is erythropoiesis, and what hormone controls this process?

                              References (from Curriculum for CN-1102):

                              Below are the core and other references listed in the curriculum for Module CN-1102. Refer to the original document for full details.

                              • Cohen, JB and Hull, L.K (2016) Memmlers – The Human body in Health and diseases 13th Edition, Wolters, Kluwer. (Core Reference)
                              • Cohen, J.B and Hull, L.K (2016) Memmler's Structure and Function of the Human Body. 11th Edition. Wolters Kluwer, China
                              • Kumar, M and Anand, M (2010) Human Anatomy and Physiology for Nursing and Allied Sciences. 2nd Edition. Jaypee Brothers Medical Publishers Ltd.
                              • Scott, N.W. (2011) Anatomy and Physiology made incredibly easy. 1st Edition. Wolwers Kluwers, Lippincotts Williams and Wilkins.
                              • Moore, L. K, Agur, M.R.A and Dailey, F.A. (2015) Essential Clinical Anatomy.15th Edition. Wolters Kluwer.
                              • Snell, S. R. (2012) Clinical Anatomy by Regions. 9th Edition. Wolters Kluwer, Lippincott Williams and Wilkins, China
                              • Wingerd, B, (2014) The Human Body-Concepts of Anatomy and Physiology. 3rd Edition Lippincott Williams and Wilkins and Wolters Kluwer.
                              • Rohen, Y.H-Orecoll. (2015) Anatomy.A Photographic Atlas 8th Edition. Lippincott Williams & Wilkins
                              • Waugh, A., & Grant, A. (2014). Ross and Wilson Anatomy & Physiology in Health and Illness (12th ed.). Churchill Livingstone Elsevier. (Added as per user's reference)

                               Blood and its composition Read More »

                              Hodgkin's Disease

                              Hodgkin’s Disease

                              Hodgkin's Disease and Non-Hodgkin's Lymphoma
                              Hodgkin's Disease and Non-Hodgkin's Lymphoma

                              To understand Hodgkin's disease and Non-Hodgkin's lymphoma, we must first define what lymphomas are as a group of diseases.

                              Lymphomas are a diverse group of cancers that originate in the lymphocytes, a type of white blood cell crucial for the immune system. These malignant lymphocytes typically arise in the lymphatic system, which is a network of tissues and organs that help rid the body of toxins, waste, and other unwanted materials. The primary components of the lymphatic system include the lymph nodes, spleen, thymus, bone marrow, and lymphatic vessels.

                              Hodgkin’s Lymphoma is a malignant disease in which the lymph glands are enlarged and there is an increase of lymphoid tissue in the liver spleen and bone marrow. This disease is fatal if not treated early It was described by a British physician called Thomas Hodgkin in 1832

                              Key characteristics of lymphomas:
                              1. Origin in Lymphocytes: The cancerous cells are mutated lymphocytes (either B-lymphocytes or T-lymphocytes). These cells normally play a vital role in recognizing and fighting off infections and foreign invaders.
                              2. Location: While they can originate in any part of the body that contains lymphatic tissue, they most commonly start in the lymph nodes, which are small, bean-shaped glands found throughout the body (e.g., in the neck, armpits, groin, chest, and abdomen).
                              3. Growth Pattern: Unlike leukemias (which primarily involve the bone marrow and blood), lymphomas typically present as solid tumors within the lymphatic system. However, in advanced stages, they can spread to the blood, bone marrow, and other organs (e.g., liver, brain).
                              4. Types: Lymphomas are broadly classified into two main categories:
                                • Hodgkin Lymphoma (HL): Characterized by the presence of a specific type of abnormal cell called the Reed-Sternberg cell.
                                • Non-Hodgkin Lymphoma (NHL): A much more diverse group that includes all lymphomas that are not Hodgkin Lymphoma.
                              In essence, lymphomas represent an uncontrolled proliferation of abnormal lymphocytes that accumulate, forming tumors and impairing the normal function of the immune system and affected organs.
                              Classification of Lymphomas

                              Lymphomas are broadly classified into two major categories based on specific pathological and clinical characteristics:

                              1. Hodgkin Lymphoma (HL)
                              2. Non-Hodgkin Lymphoma (NHL)

                              The distinction between these two types is critical because they differ significantly in their epidemiology, pathology, clinical presentation, and, importantly, their treatment approaches and prognosis.

                              I. Hodgkin Lymphoma (HL)
                              • Defining Feature: The hallmark of Hodgkin Lymphoma is the presence of a unique, large, often multi-nucleated malignant cell known as the Reed-Sternberg cell (or a variant thereof) in a characteristic inflammatory background. These cells are typically derived from B-lymphocytes.
                              • Prevalence: It is less common than Non-Hodgkin Lymphoma, accounting for approximately 10-15% of all lymphomas.
                              • Age Distribution: Hodgkin Lymphoma has a bimodal age distribution, with peaks in young adulthood (ages 20-30) and in older adulthood (after age 55).
                              • Spread Pattern: Tends to spread in an orderly fashion, typically from one lymph node group to contiguous lymph node groups. This predictable pattern often allows for earlier detection and more localized disease.
                              • Prognosis: Generally considered one of the most curable cancers, especially when diagnosed in earlier stages.
                              II. Non-Hodgkin Lymphoma (NHL)
                              • Defining Feature: Non-Hodgkin Lymphoma encompasses all lymphomas that lack the characteristic Reed-Sternberg cells. This group is incredibly heterogeneous, meaning it includes many different types of lymphoma with diverse origins, behaviors, and prognoses.
                              • Prevalence: Much more common than Hodgkin Lymphoma, accounting for approximately 85-90% of all lymphomas.
                              • Age Distribution: The incidence generally increases with age, with most cases occurring in older adults.
                              • Cell Origin: Can originate from either B-lymphocytes (most common, ~85%) or T-lymphocytes (~15%).
                              • Spread Pattern: Tends to spread in a less orderly and more unpredictable fashion, often disseminating to non-contiguous lymph node groups and extranodal sites (organs outside the lymphatic system) early in the disease course.
                              • Prognosis: Varies widely depending on the specific subtype, grade (aggressiveness), and stage at diagnosis. Some types are indolent (slow-growing) and may be managed for years, while others are aggressive and require immediate, intensive treatment.
                              In summary: The presence or absence of the Reed-Sternberg cell is the primary diagnostic differentiator. Hodgkin Lymphoma is characterized by these cells, has a more predictable spread, and generally a better prognosis. Non-Hodgkin Lymphoma is a much larger and more diverse group of lymphomas without Reed-Sternberg cells, often with less predictable spread and a more variable prognosis.
                              Hodgkin's Lymphoma

                              Hodgkin's Lymphoma (HL), also known as Hodgkin Disease, is a type of cancer that originates in the lymphatic system. It is distinctly characterized by the presence of a specific type of cancerous cell called the Reed-Sternberg (RS) cell.

                              Defining aspects of Hodgkin's Lymphoma:
                              1. Malignant Cell of Origin: The defining feature is the Reed-Sternberg cell. These are large, often multinucleated cells with prominent nucleoli, frequently described as having an "owl's eye" appearance due to their bilobed nuclei and central nucleoli. While RS cells are the malignant component, they constitute only a small proportion (typically 0.5-10%) of the cells within the affected lymph node.
                              2. Microenvironment: The vast majority of the tumor mass in Hodgkin's Lymphoma consists of a reactive cellular infiltrate (normal lymphocytes, plasma cells, eosinophils, histiocytes, and fibroblasts) that surrounds and interacts with the RS cells. This rich inflammatory microenvironment is characteristic.
                              3. Cellular Lineage: Most Reed-Sternberg cells are derived from germinal center B-lymphocytes that have undergone malignant transformation, but have lost their typical B-cell phenotype and often express markers usually associated with other cell types.
                              4. Clinical Behavior: HL typically presents with painless lymphadenopathy (enlarged lymph nodes), most commonly in the cervical (neck) or supraclavicular (above the collarbone) regions. It classically spreads in an orderly and contiguous fashion from one lymph node region to adjacent lymph node regions.
                              5. Prognosis and Curability: Hodgkin's Lymphoma is one of the most curable cancers, especially with modern treatment protocols. The presence of RS cells and the characteristic inflammatory background are key to its diagnosis and differentiation from Non-Hodgkin Lymphoma, which guides treatment strategies and often results in a favorable outcome.
                              WHO Classification of Hodgkin's Lymphoma

                              The World Health Organization (WHO) classification divides Hodgkin Lymphoma (HL) into two main types:

                              1. Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)
                              2. Classical Hodgkin Lymphoma (CHL), which is further subdivided into four histological subtypes.
                              1. Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)
                              • Prevalence: Accounts for about 5% of all Hodgkin Lymphoma cases.
                              • Characteristic Cell: Defined by the presence of unique large, often lobulated, pale-staining cells known as "popcorn cells" (or L&H cells – Lymphocytic and Histiocytic cells). These are variants of Reed-Sternberg cells, but are typically CD20-positive (a B-cell marker) and lack CD15 and CD30 (markers typical for classical RS cells).
                              • Microenvironment: The tumor cells are found within a background rich in small lymphocytes, often forming a nodular pattern.
                              • Clinical Features:
                                • More common in males.
                                • Typically presents with localized peripheral lymphadenopathy, often in the cervical, axillary, or inguinal regions.
                                • Usually has an indolent (slow-growing) course.
                                • Patients rarely present with "B symptoms" (fever, night sweats, weight loss).
                                • Has a tendency for late relapses and can transform into aggressive B-cell non-Hodgkin lymphoma (diffuse large B-cell lymphoma) in a small percentage of cases.
                              • Prognosis: Generally has an excellent prognosis, often better than classical HL.
                              2. Classical Hodgkin Lymphoma (CHL)
                              • Prevalence: Accounts for the vast majority (95%) of Hodgkin Lymphoma cases.
                              • Characteristic Cell: Defined by the presence of typical Reed-Sternberg (RS) cells and their variants (e.g., lacunar cells, mummified cells). These cells are typically CD15-positive and CD30-positive, and usually CD20-negative or weakly positive.
                              • Microenvironment: RS cells are surrounded by a diverse inflammatory infiltrate.
                              • Clinical Features:
                                • Often presents with mediastinal and/or cervical lymphadenopathy.
                                • "B symptoms" are more common.
                                • Spreads contiguously through lymph node chains.
                              Subtypes of Classical Hodgkin Lymphoma:
                            1. a. Nodular Sclerosis Classical Hodgkin Lymphoma (NSCHL):
                              • * Most Common Subtype: Accounts for 60-80% of all CHL cases.
                              • * Characteristic Features: Presence of "lacunar cells" (RS variants that appear to sit in empty spaces or lacunae due to artifactual retraction during processing), often with broad bands of collagen fibrosis (sclerosis) that divide the lymph node into nodules.
                              • * Demographics: More common in adolescents and young adults, and more prevalent in women.
                              • * Clinical Presentation: Frequently involves mediastinal lymph nodes.
                              • * Prognosis: Generally excellent.
                            2. b. Mixed Cellularity Classical Hodgkin Lymphoma (MCCHL):
                              • * Second Most Common Subtype: Accounts for 15-30% of CHL cases.
                              • * Characteristic Features: A diffuse effacement of the lymph node architecture by a pleomorphic infiltrate containing numerous classical RS cells and various inflammatory cells (lymphocytes, plasma cells, eosinophils, histiocytes) without significant nodularity or sclerosis.
                              • * Demographics: More common in older adults, individuals with HIV, and those in developing countries.
                              • * Clinical Presentation: Often associated with "B symptoms."
                              • * Prognosis: Good, though sometimes slightly less favorable than NSCHL at advanced stages.
                            3. c. Lymphocyte-Rich Classical Hodgkin Lymphoma (LRCHL):
                              • * Less Common Subtype: Accounts for about 5% of CHL cases.
                              • * Characteristic Features: Contains a relatively high proportion of small lymphocytes and relatively few classical RS cells, which are often difficult to find. There is typically no nodularity or sclerosis.
                              • * Clinical Presentation: Often presents in early stages, with peripheral lymphadenopathy.
                              • * Prognosis: Excellent, often similar to NSCHL.
                            4. d. Lymphocyte-Depleted Classical Hodgkin Lymphoma (LDCHL):
                              • * Rarest Subtype: Accounts for less than 1% of CHL cases.
                              • * Characteristic Features: Characterized by a paucity of lymphocytes and an abundance of classical RS cells, often with diffuse fibrosis or necrosis. Can be confused with diffuse large B-cell lymphoma.
                              • * Demographics: More common in older adults and those with HIV.
                              • * Clinical Presentation: Often presents in advanced stages with "B symptoms" and involvement of bone marrow, liver, and spleen.
                              • * Prognosis: Historically the least favorable prognosis among CHL subtypes, though outcomes have improved with modern therapy.
                            5. Clinical Features of Hodgkin's Lymphoma
                              I. Nodal Involvement (Most Common Presentation)

                              1. Painless Lymphadenopathy:

                              • This is the most common presenting symptom, occurring in about 80-90% of patients.
                              • Description: Firm, rubbery, discrete, non-tender, and mobile enlarged lymph nodes. They generally do not cause pain unless they grow very large and compress surrounding structures or are rapidly enlarging.
                              • Location:
                                • Cervical (neck) and supraclavicular (above collarbone) regions: Most frequently involved (60-80% of cases).
                                • Axillary (armpit) regions: Common.
                                • Inguinal (groin) regions: Less common as the primary site.
                                • Mediastinal (chest) involvement: Very common, especially with nodular sclerosis HL. Can be asymptomatic but may cause cough, shortness of breath, or chest discomfort if large enough to compress airways or blood vessels.

                              2. Orderly Spread: HL typically spreads in a contiguous fashion, meaning it moves from one lymph node group to an adjacent one.

                              II. Systemic Symptoms ("B Symptoms")

                              Approximately one-third of HL patients, especially those with advanced disease, experience systemic symptoms collectively known as "B symptoms." The presence of B symptoms is important for staging and prognosis.

                              1. Unexplained Fever:
                                • Temperature > 38°C (100.4°F) for three consecutive days, without any evidence of infection.
                                • Pel-Ebstein fever: A classic but rare pattern of high fever for several days alternating with afebrile periods of similar duration.
                              2. Drenching Night Sweats: So severe that clothes and bedding need to be changed, occurring without an apparent environmental cause.
                              3. Unexplained Weight Loss: Loss of more than 10% of body weight within the past six months, without dieting or other illness.
                              III. Other Less Common Clinical Features
                              • Pruritus (Itching): Generalized, often severe, and non-specific itching, which can be quite distressing. The cause is not fully understood.
                              • Alcohol-Induced Pain: A classic but rare symptom where pain occurs in affected lymph nodes shortly after alcohol consumption. The mechanism is unknown.
                              • Fatigue: Generalized tiredness and lack of energy, often out of proportion to activity.
                              • Splenomegaly: Enlargement of the spleen, indicating splenic involvement, found in about 30% of patients, usually palpable.
                              • Hepatomegaly: Enlargement of the liver, indicating hepatic involvement, less common than splenomegaly.
                              • Extranodal Disease: While HL is primarily a nodal disease, direct extension from adjacent lymph nodes (e.g., to lung, bone, pleura) or distant extranodal involvement (e.g., bone marrow, liver, bone) can occur, particularly in advanced stages.
                              • Immunosuppression: Patients with HL, particularly those with advanced disease or after treatment, can experience compromised cellular immunity, leading to increased susceptibility to infections (e.g., fungal infections, Herpes zoster).
                              Clinical Staging of Hodgkin's Lymphoma

                              The most widely used system for staging Hodgkin's Lymphoma is the Ann Arbor Staging Classification.

                              Key Principles of Ann Arbor Staging:
                              • Lymphatic Regions: The diaphragm is considered a key anatomical landmark. Lymph node involvement is categorized as occurring above or below the diaphragm.
                              • Contiguous Spread: As HL typically spreads contiguously, the number of involved regions and their location relative to the diaphragm are important.
                              • Extranodal Involvement: Involvement of organs outside the lymphatic system is denoted.
                              • Systemic Symptoms: The presence or absence of "B symptoms" (fever, night sweats, weight loss) is appended to the stage.
                              The Ann Arbor Staging Classification:
                              • Stage I: Involvement of a single lymph node region (e.g., one group of nodes in the neck) or a single extralymphatic organ site (IE). Location: Confined to one side of the diaphragm.
                              • Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm, or localized involvement of a single extralymphatic organ or site and its regional lymph nodes (IIE). Location: Confined to one side of the diaphragm.
                              • Stage III: Involvement of lymph node regions on both sides of the diaphragm.
                                • III(1): Involvement of abdominal lymph nodes (e.g., spleen, celiac, portal, or peri-aortic nodes).
                                • III(2): Involvement of inguinal, mesenteric, or para-aortic lymph nodes.
                                • Spleen Involvement (S): If the spleen is involved, it is often denoted with 'S'.
                              • Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement with distant (non-regional) lymph node involvement. Common Extralymphatic Sites: Bone marrow, liver, lung, bone.
                              Modifiers to the Ann Arbor Staging:
                              • A: Absence of B symptoms.
                              • B: Presence of B symptoms.
                              • E: Involvement of a single extralymphatic organ or site.
                              • X: Bulky disease (large tumor mass).
                              Differential Diagnoses for Hodgkin's Lymphoma
                              Condition Why it's similar Key difference
                              Non-Hodgkin Lymphoma (NHL) Also presents with painless lymphadenopathy and can have B symptoms. Histopathology (lack of Reed-Sternberg cells, different cellular morphology, immunophenotype) is the definitive differentiator. NHL is a much more heterogeneous group.
                              Metastatic Carcinoma Enlarged, firm lymph nodes, often in the cervical or supraclavicular regions. Biopsy will reveal epithelial cells (carcinoma) rather than lymphoid cells, and immunohistochemistry will show different markers. Often, there's a known primary tumor.
                              Leukemias (especially CLL) Can cause generalized lymphadenopathy. Primarily involve the bone marrow and peripheral blood. Diagnosis involves blood counts, bone marrow biopsy, and flow cytometry.
                              Sarcomas Can present as masses that may be mistaken for lymph nodes. Originates from connective tissue, not lymphoid cells. Histopathology is distinct.
                              Castleman Disease A rare lymphoproliferative disorder causing localized or generalized lymphadenopathy. Histopathology shows characteristic features distinct from lymphoma (e.g., hypervascularity, onion-skinning of follicles).
                              Infectious Mononucleosis (EBV) Widespread lymphadenopathy, fever, fatigue, splenomegaly. Acute onset, often with sore throat. Diagnosis by serology and atypical lymphocytes on blood smear. Biopsy shows reactive hyperplasia.
                              Tuberculosis (TB) Lymphadenitis Chronic, often painless, progressive lymph node enlargement (cervical). Diagnosis by PCR for Mycobacterium tuberculosis, culture, and histopathology showing granulomatous inflammation with caseous necrosis.
                              HIV Lymphadenopathy Chronic, painless, generalized lymphadenopathy. Positive HIV test. Biopsy shows follicular hyperplasia.
                              Toxoplasmosis Cervical lymphadenopathy, sometimes with fever and fatigue. Diagnosis by serology. Biopsy shows characteristic reactive changes.
                              Cat Scratch Disease Localized lymphadenopathy following cat scratch/bite. History of cat exposure. Diagnosis by serology or PCR. Biopsy shows characteristic suppurative granulomas.
                              Bacterial Lymphadenitis Enlarged, often painful lymph nodes, signs of acute infection. Acute onset, pain, redness, warmth. Resolves with antibiotics.
                              Sarcoidosis Bilateral hilar lymphadenopathy and peripheral lymphadenopathy. Biopsy shows non-caseating granulomas. Elevated ACE levels.
                              SLE or Rheumatoid Arthritis Generalized lymphadenopathy, systemic inflammation. Presence of other systemic autoimmune features and positive autoantibody tests (ANA, RF).
                              Treatment Modalities for Hodgkin's Lymphoma
                              I. Chemotherapy
                              • 1. ABVD Regimen:
                                • Components: Adriamycin (Doxorubicin), Bleomycin, Vinblastine, and Dacarbazine.
                                • Usage: The most common and standard first-line chemotherapy regimen.
                                • Side Effects: Nausea, vomiting, hair loss, fatigue, myelosuppression, cardiotoxicity (doxorubicin), and pulmonary toxicity (bleomycin).
                              • 2. BEACOPP Regimen:
                                • Components: Bleomycin, Etoposide, Adriamycin, Cyclophosphamide, Oncovin (Vincristine), Procarbazine, and Prednisone.
                                • Usage: A more intensive regimen for advanced-stage HL and unfavorable prognostic factors.
                                • Side Effects: Higher rates of myelosuppression, secondary malignancies, and infertility.
                              • 3. Other Regimens/Salvage Chemotherapy: For relapsed or refractory HL (e.g., ICE, DHAP, GVD), often followed by autologous stem cell transplantation.
                              II. Radiation Therapy (RT)
                              • Involved-Site Radiation Therapy (ISRT): Targets only the initially involved lymph node regions. Used to consolidate remission and reduce local recurrence.
                              • Involved-Node Radiation Therapy (INRT): A more precise form of ISRT targeting only involved nodes.
                              III. Immunotherapy/Targeted Therapy
                              • Brentuximab Vedotin (BV): An antibody-drug conjugate that targets CD30 on RS cells.
                              • PD-1 Inhibitors (e.g., Nivolumab, Pembrolizumab): Block the PD-1 checkpoint pathway to unleash the body's immune system against cancer cells.
                              IV. High-Dose Chemotherapy with Autologous Stem Cell Transplantation (ASCT)
                              • Usage: Standard for relapsed or refractory HL. Patients receive very high doses of chemotherapy followed by infusion of their own stem cells.
                              Non-Hodgkin Lymphoma

                              Non-Hodgkin Lymphoma (NHL) refers to a diverse group of cancers that originate in the lymphocytes. Unlike Hodgkin's Lymphoma, NHL encompasses a wide spectrum of lymphoid malignancies with varying cellular origins, histological features, clinical behaviors, and prognoses.

                              Key Characteristics and Distinctions:
                              1. Origin: NHL arises from either B lymphocytes (B-cells) or T lymphocytes (T-cells), and rarely from natural killer (NK) cells. The vast majority (~85-90%) are of B-cell origin.
                              2. Absence of Reed-Sternberg Cells: The defining feature distinguishing NHL from HL is the absence of Reed-Sternberg cells.
                              3. Heterogeneity: NHL is a collection of over 60 distinct subtypes varying in histology, immunophenotype, genetics, and clinical behavior.
                              4. Spread Pattern: Unlike HL, NHL often spreads in a non-contiguous, unpredictable manner. It can involve distant lymph node sites and extranodal organs early in the disease course.
                              5. Incidence: NHL is significantly more common than HL.
                              Categorization and Classification of NHL
                              Simplified Categorization based on Growth Rate:
                              • Indolent (Slow-Growing): Grow slowly, often disseminated at diagnosis, may not require immediate treatment ("watch and wait"). Incurable but controllable. (e.g., Follicular Lymphoma, SLL/CLL).
                              • Aggressive (Fast-Growing): Grow rapidly, severe symptoms, require prompt treatment. Potentially curable. (e.g., DLBCL).
                              • Highly Aggressive (Very Fast-Growing): Grow extremely rapidly, require immediate intensive chemotherapy. (e.g., Burkitt Lymphoma).
                              Key Examples of NHL Subtypes (WHO Classification):
                              I. Mature B-cell Neoplasms (Most Common)
                              • Indolent:
                                • Follicular Lymphoma (FL): Nodular growth, t(14;18) translocation (BCL2 overexpression). Widespread painless lymphadenopathy.
                                • Small Lymphocytic Lymphoma (SLL) / Chronic Lymphocytic Leukemia (CLL): Small, mature-looking lymphocytes.
                                • Marginal Zone Lymphoma (MZL): Can be extranodal (MALT lymphoma).
                                • Lymphoplasmacytic Lymphoma (Waldenström Macroglobulinemia): Secretes IgM paraprotein.
                              • Aggressive:
                                • Diffuse Large B-cell Lymphoma (DLBCL): Most common NHL. Large atypical B-cells, diffuse pattern. Rapidly enlarging.
                                • Mantle Cell Lymphoma (MCL): t(11;14) translocation (Cyclin D1). Aggressive course.
                              • Highly Aggressive:
                                • Burkitt Lymphoma (BL): t(8;14) involving MYC oncogene. Extremely rapid growth. Endemic (Africa), Sporadic, or Immunodeficiency-associated.
                              II. Mature T-cell and NK-cell Neoplasms (Less Common)
                              • Peripheral T-cell Lymphoma (PTCL, NOS): "Wastebasket" category, often aggressive.
                              • Anaplastic Large Cell Lymphoma (ALCL): Large pleomorphic T-cells, can be ALK-positive or negative.
                              • Mycosis Fungoides / Sézary Syndrome: Cutaneous T-cell lymphomas.
                              Clinical Features of Non-Hodgkin Lymphoma
                              • Generalized Symptoms ("B Symptoms"): Fever, Night Sweats, Weight Loss. (Less frequent in indolent NHL).
                              • Lymphadenopathy: Painless swelling of lymph nodes. Can be generalized.
                              • Extranodal Disease: A hallmark differentiating NHL from HL. Common sites:
                                • GI Tract: Pain, bleeding, obstruction.
                                • Bone Marrow: Cytopenias (fatigue, bleeding, infection).
                                • Skin: Rashes, nodules, ulcers.
                                • CNS: Headaches, seizures, deficits.
                                • Spleen/Liver/Bone/Waldeyer's Ring.
                              Clinical Staging of Non-Hodgkin Lymphoma

                              Uses the Ann Arbor/Lugano Staging Classification, similar to HL but adapted for non-contiguous spread.

                              • Stage I: Single node region or single extralymphatic site.
                              • Stage II: Two or more regions on same side of diaphragm.
                              • Stage III: Regions on both sides of diaphragm.
                              • Stage IV: Diffuse/disseminated extralymphatic involvement.

                              International Prognostic Index (IPI): For aggressive NHL (e.g., DLBCL). Risk factors: Age > 60, Elevated LDH, Performance Status ≥ 2, Stage III/IV, Extranodal sites > 1.

                              Investigations for NHL
                              • Biopsy (Gold Standard): Excisional Biopsy is crucial for morphology, Immunohistochemistry (IHC), Flow Cytometry, and Molecular Genetics (FISH/PCR).
                              • Imaging: PET-CT Scan (metabolically active disease), CT Scans, MRI (CNS).
                              • Labs: CBC, LFTs, KFTs, LDH (prognostic), Uric Acid, Beta-2 Microglobulin, Viral Studies (HIV, HBV, HCV, EBV).
                              • Procedures: Bone Marrow Biopsy, Lumbar Puncture (if CNS suspicion).
                              Treatment Modalities for Non-Hodgkin Lymphoma
                              1. Chemotherapy:
                                • CHOP Regimen: Cyclophosphamide, Hydroxydaunorubicin, Oncovin, Prednisone. Foundational for aggressive B-cell lymphomas.
                                • High-Dose Chemotherapy with ASCT.
                              2. Immunotherapy:
                                • Rituximab (Anti-CD20): Monoclonal antibody targeting B-cells. Often added to CHOP (R-CHOP).
                                • Antibody-Drug Conjugates (ADCs).
                                • Immune Checkpoint Inhibitors.
                                • CAR T-cell Therapy: Genetically modified patient T-cells targeting cancer antigens (e.g., CD19).
                                • Bispecific Antibodies.
                              3. Radiation Therapy: For local control or palliative care.
                              4. Targeted Therapies: BTK Inhibitors (Ibrutinib), PI3K Inhibitors, BCL2 Inhibitors (Venetoclax), etc.
                              5. "Watch and Wait": For asymptomatic indolent lymphomas.

                              Management of Hodgkin’s lymphoma

                              • Radiation therapy for localized disease
                              • Short course combination therapy with less extensive radiation
                              • Radiation is combined with chemotherapy to treat disseminated disease
                              • Cytotoxic drugs are combined with steroids
                              • Two regimens are used i.e
                              • MOPP
                              Mustin/nitrogen ------------------- mustard on day 1 and 8
                              Oncorin/ vincristine------------------- day 1 and 8
                              Procarbazine------------------- day 1 and 14
                              Predisone------------------- day I and 14

                              • ABVD
                              Adriamycin/ dexorubium ------------------ day 1 and 15
                              Bleomycin------------------ day 1 and 15
                              Vinblastin------------------ day 1 and 15
                              Decarbazine------------------ day 1 and 15

                              • Nursing care is based on pancytopenia (A condition in which there is a lower-than-normal number of red and white blood cells and platelets in the blood.) and other drug effects
                              • Psychological support
                              • Nutrition support
                              • Regular hygiene to prevent infections
                              NURSING INTERVENTIONS FOR PATIENTS WITH LYMPHOMA (HL & NHL)
                              I. Managing Treatment-Related Side Effects
                              Condition & Assessment Interventions
                              Neutropenia (Low WBCs/Risk of Infection)
                              Assessment: Monitor ANC, temperature (q4h), signs of infection (chills, redness, swelling, sore throat).
                              • Implement strict hand hygiene.
                              • Administer colony-stimulating factors (filgrastim).
                              • Education: Avoid crowds, sick contacts, raw foods.
                              • Maintain aseptic technique for invasive procedures.
                              • Avoid rectal temps/enemas.
                              • Encourage oral hygiene with soft toothbrush.
                              Thrombocytopenia (Low Platelets/Risk of Bleeding)
                              Assessment: Monitor platelets, observe for bleeding (petechiae, purpura, epistaxis, hematuria, melena). Neuro status.
                              • Administer platelet transfusions.
                              • Avoid aspirin/NSAIDs.
                              • Bleeding precautions: soft toothbrush, electric razor, avoid IM injections.
                              • Education: Avoid falls, contact sports, vigorous nose blowing.
                              Anemia (Low RBCs/Fatigue)
                              Assessment: Monitor Hb/Hct, fatigue, pallor, dyspnea, tachycardia.
                              • Administer packed RBC transfusions.
                              • Encourage rest periods; assist with ADLs.
                              • Educate on energy conservation.
                              Condition & Assessment Interventions
                              Nausea and Vomiting
                              Assessment: Frequency, severity, triggers.
                              • Administer antiemetics proactively.
                              • Offer small, frequent, bland meals.
                              • Encourage clear liquids, ginger ale, crackers.
                              • Relaxation techniques.
                              Mucositis/Stomatitis (Oral Sores)
                              Assessment: Inspect mucosa daily for redness/lesions. Assess pain.
                              • Frequent oral care with soft brush, non-irritating mouthwash.
                              • Administer pain meds (topical/systemic).
                              • Avoid acidic, spicy, hot foods. Offer soft, moist foods.
                              Diarrhea/Constipation
                              Assessment: Bowel habits, consistency.
                              • Diarrhea: Antidiarrheals, low-fiber diet, hydration.
                              • Constipation: Laxatives/stool softeners, fluids, fiber (if not neutropenic), ambulation.
                              Condition & Assessment Interventions
                              Fatigue
                              Assessment: Severity, impact on ADLs.
                              • Encourage balanced rest/activity.
                              • Prioritize activities.
                              • Energy conservation strategies.
                              • Light exercise if tolerated.
                              Peripheral Neuropathy
                              Assessment: Numbness, tingling, burning, weakness.
                              • Safety education (fall prevention, water temp).
                              • Administer neuropathic pain meds.
                              • Assistive devices.
                              Skin Reactions (Radiation)
                              Assessment: Redness, dryness, itching, peeling.
                              • Gentle skin care: mild soap, pat dry, no rubbing.
                              • Non-perfumed lotions recommended by oncologist.
                              • Avoid tight clothing. Protect from sun.
                              Alopecia
                              Assessment: Discuss expectations/emotional impact.
                              • Info on wigs, scarves, hats.
                              • Emphasize hair growth resumes after treatment.
                              II. Preventing and Managing Complications
                              Complication & Assessment Interventions
                              Tumor Lysis Syndrome (TLS)
                              Assessment: Electrolytes (K+, Phos, Ca), Uric acid, cardiac arrhythmias, muscle cramps, decreased urine output.
                              • Vigorous hydration.
                              • Allopurinol or rasburicase.
                              • Monitor cardiac rhythm.
                              Superior Vena Cava (SVC) Syndrome
                              Assessment: Facial/neck edema, dyspnea, distended neck veins.
                              • Elevate head of bed.
                              • Avoid tight clothing/restraints.
                              • Corticosteroids/diuretics. Emergency radiation/chemo.
                              Infections (Opportunistic)
                              Assessment: Assess for fungal/viral infections.
                              • Prophylactic antibiotics/antivirals/antifungals.
                              • Strict infection control.
                              III. Psychosocial, Education, and Quality of Life
                              • Emotional Distress: Provide empathetic support, encourage verbalization, refer to support groups. Address body image changes (wigs, self-worth). Teach coping mechanisms.
                              • Patient Education: Disease/treatment plan, medication management, self-care strategies, signs to report (fever, bleeding), follow-up care, nutrition/hydration.
                              • Pain Management: Assess pain. Administer analgesics. Non-pharmacological methods.
                              • Sleep Promotion: Optimize environment, consistent times, sleep aids if prescribed.

                              Management of Non Hodgkin’s disease

                              Specialists who treat non-Hodgkin lymphoma include hematologists, medical oncologists, radiation oncologists, oncology nurses and a registered dietitian. The choice of treatment depends mainly on the following:
                              1. The type of non-Hodgkin lymphoma
                              2. Stage of lymphoma
                              3. How quickly the cancer is growing (whether it is indolent or aggressive lymphoma)
                              4. Age of the patient
                              5. Other patient’s health problems
                              1.Watchful waiting:
                              • If a patient has indolent non-Hodgkin lymphoma without symptoms, treatment for the cancer is not initiated immediately. The treatment team watches the patient’s health closely so that treatment can start when symptoms begin
                              • Indolent lymphoma with symptoms needs chemotherapy and biological Radiation therapy may be used for people with Stage I or Stage II lymphoma
                              • In aggressive lymphoma, the treatment is usually chemotherapy and biological therapy People with lymphoma that comes back after treatment may receive high doses of chemotherapy, radiation therapy, or both, followed by stem cell transplantation
                              Before treatment starts, health care team should explain possible side effects and ways of managing them to the patient
                              2. Chemotherapy uses drugs to kill cancer cells throughout the body; drug can be administered by oral route, intravenous or into spinal cord in phases depending on the cancer stage and nature of the drug. Drugs in initial stage cyclophosphamide and chlorambucil In recurrence CDVP (cyclophosphamide, doxorubicin, vincristine and prednisone) or CVPP (cyclophoshamide, vinchristine, procarbozine and prednisone) Side effects poor appetite, nausea and vomiting, diarrhea, trouble swallowing, or mouth and lip sores, hair loss, infections, bruise or bleeding easily, skin rashes or blisters, headaches, weakness and tiredness
                              3.Biological therapy:
                              • People with certain types of non-Hodgkin lymphoma may have biological therapy. This type of treatment helps the immune system fight cancer.
                              Monoclonal antibodies i.e interferon, interlukin 2 and tumor necrosis factor (proteins made in the lab that can bind to cancer cell so that they can be destroyed). Patients receive this treatment through a vein at the doctor's office, clinic, or hospital.
                              • Flu-like symptoms such as fever, chills, headache, weakness, and nausea may Most side effects are easy to treat. Rarely, a person may have more serious side effects, such as breathing problems, low blood pressure, or severe skin rashes.

                              4. Radiation therapy/ radiotherapy: uses high-energy rays to kill lymphoma cells. It can shrink tumors and help control Two types of radiation therapy are used for people with lymphoma:
                              • External radiation: A large machine aims the rays at the part of the body where lymphoma cells have collected. This is local therapy because it affects cells in the treated area only. Most people go to a hospital or clinic for treatment 5 days a week for several
                              • Systemic radiation: Some people with lymphoma receive an injection of radioactive material that travels throughout the body. The radioactive material is bound to monoclonal antibodies that seek out lymphoma The radiation destroys the lymphoma cells.
                              • External radiation to abdomen can cause nausea, vomiting, and diarrhea, on chest and neck there may be dry sore throat and difficult in swallowing, the skin may become red, dry, and People who get systemic radiation also may feel very tired, get infections and above signs worsen

                              5.Stem cell transplantation: If lymphoma returns after treatment, stem cell transplantation is considered. A transplant of blood-forming stem cells allows a patient to receive high doses of chemotherapy, radiation therapy, or both. The high doses destroy both lymphoma cells and healthy blood cells in the bone marrow. Transplant given through a flexible tube placed in a large vein in the neck or chest area after heavy chemotherapy. New blood cells develop from the transplanted stem cells. The stem cells may come from body of the patient (Autologous stem cell transplantation) or a donor who is a brother, sister or parent (Allogeneic stem cell transplantation) and Syngeneic stem cell transplantation for identical twins Supportive care aims at controlling pain and other symptoms, to relieve the side effects of therapy and to help the patient cope with the diagnosis. It includes
                              6. Nutrition: give calories to maintain a good weight, protein to keep promote strength. Eating well may help the patient feel better and have more
                              7. Activity: Walking, swimming, and other activities can keep the patient strong and Exercise may reduce nausea and pain and make treatment easier to handle. It also can help relieve stress
                              8. Follow-Up Care: regular checkups after treatment for non-Hodgkin The health team watches patient’s recovery closely and check for recurrence of the lymphoma. Checkups monitors change in health and treatment needs of the patient. Checkups may include a physical exam, lab tests, chest x-rays, and other procedures.
                              9. Social support: this can be provided by Doctors, nurses, and other members of the health care team who answer many questions about patient’s treatment, working, or other procedures.
                              Social workers can suggest resources for financial aid, transportation, home care, or emotional support. Support groups like patients or family members meet with other patients or their families to share what they have learned about coping with the disease and the effects of treatment. Groups may offer support in person, over the telephone, or on the Internet. A patient may want to talk with a member of the health care team about finding a support group.
                              10. Treat treatment side effects appropriately
                              1. Helicobacter pylori is treated with antibiotics
                              2. Surgical: this corrects stricture and obstruction
                              3. Encourage bladder training , habit retraining and intake of oral fluids

                              Hodgkin’s Disease Read More »

                              lymph vessle

                              DISEASE OF LYMPH VESSELS

                              Lymphedema Lecture Notes

                              Lymphedema (pronounced lim-fa-DEE-ma) is a chronic, progressive, and often debilitating condition characterized by localized tissue swelling and fluid retention, which occurs when the lymphatic system is impaired or damaged.

                              Breakdown of the key elements of this definition:
                              1. Chronic and Progressive:
                                • Chronic: It is a long-term condition that typically does not resolve on its own.
                                • Progressive: If left untreated, the swelling tends to worsen over time, leading to more significant tissue changes.
                              2. Localized Tissue Swelling and Fluid Retention:
                                • The most visible and primary symptom is swelling, usually in one or more limbs (arms or legs), but it can also affect other body parts such as the trunk, head and neck, or genitalia.
                                • The fluid that accumulates is rich in protein, which is a distinguishing feature from other types of edema.
                              3. Impaired or Damaged Lymphatic System:
                                • This is the defining characteristic. Lymphedema specifically results from a failure of the lymphatic system to adequately drain lymph fluid from a particular area of the body.
                                • The lymphatic system is a network of vessels, nodes, and organs responsible for collecting excess interstitial fluid (lymph) from tissues, filtering it, and returning it to the bloodstream.
                                • When this system is compromised, lymph fluid accumulates in the interstitial spaces, leading to swelling.
                              4. Distinguishing from General Edema:
                                • Edema is a general term for swelling caused by fluid accumulation. Many conditions can cause edema (e.g., heart failure, kidney disease, venous insufficiency).
                                • Lymphedema is a specific type of edema characterized by:
                                  • High Protein Content: Unlike many other forms of edema where the fluid is mainly water and electrolytes, lymphedema fluid is rich in protein. This high protein content is crucial because it draws more water into the interstitial space, stimulates fibroblast activity, and contributes to tissue fibrosis (hardening/thickening of the skin and subcutaneous tissue).
                                  • Non-pitting (in later stages): While early lymphedema may be pitting (an indentation remains after pressure is applied), as the condition progresses and fibrosis occurs, the tissue becomes harder and the swelling becomes non-pitting.
                                  • Asymmetrical (often): Lymphedema often affects one limb or one side of the body, though it can be bilateral if the underlying cause affects both sides. Other systemic edemas are typically symmetrical.

                              In essence, lymphedema is the specific and chronic swelling that occurs when the body's natural drainage system for protein-rich fluid (the lymphatic system) is not working correctly.

                              Classification of Lymphedema

                              Lymphedema is broadly classified into two main types: primary lymphedema and secondary lymphedema. The distinction lies in whether the impairment of the lymphatic system is due to a congenital abnormality or an acquired damage/disruption.

                              I. Primary Lymphedema
                              • Definition: Primary lymphedema results from an inherited or congenital abnormality or malformation of the lymphatic system itself. This means the lymphatic vessels or nodes are underdeveloped, malformed, or absent from birth, or develop abnormally later in life without an identifiable external cause.
                              • Onset: Can be present at birth, develop during puberty, or even manifest in adulthood.
                              • Causes (Congenital Malformations): These are structural abnormalities of the lymphatic system, often genetic in origin, leading to insufficient lymphatic transport capacity.
                                • Aplasia: Complete absence of lymphatic vessels in a given area.
                                • Hypoplasia: Underdevelopment or reduced number of lymphatic vessels, or vessels that are too small. This is the most common cause of primary lymphedema.
                                • Hyperplasia (or Megalymphatics): Abnormally dilated and tortuous lymphatic vessels, often with incompetent valves, leading to reflux and inefficient drainage.
                                • Lymphatic Dysfunction: Impaired function of otherwise normally structured vessels, e.g., due to impaired contractility.
                              • Clinical Syndromes Associated with Primary Lymphedema:
                                • Congenital Lymphedema (Milroy's Disease): Present at birth or develops within the first 2 years of life. Often affects one or both lower limbs. It is caused by mutations in the FLT4 gene (VEGFR3), leading to lymphatic hypoplasia.
                                • Lymphedema Praecox (Meige's Disease): The most common form of primary lymphedema, usually developing around puberty or before age 35. Affects primarily females and typically the lower limbs. May be associated with mutations in the FOXC2 gene.
                                • Lymphedema Tarda: Develops after age 35.
                                • Other Genetic Syndromes: Primary lymphedema can also be a feature of certain genetic syndromes, such as Turner syndrome, Noonan syndrome, and yellow nail syndrome.
                              II. Secondary Lymphedema
                              • Definition: Secondary lymphedema is much more common than primary lymphedema. It results from damage to or obstruction of a previously normal lymphatic system. The lymphatic system is acquiredly injured, leading to its inability to adequately drain lymph fluid.
                              • Onset: Typically develops after an event that damages the lymphatic system, such as surgery, radiation, infection, or trauma.
                              • Causes (Acquired Damage/Disruption):
                                1. Cancer Treatment (Most Common Cause in Developed Countries):
                                  • Lymph Node Dissection/Removal: Surgical removal of lymph nodes (e.g., sentinel lymph node biopsy, axillary dissection for breast cancer, groin dissection for melanoma, pelvic dissection for gynecological cancers) is a major risk factor. This physically removes critical drainage pathways.
                                  • Radiation Therapy: Radiation used to treat cancer can damage lymphatic vessels and nodes, causing fibrosis and scarring that impede lymph flow.
                                2. Infection (Most Common Cause Worldwide):
                                  • Filariasis (Elephantiasis): A parasitic infection (caused by filarial worms) transmitted by mosquitoes. The adult worms live in and block lymphatic vessels, causing severe damage and leading to massive lymphedema, particularly in the lower limbs and genitalia. This is a major cause of lymphedema in tropical and subtropical regions.
                                  • Cellulitis/Erysipelas: Recurrent severe bacterial infections of the skin and subcutaneous tissue can cause inflammation and scarring of lymphatic vessels, leading to damage.
                                3. Trauma/Injury: Severe burns, crush injuries, or extensive wounds can directly damage or disrupt lymphatic vessels.
                                4. Surgery (Non-Cancer Related): Any extensive surgery that involves large incisions or removal of tissue can inadvertently damage lymphatic pathways.
                                5. Venous Insufficiency: Severe, chronic venous insufficiency can lead to an overload of the lymphatic system. While primarily venous edema, it can eventually lead to lymphatic damage and secondary lymphedema (phlebolymphedema).
                                6. Obesity: Severe obesity can place mechanical stress on lymphatic vessels, impair lymphatic flow, and is increasingly recognized as a significant risk factor and contributor to lymphedema development and progression.
                                7. Immobility/Lack of Muscle Pump: Prolonged immobility can reduce the effectiveness of the muscle pump, which aids lymphatic flow, exacerbating existing lymphatic issues or contributing to edema.
                                8. Tumor Obstruction: Tumors themselves can grow and directly compress or invade lymphatic vessels and nodes, blocking lymph drainage.
                              Causes and Risk Factors

                              The development of lymphedema is a multifactorial process, influenced by a primary insult to the lymphatic system coupled with various risk factors that can exacerbate or trigger the condition.

                              I. General Risk Factors for Developing Lymphedema

                              These factors don't necessarily cause lymphatic damage themselves but increase the likelihood or severity of lymphedema when lymphatic damage is present or imminent.

                              • Genetics/Family History: A family history of primary lymphedema increases risk.
                              • Obesity: As mentioned, it's a significant risk factor for both onset and progression.
                              • Increased Age: The lymphatic system may become less efficient with age.
                              • Presence of Scar Tissue: Extensive scarring can obstruct lymphatic pathways.
                              • Impaired Wound Healing: Can lead to chronic inflammation and further lymphatic damage.
                              • Chronic Inflammation: Any condition causing persistent inflammation can contribute.
                              • Female Sex: Women are more susceptible to certain cancers that involve lymph node dissection (e.g., breast cancer), increasing their risk of secondary lymphedema.
                              • Severity of Initial Lymphatic Insult: More extensive surgery, higher doses of radiation, or severe infections increase the risk.
                              Pathophysiology of Lymphedema

                              Lymphedema originates from a fundamental imbalance between the production of interstitial fluid and its drainage by the lymphatic system. This leads to a vicious cycle of fluid accumulation, inflammation, and progressive tissue changes.

                              I. Initial Lymphatic Impairment and Fluid Accumulation
                              1. Reduced Lymphatic Transport Capacity:
                                • Primary Lymphedema: The lymphatic system is intrinsically deficient from birth. Its maximal transport capacity (MTC) is inherently lower than normal.
                                • Secondary Lymphedema: A previously normal lymphatic system is damaged. This damage reduces the number and function of lymphatic vessels and nodes, thereby lowering the MTC.
                                • The "Safety Factor": A healthy lymphatic system has a significant "safety factor," meaning it can handle a much higher volume of fluid (up to 10-20 times normal) than it typically drains without swelling. When the MTC drops below the actual lymphatic load, lymphedema begins.
                              2. Accumulation of Protein-Rich Interstitial Fluid:
                                • When the lymphatic system's capacity is overwhelmed or reduced, the interstitial fluid cannot be adequately drained.
                                • Crucially, the lymphatic system is the only pathway for large proteins, cellular debris, and large molecules to be removed from the interstitial space.
                                • Therefore, in lymphedema, there is a characteristic accumulation of protein-rich fluid in the affected tissues.
                              II. The Vicious Cycle: Inflammation, Fibrosis, and Tissue Remodeling

                              The accumulation of protein-rich fluid is not benign. The high protein concentration in the interstitial space acts as an osmotic force, drawing even more water from the capillaries into the tissue, thereby exacerbating the swelling. Furthermore, this protein-rich environment initiates a cascade of inflammatory and fibrotic changes:

                              1. Inflammation and Immune Response:
                                • Macrophage Activation: The stagnant, protein-rich lymph is an ideal medium for chronic low-grade inflammation. Macrophages are attracted to the area and activated.
                                • Cytokine Release: Activated macrophages and other immune cells release pro-inflammatory cytokines (e.g., TNF-α, IL-1, IL-6) and growth factors (e.g., TGF-β, VEGF-C).
                                • Impaired Local Immunity: The impaired lymphatic drainage also means that immune cells cannot effectively patrol and respond to local infections, making the lymphedematous limb more prone to recurrent infections (e.g., cellulitis), which in turn further damages the lymphatic system.
                              2. Stimulation of Fibrosis (Connective Tissue Proliferation):
                                • Fibroblast Activation: The high protein concentration and the persistent inflammatory mediators (especially TGF-β) stimulate fibroblasts in the subcutaneous tissue to produce and deposit excess collagen and other extracellular matrix components.
                                • Adipose Tissue Accumulation: There is also a significant proliferation of adipocytes (fat cells) in the affected area. This is a characteristic feature of chronic lymphedema, contributing significantly to the increased limb volume and hardening.
                                • Increased Tissue Viscosity: The deposition of collagen and fat leads to hardening and thickening of the subcutaneous tissue, making the limb feel firm and eventually non-pitting. This is known as fibrosis or sclerosis.
                              3. Further Compromise of Lymphatic Function:
                                • The chronic inflammation and fibrosis within the tissues can further compress and destroy remaining functional lymphatic vessels, leading to a further reduction in MTC. This creates a self-perpetuating cycle where lymphatic insufficiency leads to fluid accumulation, which leads to inflammation and fibrosis, which then worsens lymphatic insufficiency.
                              III. Clinical Progression and Tissue Changes

                              This pathological process leads to the characteristic signs and symptoms of lymphedema, progressing through stages:

                              • Initial Stages (Stage 0, Stage 1):
                                • Pitting Edema: Early lymphedema is often characterized by pitting edema (an indentation remains after pressure is applied), as the tissue is still relatively soft.
                                • Reversible Swelling: The swelling may partially or fully resolve with elevation or overnight rest.
                              • Later Stages (Stage 2, Stage 3):
                                • Non-pitting Edema: As fibrosis and fat deposition increase, the tissue becomes firmer, and the swelling becomes non-pitting.
                                • Skin Changes: The skin becomes thickened, hardened, and takes on an "orange peel" appearance (peau d'orange). There may be hyperkeratosis (thickening of the outer layer of the skin), papillomatosis (wart-like growths), and skin folds deepen.
                                • Loss of Function: The increased limb volume and tissue changes can lead to pain, discomfort, reduced range of motion, and impaired mobility.
                                • Increased Susceptibility to Infection: Due to impaired local immunity and stagnant fluid, recurrent episodes of cellulitis are common, further damaging the lymphatic system.
                                • Lymphangiectasia/Dermal Backflow: In severe cases, lymphatic vessels in the skin may dilate, sometimes leaking lymph (lymphorrhea).
                              Signs and Symptoms / Clinical Presentation

                              The clinical presentation of lymphedema can vary based on its cause, location, and severity, but there are characteristic signs and symptoms that guide diagnosis.

                              I. General Signs and Symptoms
                              1. Swelling (Edema):
                                • Primary Symptom: The most obvious sign. Can affect arms, legs, trunk, head/neck, or genitalia.
                                • Onset: Often gradual, but can be sudden, especially after an inciting event (e.g., surgery).
                                • Location: Usually asymmetrical (affecting one limb or side), though bilateral involvement is possible.
                                • Feeling of Heaviness/Fullness: The affected limb feels heavy, full, or tight, even before visible swelling is pronounced.
                                • "Stocking/Glove" Pattern: Swelling often starts distally (in the hand or foot) and progresses proximally up the limb, though this is not always the case.
                                • Reduced Pitting: Early on, the swelling may "pit." As the condition progresses and fibrosis occurs, it becomes less pitting or non-pitting.
                              2. Skin Changes:
                                • Thickening and Hardening (Fibrosis): The skin and subcutaneous tissue become firm, tough, and rubbery.
                                • Peau d'Orange: The skin may take on an "orange peel" texture due to pitting around hair follicles.
                                • Hyperkeratosis: Thickening of the outer layer of the skin, leading to a rough, scaly, or wart-like appearance.
                                • Papillomatosis: Formation of small, wart-like growths on the skin surface.
                                • Skin Folds: Deepening of natural skin folds or the formation of new folds.
                                • Dryness and Cracking: The skin can become dry, flaky, and prone to cracking, increasing the risk of infection.
                                • Discoloration: The skin may appear pale, reddish, or brownish (hyperpigmentation) due to chronic inflammation or hemosiderin deposition.
                              3. Discomfort and Functional Impairment:
                                • Pain/Aching: While often not severely painful, dull aching or discomfort is common, particularly in later stages or during inflammatory episodes.
                                • Tightness/Tension: A constant feeling of pressure or tightness in the affected area.
                                • Restricted Range of Motion: Swelling and tissue thickening can limit movement in joints.
                                • Difficulty with Clothing/Jewelry: Rings, watches, or clothing become tight or no longer fit.
                                • Impaired Function: Reduced ability to perform daily activities due to the size, weight, and stiffness of the limb.
                                • Numbness/Tingling: May occur due to nerve compression from swelling.
                              4. Increased Susceptibility to Infection:
                                • Cellulitis: Recurrent bacterial infections (e.g., cellulitis, erysipelas) are a hallmark of lymphedema. Symptoms include redness, warmth, increased swelling, intense pain, fever, and malaise.
                                • Fungal Infections: The moist environment in skin folds makes fungal infections more common.
                              5. Stemmer's Sign (Diagnostic Feature):
                                • A positive Stemmer's sign is often considered a hallmark of lymphedema in the toes or fingers. It is present when the skin at the base of the second toe (or middle finger) cannot be lifted into a fold. This indicates thickening and fibrosis of the skin and subcutaneous tissue. A negative Stemmer's sign (skin can be lifted) does not rule out lymphedema elsewhere in the limb.
                              II. Stages of Lymphedema (ISL Staging)
                              • Stage 0 (Latency or Subclinical Lymphedema):
                                • Description: The lymphatic system is damaged, but there is no visible or palpable swelling. The transport capacity of the lymphatic system is impaired, but it can still manage the lymphatic load.
                                • Symptoms: Patients may report vague symptoms like occasional feelings of heaviness, fullness, or mild aching.
                                • Reversible: Potentially reversible with early intervention, or can remain at this stage for years.
                              • Stage 1 (Spontaneously Reversible Lymphedema):
                                • Description: Visible swelling is present. The edema is typically soft and pitting.
                                • Symptoms: Limb volume may increase. The swelling often reduces with limb elevation or overnight rest. Stemmer's sign may be negative or positive.
                                • Reversible: At this stage, the condition is largely reversible if effectively treated, as significant fibrotic changes have not yet occurred.
                              • Stage 2 (Spontaneously Irreversible Lymphedema):
                                • Description: The swelling is persistent and does not significantly reduce with elevation. The tissue texture begins to change, becoming firmer or "brawny" due to the accumulation of protein and the onset of fibrosis.
                                • Symptoms: The edema is less pitting or non-pitting. Stemmer's sign is typically positive. Skin changes (e.g., thickening, hyperkeratosis) may begin to appear.
                                • Irreversible: While the volume can be managed, the fibrotic changes make the tissue irreversible to complete normal appearance.
                              • Stage 3 (Lymphostatic Elephantiasis):
                                • Description: This is the most advanced and severe stage, characterized by significant and irreversible swelling, often referred to as "elephantiasis."
                                • Symptoms: Extreme increase in limb volume, gross tissue changes, extensive fibrosis, severe hyperkeratosis, papillomatosis, deep skin folds, and often impaired mobility. Recurrent infections (cellulitis) are common. Lymphorrhea (leaking lymph fluid) may occur from skin lesions.
                                • Irreversible: Severe and debilitating, often with significant impact on quality of life.
                              Diagnostic Methods of Lymphedema

                              The diagnosis of lymphedema is primarily clinical, based on a thorough history and physical examination. Imaging studies are often used to confirm the diagnosis, differentiate lymphedema from other edemas, and identify the underlying cause and lymphatic anatomy.

                              I. Clinical History
                              1. Onset and Progression of Swelling: When did it start? Sudden or gradual? Unilateral or bilateral? Does it fluctuate? How has it changed?
                              2. Medical History:
                                • Cancer Treatment: History of cancer, lymph node dissection, radiation therapy.
                                • Infections: History of recurrent cellulitis/erysipelas or parasitic infections.
                                • Trauma/Surgery: Previous injury or surgery to the affected region.
                                • Venous Disease: DVT or chronic venous insufficiency.
                                • Genetic Conditions: Family history.
                              3. Symptoms: Heaviness, tightness, aching, skin changes, difficulty with clothing.
                              II. Physical Examination
                              1. Inspection: Asymmetry, Skin Changes (erythema, hyperpigmentation, hyperkeratosis), Hair Distribution (reduced/absent), Venous Patterns.
                              2. Palpation: Temperature, Consistency (soft, pitting, firm, brawny), Stemmer's Sign.
                              3. Measurements: Circumference Measurements, Volume Measurement (perometry, water displacement), Bioimpedance Spectroscopy (BIS).
                              III. Diagnostic Imaging
                              Modality Procedure / Use Findings in Lymphedema
                              1. Lymphoscintigraphy (Radionuclide Lymphangioscintigraphy)
                              • Gold Standard (Functional Assessment).
                              • Radioactive tracer injected into web space of toes/fingers. Images taken over time to visualize vessels/nodes and tracer transport.
                              Delayed or absent lymphatic uptake, visualization of collateral channels, dermal backflow (tracer remaining in skin), absence of lymph node visualization.
                              2. Indocyanine Green (ICG) Lymphography Fluorescent dye (ICG) injected intradermally and illuminated with near-infrared light. Visualizes superficial vessels. Shows "dermal backflow," abnormal patterns ("splashes," "stardust"), and areas of obstruction. Useful for surgical planning.
                              3. Magnetic Resonance Lymphangiography (MRL) Uses MRI (with/without contrast) to visualize deeper lymphatic vessels and nodes. Identifies vessel abnormalities, lymph node status, and differentiates lymphedema from other conditions.
                              4. Ultrasonography (Ultrasound) Primarily used to rule out DVT or cysts, and assess tissue thickness. Increased subcutaneous tissue thickness, "honeycomb" patterns (dilated channels), thickening of dermis.
                              5. CT Scan & MRI Assess tumor involvement, quantify limb volume, differentiate from lipedema. Show characteristic patterns of subcutaneous edema and thickening.
                              IV. Differential Diagnosis
                              • Chronic Venous Insufficiency (CVI): Often bilateral, varicose veins, skin discoloration (brawny), ulcers.
                              • Cardiac Edema (CHF): Bilateral, symmetrical, pitting, shortness of breath, JVD.
                              • Renal Edema: Bilateral, symmetrical, pitting, facial puffiness.
                              • Hepatic Edema: Ascites, jaundice, bilateral pitting edema.
                              • Hypothyroidism (Myxedema): Non-pitting edema.
                              • Lipedema: Chronic adipose disorder (mostly women), symmetrical, painful fat accumulation, feet spared, Stemmer's sign negative.
                              • Deep Vein Thrombosis (DVT): Acute, unilateral, painful, warmth, redness.
                              Management and Treatment Options

                              The goal is to reduce swelling, prevent progression, manage symptoms, and improve quality of life. Treatment is primarily conservative.

                              I. Conservative Management: Complete Decongestive Therapy (CDT)

                              The cornerstone of treatment. A two-phase program.

                              Phase I: Intensive Treatment (Decongestion Phase)
                              1. Manual Lymphatic Drainage (MLD):
                                • Description: Gentle, rhythmic massage to stimulate flow and reroute lymph.
                                • Mechanism: Promotes lymphangiomotoricity and opens alternative pathways.
                              2. Compression Bandaging:
                                • Description: Multiple layers of short-stretch bandages applied to the limb.
                                • Mechanism: Provides external pressure to reduce swelling, improve muscle pump efficiency, and break down fibrotic tissue. Worn 24 hours/day.
                              3. Skin Care:
                                • Description: Meticulous hygiene and moisturizing.
                                • Mechanism: Prevents infection (cellulitis) in compromised skin.
                              4. Decongestive Exercises:
                                • Description: Low-impact exercises worn with compression.
                                • Mechanism: Activates muscle pump to move fluid.
                              5. Education: Self-care techniques and infection prevention.
                              Phase II: Maintenance Treatment (Self-Management Phase)
                              1. Compression Garments: Custom-fitted or ready-to-wear garments worn daily. Replace bandages once volume is stabilized.
                              2. Self-MLD: Patients taught simplified techniques.
                              3. Self-Bandaging: Applied at night or during flare-ups.
                              4. Regular Exercise & Lifelong Skin Care.
                              5. Regular Follow-ups.
                              II. Additional Conservative Modalities
                              • Pneumatic Compression Pumps: Devices applying sequential pressure. Adjunct to CDT.
                              • Weight Management: Crucial for obese patients to reduce mechanical compression on vessels.
                              III. Surgical Interventions
                              A. Reconstructive/Physiologic Procedures (Aim to improve function):
                              1. Lymphaticovenous Anastomosis (LVA) / Bypass (LVB):
                                • Description: Microsurgical connection of lymphatic vessels to small veins.
                                • Mechanism: Bypasses obstruction by draining into venous system.
                                • Indication: Early to moderate lymphedema.
                              2. Vascularized Lymph Node Transfer (VLNT):
                                • Description: Transplantation of healthy lymph nodes to the affected area.
                                • Mechanism: Provides new drainage pathways and growth factors.
                              B. Excisional/Ablative Procedures (Aim to reduce volume):
                              1. Direct Excision/Debulking: Surgical removal of excess fibrotic tissue. For very advanced/disfigured limbs.
                              2. Liposuction (Suction-Assisted Lipectomy):
                                • Description: Removal of excess adipose tissue.
                                • Indication: Chronic Stage 2 or 3 where maximal decongestion is achieved but fat remains. Requires lifelong compression post-op.
                              NURSING DIAGNOSES AND INTERVENTIONS
                              A. Impaired Tissue Integrity
                              • Related to: Edema, altered circulation, chronic inflammation, skin changes.
                              • As evidenced by: Swelling, thickened skin, discoloration, fissures, positive Stemmer's sign.
                              • Interventions:
                                • Assess skin integrity daily: Inspect for redness, warmth, cracks, blisters, signs of infection.
                                • Provide meticulous skin care: Wash daily with mild soap, pat dry (especially folds). Apply low pH, non-perfumed moisturizer.
                                • Protect skin from injury: Wear gloves for chores, use electric razor, avoid tight clothing/jewelry.
                                • Elevate affected limb when resting.
                                • Implement wound care protocols for breakdown.
                                • Ensure proper fit of compression garments to prevent irritation.
                              B. Risk for Infection
                              • Related to: Accumulation of protein-rich fluid (bacterial medium), altered skin integrity, decreased local immune response.
                              • Interventions:
                                • Educate on signs of infection: Redness, warmth, increased swelling, pain, fever, streaks. Report immediately.
                                • Emphasize strict skin care regimen.
                                • Advise on avoiding trauma: Prevent cuts, insect bites, sunburns, needle sticks (no blood draws/BP in affected limb).
                                • Discuss prophylactic antibiotics if history of recurrent cellulitis.
                                • Encourage prompt treatment of minor cuts with antiseptic.
                              C. Chronic Pain
                              • Related to: Tissue distension, nerve compression, fibrosis, heavy limb.
                              • Interventions:
                                • Assess pain characteristics.
                                • Administer prescribed analgesics.
                                • Implement non-pharmacological strategies: Elevation, cold/warm packs (caution with sensation), gentle massage, relaxation.
                                • Ensure proper fit of compression garments to avoid constriction.
                                • Encourage gentle exercises to reduce stiffness.
                              D. Impaired Physical Mobility
                              • Related to: Increased limb size/weight, stiffness, fear of injury.
                              • Interventions:
                                • Assess mobility and ROM.
                                • Encourage gentle active/passive ROM exercises.
                                • Collaborate with PT/OT for tailored programs.
                                • Instruct on proper body mechanics.
                              E. Disrupted Body Image
                              • Related to: Limb disfigurement, clothing difficulties.
                              • Interventions:
                                • Provide safe environment to express feelings.
                                • Listen actively and empathetically.
                                • Focus on functional improvements rather than just cosmetic.
                                • Suggest coping strategies: Clothing choices, support groups, counseling.
                              F. Inadequate Health Knowledge / Ineffective Health Maintenance
                              • Related to: Complexity of treatment, lack of information, barriers to adherence.
                              • Interventions:
                                • Assess current knowledge and learning style.
                                • Provide clear education on: MLD, compression, skin care, infection prevention, signs of complications.
                                • Use teach-back method.
                                • Provide written materials/videos.
                                • Address barriers (cost, time).
                                • Refer to Certified Lymphedema Therapist (CLT).
                              III. Collaborative Interventions
                              • Certified Lymphedema Therapist (CLT): Essential for CDT implementation.
                              • Physician/Specialist: Diagnosis and medical management.
                              • PT/OT: Functional adaptations.
                              • Dietitian: Weight management.
                              • Social Worker/Psychologist: Emotional support.

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